Midhat Abdulreda, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: MAbdulreda@med.miami.edu
Center: University of Miami

  • ORCID
  • LinkedIn

Lab:

https://hirnetwork.org/about/participants#short-profile-midhat-abdulreda-phd

HIRN Investigator Profile:

http://www.example.com/

Projects

  • Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity

Kristin Abraham, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: NIDDK Program Staff
Email: abrahamk@niddk.nih.gov
Center: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Bio

Kristin Abraham is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her interests are the role of the immune response in metabolic dysfunction and type 2 Diabetes, and projects that develop and validate the utility of new animal models for basic and preclinical research in diabetes, endocrinology and metabolic diseases.

Domenico Accili, MD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: da230@columbia.edu
Center: Columbia University

  • ORCID

Bio

Domenico Accili a Professor of Medicine at Columbia University, Attending Physician at Columbia-Presbyterian Hospital and Director of the Columbia University Diabetes and Endocrinology Research Center in New York, New York. His research focuses on understanding how insulin-producing cells are born, live, function, and die.

Projects

  • Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Domenico+Accili

Amanda Ackermann, MD, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Research Staff
Email: ackermanna@email.chop.edu
Center: University of Pennsylvania

Projects

  • Epigenetic Rejuvenation of Human Beta-Cells

Ashu Agarwal, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: a.agarwal2@miami.edu
Center: University of Miami

Projects

  • Engineering a Human Physiomimetic Islet Microsystem
  • Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems
  • Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Joana Almaca, PhD

Consortia: Human Pancreas Analysis Consortium, New Investigators, Opportunity Pool Projects
Role: Investigator
Email: JAlmaca@med.miami.edu
Center: University of Miami

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Joana Almaça is a HIRN New Investigator and an Assistant Professor of Medicine at the University of Miami Miller School of Medicine. Her current research focuses on the vasculature of the islet. In her work, Dr. Almaça is testing the hypothesis that microvascular dysfunction in the islet leads to a disturbance of hormone secretion, to glucose intolerance, and eventually to diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/profile-almaca

Projects

  • Changes in Human Islet Microvasculature during Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Joana+Almaca

Juan Alvarez, PhD

Consortia: Consortium on Human Islet Biomimetics, New Investigators
Role: Investigator
Email: Juan.Alvarez@pennmedicine.upenn.edu
Center: University of Pennsylvania

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Juan Alvarez is a HIRN Emerging Leader Award Recipient and an Assistant Professor of Cell and Developmental Biology at the University of Pennsylvania Perelman School of Medicine. His research focuses on human stem cell-derived pancreatic islet organoids and mice as model systems to study islet development, physiology, and pathology, and to develop replacement therapies for insulin-dependent diabetes. We focus on the interplay between circadian rhythms, metabolism, and islet cell maturation.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-juan-r-alvarez

Projects

  • Measuring Islet-wide Function with Soft Integrated Nanoelectronics

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=juan+alvarez

Mark S. Anderson, MD, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Mark.Anderson@ucsf.edu
Center: University of California, San Francisco

Projects

  • Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
  • Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance

Charles Ansong, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: Charles.Ansong@pnnl.gov
Center: Pacific Northwest National Laboratory

  • ORCID
  • LinkedIn

Bio

Charles Ansong was a Senior Research Scientist within the Integrative Omics group, Biological Sciences Division at PNNL. His research focused on the centers on the utilization of advanced mass spectrometry-based omics technologies and systems biology approaches to better understand complex biological systems relevant to human health and the environment. Currently, he is a Program Director at The National Institutes of Health at the National Institute of General Medical Sciences (NIGMS).

Projects

  • The Proteome of Replicating Cells
  • Single Cell Resolution of Omics Analysis of T1D Islets
  • Alternative RNA Splicing Events Contribute to the Onset of islet dysfunction in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Charles+Ansong

Efsun Arda, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Postdoctoral Fellow
Email: ardah@stanford.edu
Center: Stanford University

Lab:

https://hirnetwork.org/about/participants#short-profile-seung-kim-md-phd

Projects

  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Radhika Armandla

Consortia: Consortium on Targeting and Regeneration, Human Pancreas Analysis Consortium
Role: Research Staff
Email: aramandla.radhika@vumc.org
Center: Vanderbilt University

Lab:

https://hirnetwork.org/about/participants#short-profile-al-powers-md

Projects

  • High-Resolution Analysis of Juvenile Human Pancreas Maturation
  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Lucas Armitage

Consortia: Consortium on Modeling Autoimmune Interactions, Consortium on Beta Cell Death & Survival
Role: Research Staff
Email: lucasarmitage@ufl.edu
Center: University of Colorado, Denver

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Lucas Armitage first participated in the HIRN while as a graduate student in the Wallet & Brusko Labs at the University of Florida. Currently, he is a Postdoctoral Research Fellow with the Russ Lab at the University of Colorado Denver.

