Domenico Accili a Professor of Medicine at Columbia University, Attending Physician at Columbia-Presbyterian Hospital and Director of the Columbia University Diabetes and Endocrinology Research Center in New York, New York. His research focuses on understanding how insulin-producing cells are born, live, function, and die.
Charles Ansong was a Senior Research Scientist within the Integrative Omics group, Biological Sciences Division at PNNL. His research focused on the centers on the utilization of advanced mass spectrometry-based omics technologies and systems biology approaches to better understand complex biological systems relevant to human health and the environment. Currently, he is a Program Director at The National Institutes of Health at the National Institute of General Medical Sciences (NIGMS).
Lucas Armitage first participated in the HIRN while as a graduate student in the Wallet & Brusko Labs at the University of Florida. Currently, he is a Postdoctoral Research Fellow with the Russ Lab at the University of Colorado Denver.
Rafael Arrojo e Drigo is a Gateway Award Recipient and co-Investigator on a HPAC Grant. He is an Assistant Professor in the Department of Molecular Physiology and Biophysics at Vanderbilt School of Medicine. His research focuses on understanding the mechanisms regulating post-mitotic cell homeostasis and longevity.
Peter Arvan is the Division of Metabolism, Endocrinology, & Diabetes at the University of Michigan. His research focus is to examine molecular mechanisms involved in the folding, trafficking, and targeting of newly-synthesized endocrine secretory proteins
Mark Atkinson is currently the American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at the University of Florida. He also is the Director of the Diabetes Institute at the University of Florida. Additionally, he is the Executive Director of the JDRF Network for Pancreatic Organ donors with Diabetes (nPOD) program and the President of Insulin for Life USA, the world’s second largest charity dedicated to providing insulin to persons living with diabetes in the developing world. His research focuses on type 1 diabetes, pancreatic pathology, immune therapy, autoimmunity, clinical trials, translational research, emerging technologies, psychosocial behaviors, and metabolism.
Olivier Blondel is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests lie in research that focuses on endocrine signaling, stem cell biology, organ development, regenerative medicine and biomarker discovery as it relates to diabetes (type 1 and type 2) and metabolic diseases, particularly in combination with experimental approaches such as large-scale genomics, synthetic biology, bioengineering, epigenetics, nuclear organization of mammalian genomes, chromatin biology, genome editing, gene therapy
Bernd Bodenmiller is the Director of the Department of Quantitative Biomedicine at University of Zurich. He has pioneered a single-cell mass spectrometric imaging approach called "imaging mass cytometry". This technology allows the simultaneous and high-throughput imaging of approximately 50 markers, including proteins, their modifications, and transcripts on single cells in tissues in situ. The Bodenmiller group employs mass cytometry-based methods to study the cellular composition and regulation of tissue ecosystems, for insights into health and disease.
Kristin Burnum-Johnson is a Senior Scientist and Team Lead of the Environmental Molecular Sciences Laboratory's Metabolomics group at Pacific Northwest National Laboratory. Her research is dedicated to characterizing the molecular landscape of heterogeneous samples using novel mass spectrometry approaches to address specific biological, medical, and environmental research questions. These approaches involve multi-dimensional liquid chromatography and ion mobility separations in conjunction with mass spectrometry to measure proteins, lipids, and metabolites.
Martha Campbell-Thompson is a Professor, Director of the Molecular Pathology Core at the University of Florida and Director of the JDRF nPOD Organ Procurement and Pathology Core. Her research interests are in beta cell biology, beta cell regeneration for type 1 diabetes, islet inflammation and neuromodulation of beta cell function.
Richard Caprioli is the Director of the Mass Spectrometry Research Center at Vanderbilt University School of Medicine and a Professor in the Departments of Chemistry and Pharmacology at Vanderbilt University. The research interests of this laboratory are aimed at the investigation of biological processes involving the synthesis, modification, storage and degradation of certain peptides and proteins using modern mass spectrometric methods of analysis to follow molecular events. In recent years there has been a great amount of interest in investigating the biochemical events involved in the metabolism of peptides, primarily in the brain and gut of mammals, encompassing the enzymatic breakdown of these peptides, their production from peptide and protein precursors, and the disruption of these processes by certain xenobiotics.
Hao Chen is an Associate Professor in the Department of Pharmacology, Addiction Science, and Toxicology at the University of Tennessee Health Science Center. His research interests are in Genetic variants influcing operant drug intake in rats, novel rat models of drug abuse, integrating computation into rodent behavioral experiments, and genomics and transcriptomics.
