Participants

Bio

Midhat Abdulreda is an Associate Professor of Surgery, Microbiology and Immunology at the University of Miami Miller School of Medicine. Dr. Abdulreda has developed the “living window” model to study immune responses during diabetes development or rejection of transplanted pancreatic islets. With collaborators he is exploring islet transplantation into the anterior chamber of the eye as a potential clinical transplantation site in the treatment of type 1 diabetes.

Bio

Ashutosh Agarwal is an Associate Professor in the Department of Biomedical Engineering and Department of Pathology at the University of Miami Miller School of Medicine. He completed his postdoctoral research in Biomedical Engineering at Columbia University, and at the Wyss Institute for Biologically Inspired Engineering at Harvard University. The mission of his Physiomimetic Microsystems Laboratory at the University of Miami is to develop human relevant organ mimic platforms for discovery of therapies and drugs, for modeling of disease states, for conducting mechanistic studies, and for differentiation, maturation and evaluation of stem cells.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Ashu+Agarwal

Bio

Joana Almaça is a HIRN New Investigator and an Assistant Professor of Medicine at the University of Miami Miller School of Medicine. Her current research focuses on the vasculature of the islet. In her work, Dr. Almaça is testing the hypothesis that microvascular dysfunction in the islet leads to a disturbance of hormone secretion, to glucose intolerance, and eventually to diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/profile-almaca

Projects

Changes in Human Islet Microvasculature during Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Joana+Almaca

Bio

Juan Alvarez is a HIRN Emerging Leader Award Recipient and an Assistant Professor of Cell and Developmental Biology at the University of Pennsylvania Perelman School of Medicine. His research focuses on human stem cell-derived pancreatic islet organoids and mice as model systems to study islet development, physiology, and pathology, and to develop replacement therapies for insulin-dependent diabetes. We focus on the interplay between circadian rhythms, metabolism, and islet cell maturation.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-juan-r-alvarez

Projects

Measuring Islet-wide Function with Soft Integrated Nanoelectronics

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=juan+alvarez

Bio

Charles Ansong was a Senior Research Scientist within the Integrative Omics group, Biological Sciences Division at PNNL. His research focused on the centers on the utilization of advanced mass spectrometry-based omics technologies and systems biology approaches to better understand complex biological systems relevant to human health and the environment. Currently, he is a Program Director at The National Institutes of Health at the National Institute of General Medical Sciences (NIGMS).

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Charles+Ansong

Bio

Hugh Bender was a Postdoctoral Research Fellow in the Chris Hughes Lab at the University of California, Irvine. He is now a Lead Scientist at Aracari Biosciences. Dr. Bender received his PhD in 2015 from Washington University in St. Louis. His research focuses on developing a novel micro-vascularized organ system for modeling Type I diabetes in the lab.

Lab:

https://faculty.sites.uci.edu/hugheslab/

HIRN Investigator Profile:

https://hirnetwork.org/staff_hbender

Projects

Bio

Sangeeta Bhatia is a biomedical researcher, MIT professor, and biotech entrepreneur who works to adapt technologies developed in the computer industry for medical innovation. he and her trainees have launched multiple biotechnology companies to improve human health. As a prolific inventor and passionate advocate for diversity in science and engineering, Bhatia has received many honors including the Lemelson-MIT Prize, known as the ‘Oscar for inventors,’ and the Heinz Medal for groundbreaking inventions and advocacy for women in STEM fields. She is a Howard Hughes Medical Institute Investigator, the Director of the Marble Center for Cancer Nanomedicine at the Koch Institute for Integrative Cancer Research at MIT, and an elected member of the National Academy of Sciences, the National Academy of Engineering, the American Academy of Arts and Science, the National Academy of Inventors, and Brown University’s Board of Trustees.