Lab:

https://hirnetwork.org/about/participants#short-profile-prashanth-vallabhajosyula-md

Projects

  • Genetic Regulation of Human Beta Cell Destruction

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Lucas+Armitage

Guillermo Arreaza-Rubin, MD

Consortia: Consortium on Human Islet Biomimetics, Consortium on Modeling Autoimmune Interactions, Human Pancreas Analysis Consortium
Role: NIDDK Program Staff
Email: arreaza-rubing@niddk.nih.gov
Center: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Bio

Guillermo Arreaza-Rubin is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in diabetes and endocrine disease bioengineering and glucose sensing.

Rafael Arrojo e Drigo, PhD

Consortia: Human Pancreas Analysis Consortium, Consortium on Beta Cell Death & Survival, New Investigators
Role: Investigator
Email: r.drigo@vanderbilt.edu
Center: Vanderbilt University

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Rafael Arrojo e Drigo is a Gateway Award Recipient and co-Investigator on a HPAC Grant. He is an Assistant Professor in the Department of Molecular Physiology and Biophysics at Vanderbilt School of Medicine. His research focuses on understanding the mechanisms regulating post-mitotic cell homeostasis and longevity.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-rafael-arrojo-e-drigo?hilite=%27rafael%27

Projects

  • Mapping the Association of Beta Cell Longevity and Senescence in T1D
  • Linking Islet Cell Function and Identity from in vitro to in situ

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Rafael+Arrojo+e+Drigo

Peter Arvan, MD, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: parvan@med.umich.edu

  • ORCID
  • LinkedIn

Bio

Peter Arvan is the Division of Metabolism, Endocrinology, & Diabetes at the University of Michigan. His research focus is to examine molecular mechanisms involved in the folding, trafficking, and targeting of newly-synthesized endocrine secretory proteins

Projects

  • A Stress-Induced Vicious Cycle in the Development of T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Peter+Arvan

Mark Atkinson, PhD

Consortia: Human Pancreas Analysis Consortium, Consortium on Beta Cell Death & Survival
Role: Investigator
Email: atkinson@pathology.ufl.edu
Center: University of Florida

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Mark Atkinson is currently the American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at the University of Florida. He also is the Director of the Diabetes Institute at the University of Florida. Additionally, he is the Executive Director of the JDRF Network for Pancreatic Organ donors with Diabetes (nPOD) program and the President of Insulin for Life USA, the world’s second largest charity dedicated to providing insulin to persons living with diabetes in the developing world. His research focuses on type 1 diabetes, pancreatic pathology, immune therapy, autoimmunity, clinical trials, translational research, emerging technologies, psychosocial behaviors, and metabolism.

Projects

  • Defining Islet Heterogeneity Using Single Islet Transcriptomics
  • HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.)
  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
  • Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry
  • Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Mark+Atkinson

Dana Avrahami-Tzfati, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: danaav@mail.med.upenn.edu
Center: Hadassah-Hebrew University

Projects

  • Epigenetic Rejuvenation of Human Beta-Cells
  • The Role of Beta Cell Senescence in the Pathogenesis of Diabetes

Rhonda Bacher, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: rbacher@ufl.edu
Center: University of Florida

Hugh Bender, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Postdoctoral Fellow
Email: rhbender@uci.edu
Center: University of California at Irvine

  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Hugh Bender is a Postdoctoral Research Fellow in the Chris Hughes Lab at the University of California, Irvine. He is also Lead Scientist at Aracari Biosciences. Dr. Bender received his PhD in 2015 from Washington University in St. Louis. His research focuses on developing a novel micro-vascularized organ system for modeling Type I diabetes in the lab. Dr. Bender is an active member of CHIB and a member of the HIRN Technical User Group.