Shuibing Chen is an Associate Professor in the Department of Surgery and Department of Biochemistry at Weill Cornell Medical College. Her research interest is to manipulate stem cell fate using chemical and biological approaches and to generate functional tissues and organs that can be used for translational research.
Yuval Dor is a Professor of Biology at the Hebrew University of Jerusalem. He has worked in the past mostly on diabetes and tissue regeneration in the pancreas, but in recent years much of our focus has shifted to a new technology that we are developing, for non-invasive monitoring of cell death in humans, based on circulating DNA.
Decio L. Eizirik is a Professor at the ULB Center for Diabetes Research Medical Faculty, Universite Libre de Bruxells (ULB) in Brussels, Belgium. His research focuses on the molecular mechanisms regulating insulitis and beta cell apoptosis in type 1 diabetes and on the search for novel approaches to prevent the progressive loss of beta cell mass in diabetes.
Carmella Evans-Molina is the Director of the Indiana University Center for Diabetes and Metabolic Diseases, J. O. Ritchey Professor of Medicine and Pediatrics at Indiana University School of Medicine, and Director of the IDRC Islet and Physiology Core.. She directs the Diabetes Research Program in the Herman B. Wells Center for Pediatric Research and is a staff physician at the Richard L. Roudebush VA Medical Center. Her research is focused on defining the molecular and inflammatory etiologies of β-cell dysfunction that contribute to diabetes pathophysiology. She has a clinical research interest focused on leveraging activation of β-cell stress pathways to inform the development of biomarkers that predict diabetes risk and define disease endotypes.
Jorge Ferrer is Chair in Genetics and Medicine, Head of the Section of Epigenomics and Disease, and Lead for Genetics and Genomics in the NIHR Imperial Biomedical Research Centre. His research interest is in understanding genome regulation of pancreatic beta cells and its implications for human diabetes. His team has combined genetic model systems and advanced genomics to address key questions in human beta cell biology, regeneration, and disease.
Yuqian Gao is an analytical chemist working on the development of targeted mass spectrometry assays to validate new biomarker candidates that are initially identified in untargeted mass spectrometry-based omics analyses.
Ivan Gerling is a Professor of Medicine in the Division of Medical Endocrinology at the University of Tennessee Health Science Center. His research interests are in autoimmunity, diabetes, oxidative stress, aldosteronism, and systems biology.
Viviana Gradinaru is a Professor of Neuroscience and Biological Engineering and the Director of the Center for Molecular and Cellular Neuroscience at California Institute of Technology (CalTech). Her research has focused on developing technologies for neuroscience and using them to probe circuits underlying locomotion, reward, and sleep.
Carla Greenbaum is the Director, of the Center for Interventional Immunology and the Director of the Diabetes Research Program at Benaroya Research Institute. Her research interests are in clinical investigations and trials to prevent or intervene in the diabetes autoimmune disease process.
Manami Hara is a Research Professor in the Division of Endocrinology, Diabetes and Metabolism at the University of Chicago. Her research focus is on the developmental biology of pancreatic islets. The islet of Langerhans is a micro-organ composed of insulin-secreting beta-cells and other endocrine cells that work together to maintain glucose homeostasis.
Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry at the University of Chicago. His research spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, and bioinorganic chemistry.
Kevan Herold is the C.N.H. Long Professor of Immunobiology and of Medicine at Yale School of Medicine. He studies autoimmune diseases, whether they occur naturally or as a consequence of immunomodulator therapy.
Klaus Kaestner Professor in Genetics at the Perelman School of Medicine at the University of Pennsylvania and the Director of the Functional Genomics Core at the University of Pennsylvania. His research interest is in employing modern genetic, genomic and epigenomic approaches (ChIP-Seq, RNA-Seq, gene targeting, tissue-specific and inducible gene ablation, CyTOF) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. Disease areas targeted by our research include diabetes and cancer.
Yuong-Mo Kim is an analytical chemist and expert in gas chromatography-mass spectrometry-based metabolomics analysis. His participates in various research projects using mass spectrometry based metabolomics approaches to solve biological questions from microbial transformation, synthetic biology, biofuel production, microbiome, carbon flow in the environment and a few others.
Rohit Kulkarni is a Professor of Medicine at Harvard Medical School and Co-Head of the Section on Islet & Regenerative Biology at Joslin Diabetes Center. His research explores the significance of growth factor signaling mechanisms in the regulation of islet biology by creating genetic models to examine the roles of insulin/IGF-1 receptors and their substrate proteins.