Projects

A Vascularized 3D Biomimetic for Islet Function and Physiology

Bio

Jeffrey Bluestone is a Professor of Metabolism and Endocrinology at University of California, San Francisco. He is currently serving as the president and CEO of the Parker Institute for Cancer Immunotherapy. His current research focuses on the understanding Tregs has been discussed as an avenue to further developments in the treatment Type 1 Diabetes.

Projects

Investigator Contributed Resources:

chttps://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Jeffrey+Bluestone

Bio

Bernd Bodenmiller is the Director of the Department of Quantitative Biomedicine at University of Zurich. He has pioneered a single-cell mass spectrometric imaging approach called "imaging mass cytometry". This technology allows the simultaneous and high-throughput imaging of approximately 50 markers, including proteins, their modifications, and transcripts on single cells in tissues in situ. The Bodenmiller group employs mass cytometry-based methods to study the cellular composition and regulation of tissue ecosystems, for insights into health and disease.

Projects

Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Bernd+Bodenmiller

Bio

Michael Brehm is an Associate Professor of Molecular Medicine and Co-Director of the Humanized Mouse Core Facility at UMass Chan Medical School. He works with these unique animal models of human immune responses to investigate approaches to downregulate as well as activate the human immune system for treatments of type 1 diabetes (T1D) and cancer. Dr. Brehm studies human beta cells from individuals with type 1 diabetes in a real-life setting as they interact with intact T1D immune systems.

Projects

Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Michael+Brehm

HIRN Webinar:

Bio

Todd Brusko is a Professor at Department of Pathology, Immunology and Laboratory Medicine and the scientific director at University of Florida Diabetes Institute (UFDI). The research aims of Dr. Brusko’s academic lab are centrally themed around understanding the mechanisms by which the immune system maintains a state of control, often referred to as immunological tolerance and understanding how genetic risk variants and age influence this process, as well as identifying pathway defects in individuals who develop autoimmune diseases. These studies have focused primarily on genes impacting key checkpoints in T cell activation, including T cell receptor (TCR) signaling, co-stimulation, and the IL-2 signaling pathway. His laboratory is involved a number of ongoing team science initiatives including an NIH-NIAID P01 grant, NIH Director’s Initiative – Human BioMolecular Atlas Program (HuBMAP), Brehm Coalition, and the JDRF biomarker working group and autoimmunity working group.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_tbrusko?hilite=todd+brusko

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=todd+brusko

Bio

Peter Buchwald is an Associate Professor in the Department of Molecular and Cellular Pharmacology at the University of Miami Miller School of Medicine and the Director of the Drug Discovery Program at the Diabetes Research Institute. He has published numerous articles in peer-reviewed journals focused on the physicochemical and metabolic aspects of drug design and drug action, as well as on computer-aided quantitative modeling. Dr. Buchwald is directing the DRI’s efforts aimed at developing safer and more effective drugs for islet replacement therapies.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Peter+Buchwald

Bio

Kristin Burnum-Johnson is a Senior Scientist and Team Lead of the Environmental Molecular Sciences Laboratory's Metabolomics group at Pacific Northwest National Laboratory. Her research is dedicated to characterizing the molecular landscape of heterogeneous samples using novel mass spectrometry approaches to address specific biological, medical, and environmental research questions. These approaches involve multi-dimensional liquid chromatography and ion mobility separations in conjunction with mass spectrometry to measure proteins, lipids, and metabolites.

Projects

Single Cell Resolution of Omics Analysis of T1D Islets

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Kristin+Burnum-Johnson

Bio

Martha Campbell-Thompson is a Professor, Director of the Molecular Pathology Core at the University of Florida and Director of the JDRF nPOD Organ Procurement and Pathology Core. Her research interests are in beta cell biology, beta cell regeneration for type 1 diabetes, islet inflammation and neuromodulation of beta cell function.

