Bio

Ashutosh Agarwal is an Associate Professor in the Department of Biomedical Engineering and Department of Pathology at the University of Miami Miller School of Medicine. He completed his postdoctoral research in Biomedical Engineering at Columbia University, and at the Wyss Institute for Biologically Inspired Engineering at Harvard University. The mission of his Physiomimetic Microsystems Laboratory at the University of Miami is to develop human relevant organ mimic platforms for discovery of therapies and drugs, for modeling of disease states, for conducting mechanistic studies, and for differentiation, maturation and evaluation of stem cells.

Projects

• Engineering a Human Physiomimetic Islet Microsystem
• Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems
• Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Ashu+Agarwal

Projects

• Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses

Bio

Juan Alvarez is a HIRN Emerging Leader Award Recipient and an Assistant Professor of Cell and Developmental Biology at the University of Pennsylvania Perelman School of Medicine. His research focuses on human stem cell-derived pancreatic islet organoids and mice as model systems to study islet development, physiology, and pathology, and to develop replacement therapies for insulin-dependent diabetes. We focus on the interplay between circadian rhythms, metabolism, and islet cell maturation.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-juan-r-alvarez

Projects

• Measuring Islet-wide Function with Soft Integrated Nanoelectronics

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=juan+alvarez

Bio

Dr. Justin Annes specializes in the treatment of hereditary endocrine disorders with particular focus on neuroendocrine-related conditions. He developed the Stanford Endocrine Genetics Clinic in 2012 which is part of the interdisciplinary Stanford Hypertension Center and Stanford Neuroendocrine Tumor Program. Additionally, he has had a medical practice focused on hereditary endocrine disease since 2008.

Projects

• Developing a Platform Technology for β-Cell-Targeted Drug Delivery

Bio

Guillermo Arreaza-Rubin is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in diabetes and endocrine disease bioengineering and glucose sensing.

Bio

Peter Arvan is the Division of Metabolism, Endocrinology, & Diabetes at the University of Michigan. His research focus is to examine molecular mechanisms involved in the folding, trafficking, and targeting of newly-synthesized endocrine secretory proteins

Projects

• A Stress-Induced Vicious Cycle in the Development of T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Peter+Arvan

Projects

• A microwell perfusion plate for manufacturing and testing Islet-like clusters

Bio

Mark Atkinson is currently the American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at the University of Florida. He also is the Director of the Diabetes Institute at the University of Florida. Additionally, he is the Executive Director of the JDRF Network for Pancreatic Organ donors with Diabetes (nPOD) program and the President of Insulin for Life USA, the world’s second largest charity dedicated to providing insulin to persons living with diabetes in the developing world. His research focuses on type 1 diabetes, pancreatic pathology, immune therapy, autoimmunity, clinical trials, translational research, emerging technologies, psychosocial behaviors, and metabolism.

Projects

• Defining Islet Heterogeneity Using Single Islet Transcriptomics
• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• Integrated Program for Human Pancreas Procurement and Analysis
• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry
• Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Mark+Atkinson

Bio

Rhonda Bacher is an Assistant Professor of Biostatistics at the University of Florida. Her research focuses on the development of statistical methods and computational tools for analyzing high-throughput genomic and next-generation sequencing data. My current focus is on single-cell transcriptomics and epigenomics and time-course transcriptomics.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_rbacher?hilite=rhonda

Projects

• Driving Next Generation UPR Inhibitory Kinase Inhibitors for T1D

HIRN Investigator Profile:

https://hirnetwork.org/hirecstaff_nberger

Projects

• Human Islet Research Enhancement Center (HIREC)

HIRN Investigator Profile:

https://hirnetwork.org/hirec-staff-sandy-beshir

Projects

• Human Islet Research Enhancement Center (HIREC)

Projects

• Identification of Novel Regulatory Mechanisms Driving Human Beta-Cell Maturation and Function

Projects

• Positron emission tomography to characterize beta cell mass in individuals from multiple stages in the progression of type 1 diabetes

Bio

Olivier Blondel is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests lie in research that focuses on endocrine signaling, stem cell biology, organ development, regenerative medicine and biomarker discovery as it relates to diabetes (type 1 and type 2) and metabolic diseases, particularly in combination with experimental approaches such as large-scale genomics, synthetic biology, bioengineering, epigenetics, nuclear organization of mammalian genomes, chromatin biology, genome editing, gene therapy

Bio

Michael Brehm is an Associate Professor of Molecular Medicine and Co-Director of the Humanized Mouse Core Facility at UMass Chan Medical School. He works with these unique animal models of human immune responses to investigate approaches to downregulate as well as activate the human immune system for treatments of type 1 diabetes (T1D) and cancer. Dr. Brehm studies human beta cells from individuals with type 1 diabetes in a real-life setting as they interact with intact T1D immune systems.