Jennifer Kyle was a Postdoctoral Research Fellow in the Metz Lab at Pacific Northwest National Laboratory. For her HIRN project, her responsibilities focused on refining liquid chromatography-mass spectrometry-based lipidomics analyses, including the development of novel informatics tools for confident lipid identification, and in performing lipidomics analyses of pancreatic islets.
Maggie Lam is an Assistant Professor in the Division of Cardiology at the University of Colorado Anschutz Medical Campus. Her research focuses on mass spectrometry and computational techniques to understand the mechanisms driving disease progression in humans, protein dynamics, protein alternative isoform, and protein annotation methods.
Julia Laskin is a Professor of Chemistry at Purdue University. Her research at the interface of physical and analytical chemistry is focused on the advanced development of preparative and analytical mass spectrometry for applications in materials synthesis, imaging and chemical analysis of biological systems at a subcellular level, and environmental sciences.
Karla Leavens is a HIRN Emerging Leader Award Recipient and Pediatric Endocrinologist in the Division of Endocrinology at Children's Hospital of Philadelphia. She is also a Postdoctoral Research Fellow in the Gadue Lab.
Amelia Linnemann is a HIRN Emerging Leader Award Recipient and a HIRN New Investigator. She is an Associate Professor of Pediatrics at the Indiana University School of Medicine. Her primary research focus is to understand mechanisms of pancreatic β-cell death/survival, islet compensatory adaptation to cellular stress, and how these factors contribute to diabetes pathogenesis.
Mark Mamula is a Professor of Medicine (Rheumatology) at the Yale School of Medicine. His research focuses on biochemical forms of autoantigens capable of breaking immunologic tolerance to intracellular autoantigens in systemic lupus erythematosus (SLE), and type 1 diabetes (T1D).
Jason McDermott is a Senior Research Scientist at Pacific Northwest National Laboratory. His has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology.
Thomas Metz is a principal investigator in the Integrative Omics group within the Biological Sciences Division and is the team lead for a group of scientists that focuses on development and applications of high throughput metabolomics and lipidomics methods to various biological questions. His research interests span the development of both untargeted and targeted metabolomics and lipidomics capabilities, based on liquid and gas chromatography coupled with mass spectrometry, both for fundamental studies of metabolism and metabolic interactions
Raghavendra Mirmira is the Director of the Department of Medicine Translational Research Center and Professor of Medicine in the Department of Endocrinology, Diabetes and Metabolism at the University of Chicago.
His research focuses his efforts on the pathogenesis of diabetes mellitus and the biology of the islet. His laboratory is interested in three key areas: the role of mRNA translation in the cellular response of islet β cells to inflammation; the role of lipoxygenases in dysfunction of β cells in Type 1 and Type 2 diabetes; and the identification of biomarkers of β-cell stress and death in diabetes.
Jerry Nadler is a Professor of Medicine and Pharmacology and the Dean of the School of Medicine of New York Medical College. He is an internationally recognized diabetes researcher and has been a member of a Special Advisory Committee on Type I Diabetes with the director of the NIH. As a prominent voice in his field, he has authored more than 200 peer-reviewed publications and has been an invited speaker at major international conferences, including the American Diabetes Association, Australian Diabetes Association, World Diabetes Congress and International Meetings of the European Association of Diabetes.
Ernesto Nakayasu is a senior research scientist focused on understanding molecular mechanisms of diseases. Nakayasu has been applying systems biology and mass spectrometry-based omics measurements to study how pathogens and metabolic alterations cause human diseases; the goal is to identify diagnostic and therapeutic targets. He has been integrating multi-omics approaches to develop biomarkers of diseases and to study signaling and metabolic pathways that are altered or targeted in infectious and metabolic diseases.
Harry Nick, PHD, is a Professor of Neuroscience at the University of Florida. Dr Nick has funding from the National Institutes of Health, JDRF, and the Leona M. and Harry B. Helmsley Charitable Trust, and the JDRF nPOD.
Jeremy Norris is the Managing Director of the Vanderbilt University Mass Spectrometry Research Center and a Research Associate Professor in the Department of Biochemistry. Jeremy earned his Ph.D. in analytical and organic chemistry from Vanderbilt University in 2003. His research interests are in the application of mass spectrometry and separations science to measure biologically and clinically important analytes. He is the Managing Director for the National Resource for Imaging Mass Spectrometry and the DARPA-funded Rapid Threat Assessment Program at Vanderbilt University.