Lab:

https://faculty.sites.uci.edu/hugheslab/

HIRN Investigator Profile:

https://hirnetwork.org/staff_hbender

Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
  • A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes

Nelly Berger

Consortia: Enhancement Center
Role: Administrator, HIREC Staff
Email: nberger@coh.org
Center: City of Hope

HIRN Investigator Profile:

https://hirnetwork.org/hirecstaff_nberger

Projects

  • Human Islet Research Enhancement Center (HIREC)

Sandy Beshir, MPH

Consortia: Enhancement Center
Role: HIREC Staff, Administrator
Email: sbeshir@coh.org
Center: City of Hope

  • LinkedIn

HIRN Investigator Profile:

https://hirnetwork.org/hirec-staff-sandy-beshir

Projects

  • Human Islet Research Enhancement Center (HIREC)

Michael Betts, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: betts@mail.med.upenn.edu
Center: University of Pennsylvania

Projects

  • HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania)

Sangeeta Bhatia, MD, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: sbhatia@MIT.EDU
Center: Massachusetts Institute of Technology

Projects

  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Anil Bhushan, PhD

Consortia: Consortium on Targeting and Regeneration
Role: External Scientific Panel
Email: Anil.Bhushan@ucsf.edu
Center: University of California, San Francisco

Olivier Blondel, PhD

Consortia: Consortium on Beta Cell Death & Survival, Consortium on Targeting and Regeneration, Human Pancreas Analysis Consortium
Role: NIDDK Program Staff
Email: blondelol@niddk.nih.gov
Center: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Bio

Olivier Blondel is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests lie in research that focuses on endocrine signaling, stem cell biology, organ development, regenerative medicine and biomarker discovery as it relates to diabetes (type 1 and type 2) and metabolic diseases, particularly in combination with experimental approaches such as large-scale genomics, synthetic biology, bioengineering, epigenetics, nuclear organization of mammalian genomes, chromatin biology, genome editing, gene therapy

Jeffrey Bluestone, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Jeff.Bluestone@ucsf.edu
Center: University of California, San Francisco

Projects

  • Therapeutic Targeting of the Human Islet Environment
  • Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance

Bernd Bodenmiller, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: bernd.bodenmiller@imls.uzh.ch
Center: University of Zurich

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Projects

  • Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Bernd+Bodenmiller

Chiara Borsotti, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Postdoctoral Fellow
Email: cb2943@columbia.edu
Center: Columbia University

Lab:

https://hirnetwork.org/about/participants#short-profile-megan-sykes-md

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Rita Bortell, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: rita.bortell@umassmed.edu
Center: University of Massachusetts Medical School

Rita Bottino, PhD

Consortia: Consortium on Targeting and Regeneration, Human Pancreas Analysis Consortium
Role: Investigator
Email: RBottino@wpahs.org
Center: Allegheny Health Network

Projects

  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Annie Bowles, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Postdoctoral Fellow
Email: acb233@miami.edu
Center: University of Miami

Projects

  • Engineering a Human Physiomimetic Islet Microsystem

Michael Brehm, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: michael.brehm@umassmed.edu
Center: University of Massachusetts Medical School

  • ORCID
  • LinkedIn

Projects

  • Humanized Mouse Avatars for T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Michael+Brehm

HIRN Webinar:

Linford Briant, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Collaborator
Email: linford.briant@ocdem.ox.ac.uk
Center: University of Oxford

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Marcela Brissova, PhD

Consortia: Human Pancreas Analysis Consortium, Consortium on Targeting and Regeneration
Role: Investigator
Email: marcela.brissova@vanderbilt.edu
Center: Vanderbilt University

Projects

  • In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas
  • High-Resolution Analysis of Juvenile Human Pancreas Maturation
  • HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.)
  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/Contributor/Index/marcela_brissova@hirnetwork.org

Todd Brusko, PhD

Consortia: Consortium on Human Islet Biomimetics, Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: tbrusko@ufl.edu
Center: University of Florida

Projects

  • Genetic Regulation of Human Beta Cell Destruction
  • Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
  • Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D
  • Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Peter Buchwald, PhD

Consortia: Consortium on Human Islet Biomimetics, Consortium on Targeting and Regeneration
Role: Investigator
Email: pbuchwald@med.miami.edu
Center: University of Miami

Projects

  • Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity
  • Engineering a Human Physiomimetic Islet Microsystem

Kristin Burnum-Johnson, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: kristin.burnum-johnson@pnnl.gov
Center: Pacific Northwest National Laboratory

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Kristin Burnum-Johnson is a Senior Scientist and Team Lead of the Environmental Molecular Sciences Laboratory's Metabolomics group at Pacific Northwest National Laboratory. Her research is dedicated to characterizing the molecular landscape of heterogeneous samples using novel mass spectrometry approaches to address specific biological, medical, and environmental research questions. These approaches involve multi-dimensional liquid chromatography and ion mobility separations in conjunction with mass spectrometry to measure proteins, lipids, and metabolites.