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Michael+Brehm

HIRN Webinar:

Bio

Marcela Brissova is an Research Professor of Medicine and Director of the Islet Procurement & Analysis Core at Vanderbilt University. She is also the Director of the Human Islet Phenotyping Program (HIPP) of IIDP. Her research focuses on the biology of pancreatic islets and pancreas and islet development, especially the development of pancreatic islet vasculature and innervation and their role in regulation of pancreatic islet function.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_brissova?hilite=Marcela+Brissova

Projects

• Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution
• In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas
• High-Resolution Analysis of Juvenile Human Pancreas Maturation
• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• Integrated Program for Human Pancreas Procurement and Analysis
• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/Contributor/Index/marcela_brissova@hirnetwork.org

Bio

Todd Brusko is a Professor at Department of Pathology, Immunology and Laboratory Medicine and the scientific director at University of Florida Diabetes Institute (UFDI). The research aims of Dr. Brusko’s academic lab are centrally themed around understanding the mechanisms by which the immune system maintains a state of control, often referred to as immunological tolerance and understanding how genetic risk variants and age influence this process, as well as identifying pathway defects in individuals who develop autoimmune diseases. These studies have focused primarily on genes impacting key checkpoints in T cell activation, including T cell receptor (TCR) signaling, co-stimulation, and the IL-2 signaling pathway. His laboratory is involved a number of ongoing team science initiatives including an NIH-NIAID P01 grant, NIH Director’s Initiative – Human BioMolecular Atlas Program (HuBMAP), Brehm Coalition, and the JDRF biomarker working group and autoimmunity working group.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_tbrusko?hilite=todd+brusko

Projects

• Genetic Regulation of Human Beta Cell Destruction
• Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
• Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D
• Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=todd+brusko

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas

Bio

Alejandro Caicedo is a Professor of Medicine at the University of Miami Miller School of Medicine. iginally trained as a sensory neurobiologist, Dr. Caicedo started working in the field of pancreatic islet biology in 2005. His work focuses on fundamental aspects of the anatomy and physiology of the human islet. His primary goal is to provide detailed knowledge of islet biology that is relevant to understand the control of glucose homeostasis and its derangement in diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_caicedo

Projects

• Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution
• In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas
• High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential
• Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Alejandro+Caicedo

HIRN Webinar:

Bio

Martha Campbell-Thompson is a Professor, Director of the Molecular Pathology Core at the University of Florida and Director of the JDRF nPOD Organ Procurement and Pathology Core. Her research interests are in beta cell biology, beta cell regeneration for type 1 diabetes, islet inflammation and neuromodulation of beta cell function.

Projects

• Defining Islet Heterogeneity Using Single Islet Transcriptomics
• Survival and Potential of Insulin-deficient Beta Cells in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Martha+Campbell+Thompson

HIRN Webinar:

Projects

• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Bio

Shuibing Chen is a Professor in the Department of Surgery and Department of Biochemistry at Weill Cornell Medical College. Her research interest is to manipulate stem cell fate using chemical and biological approaches and to generate functional tissues and organs that can be used for translational research.

Projects

• Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression
• Decoding the Cell-specific Impact of Epigenomic and Alternative Splicing Regulation during T1D Progression
• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Shuibing+Chen

Projects

• GABP is a novel regulator of beta cell metabolism and proliferation

Bio

Remi Creusot is an Associate Professor in the Department of Medicine at Columbia University Medical Center and an Investigator within the Columbia Center for Translational Immunology and the Naomi Berrie Diabetes Center. His research interests revolve around the pathogenesis and prevention of Type 1 Diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_rcreusot?hilite=Remi+Creusot

Projects

• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Bio

Chunhua Dai is a Research Associate Professor in the Powers & Brissova Research Group at Vanderbilt University. Her research focuses on the molecular, cellular, and vascular changes in human islets when they are challenged with hyperglycemia and/or insulin resistance in vivo. She is investigating in vivo age-dependent human beta cell proliferation and how current therapeutic agents for type 2 diabetes preserve and/or enhance human beta cell function or survival in vivo.

Projects

• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Chunhua+Dai

Bio

George Daley is Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. His research seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered human cell culture-based and murine models of human blood disease and cancer.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_gdaley?hilite=George+Daley

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=George+Daley

Projects

• Using ex vivo, in vivo Models and Patient Mutations to Interrogate Pancreatic Exocrine-Endocrine Cross Talk

Projects

• The Role of Granular Acidification in the Pathogenesis of Type 1 Diabetes

Bio

Nicolai Doliba is a Research Associate Professor of Biochemistry and Biophysics at the University of Pennsylvania. His research focuses on the role of bioenergetics, ion transport and metabolic coupling factors in nutrient- and drug-stimulated insulin release at normal conditions and during diabetes mellitus.

Projects

• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)

Bio

Juan Dominguez-Bendala is a Research Professor of Surgery at the Diabetes Research Institute, University of Miami Miller School of Medicine. He is also the Director of Stem Cell & Pancreatic Regeneration and Research Professor of Surgery at the Diabetes Research Institute (DRI). His research focuses on the use of stem cells to obtain pancreatic islets that could potentially be transplanted into patients with type 1 diabetes. He is also currently working on new methods for expansion/regeneration of pancreatic beta cells.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_bendala?hilite=Juan+Dominguez-Bendala

Projects

• High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential
• Using ex vivo, in vivo Models and Patient Mutations to Interrogate Pancreatic Exocrine-Endocrine Cross Talk

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Juan+Dominguez-Bendala

Bio

Thomas Eggerman is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in cystic fibrosis research and translation centers, inborn errors of metabolism, clinical trials, and islet transplantation, and inborn errors of metabolism.