Julius Nyalwidhe has become a pioneer in the field of proteomics and is now a leading cancer researcher with an international reputation. His laboratory focuses on molecular biology, functional genomics and proteomic approaches to study cancer for the purposes of understanding cancer biology as well as to discover clinical biomarkers. The focus is on understanding the molecular events and signaling mechanisms that are involved in cancer progression and disease severity. The objective is to identify and disrupt signaling mechanisms that are involved in cancer progression and severity.
Scott Oakes’s laboratory studies how mammalian cells commit “suicide” in response to various forms of damage and what goes wrong with this process in cancer and other diseases. In particular, they focus on a type of stress that occurs when the cell’s protein folding factory—an organelle called the endoplasmic reticulum—is overwhelmed and protein quality control fails. He is actively engaged in developing drugs to control cell fate under these conditions, which have potential to benefit patients with diseases from cancer to neurodegeneration.
Dr. Galya Orr is a biomedical scientist with the Cell Signaling and Communications team in PNNL’s Environmental Molecular Sciences Division and the Environmental Molecular Sciences Laboratory (EMSL) user program. For over 20 years, she has led the development and capability applications for biological research at the single-cell and single-molecule levels. Orr and her team are pursuing interdisciplinary efforts that combine the development of non-conventional quantitative fluorescence imaging and molecular biology approaches and their applications to better understand cellular and molecular processes in the intact cells and tissues.
Stephen Parker is an Associate Professor of Computational Medicine and Bioinformatics at the University of Michigan. The major goal of his lab is to generate mechanistic knowledge about how disease susceptibility is encoded in the non-coding portion of the genome, with a focus on type 2 diabetes.
Vladislav Petyuk is a Scientist at Pacific Northwest National Laboratory. His research focuses on quantitative proteomics and in particular involves development of algorithms for data preprocessing, assessment of data quality and statistical approaches for data exploration, hypothesis testing and inference of new biological knowledge.
Wei-Jun Qian is a bioanalytical chemist whose research centers primarily on the development and applications of mass spectrometry-based approaches for better quantify the dynamic changes in protein abundances and protein post-translational modifications in biological and clinical applications. His current research involves the development of chemical proteomic approaches for site-specific quantification of cysteine-based redox modifications and more sensitive selected reaction monitoring (SRM)-based targeted quantification techniques with applications in pancreatic islets, diabetes, and oxidative stress-related disease areas.
Dr. Chris Rhdoes is the Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, and Chair of AstraZeneca’s postdoc programme. He is a renowned leader in the field of diabetes, obesity and metabolism research, with a career spanning over three decades. He has more than 180 published manuscripts, and has held industry and academic leadership roles at top institutions that include Harvard Medical School and the University of Washington. Chris is also Professor Emeritus at the University of Chicago, Department of Medicine
Dr. Bart O. Roep is Professor of Diabetology, Immunopathology & Intervention and Director of the National Diabetes Center of Excellence at the Leiden University Medical Center in The Netherlands and Visiting Professor of the Danish Diabetes Academy. He is also Founding Chair and Professor of Medicine of the Department of Diabetes Immunology, and holds the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes at the Diabetes & Metabolism Research Institute at the Beckman Research Institute of the City of Hope in Los Angeles.
Holger Russ is a HIRN New Investigator and an Assistant Professor of Pediatrics at the University of Colorado Denver. His research focuses on using human stem cells to generate novel sources of beta cells for transplantation and to model human T1D in a dish.
Dr. Leslie Satin is a Professor of Pharmacology in the University of Michigan Medical School. Dr. Satin’s research has combined several strands, involving studies of the electrophysiology of neurons and synaptic changes after traumatic brain injury, the production of oscillations in neurosecretory cells and their theoretical basis, and the regulation of intracellular free Calcium and ion channels by cell fuel metabolism. Dr. Satin is an expert on the cellular signaling mechanisms, ion channel biophysics, the application of theoretical models to biomedical systems, and synaptic mechanisms of plasticity in the brain. He has served on the editorial boards of Neurochemistry International, Endocrinology, Endocrine, Diabetes, J. Biol. Chem., and American Journal of Physiology. He has served on many NIH study sections, including those devoted to TBI and stroke, and diabetes and metabolic diseases.
Desmond Schatz, MD is Professor and Interim Chair of Pediatrics, Medical Director of the Diabetes Institute and Director of the Clinical Research Center within the CTSI at the University of Florida, Gainesville. He is the PI of the University of Florida Clinical Center participating in the NIH-funded TrialNet (a founding member of the DPT-1 in 1994). He served as President of Science and Medicine of the American Diabetes Association in 2016.