Projects

  • Single Cell Resolution of Omics Analysis of T1D Islets

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Kristin+Burnum-Johnson

Long Cai, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: lcai@caltech.edu
Center: California Institute of Technology

  • Twitter

Bio

Long Cai is a Professor of Biology and Biological Engineering at CalTech. His research develops sequential FISH (seqFISH), MEMOIR, and RNA SPOTs, apply them to study various biological questions.

Projects

  • High-Resolution Analysis of Juvenile Human Pancreas Maturation

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Long+Cai

Alejandro Caicedo, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: ACaicedo@med.miami.edu
Center: University of Miami

  • ORCID
  • ResearchGate
  • LinkedIn

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_caicedo

Projects

  • In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas
  • High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential
  • Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Alejandro+Caicedo

HIRN Webinar:

 

Martha Campbell-Thompson, DVM PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: mct@ufl.edu
Center: University of Florida

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Martha Campbell-Thompson is a Professor, Director of the Molecular Pathology Core at the University of Florida and Director of the JDRF nPOD Organ Procurement and Pathology Core. Her research interests are in beta cell biology, beta cell regeneration for type 1 diabetes, islet inflammation and neuromodulation of beta cell function.

Projects

  • Defining Islet Heterogeneity Using Single Islet Transcriptomics

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Martha+Campbell+Thompson

HIRN Webinar:

Sean Campbell, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Research Staff
Email: src2138@cumc.columbia.edu
Center: Columbia University

Lab:

https://hirnetwork.org/about/participants#short-profile-megan-sykes-md

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Joan Camunas, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Postdoctoral Fellow
Email: jcamunas@stanford.edu
Center: Stanford University

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Joseph Canzano

Role: Research Staff
Email: jcanzano@ufl.edu
Center: University of Florida

Lab:

https://hirnetwork.org/about/participants#short-profile-martha-campbell-thompson-dvm-phd

Projects

  • Defining Islet Heterogeneity Using Single Islet Transcriptomics

Richard Caprioli, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: richard.m.caprioli@vanderbilt.edu
Center: Vanderbilt University

  • ORCID
  • Twitter

Bio

Richard Caprioli is the Director of the Mass Spectrometry Research Center at Vanderbilt University School of Medicine and a Professor in the Departments of Chemistry and Pharmacology at Vanderbilt University. The research interests of this laboratory are aimed at the investigation of biological processes involving the synthesis, modification, storage and degradation of certain peptides and proteins using modern mass spectrometric methods of analysis to follow molecular events. In recent years there has been a great amount of interest in investigating the biochemical events involved in the metabolism of peptides, primarily in the brain and gut of mammals, encompassing the enzymatic breakdown of these peptides, their production from peptide and protein precursors, and the disruption of these processes by certain xenobiotics.

Projects

  • High-Resolution Analysis of Juvenile Human Pancreas Maturation

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Richard+Caprioli

Fabian Cardenas

Consortia: Consortium on Human Islet Biomimetics
Role: Research Staff
Email: fcar@sas.upenn.edu
Center: University of Pennsylvania

Lab:

https://hirnetwork.org/about/participants#short-profile-paul-gadue-phd

Projects

  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Melanie Cash

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Research Staff
Email: mcash@pathology.ufl.edu
Center: University of Florida

Lab:

https://hirnetwork.org/about/participants#short-profile-mark-wallet-phd

Projects

  • Genetic Regulation of Human Beta Cell Destruction

Xiaojuan Chen, MD, PhD

Role: Investigator
Email: xc2248@cumc.columbia.edu
Center: Columbia University

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Chris Chen, MD, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: chencs@bu.edu
Center: Boston University

Projects

  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Hao Chen, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: hchen@uthsc.edu
Center: University Tennessee

Bio

Hao Chen is an Associate Professor in the Department of Pharmacology, Addiction Science, and Toxicology at the University of Tennessee Health Science Center. His research interests are in Genetic variants influcing operant drug intake in rats, novel rat models of drug abuse, integrating computation into rodent behavioral experiments, and genomics and transcriptomics.

Projects

  • Defining Islet Heterogeneity Using Single Islet Transcriptomics

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Hao+Chen

Jing Chen, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: jic24@pathology.ufl.edu
Center: University of Florida

Projects

  • Genetic Regulation of Human Beta Cell Destruction

Shuibing Chen, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: shc2034@med.cornell.edu
Center: Weill Cornell Medical College

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Shuibing Chen is an Associate Professor in the Department of Surgery and Department of Biochemistry at Weill Cornell Medical College. Her research interest is to manipulate stem cell fate using chemical and biological approaches and to generate functional tissues and organs that can be used for translational research.