Projects

Defining Islet Heterogeneity Using Single Islet Transcriptomics

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Martha+Campbell+Thompson

HIRN Webinar:

Bio

Richard Caprioli is the Director of the Mass Spectrometry Research Center at Vanderbilt University School of Medicine and a Professor in the Departments of Chemistry and Pharmacology at Vanderbilt University. The research interests of this laboratory are aimed at the investigation of biological processes involving the synthesis, modification, storage and degradation of certain peptides and proteins using modern mass spectrometric methods of analysis to follow molecular events. In recent years there has been a great amount of interest in investigating the biochemical events involved in the metabolism of peptides, primarily in the brain and gut of mammals, encompassing the enzymatic breakdown of these peptides, their production from peptide and protein precursors, and the disruption of these processes by certain xenobiotics.

Projects

High-Resolution Analysis of Juvenile Human Pancreas Maturation

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Richard+Caprioli

Bio

Shuibing Chen is an Associate Professor in the Department of Surgery and Department of Biochemistry at Weill Cornell Medical College. Her research interest is to manipulate stem cell fate using chemical and biological approaches and to generate functional tissues and organs that can be used for translational research.

Projects

Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Shuibing+Chen

Bio

Josh Chiou was a graduate student in the lab of Kyle Gaulton at the University of California, San Diego. His primary responsibilities include performing integrative analyses of epigenome, transcriptome and diabetes genetic association data. He is currently a Computational Geneticist with Pfizer.

HIRN Investigator Profile:

https://hirnetwork.org/staff_profile_chiou?hilite=Josh+Chiou

Projects

Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Josh+Chiou

Bio

Karen Christman is a Professor of Bioengineering at the University of California in San Diego. Her lab focuses on developing novel biomaterials for tissue engineering and regenerative medicine applications. Projects are highly interdisciplinary and include the development of materials for in vitro differentiation of stem cells to injectable biomaterials for tissue repair and regeneration. The lab has a strong translational focus with the main goal of developing novel minimally invasive therapies for cardiovascular disease

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_kchristman?hilite=Karen+Christman

Projects

Bio

Remi Creusot is an Associate Professor in the Department of Medicine at Columbia University Medical Center and an Investigator within the Columbia Center for Translational Immunology and the Naomi Berrie Diabetes Center. His research interests revolve around the pathogenesis and prevention of Type 1 Diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_rcreusot?hilite=Remi+Creusot

Projects

Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems

Bio

George Daley is Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. His research seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered human cell culture-based and murine models of human blood disease and cancer.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_gdaley?hilite=George+Daley

Projects

Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=George+Daley

Bio

Nichole Danzl is an Associate Research Scientist at Columbia University Medical Center. Her research studies for optimization of the PI mouse model and implements these advances into the basic paired T1D versus Healthy Control comparative experiments. She also leads the in vivo functional testing of ES and iPS derivatives to make human islets and a human thymus from the hematopoietic stem cell donor.

Lab:

https://hirnetwork.org/about/participants#short-profile-megan-sykes-md

Projects

Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Nichole+Danzl

Bio

Juan Dominguez-Bendala is a Research Professor of Surgery at the Diabetes Research Institute, University of Miami Miller School of Medicine. He is also the Director of Stem Cell & Pancreatic Regeneration and Research Professor of Surgery at the Diabetes Research Institute (DRI). His research focuses on the use of stem cells to obtain pancreatic islets that could potentially be transplanted into patients with type 1 diabetes. He is also currently working on new methods for expansion/regeneration of pancreatic beta cells.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_bendala?hilite=Juan+Dominguez-Bendala

Projects

High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Juan+Dominguez-Bendala

Bio

Dieter Egli Assistant Professor at Columbia University. His research focuses on the generation of therapeutically relevant cells for diabetes. His work has relevance for the use of stem cells to study disease, screen for new drugs, and cell replacement therapy.