Bio

Carmella Evans-Molina is the Director of the Indiana University Center for Diabetes and Metabolic Diseases, J. O. Ritchey Professor of Medicine and Pediatrics at Indiana University School of Medicine, and Director of the IDRC Islet and Physiology Core.. She directs the Diabetes Research Program in the Herman B. Wells Center for Pediatric Research and is a staff physician at the Richard L. Roudebush VA Medical Center. Her research is focused on defining the molecular and inflammatory etiologies of β-cell dysfunction that contribute to diabetes pathophysiology. She has a clinical research interest focused on leveraging activation of β-cell stress pathways to inform the development of biomarkers that predict diabetes risk and define disease endotypes.

Projects

• Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
• Interferon Signaling in the T1D Islet Microenvironment
• Integrated Stress Response in Human Islets during Early T1D
• Workshop for Continued Harmonization of Beta Cell Death Assays

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Carmella+Evans-Molina

Bio

Robert Babak Faryabi is an Assistant Professor of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. His research goal is to understand the epigenetic mechanisms of transcriptional addiction in cancer and exploit this information to advance cancer therapeutics.

Projects

• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)

Bio

Leonardo Ferreira is a HIRN Emerging Leader Award Recipient and an Assistant Professor of Microbiology and Immunology at the Medical University of South Carolina. His research focuses on phenomenon of immune tolerance, his long term goal is to control how the immune system defines self and non-self. Such knowledge will allow the design and development of powerful new engineered immune cell therapies to fight autoimmune disease, cancer, and aging.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-leonardo-m-r-ferreira

Projects

• Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D

Bio

Paul Gadue is a Professor of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania. His laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using human ES cells and iPS cells. ES/iPS cells can differentiate into all cell types in the body and can be propagated in culture almost indefinitely, generating a virtually unlimited supply of cells. These unique characteristics lead to the exciting prospect of using these cells to study disease processes and developmental pathways in vitro and eventually to treat a wide variety of diseases using cell replacement therapies.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_pgadue?hilite=Gadue

Projects

• Functional Testing of Candidate HSC-derived Islet Cells
• Generation of Functional Endocrine Cell Reporter Pluripotent Cell Lines
• Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes
• A Vascularized 3D Biomimetic for Islet Function and Physiology

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Paul+Gadue

Bio

Kyle Gaulton is an Associate Professor in the Department of Pediatrics at the University of California, San Diego. His research focuses on human genetics and single cell genomics to define cell type-specific gene regulatory programs that affect risk of complex disease, in particular type 1 diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_gaulton?hilite=Kyle+Gaulton

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas
• Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Kyle+Gaulton

HIRN Webinar:

Bio

George Davis is a Professor and the Department Chair of Biomedical Engineering at the University of California, Davis. His research uses stem cell, microfluidic and computational technologies to develop 3D mimics of human organs, known as "organs-on-a-chip." The lab specifically focuses on cancer (pancreatic, colorectal and breast), the cardiovascular system (perfused microcirculation, cariomyocytes) and the pancreas.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_sgeorge?hilite=Steven+George

Projects

• A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
• A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Steven+George

Bio

Anna Gloyn is a Professor of Pediatrics, Endocrinology and Genetics at Stanford University. Her research uses human genetics as a tool to understand cellular and molecular mechanisms for pancreatic beta cell failure in diabetes and related conditions. he aim of her research is to capitalize on an improved mechanistic understanding of pancreatic islet cell dysfunction to improve treatment options for patients via the identification of safe and effective therapeutic targets (drug development) and patient stratification (precision medicine).

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas
• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)

Bio

Robin Goland is a Professor of Medicine and Pediatrics at Columbia University, and directs the patient care and clinical research programs at the Berrie Diabetes Center.

Projects

• Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Robin+Goland

Bio

Dale Greiner is the Chair in Biomedical Research and Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. His research focuses on the development and use of a unique mouse model, engrafted with functional human cells and tissues. His work has generated high interest in the biomedical research community for use as a preclinical model for the investigation of human diabetes, cancer, infectious disease, regenerative medicine and autoimmunity.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_dgreiner?hilite=Dale+Greiner

Projects

• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Dale+Greiner

Bio

Manami Hara is a Research Professor in the Division of Endocrinology, Diabetes and Metabolism at the University of Chicago. Her research focus is on the developmental biology of pancreatic islets. The islet of Langerhans is a micro-organ composed of insulin-secreting beta-cells and other endocrine cells that work together to maintain glucose homeostasis.

Projects

• Integrated Stress Response in Human Islets during Early T1D
• Role of Pancreatic Elastase in Beta Cell Health, Autoimmunity and Type 1 Diabetes

HIRN Webinar:

Bio

Dale Greiner is a Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. He has led basic and clinical research exploring the pathophysiology underlying diabetes. Dr. Harlan conducts clinical trials to test new therapies and explain human biology as it relates to diabetes and its treatment. His current research focuses on exploring beta cell biology and the anti-beta cell immune response underlying type 1 diabetes.

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=David+Harlan

Bio

Kevan Herold is the C.N.H. Long Professor of Immunobiology and of Medicine at Yale School of Medicine. He studies autoimmune diseases, whether they occur naturally or as a consequence of immunomodulator therapy.