Projects

  • Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Shuibing+Chen

Josh Chiou

Consortia: Human Pancreas Analysis Consortium
Role: Research Staff
Email: joshchiou@ucsd.edu
Center: University of California, San Diego

Projects

  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Amit Choudhary, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: achoud@broadinstitute.org
Center: Broad Institute

Projects

  • Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
  • One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery

Karen Christman, PhD, FAHA

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: christman@eng.ucsd.edu
Center: University of California at San Diego

Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
  • Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM
  • A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes

Remi Creusot, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: rjc2150@cumc.columbia.edu
Center: Columbia University

Projects

  • Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems

Chunhua Dai, MD

Consortia: Consortium on Targeting and Regeneration, Human Pancreas Analysis Consortium
Role: Investigator
Email: chunhua.dai@vanderbilt.edu
Center: Vanderbilt University

Projects

  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

XiaoQing Dai, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Research Staff
Email: xdai@ualberta.ca
Center: University of Alberta

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

George Daley, MD, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: George_Daley@hms.harvard.edu
Center: Harvard Medical School

Projects

  • Humanized Mouse Avatars for T1D

Nichole Danzl, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: nmd2101@columbia.edu
Center: Columbia University

Lab:

https://hirnetwork.org/about/participants#short-profile-megan-sykes-md

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Sangeeta Dhawan, PhD

Consortia: Consortium on Targeting and Regeneration, New Investigators, Opportunity Pool Projects
Role: Investigator
Email: sdhawan@coh.org
Center: City of Hope

  • ORCID
  • LinkedIn

Bio

Sangeeta Dhawan is a HIRN New Investigator and an Assistant Professor in the Department of Translational Research & Cellular Therapeutics. Her research focuses on the understanding the biology of the insulin producing beta cells.

HIRN Investigator Profile:

https://hirnetwork.org/profile-dhawan

Projects

  • Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Sangeeta+Dhawan

Teresa DiLorenzo, PhD

Role: External Scientific Panel
Email: teresa.dilorenzo@einstein.yu.edu
Center: Albert Einstein College of Medicine

Xiaolan Ding

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Postdoctoral Fellow
Email: xd2150@cumc.columbia.edu

Nicolai Doliba, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: nicolai@pennmedicine.upenn.edu

Juan Dominguez-Bendala, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: jdominguez2@med.miami.edu
Center: University of Miami

Projects

  • High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential

Yuval Dor, PhD

Consortia: Consortium on Beta Cell Death & Survival, Consortium on Targeting and Regeneration
Role: Investigator
Email: yuvald@ekmd.huji.ac.il
Center: Hebrew University of Jerusalem

  • ORCID
  • ResearchGate

Bio

Yuval Dor is a Professor of Biology at the Hebrew University of Jerusalem. He has worked in the past mostly on diabetes and tissue regeneration in the pancreas, but in recent years much of our focus has shifted to a new technology that we are developing, for non-invasive monitoring of cell death in humans, based on circulating DNA.

Projects

  • Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
  • Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms
  • Non-invasive Diagnosis of Human Beta Cell Damage and Death
  • The Proteome of Replicating Cells

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Yuval+Dor

Thomas Eggerman, MD, PhD

Consortia: Enhancement Center
Role: NIDDK Program Staff
Email: eggermant@mail.nih.gov
Center: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Bio

Thomas Eggerman is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in cystic fibrosis research and translation centers, inborn errors of metabolism, clinical trials, and islet transplantation, and inborn errors of metabolism.

Dieter Egli, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: de2220@columbia.edu
Center: Columbia University

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Decio Eizirik, MD, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: Decio.Laks.Eizirik@ulb.ac.be
Center: University of Brussels

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Decio L. Eizirik is a Professor at the ULB Center for Diabetes Research Medical Faculty, Universite Libre de Bruxells (ULB) in Brussels, Belgium. His research focuses on the molecular mechanisms regulating insulitis and beta cell apoptosis in type 1 diabetes and on the search for novel approaches to prevent the progressive loss of beta cell mass in diabetes.