Projects

Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Dieter+Egli

Bio

Decio L. Eizirik is a Professor at the ULB Center for Diabetes Research Medical Faculty, Universite Libre de Bruxells (ULB) in Brussels, Belgium. His research focuses on the molecular mechanisms regulating insulitis and beta cell apoptosis in type 1 diabetes and on the search for novel approaches to prevent the progressive loss of beta cell mass in diabetes.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Decio+Eizirik%2C

HIRN Webinar:

Bio

Carmella Evans-Molina is the Director of the Indiana University Center for Diabetes and Metabolic Diseases, J. O. Ritchey Professor of Medicine and Pediatrics at Indiana University School of Medicine, and Director of the IDRC Islet and Physiology Core.. She directs the Diabetes Research Program in the Herman B. Wells Center for Pediatric Research and is a staff physician at the Richard L. Roudebush VA Medical Center. Her research is focused on defining the molecular and inflammatory etiologies of β-cell dysfunction that contribute to diabetes pathophysiology. She has a clinical research interest focused on leveraging activation of β-cell stress pathways to inform the development of biomarkers that predict diabetes risk and define disease endotypes.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Carmella+Evans-Molina

Bio

Robert Babak Faryabi is an Assistant Professor of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. His research goal is to understand the epigenetic mechanisms of transcriptional addiction in cancer and exploit this information to advance cancer therapeutics.

Projects

Bio

Leonardo Ferreira is a HIRN Emerging Leader Award Recipient and an Assistant Professor of Microbiology and Immunology at the Medical University of South Carolina. His research focuses on phenomenon of immune tolerance, his long term goal is to control how the immune system defines self and non-self. Such knowledge will allow the design and development of powerful new engineered immune cell therapies to fight autoimmune disease, cancer, and aging.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-leonardo-m-r-ferreira

Projects

Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells

Bio

Jorge Ferrer is Chair in Genetics and Medicine, Head of the Section of Epigenomics and Disease, and Lead for Genetics and Genomics in the NIHR Imperial Biomedical Research Centre. His research interest is in understanding genome regulation of pancreatic beta cells and its implications for human diabetes. His team has combined genetic model systems and advanced genomics to address key questions in human beta cell biology, regeneration, and disease.

Projects

Non-invasive Diagnosis of Human Beta Cell Damage and Death

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Jorge+Ferrer

Bio

Paul Gadue is a Professor of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania. His laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using human ES cells and iPS cells. ES/iPS cells can differentiate into all cell types in the body and can be propagated in culture almost indefinitely, generating a virtually unlimited supply of cells. These unique characteristics lead to the exciting prospect of using these cells to study disease processes and developmental pathways in vitro and eventually to treat a wide variety of diseases using cell replacement therapies.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_pgadue?hilite=Gadue

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Paul+Gadue

Bio

Kyle Gaulton is an Associate Professor in the Department of Pediatrics at the University of California, San Diego. His research focuses on human genetics and single cell genomics to define cell type-specific gene regulatory programs that affect risk of complex disease, in particular type 1 diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_gaulton?hilite=Kyle+Gaulton

Projects

Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Kyle+Gaulton

HIRN Webinar:

Bio

Ronald Gill is a Professor of Surgery and Immunology a the University of Colorado, Denver. His research is focused on nature of immune-mediated injury and tolerance induction to tissue and organ transplants. His primary research activity has been in the area pancreatic islet transplantation as a treatment for insulin-dependent diabetes.

Projects

Analysis of Human Autoreactive T Cell Receptors in vivo

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Ronald+Gill

Bio

Anna Gloyn is a Professor of Pediatrics, Endocrinology and Genetics at Stanford University. Her research uses human genetics as a tool to understand cellular and molecular mechanisms for pancreatic beta cell failure in diabetes and related conditions. he aim of her research is to capitalize on an improved mechanistic understanding of pancreatic islet cell dysfunction to improve treatment options for patients via the identification of safe and effective therapeutic targets (drug development) and patient stratification (precision medicine).

