HPAP T2D: Human Pancreas Analysis Program

Contact PI: Klaus Kaestner, PhD, University of Pennsylvania (U01DK123594)

Ali Naji, MD, PhD, Investigator, University of Pennsylvania
Mark Atkinson, PhD Investigator, University of Florida
Al Powers, MD, Investigator, Vanderbilt University
Doris Stoffers, MD, PhD, co-Investigator, University of Pennsylvania
Anna Gloyn, PhD, co-Investigator, Stanford University
Parker Wilson, MD, PhD, co-Investigator, University of Pennsylvania
Golnaz Vahedi, PhD, co-Investigator, University of Pennsylvania
Babak Faryabi, PhD, co-Investigator, University of Pennsylvania

Start Date: September 30, 2019

Abstract

The past decades have seen a dramatic improvement in our ability to phenotype and molecularly profile human tissues relevant to the etiology of type 2 diabetes with unprecedented resolution, at the genomic, epigenomic, protein, and functional levels. Here we will employ state-of-the-art technologies to determine all aspects of pancreas biology as it pertains to type 2 diabetes, profile human pancreatic islets with multiple assay modalities, and make the vast data accumulated available through the highly accessible PANC-DB. This comprehensive profiling of the natural history of Type 2 diabetes will pave the way for future discoveries of new treatment modalities for diabetes.