Projects

  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
  • Integrated Stress Response in Human Islets during Early T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Decio+Eizirik%2C

Abdelfattah El Ouaamari, PhD

Consortia: New Investigators, Consortium on Targeting and Regeneration, Opportunity Pool Projects
Role: Investigator
Email: abdelfattah.elouaamari@rutgers.edu
Center: Rutgers University

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Abdelfattah El Ouaamari is a HIRN New Investigator and an Assistant Professor in Medicine at Robert Wood Johnson Medical School at Rutgers University. His research employs a multidisciplinary approach to identify local, systemic and neuronal signals regulating the number and the function of pancreatic islet insulin-producing β cells in mouse and human models of obesity and diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/profile-elouaamari

Projects

  • Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells.

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Abdel+El+Ouaamari

Elise Engquist

Consortia: Consortium on Human Islet Biomimetics
Role: Research Staff
Email: eliseengquist@fas.harvard.edu
Center: Harvard University

Projects

  • Biomarkers for Diabetes using Stem Cell-derived Beta Cells

Carmella Evans-Molina, MD, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: cevansmo@iupui.edu
Center: Indiana University

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Projects

  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
  • Integrated Stress Response in Human Islets during Early T1D
  • Workshop for Continued Harmonization of Beta Cell Death Assays

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Carmella+Evans-Molina

Michael Feldman, MD, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: feldmanm@mail.med.upenn.edu
Center: University of Pennsylvania

Projects

  • HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania)
  • HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)

Leonardo Ferreira, PhD

Consortia: Consortium on Modeling Autoimmune Interactions, New Investigators
Role: Investigator
Email: ferreirl@musc.edu
Center: Medical University of South Carolina

  • ORCID
  • LinkedIn
  • Twitter

Bio

Leonardo Ferreira is a HIRN Emerging Leader Award Recipient and an Assistant Professor of Microbiology and Immunology at the Medical University of South Carolina. His research focuses on phenomenon of immune tolerance, his long term goal is to control how the immune system defines self and non-self. Such knowledge will allow the design and development of powerful new engineered immune cell therapies to fight autoimmune disease, cancer, and aging.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-leonardo-m-r-ferreira

Projects

  • Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells

Jorge Ferrer, MD, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: j.ferrer@imperial.ac.uk
Center: Imperial College of London

  • ORCID
  • Twitter

Projects

  • Non-invasive Diagnosis of Human Beta Cell Damage and Death

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Jorge+Ferrer

Kenichiro Furuyama, MD, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: kenichiro.furuyama@unige.ch
Center: University of Geneva

Projects

  • Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery

Paul Gadue, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: gaduep@email.chop.edu
Center: Children's Hospital of Philadelphia

Projects

  • Functional Testing of Candidate HSC-derived Islet Cells
  • Generation of Functional Endocrine Cell Reporter Pluripotent Cell Lines
  • Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes
  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Roberto Gaetani

Role: Research Staff
Email: rgaetani@eng.ucsd.edu
Center: University of California at San Diego

Lab:

https://hirnetwork.org/about/participants#short-profile-karen-christman-phd-faha

Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease

Feorillo Galivo, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Postdoctoral Fellow
Email: galivo@ohsu.edu
Center: Oregon Health and Science University

Lab:

https://hirnetwork.org/about/participants#short-profile-markus-grompe-md

Projects

  • In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors

Alannon Gannon, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Postdoctoral Fellow
Email: agannon@seas.harvard.edu
Center: Harvard University

Lab:

https://hirnetwork.org/about/participants#short-profile-kit-parker-phd

Projects

  • Islet on a Chip

Yuqian Gao

Role: Research Staff
Email: yuqian.gao@pnnl.gov
Center: Pacific Northwest National Laboratory

Lab:

https://hirnetwork.org/about/participants#short-profile-thomas-metz-phd

Projects

  • Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Kerim Gattas-Asfura, PhD

Role: Research Staff
Email: Kerim.GattasAsfura@bme.ufl.edu
Center: University of Florida

Lab:

https://hirnetwork.org/about/participants#short-profile-cherie-stabler-phd

Projects

  • Engineering a Human Physiomimetic Islet Microsystem

Kyle Gaulton, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: kgaulton@ucsd.edu
Center: University of California, San Diego

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Projects

  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Kyle+Gaulton

HIRN Webinar:

Steven George, MD, PhD

Role: Investigator
Email: scgeorge@ucdavis.edu
Center: University of California, Davis

Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
  • A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes

Ivan Gerling, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: igerling@uthsc.edu
Center: University of Tennessee

  • ORCID

Projects

  • Defining Islet Heterogeneity Using Single Islet Transcriptomics

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Ivan+Gerling

Ronald Gill, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Ronald.gill@ucdenver.edu
Center: University of Colorado at Denver