Projects

HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)

Bio

Dale Greiner is the Chair in Biomedical Research and Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. His research focuses on the development and use of a unique mouse model, engrafted with functional human cells and tissues. His work has generated high interest in the biomedical research community for use as a preclinical model for the investigation of human diabetes, cancer, infectious disease, regenerative medicine and autoimmunity.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_dgreiner?hilite=Dale+Greiner

Projects

Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Dale+Greiner

Bio

Dale Greiner is a Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. He has led basic and clinical research exploring the pathophysiology underlying diabetes. Dr. Harlan conducts clinical trials to test new therapies and explain human biology as it relates to diabetes and its treatment. His current research focuses on exploring beta cell biology and the anti-beta cell immune response underlying type 1 diabetes.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=David+Harlan

Bio

Matthias Hebrok is an Professor in Diabetes Research and Director of the Diabetes Center at the University of California, San Francisco. His research focuses on the mechanisms that underlie mammalian pancreas organogenesis and pancreatic diseases, including diabetes and pancreatic cancer. His laboratory has made seminal contributions to our understanding of how embryonic signals control the fetal development of the pancreas and its insulin-producing beta cells. His recent work has implemented the information gained from these studies to generate functional beta cells from human stem cell populations for cell therapy purposes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_mhebrok?hilite=Matthias+Hebrok

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Matthias+Hebrok

Bio

Jing Hughes is a Gateway Award Recipient and an Assistant Professor of Medicine in the Division of Endocrinology, Metabolism, and Lipid Research at the Washington University School of Medicine in St Louis. Her research focuses on the islet cell-cell interactions and the regulation of islet hormone secretion.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-jing-hughes

Projects

Primary Cilia in Human T1D Pancreas

Bio

Matthew Ishahak was a graduate student with the Agarwal Lab at the University of Miami and is currently a Postdoctoral Research Associate with in the Millman Lab at Washington University School of Medicine in St Louis. His work developing a glomerulus-on-chip was funded by a National Research Service Award Predoctoral Fellowship (F31) from the NIH. Additionally, Matthew co-founded a Bio-Vitro, a startup aimed at commercializing the organ-on-chip technology he helped developed.

HIRN Investigator Profile:

https://hirnetwork.org/staff_mishahak?hilite=Matthew+Ishahak

Projects

Engineering a Human Physiomimetic Islet Microsystem

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Matthew+Ishahak

Bio

Alok Joglekar is a Gateway Award Recipient and an Assistant Research Professor of Immunology at the University of Pittsburgh. His research aims to examine the shifting antigenic landscape of anti-tumor T cell responses, determine the fundamental rules of TCR-pMHC interactions, and to investigate novel immunotherapies to autoimmune diseases.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-alok-joglekar

Projects

Identification of the Cognate Epitopes of Autoreactive T Cells in T1D

HIRN Webinar:

Bio

Mark Kay is a Professor of Pediatrics and Genetics at Stanford University. His laboratory is focused in the development of gene transfer vectors for gene therapy as well as manipulating non-coding RNAs for therapeutic purposes. His research has focused on two vector systems, mini-circles and recombinant AAVs (rAAV). Using gene transfer vectors, we studied the potential of using transcriptional-based RNAi to treat human disease.

Projects

HIRN Webinar:

Bio

Hirotake Komatsu is a Gateway Award Recipient and an Assistant Research Professor in the Department of Translational Research & Cellular Therapeutics at City of Hope. His expertise is derived from a broad training in medicine and basic research in the fields of pancreas surgery and pancreatic islet transplantation.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-hirotake-komatsu?hilite=%27hirotake%27

Projects

Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft

Bio

Vira Kravets is a HIRN Emerging Leader Award Recipient and a Postdoctoral Research Fellow in the Department of Bioengineering at the University of Colorado Anschutz Medical Campus. She is currently leading interdisciplinary projects in search for the underlying causes for Diabetes. Juvenile Diabetes Research Foundation supported Fellow, skilled in Islet Biology, Surface Plasmon Resonance, Microscopy, Optics and Public Speaking

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-vira-kavets

Projects

Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets

Bio

Irina Kusmartseva is the Director of the JDRF nPOD Organ Processing and Pathology Core. She has unique experience with the molecular and primary cell culture. Her key area of expertise includes mechanisms of immunoregulation in inflammation, cancer and autoimmune diseases.