Projects

• Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D
• Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Kevan+Herold

Bio

Christopher Hughes is a Professor of Molecular Biology and Biochemistry School of Biological Sciences and Professor of Biomedical Engineering at the University of California, Irvine. His lab has identified several genes involved in regulating the multiple steps of angiogenesis and are developing reagents to specifically interfere with these processes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_chughes?hilite=Chris+Hughes

Projects

• A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
• Modular Monitoring of Hormone Release from Human Islets
• A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes
• Studying the Mechanisms of Initiation and Progression of Beta Cell Death in T1D

Bio

Dan Huh is an Associate Professor of Engineering at the University of Pennsylvania. He is a pioneer of “organ-on-a-chip” technology, and his research group at Penn focuses on developing microengineered models of human physiological systems for a wide variety of biomedical applications.

Projects

• Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes
• A Vascularized 3D Biomimetic for Islet Function and Physiology

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Dan+Huh

HIRN Webinar:

Bio

Albert Hwa is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in the basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease; generation of islet cells from stem cells for disease modeling and regenerative medicine.

Lab:

https://tinyurl.com/kaddislab

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_jkaddis

Projects

• Human Islet Research Enhancement Center (HIREC)

HIRN Webinar:

Bio

Klaus Kaestner Professor in Genetics at the Perelman School of Medicine at the University of Pennsylvania and the Director of the Functional Genomics Core at the University of Pennsylvania. His research interest is in employing modern genetic, genomic and epigenomic approaches (ChIP-Seq, RNA-Seq, gene targeting, tissue-specific and inducible gene ablation, CyTOF) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. Disease areas targeted by our research include diabetes and cancer.

Projects

• Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
• Epigenetic Rejuvenation of Human Beta-Cells
• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)
• The Role of Senescent Beta Cells in Type 1 Diabetes and Type 2 Diabetes
• Beta Cell Death in early Type 1 Diabetes caused by Innate Immune Response to Inefficient RNA Editing
• A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
• Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes?
• Mass Spectrometry-based Proteome Maps for Human Islet Cells

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Klaus+Kaestner

HIRN Webinar:

Projects

• Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses

Projects

• Decoding the Cell-specific Impact of Epigenomic and Alternative Splicing Regulation during T1D Progression

Projects

• Beta Cell Death in early Type 1 Diabetes caused by Innate Immune Response to Inefficient RNA Editing

Projects

• Interferon Signaling in the T1D Islet Microenvironment

Bio

Vira Kravets is a HIRN Emerging Leader Award Recipient. She recently accepted a position as an Assistant Professor II at the University of California San Diego. Jointly appointed to the Department of Bioengineering and Department of Pediatrics. She is currently leading interdisciplinary projects in search for the underlying causes for Diabetes. Juvenile Diabetes Research Foundation supported Fellow, skilled in Islet Biology, Surface Plasmon Resonance, Microscopy, Optics and Public Speaking

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-vira-kavets

Projects

• Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets

Bio

Rohit Kulkarni is a Professor of Medicine at Harvard Medical School and Co-Head of the Section on Islet & Regenerative Biology at Joslin Diabetes Center. His research explores the significance of growth factor signaling mechanisms in the regulation of islet biology by creating genetic models to examine the roles of insulin/IGF-1 receptors and their substrate proteins.

Projects

• Development of platforms for beta cell-specific delivery and ligand discovery
• Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
• Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes
• Using ex vivo, in vivo Models and Patient Mutations to Interrogate Pancreatic Exocrine-Endocrine Cross Talk
• Role of Pancreatic Elastase in Beta Cell Health, Autoimmunity and Type 1 Diabetes
• Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
• One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Rohit+Kulkarni

HIRN Webinar:

Bio

Irina Kusmartseva is the Director of the JDRF nPOD Organ Processing and Pathology Core. She has unique experience with the molecular and primary cell culture. Her key area of expertise includes mechanisms of immunoregulation in inflammation, cancer and autoimmune diseases.

Projects

• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• Integrated Program for Human Pancreas Procurement and Analysis

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Irina+Kusmartseva

Bio

Maggie Lam is an Assistant Professor in the Division of Cardiology at the University of Colorado Anschutz Medical Campus. Her research focuses on mass spectrometry and computational techniques to understand the mechanisms driving disease progression in humans, protein dynamics, protein alternative isoform, and protein annotation methods.

Projects

• Alternative RNA splicing events contribute to the onset of islet dysfunction in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Maggie+Lam

Bio

Karla Leavens is a HIRN Emerging Leader Award Recipient and Pediatric Endocrinologist in the Division of Endocrinology at Children's Hospital of Philadelphia. She is also a Postdoctoral Research Fellow in the Gadue Lab.

Lab:

https://hirnetwork.org/about/participants#short-profile-paul-gadue-phd

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-karla-leavens

Projects

• Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes
• A Vascularized 3D Biomimetic for Islet Function and Physiology

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=karla+leavens

Projects

• Integrated Stress Response in Human Islets during Early T1D

Projects

• Beta Cell Death in early Type 1 Diabetes caused by Innate Immune Response to Inefficient RNA Editing

Projects

• Interferon Signaling in the T1D Islet Microenvironment

Bio

Chengyang Liu is an Adjunct Professor of Surgery and the Director of the Human Islet Laboratory & Clinical GMP Facility at the University of Pennsylvania School of Medicine.