Projects

  • Analysis of Human Autoreactive T Cell Receptors in vivo

Benjamin Glaser, MD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: ben.glaser@mail.huji.ac.il
Center: Hadassah-Hebrew University

Projects

  • Epigenetic Rejuvenation of Human Beta-Cells
  • The Role of Beta Cell Senescence in the Pathogenesis of Diabetes

Anna Gloyn, D Phil

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: agloyn@stanford.edu
Center: Stanford University

Projects

  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)

Robin Goland, MD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: rsg2@columbia.edu
Center: Columbia University

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
  • Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems

Maria Golson, PhD

Role: Research Staff
Email: mgolson@mail.med.upenn.edu
Center: University of Pennsylvania

Lab:

https://hirnetwork.org/about/participants#short-profile-klaus-kaestner-phd

Projects

  • Epigenetic Rejuvenation of Human Beta-Cells
  • HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania)

David Gonzalez

Role: Research Staff
Email: david_gonzalez@harvard.edu
Center: Harvard University

Lab:

https://hirnetwork.org/about/participants#short-profile-douglas-melton-phd

Projects

  • Islet on a Chip

Bryan Gonzalez

Role: Research Staff
Email: bg2450@cumc.columbia.edu
Center: Columbia University

Lab:

https://hirnetwork.org/about/participants#short-profile-dieter-egli-phd

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

David Gorkin, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: dgorkin@ucsd.edu
Center: University of California, San Diego

Projects

  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Peter Gottlieb, MD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: peter.gottlieb@ucdenver.edu
Center: University of Colorado at Denver

Projects

  • Analysis of Human Autoreactive T Cell Receptors in vivo

Viviana Gradinaru, PhD

Role: Investigator
Email: viviana@caltech.edu
Center: California Institute of Technology

Projects

  • High-Resolution Analysis of Juvenile Human Pancreas Maturation

Rafael Gras, PhD

Role: Postdoctoral Fellow
Email: rg2837@columbia.edu
Center: Columbia University

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Carla Greenbaum, MD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: cjgreen@benaroyaresearch.org
Center: Benaroya Research Institute

  • ORCID

Bio

Carla Greenbaum is the Director, of the Center for Interventional Immunology and the Director of the Diabetes Research Program at Benaroya Research Institute. Her research interests are in clinical investigations and trials to prevent or intervene in the diabetes autoimmune disease process.

Projects

  • Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Carla+Greenbaum

Dale Greiner, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Dale.greiner@umassmed.edu
Center: University of Massachusetts Medical School

Projects

  • Humanized Mouse Avatars for T1D

Jeffrey Grethe, PhD

Role: External Scientific Panel
Email: jgrethe@ncmir.ucsd.edu
Center: University of California at San Diego

Marina Gritsenko

Role: Research Staff
Email: marina.gritsenko@pnnl.gov
Center: Pacific Northwest National Laboratory

Lab:

https://hirnetwork.org/about/participants#short-profile-thomas-metz-phd

Projects

  • Single Cell Resolution of Omics Analysis of T1D Islets

Markus Grompe, MD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: grompem@ohsu.edu
Center: Oregon Health & Science University

Projects

  • In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
  • Gene Therapy for Diabetes
  • Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry

Kirk Hansen, PhD

Role: Collaborator
Email: kirk.hansen@ucdenver.edu
Center: University of Colorado at Denver

Projects

  • Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM

Manami Hara, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: mhara@medicine.bsd.uchicago.edu
Center: University of Chicago

  • ORCID

Bio

Manami Hara is a Research Professor in the Division of Endocrinology, Diabetes and Metabolism at the University of Chicago. Her research focus is on the developmental biology of pancreatic islets. The islet of Langerhans is a micro-organ composed of insulin-secreting beta-cells and other endocrine cells that work together to maintain glucose homeostasis.

Projects

  • Integrated Stress Response in Human Islets during Early T1D

HIRN Webinar:

David Harlan, MD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: David.Harlan@umassmemorial.org
Center: University of Massachusetts Medical School

Projects

  • Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
  • Humanized Mouse Avatars for T1D

Chuan He, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: chuanhe@uchicago.edu
Center: University of Chicago

  • LinkedIn

Bio

Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry at the University of Chicago. His research spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, and bioinorganic chemistry.

Projects

  • Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Chuan+He

Matthias Hebrok, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Mhebrok@diabetes.ucsf.edu
Center: University of California, San Francisco

Projects

  • Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
  • Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance

Kevan Herold, MD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: Kevan.herold@yale.edu
Center: Yale University

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Kevan Herold is the C.N.H. Long Professor of Immunobiology and of Medicine at Yale School of Medicine. He studies autoimmune diseases, whether they occur naturally or as a consequence of immunomodulator therapy.