Projects

HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.)

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Irina+Kusmartseva

Bio

Julia Laskin is a Professor of Chemistry at Purdue University. Her research at the interface of physical and analytical chemistry is focused on the advanced development of preparative and analytical mass spectrometry for applications in materials synthesis, imaging and chemical analysis of biological systems at a subcellular level, and environmental sciences.

Projects

Single Cell Resolution of Omics Analysis of T1D Islets

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Julia+Laskin

Bio

Emma Lundberg is a Professor in Cell Biology Proteomics at KTH Royal Institute of Technology, Sweden, and Director of the Cell Atlas, of the Human Protein Atlas program. She recently joined the Stanford University Bioengineering Department as an Associate Professor of Bioengineering. Her research is focused on spatial proteomics and cell biology.

Projects

Linking Islet Cell Function and Identity from in vitro to in situ

Bio

Patrick MacDonald is Professor of Pharmacology at the University of Alberta and the Director of the Alberta Diabetes Institute (ADI) IsletCore. His research focuses on pancreatic islet function in health and diabetes. The research from his laboratory has spanned areas that include biophysical characterization of ion channels, intracellular signal transduction and exocytosis, and the cellular regulation of glucagon secretion.

HIRN Investigator Profile:

https://hirnetwork.org/?s=Patrick+MacDonald

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Patrick+MacDonald

Bio

Rene Maehr is an Associate Professor in Molecular Medicine at UMass Chan Medical School. His research focuses on investigating how normal differentiation of the thymic epithelial cell lineage is regulated, and recapitulating that process with pluripotent stem cells.

Projects

Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Rene+Maehr

Bio

Mark Mamula is a Professor of Medicine (Rheumatology) at the Yale School of Medicine. His research focuses on biochemical forms of autoantigens capable of breaking immunologic tolerance to intracellular autoantigens in systemic lupus erythematosus (SLE), and type 1 diabetes (T1D).

Projects

Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Mark+Mamula

Bio

Jason McDermott is a Senior Research Scientist at Pacific Northwest National Laboratory. His has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology.

Projects

Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Jason+McDermott

Bio

Thomas Metz is a principal investigator in the Integrative Omics group within the Biological Sciences Division and is the team lead for a group of scientists that focuses on development and applications of high throughput metabolomics and lipidomics methods to various biological questions. His research interests span the development of both untargeted and targeted metabolomics and lipidomics capabilities, based on liquid and gas chromatography coupled with mass spectrometry, both for fundamental studies of metabolism and metabolic interactions

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=thomas+metz

Bio

Everett Meyer is an Assciate Professor of Medicine at Stanford University Medical School. His research focus is in hematopoietic stem cell transplantation and Treg cell immunotherapy, with an emphasis on the treatment of graft-versus-host disease as well as immune tolerance induction for transplantation and autoimmunity. He is an expert on the role of T-cell populations in immune dysregulation, specifically through the mechanistic study of how CD1d-restricted invariant NKT mediate allergy and asthma in both mouse models and human clinical samples.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_emeyer?hilite=Everett+Meyer

Projects

Bio

Aaron Michels is an Endocrinologist and an Associate Professor at the University of Colorado Anschutz Medical Campus. His research focuses on understanding the underlying immunology of autoimmune disorders with a focus on type 1 diabetes. He discovered that small ‘drug-like’ molecules targeted to diabetes risk HLA molecules can block T cell responses and prevent diabetes onset in spontaneous animal models of autoimmune diabetes.