Projects

• Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression
• Decoding the Cell-specific Impact of Epigenomic and Alternative Splicing Regulation during T1D Progression

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Chengyang+Liu

Bio

Jing Liu is a Gateway Award Recipient and an Assistant Professor of Physics in the Department of Science at the Indiana University-Purdue University at Indianapolis School of Science. His lab focuses on the development of cutting-edge imaging methods and computational image processing/analysis algorithms to quantitatively interpret the complexity of images.

Projects

• Image based spatial transcriptomics to identify Beta Cell phenotypes in Type 1 Diabetes
• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Projects

• Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution

Projects

• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies

Bio

Patrick MacDonald is Professor of Pharmacology at the University of Alberta and the Director of the Alberta Diabetes Institute (ADI) IsletCore. His research focuses on pancreatic islet function in health and diabetes. The research from his laboratory has spanned areas that include biophysical characterization of ion channels, intracellular signal transduction and exocytosis, and the cellular regulation of glucagon secretion.

HIRN Investigator Profile:

https://hirnetwork.org/?s=Patrick+MacDonald

Projects

• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Linking Islet Cell Function and Identity from in vitro to in situ

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Patrick+MacDonald

Bio

Clayton Mathews is a Professor of Pathology, Immunology, and Laboratory Medicine at the University of Florida. His studies seek to improve our collective understanding on the means by which type 1 diabetes develops, both in humans and in mouse models of the disease. His efforts are extremely novel in that while the majority of researchers addressing the notion of how the disease develops focus on identifying defects in cells of the immune system.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_cmathews?hilite=Clayton+Mathews

Projects

• Defining Islet Heterogeneity Using Single Islet Transcriptomics
• Genetic Regulation of Human Beta Cell Destruction
• Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata
• Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
• Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Clayton+Mathews

Bio

Michael McManus is a Professor in the Department of Microbiology and Immunology at the University of California, San Francisco and a member of the Chan Zuckerberg Biohub, the Helen Diller Comprehensive Cancer Center, the Diabetes Center, the Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, and the Innovative Genomics Institute.

Projects

• iSTAR Tregs

Bio

Thomas Metz is a principal investigator in the Integrative Omics group within the Biological Sciences Division and is the team lead for a group of scientists that focuses on development and applications of high throughput metabolomics and lipidomics methods to various biological questions. His research interests span the development of both untargeted and targeted metabolomics and lipidomics capabilities, based on liquid and gas chromatography coupled with mass spectrometry, both for fundamental studies of metabolism and metabolic interactions

Projects

• Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
• Integrated Stress Response in Human Islets during Early T1D
• Single Cell Resolution of Omics Analysis of T1D Islets

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=thomas+metz

Bio

Everett Meyer is an Assciate Professor of Medicine at Stanford University Medical School. His research focus is in hematopoietic stem cell transplantation and Treg cell immunotherapy, with an emphasis on the treatment of graft-versus-host disease as well as immune tolerance induction for transplantation and autoimmunity. He is an expert on the role of T-cell populations in immune dysregulation, specifically through the mechanistic study of how CD1d-restricted invariant NKT mediate allergy and asthma in both mouse models and human clinical samples.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_emeyer?hilite=Everett+Meyer

Projects

• CAR T Cell Targeting of Human Islets
• Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells

Bio

Jeffrey Millman is an Associate Professor of Medicine and Biomedical Engineering at Washington University School of Medicine in St Louis. His research focus is in the in vitro production and study of pancreatic insulin-producing β cells from human pluripotent stem cells for use in cellular replacement therapy and drug screening.

Projects

• Epigenomic Engineering of Stem Cell-Derived Pancreatic Cells
• Studying the Mechanisms of Initiation and Progression of Beta Cell Death in T1D

Bio

Raghavendra Mirmira is the Director of the Department of Medicine Translational Research Center and Professor of Medicine in the Department of Endocrinology, Diabetes and Metabolism at the University of Chicago. His research focuses his efforts on the pathogenesis of diabetes mellitus and the biology of the islet. His laboratory is interested in three key areas: the role of mRNA translation in the cellular response of islet β cells to inflammation; the role of lipoxygenases in dysfunction of β cells in Type 1 and Type 2 diabetes; and the identification of biomarkers of β-cell stress and death in diabetes.

Projects

• Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
• Interferon Signaling in the T1D Islet Microenvironment
• Integrated Stress Response in Human Islets during Early T1D
• Role of Pancreatic Elastase in Beta Cell Health, Autoimmunity and Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Mirmira

HIRN Webinar:

Projects

• Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses

Bio

Ali Naji is Professor of Surgical Research at the University of Pennsylvania School of Medicine and the Associate Director of the Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine. His research efforts have focused on the immunobiology of transplantation and immune pathogenesis of autoimmune diabetes

Projects

• Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)
• Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=ali+naji

Bio

Ernesto Nakayasu is a senior research scientist focused on understanding molecular mechanisms of diseases. Nakayasu has been applying systems biology and mass spectrometry-based omics measurements to study how pathogens and metabolic alterations cause human diseases; the goal is to identify diagnostic and therapeutic targets. He has been integrating multi-omics approaches to develop biomarkers of diseases and to study signaling and metabolic pathways that are altered or targeted in infectious and metabolic diseases.

