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Project Abstracts - HPAC

HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)

Contact PI: Klaus Kaestner, PhD, University of Pennsylvania (U01DK123594)

Ali Naji, MD, PhD, Investigator, University of Pennsylvania
Ben Voight, PhD, Investigator, University of Pennsyvania
Doris Stoffers, MD, PhD, co-Investigator, University of Pennsylvania
Jason Moore, PhD, co-Investigator, University of Pennsylvania
Michael Feldman, MD, PhD, co-Investigator, University of Pennsylvania

 

Summary of Project Abstract & Publications

Start Date: September 30, 2019

Abstract

The past decades have seen a dramatic improvement in our ability to phenotype and molecularly profile human tissues relevant to the etiology of type 2 diabetes with unprecedented resolution, at the genomic, epigenomic, protein, and functional levels.  Here we will employ state-of-the-art technologies to determine all aspects of pancreas biology as it pertains to type 2 diabetes, profile human pancreatic islets with multiple assay modalities, and make the vast data accumulated available through the highly accessible PANC-DB. This comprehensive profiling of the natural history of Type 2 diabetes will pave the way for future discoveries of new treatment modalities for diabetes.

Meet the Grant Team 

   Investigators 

 

Klaus Kaestner, PhD

University of Pennsylvania

 

Ali Naji, MD, PhD

University of Pennsylvania

 

Ben Voight, PhD

University of Pennsylvania

 

 

 

 Co-Investigators

Doris Stoffers, MD, PhD

University of Pennsylvania

 

Jason Moore, PhD

University of Pennsylvania

 

 

Michael Feldman, MD, PhD

University of Pennsylvania