Projects

Analysis of Human Autoreactive T Cell Receptors in vivo

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Aaron+Michels

Bio

Raghavendra Mirmira is the Director of the Department of Medicine Translational Research Center and Professor of Medicine in the Department of Endocrinology, Diabetes and Metabolism at the University of Chicago. His research focuses his efforts on the pathogenesis of diabetes mellitus and the biology of the islet. His laboratory is interested in three key areas: the role of mRNA translation in the cellular response of islet β cells to inflammation; the role of lipoxygenases in dysfunction of β cells in Type 1 and Type 2 diabetes; and the identification of biomarkers of β-cell stress and death in diabetes.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Mirmira

HIRN Webinar:

Bio

Jason Moore was a Professor of Informatics and Director of the University of Pennsylvania Institute for Biomedical Informatics. He is currently the Chair of the Department of Computational Biomedicine at Cedars-Sinai Medical Center in Los Angeles, CA. His research is focused on the development of artificial intelligence and machine learning algorithms for the analysis of complex biomedical data.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Jason+Moore

Bio

Hiroyuki Nakai is a Professor of Molecular and Medical Genetics at the Oregon Health and Science University School of Medicine. His research goals are to comprehensively understand the biology of recombinant AAV vectors and the vector-host interactions and to develop new AAV vector-mediated gene and cell therapies to treat various human diseases.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_hnakai?hilite=Hiroyuki+Nakai

Projects

HIRN Webinar:

Bio

Maki Nakayama is an Associate Professor in the School of Medicine at the University of Colorado Anschutz Medical Campus. Her research strives to understand the mechanism of initiation of anti-beta cell autoimmunity. She focuses on the tri-molecular complex consisting of antigen, major histocompatibility complex (MHC), and T cell receptor (TCR) that could be a key component for the development of T1D.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Maki+Nakayama

Bio

Ernesto Nakayasu is a senior research scientist focused on understanding molecular mechanisms of diseases. Nakayasu has been applying systems biology and mass spectrometry-based omics measurements to study how pathogens and metabolic alterations cause human diseases; the goal is to identify diagnostic and therapeutic targets. He has been integrating multi-omics approaches to develop biomarkers of diseases and to study signaling and metabolic pathways that are altered or targeted in infectious and metabolic diseases.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=ernesto+nakayasu

Bio

Joyce Niland, Ph.D., holder of City of Hope’s Estelle & Edward Alexander Chair in Information Sciences, is professor and chair in the Department of Diabetes & Cancer Discovery Science within the Diabetes & Metabolism Research Institute at City of Hope. An internationally recognized leader in her field with hundreds of publications to her name, she has more than 30 years of experience in biostatistics, biomedical informatics, computational statistics, system development and deployment, and collaboration in translational research.

Lab:

https://tinyurl.com/nilandlab

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_jniland

Projects

Human Islet Research Enhancement Center (HIREC)

HIRN Webinar:

Bio

Jeremy Norris is the Managing Director of the Vanderbilt University Mass Spectrometry Research Center and a Research Associate Professor in the Department of Biochemistry. Jeremy earned his Ph.D. in analytical and organic chemistry from Vanderbilt University in 2003. His research interests are in the application of mass spectrometry and separations science to measure biologically and clinically important analytes. He is the Managing Director for the National Resource for Imaging Mass Spectrometry and the DARPA-funded Rapid Threat Assessment Program at Vanderbilt University.

Projects

High-Resolution Analysis of Juvenile Human Pancreas Maturation

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=jeremy+norris

Bio

Julius Nyalwidhe has become a pioneer in the field of proteomics and is now a leading cancer researcher with an international reputation. His laboratory focuses on molecular biology, functional genomics and proteomic approaches to study cancer for the purposes of understanding cancer biology as well as to discover clinical biomarkers. The focus is on understanding the molecular events and signaling mechanisms that are involved in cancer progression and disease severity. The objective is to identify and disrupt signaling mechanisms that are involved in cancer progression and severity.