Projects

• Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
• BioStructure & Function Team Leader
• Interferon Signaling in the T1D Islet Microenvironment
• Alternative RNA splicing events contribute to the onset of islet dysfunction in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=ernesto+nakayasu

Bio

Joyce Niland, Ph.D., holder of City of Hope’s Estelle & Edward Alexander Chair in Information Sciences, is professor and chair in the Department of Diabetes & Cancer Discovery Science within the Diabetes & Metabolism Research Institute at City of Hope. An internationally recognized leader in her field with hundreds of publications to her name, she has more than 30 years of experience in biostatistics, biomedical informatics, computational statistics, system development and deployment, and collaboration in translational research.

Lab:

https://tinyurl.com/nilandlab

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_jniland

Projects

• Human Islet Research Enhancement Center (HIREC)

HIRN Webinar:

Projects

• Human Islet Research Enhancement Center (HIREC)

Bio

Scott Oakes’s laboratory studies how mammalian cells commit “suicide” in response to various forms of damage and what goes wrong with this process in cancer and other diseases. In particular, they focus on a type of stress that occurs when the cell’s protein folding factory—an organelle called the endoplasmic reticulum—is overwhelmed and protein quality control fails. He is actively engaged in developing drugs to control cell fate under these conditions, which have potential to benefit patients with diseases from cancer to neurodegeneration.

Projects

• Interferon Signaling in the T1D Islet Microenvironment
• Integrated Stress Response in Human Islets during Early T1D
• Role of Pancreatic Elastase in Beta Cell Health, Autoimmunity and Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=scott+oakes

Projects

• Decoding the Cell-specific Impact of Epigenomic and Alternative Splicing Regulation during T1D Progression

Bio

Audrey Parent is a CMAI co-Investigator and a member of the Trans-Network Committee (TNC). She is Assistant Adjunct Professor and her research is focused on immune tolerance with a particular interest in the thymus.

Projects

• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies
• iSTAR Tregs

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Audrey+Parent

Bio

Stephen Parker is an Associate Professor of Computational Medicine and Bioinformatics at the University of Michigan. The major goal of his lab is to generate mechanistic knowledge about how disease susceptibility is encoded in the non-coding portion of the genome, with a focus on type 2 diabetes.

Projects

• Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution
• Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression
• Decoding the Cell-specific Impact of Epigenomic and Alternative Splicing Regulation during T1D Progression
• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=stephen+parker

Bio

Edward Phelps is an Assistant Professor in the Department of Biomedical Engineering at the University of Florida. His research focuses on biomaterials, regenerative medicine and immunoengineering.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_ephelps?hilite=Ed+Phelps

Projects

• Engineering a Human Physiomimetic Islet Microsystem
• Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Ed+Phelps

Bio

Al Powers is a Professor of Medicine, Molecular Physiology and Biophysics at Vanderbilt University. He is also the Director of the Vanderbilt Diabetes Center, Director of the Vanderbilt Diabetes Research and Training Center, and Chief of the Vanderbilt Division of Diabetes, Endocrinology, and Metabolism. His research focuses on pancreatic islet biology, vascularization, development, regeneration, and imaging.

Projects

• Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution
• High-Resolution Analysis of Juvenile Human Pancreas Maturation
• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• Integrated Program for Human Pancreas Procurement and Analysis
• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
• Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata
• Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Al+Powers

Bio

Sasanka Ramanadham is a Professor in the Department of Cell, Developmental and Integrative Biology (CDIB) and senior scientist in the Comprehensive Diabetes Center (UCDC).

Projects

• Integrated Stress Response in Human Islets during Early T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=sasanka+ramanadham

HIRN Investigator Profile:

https://hirnetwork.org/hirecstaff_lrouse

Projects

• Human Islet Research Enhancement Center (HIREC)

Bio

Holger Russ is a HIRN New Investigator and recently became an Associate Professor at the University of Florida, Department of Pharmacology and Therapeutics and the Diabetes Institute. His research focuses on using human stem cells to generate novel sources of beta cells for transplantation and to model human T1D in a dish.

HIRN Investigator Profile:

https://hirnetwork.org/profile-rholger

Projects

• Elucidating the Human Beta Cell Translatome in Health and Disease
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Holger+Russ

Bio

Nilanjana Samanta is the Data Curator for the Human Pancreas Analysis Program (HPAP) Pancreas Database (PancDB). She uses her data analysis skills for meaningful interpretation of factors associated with health outcomes, monitor healthcare access, and health disparity.

Bio

Dr. Leslie Satin is a Professor of Pharmacology in the University of Michigan Medical School. Dr. Satin’s research has combined several strands, involving studies of the electrophysiology of neurons and synaptic changes after traumatic brain injury, the production of oscillations in neurosecretory cells and their theoretical basis, and the regulation of intracellular free Calcium and ion channels by cell fuel metabolism. Dr. Satin is an expert on the cellular signaling mechanisms, ion channel biophysics, the application of theoretical models to biomedical systems, and synaptic mechanisms of plasticity in the brain. He has served on the editorial boards of Neurochemistry International, Endocrinology, Endocrine, Diabetes, J. Biol. Chem., and American Journal of Physiology. He has served on many NIH study sections, including those devoted to TBI and stroke, and diabetes and metabolic diseases.