Anath Shalev is the chair of the Consortium of Beta Cell Death and Survival (CBDS) and a member of the Trans-Network Committee (TNC). She is the Director of the University of Alabama at Birmingham Comprehensive Diabetes Center, Professor of Medicine and Senior Scientist. Her research focuses on Molecular biology of diabetes, beta cell biology, apoptosis, oxidative stress, transcriptional regulation of gene expression, and diabetes complications.
Ruth Shemer is a researcher at the Institute for Medical Research-Israel Canada (IMRIC) in the Hebrew University's Faculty of Medicine. She established a way to detect multiple disease processes —including diabetes, cancer, traumatic injury and neurodegeneration — in a highly sensitive and specific manner.
Tujin Shi s a senior scientist in the Integrative Omics group of the Biological Sciences Division at Pacific Northwest National Laboratory. His research centers on the development and applications of mass spectrometry-based approaches to address current biological and biomedical need.
Scott Soleimanpour is an Associate Professor of Internal Medicine and Director for T1D Basic Research in the University of Michigan Caswell Diabetes Center. His lab focuses on the molecular and genetic regulation of the mitochondrial life cycle, with a focus on mitophagy, a pathway to dispose of unhealthy or damaged mitochondria.
Lori Sussel is the Director of Basic and Translational Research at the Barbara Davis Center for Diabetes. The main focus of the Sussel lab is to understand the complex transcriptional networks that regulate development, differentiation and function of the pancreas. Our early studies led to the ground-breaking discovery that a ghrelin-producing “epsilon” cell population normally resides in the fetal islet, and that a close lineage relationship exists between the islet beta and epsilon cell populations. We went on to identify several novel regulatory pathways that are essential for islet lineage specification, normal pancreas development and the maintenance of beta cell maturation.
Dr. Golnaz Vahedi is currently an Associate Professor of Genetics (with tenure) at the Perelman School of Medicine, University of Pennsylvania. Golnaz. She studied Electrical Engineering at Sharif University of Technology in Iran. As an independent investigator, she uses systems-based approaches to understand molecular details of gene regulation in the immune system. She is the recipient of a number of awards including the NIH Director’s Award (twice), NIAID K22 Career Transition Award (perfect score), Alfred P. Sloan Fellowship, Chan Zuckerberg Initiative Award, W. W. Smith Charitable Trust, Burroughs Wellcome Fund, and Michael S. Brown New Investigator Research Award. She serves on the advisory boards of Cell Press journal Immunity and Science Immunology and is a standing member of GCAT study section.
Xujing Wang is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her interests are in data science, computation modeling, integrative genomics, network biology, and genotype-phenotype relationships.
Clive Wasserfall is an Assistant Professor of Pathology at the University of Florida. His research is focused on the immunopathogenesis of Type 1 Diabetes (T1D). His laboratory is involved in immune monitoring of human clinical trails to reverse or prevent T1D while searching for biomarkers of efficacy. Additionally, his laboratory houses the autoantibody screening core for the JDRF network for pancreas organ donors with diabetes (nPOD) program.
Bobbie-Jo Webb-Robertson is currently the technical group manager of the Applied Statistics and Computational Modeling group, as well as leading a body of research in the development and application of advanced statistical methods for MS-based omics analyses. Her research interests includes the development of statistical inference models, largely machine learning, with application to diverse biomarker discovery problems.
Christopher Wright is a Professor of Cell and Developmental Biology at Vanderbilt University. He is also the Director of the Vanderbilt University Program in Developmental Biology and the Associate Director of the Vanderbilt Center for Stem Cell Biology. The goal of the lab is to provide insight into the molecular mechanisms responsible for the coordinated development of complex organ systems, which has relevance to human congenital birth defects, and cryptic susceptibilities to disease or syndromes.
Wenting Wu is an Assistant Research Professor of Medical & Molecular Genetics at Indiana University School of Medicine. Her research interests are in applying the genomics and bioinformatics tools into complex disease mechanism discovery and personalizing medicine, including transcriptome genomics, genomic variations/mutations, epigenetics, long noncoding RNAs etc.
Guanlan Xu is an Instructor in the Department of Endocrinology, Diabetes and Metabolism at the University of Alabama at Birmingham. He has found that diabetes induces the beta cell miR-204, which in turn represses insulin transcription by targeting and inhibiting the insulin transcription factor MAFA. In addition, Dr. Xu also works on developing strategies to halt beta cell loss in diabetes.