Projects

Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Julius+Nyalwidhe

Bio

Kit Parker is a Professor of Bioengineering and Applied Physics at Harvard University School of Engineering and Applied Sciences. His research focuses on cardiac cell biology and tissue engineering, traumatic brain injury, and biological applications of micro- and nanotechnologies. Working in both Biomimetic Microsystems and Programmable Nanomaterials, he is involved in projects ranging from developing nanofabrics for applications in tissue regeneration to creating organs-on-chips to address pediatric diseases such as asthma, muscular dystrophy, diabetes, brain injury and congenital heart disease.

Projects

Islet on a Chip

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Kit+Parker

Bio

Vladislav Petyuk is a Scientist at Pacific Northwest National Laboratory. His research focuses on quantitative proteomics and in particular involves development of algorithms for data preprocessing, assessment of data quality and statistical approaches for data exploration, hypothesis testing and inference of new biological knowledge.

Projects

Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Bio

Wei-Jun Qian is a bioanalytical chemist whose research centers primarily on the development and applications of mass spectrometry-based approaches for better quantify the dynamic changes in protein abundances and protein post-translational modifications in biological and clinical applications. His current research involves the development of chemical proteomic approaches for site-specific quantification of cysteine-based redox modifications and more sensitive selected reaction monitoring (SRM)-based targeted quantification techniques with applications in pancreatic islets, diabetes, and oxidative stress-related disease areas.

Projects

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=wei-jun+qian

Bio

Stephen Quake is a Professor of Bioengineering and Professor of Applied Physics at Stanford University and is co-President of the Chan Zuckerberg Biohub. Quake has invented many measurement tools for biology, including new DNA sequencing technologies that have enabled rapid analysis of the human genome and microfluidic automation that allows scientists to efficiently isolate individual cells and decipher their genetic code. Quake is also well known for inventing new diagnostic tools, including the first non-invasive prenatal test for Down syndrome and other aneuploidies.

Projects

Linking Islet Cell Function and Identity from in vitro to in situ

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Stephen+Quake

Bio

James Riley is a Professor of Microbiology at University of Pennsylvania Perelman School of Medicine. His lab studies the signaling pathways that control primary human T cell activation and function with special attention to how these manipulations can be exploited to develop T cell therapies for HIV, autoimmune disease and cancer. The lab is also focused on designing HIV resistant, HIV specific T cells to be key players in the HIV Cure effort.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_jriley?hilite=James+Riley

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=James+Riley

Bio

Mike Roper is a Professor in the Department of Chemistry and Biochemistry at Florida State University. His research focuses on how the secretion of multiple peptides and small molecules from islets of Langerhans contribute to proper glucose clearance in the body. This lab develops new analytical methods and techniques to investigate biological signaling.

Projects

Modular Monitoring of Hormone Release from Human Islets

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=mike+roper

Bio

Dr. Leslie Satin is a Professor of Pharmacology in the University of Michigan Medical School. Dr. Satin’s research has combined several strands, involving studies of the electrophysiology of neurons and synaptic changes after traumatic brain injury, the production of oscillations in neurosecretory cells and their theoretical basis, and the regulation of intracellular free Calcium and ion channels by cell fuel metabolism. Dr. Satin is an expert on the cellular signaling mechanisms, ion channel biophysics, the application of theoretical models to biomedical systems, and synaptic mechanisms of plasticity in the brain. He has served on the editorial boards of Neurochemistry International, Endocrinology, Endocrine, Diabetes, J. Biol. Chem., and American Journal of Physiology. He has served on many NIH study sections, including those devoted to TBI and stroke, and diabetes and metabolic diseases.

Projects

A Stress-Induced Vicious Cycle in the Development of T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Leslie+Satin