Projects

• A Stress-Induced Vicious Cycle in the Development of T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Leslie+Satin

Bio

Desmond Schatz, MD is Professor and Interim Chair of Pediatrics, Medical Director of the Diabetes Institute and Director of the Clinical Research Center within the CTSI at the University of Florida, Gainesville. He is the PI of the University of Florida Clinical Center participating in the NIH-funded TrialNet (a founding member of the DPT-1 in 1994). He served as President of Science and Medicine of the American Diabetes Association in 2016.

Projects

• Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms
• Non-invasive Diagnosis of Human Beta Cell Damage and Death
• Survival and Potential of Insulin-deficient Beta Cells in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Desmond+Schatz

Bio

Leonard Shultz is a Professor at the Jackson Laboratory. His research leverages immunodeficient mouse models for translational studies on human hematopoiesis, immunity, autoimmunity, infectious diseases, diabetes, regenerative medicine and cancer.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_lshultz?hilite=Leonard+Shultz

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D
• Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Leonard+Shultz

Projects

• Interferon Signaling in the T1D Islet Microenvironment

HIRN Webinar:

HIRN Webinar: “Update on Type 1 Diabetes (T1D) Screening & Disease Modifying Therapies” – HIRN

Bio

Scott Soleimanpour is an Associate Professor of Internal Medicine and Director for T1D Basic Research in the University of Michigan Caswell Diabetes Center. His lab focuses on the molecular and genetic regulation of the mitochondrial life cycle, with a focus on mitophagy, a pathway to dispose of unhealthy or damaged mitochondria.

Projects

• A Stress-Induced Vicious Cycle in the Development of T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=scott+soleimanpour

Bio

Cherie Stabler is a Professor in the Department of Biomedical Engineering, College of Engineering at the University of Florida. Her research focuses on the engineering of cell-based tissues for the treatment of Type 1 diabetes, specifically the development of novel biomaterials for: cellular encapsulation; three-dimensional scaffolds; and in situ oxygen and drug release. Her laboratory works across the spectrum of research, from polymer development, benchtop studies, and preclinical models, to clinical translation.

HIRN Investigator Profile:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Cherie+Stabler

Projects

• Engineering a Human Physiomimetic Islet Microsystem
• Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Cherie+Stabler

HIRN Webinar:

Bio

Ben Stanger is the Director of the Penn Pancreatic Cancer Research Center (PCRC), the Hanna Wise Professor in Cancer Research, and a Professor of Cell and Developmental Biology at the University of Pennsylvania. His laboratory investigates multiple aspects of pancreatic cancer biology, including metastasis, tumor immunology, metabolism, and therapy resistance. His research integrates mouse models and human data to identify new vulnerabilities that can be assessed clinically. Dr. Stanger is the chair of the Consortium of Human Islet Biomimetics (CHIB) and a member of the Trans-Network Committee (TNC).

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_bstanger

Projects

• Functional Testing of Candidate HSC-derived Islet Cells
• Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes
• A Vascularized 3D Biomimetic for Islet Function and Physiology

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Ben+Stanger

Bio

Lawrence Stern is a Professor of Biochemistry and Molecular Biology at the UMass Chan Medical School. His research interest is in the biochemical processes that underlie cellular recognition and signaling. His lab concentrates on the immune system, because of its intrinsic importance to human health and disease, and because of its treasure of biochemical mechanisms by which cells communicate with their environment and with each other.

Projects

• Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function

Projects

• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Bio

Doris Stoffers is a HPAC Investigator and a member of the Trans-Network Committee (TNC). She is a the Director of the Pancreatic Islet Cell Biology Core, Director of the Pilot Feasibility Program and a Professor of Medicine at the University of Pennsylvania. Her research focuses on the embryonic development and adult regeneration of the endocrine pancreas, and the relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.

Projects

• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)

Bio

Lori Sussel is the Director of Basic and Translational Research at the Barbara Davis Center for Diabetes. The main focus of the Sussel lab is to understand the complex transcriptional networks that regulate development, differentiation and function of the pancreas. Our early studies led to the ground-breaking discovery that a ghrelin-producing “epsilon” cell population normally resides in the fetal islet, and that a close lineage relationship exists between the islet beta and epsilon cell populations. We went on to identify several novel regulatory pathways that are essential for islet lineage specification, normal pancreas development and the maintenance of beta cell maturation.

Projects

• Lactate-mediated Metabolic Reprogramming of Beta Cells in T1D Contributes to their Enhanced Plasticity and Dedifferentiation
• Single Cell Resolution of Omics Analysis of T1D Islets
• Alternative RNA splicing events contribute to the onset of islet dysfunction in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Lori+Sussel

Bio

Megan Sykes is a Professor of Medicine and Professor of Microbiology & Immunology and Surgical Sciences (in Surgery) and Director, Columbia Center for Translational Immunology. Her research focus is on hematopoietic cell transplantation, organ allograft tolerance induction, xenotransplantation tolerance and Type 1 diabetes. The Sykes lab has pioneered minimal conditioning approaches for using HCT to achieve allograft tolerance.

Projects

• Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
• Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
• Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
• Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Megan+Sykes

Bio

Qizhi Tang is a Professor of Transplant Surgery and the Director, Transplantation Research Laboratory at the University of California, San Francisco. Her research focuses on translating knowledge on mechanisms of immune tolerance into novel therapeutics for treating autoimmune diabetes and preventing transplant rejection.

Projects

• Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets
• Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies
• iSTAR Tregs
• Therapeutic Targeting of the Human Islet Environment

Investigator Contributed Resources:

https://www.linkedin.com/in/qizhi-tang-28a0a412/

Bio

Dr. Sarah Tersey is an islet biologist whose research focuses on the role of the ß-cell in the development of type 1 and type 2 diabetes. The primary goal of her research focuses on understanding the molecular pathways that play a role in the development of diabetes. Specifically, pathways that include the enzymes 12-lipoxygnease and deoxyhypusine synthase. By using inhibitors against these pathways or creating genetic deletions of either of these genes, Dr. Tersey has shown that diabetes can be prevented. A second major focus of my research is the development of biomarkers that will best predict the likelihood of any one individual’s risk to develop type 1 diabetes. Within this concept, she demonstrated that the dysfunction of the pancreatic islet precedes the onset of type 1 diabetes. This research has changed the standard dogma of the islet as a silent bystander to the immune system, to the new way of thinking – that the pancreatic islet is a major player in its own demise during the pre-course of type 1 diabetes.

Projects

• Interferon Signaling in the T1D Islet Microenvironment

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=sarah+tersey

HIRN Webinar:

Bio

Luc Teyton is a Professor in the Department of Immunology and Microbiology at Scripps Research. His research focuses on elucidating the molecular mechanisms by which the ligation of the T cell receptor to its ligand, an MHC-peptide complex, activates T cells.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_lteyton?hilite=Luc+Teyton

Projects

• A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes
• Studying the Mechanisms of Initiation and Progression of Beta Cell Death in T1D

HIRN Webinar:

Bio

Dr. Golnaz Vahedi is currently an Associate Professor of Genetics (with tenure) at the Perelman School of Medicine, University of Pennsylvania. Golnaz. She studied Electrical Engineering at Sharif University of Technology in Iran. As an independent investigator, she uses systems-based approaches to understand molecular details of gene regulation in the immune system. She is the recipient of a number of awards including the NIH Director’s Award (twice), NIAID K22 Career Transition Award (perfect score), Alfred P. Sloan Fellowship, Chan Zuckerberg Initiative Award, W. W. Smith Charitable Trust, Burroughs Wellcome Fund, and Michael S. Brown New Investigator Research Award. She serves on the advisory boards of Cell Press journal Immunity and Science Immunology and is a standing member of GCAT study section.

Projects

• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)
• Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Golnaz+Vahedi

HIRN Webinar:

Bio

Ben Voight is Associate Professor of Pharmacology and Director of the Bioinformatics Concentration at the University of Pennsylvania. His lab develops and utilizes statistical genetics, computational biology, and population genetics-based approaches to understand the biological underpinnings and evolutionary history of human traits and complex disease

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas

Bio

Xujing Wang is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her interests are in data science, computation modeling, integrative genomics, network biology, and genotype-phenotype relationships.

Bio

Clive Wasserfall is an Assistant Professor of Pathology at the University of Florida. His research is focused on the immunopathogenesis of Type 1 Diabetes (T1D). His laboratory is involved in immune monitoring of human clinical trails to reverse or prevent T1D while searching for biomarkers of efficacy. Additionally, his laboratory houses the autoantibody screening core for the JDRF network for pancreas organ donors with diabetes (nPOD) program.

Projects

• Survival and Potential of Insulin-deficient Beta Cells in Type 1 Diabetes
• Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Clive+H+Wasserfall

Bio

Bobbie-Jo Webb-Robertson is currently the technical group manager of the Applied Statistics and Computational Modeling group, as well as leading a body of research in the development and application of advanced statistical methods for MS-based omics analyses. Her research interests includes the development of statistical inference models, largely machine learning, with application to diverse biomarker discovery problems.

Projects

• Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
• Integrated Stress Response in Human Islets during Early T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Bobbie+Jo+Web+Robertson

Bio

Matthew Wortham is a Gateway Award Recipient and an Assistant Professor at the University of Colorado Anschutz Medical Campus. His research is to define the mechanisms whereby beta cells detect and respond to changes in their metabolic environment.

Lab:

https://hirnetwork.org/about/participants#short-profile-maike-sander-md

Projects

• A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
• Metabolic requirements of pancreatic beta cell proliferation

Bio

Wenting Wu is an Assistant Research Professor of Medical & Molecular Genetics at Indiana University School of Medicine. Her research interests are in applying the genomics and bioinformatics tools into complex disease mechanism discovery and personalizing medicine, including transcriptome genomics, genomic variations/mutations, epigenetics, long noncoding RNAs etc.

Projects

• Integrated Stress Response in Human Islets during Early T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Wenting+wu

Projects

• Models to Study the Synergy between Autoimmunity and Metabolism in T1D

Projects

• Role of Pancreatic Elastase in Beta Cell Health, Autoimmunity and Type 1 Diabetes

Projects

• Gene regulatory programs driving metabolic maturation of human pluripotent stem cell derived β-cells