Projects

  • Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Kevan+Herold

Pedro Herrera, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: pedro.herrera@unige.ch
Center: University of Geneva

Projects

  • Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery
  • Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Martin Hetzer, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: hetzer@salk.edu
Center: Salk Institute

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Julie Hom

Role: Administrator
Email: JHom@coh.org

Dirk Homann, MD

Consortia: Consortium on Modeling Autoimmune Interactions, Human Pancreas Analysis Consortium
Role: Investigator, External Scientific Panel
Email: dirk.homann@mssm.edu
Center: Mount Sinai Hospital

Projects

  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
  • Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
  • Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata

Jennifer Hosford

Role: Research Staff
Email: zorra@ufl.edu
Center: University of Florida

Lab:

https://hirnetwork.org/about/participants#short-profile-desmond-schatz-md

Projects

  • Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms
  • Non-invasive Diagnosis of Human Beta Cell Damage and Death

Jing Hughes, MD, PhD

Consortia: Human Pancreas Analysis Consortium, New Investigators
Role: Investigator
Email: jing.hughes@wustl.edu

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Jing Hughes is a Gateway Award Recipient and an Assistant Professor of Medicine in the Division of Endocrinology, Metabolism, and Lipid Research at the Washington University School of Medicine in St Louis. Her research focuses on the islet cell-cell interactions and the regulation of islet hormone secretion.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-jing-hughes

Projects

  • Primary Cilia in Human T1D Pancreas

Chris Hughes, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: cchughes@uci.edu
Center: University of California at Irvine

Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
  • Modular Monitoring of Hormone Release from Human Islets
  • A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes

Dan Huh, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: huhd@seas.upenn.edu
Center: University of Pennsylvania

  • ORCID
  • LinkedIn

Projects

  • Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes
  • A Vascularized 3D Biomimetic for Islet Function and Physiology

HIRN Webinar:

Mark Huising, PhD

Role: External Scientific Panel
Email: mhuising@ucdavis.edu
Center: University of California at Davis

Albert Hwa, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: NIDDK Program Staff
Email: albert.hwa@nih.gov
Center: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  • ORCID
  • LinkedIn
  • Twitter

Bio

Albert Hwa is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in the basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease; generation of islet cells from stem cells for disease modeling and regenerative medicine.

Matthew Ishahak

Role: Research Staff
Email: m.ishahak@umiami.edu
Center: University of Miami

Lab:

https://hirnetwork.org/about/participants#short-profile-ashu-agarwal-phd

Projects

  • Engineering a Human Physiomimetic Islet Microsystem

Eddie James, PhD

Consortia: Consortium on Modeling Autoimmune Interactions, New Investigators, Opportunity Pool Projects
Role: Investigator
Email: ejames@benaroyaresearch.org
Center: Benaroya Research Institute

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Eddie James is a HIRN New Investigator and a Principal Investigator at Benaroya Research Institute. His research involves applying tetramers to identify the chemical patters recognized by T cells in desirable protective immune responses directed against viruses (such as tetanus and HPV) and in undesirable destructive immune responses directed against self or therapeutic proteins (including GAD, insulin, and Factor VIII).

HIRN Investigator Profile:

https://hirnetwork.org/profile-ejames

Projects

  • HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Eddie+James

Alok Joglekar, PhD

Consortia: Consortium on Modeling Autoimmune Interactions, New Investigators
Role: Investigator
Email: JOGLEKAR@pitt.edu

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Alok Joglekar is a Gateway Award Recipient and an Assistant Research Professor of Immunology at the University of Pittsburgh. His research aims to examine the shifting antigenic landscape of anti-tumor T cell responses, determine the fundamental rules of TCR-pMHC interactions, and to investigate novel immunotherapies to autoimmune diseases.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-alok-joglekar

Projects

  • Identification of the Cognate Epitopes of Autoreactive T Cells in T1D

Robert Jones

Role: Research Staff
Email: jonesbob@stanford.edu
Center: Stanford University

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

John Kaddis, PhD

Consortia: Enhancement Center
Role: Investigator
Email: jkaddis@coh.org
Center: City of Hope

  • ORCID
  • ResearchGate

Lab:

https://tinyurl.com/kaddislab

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_jkaddis

Projects

  • Human Islet Research Enhancement Center (HIREC)

Klaus Kaestner, PhD

Consortia: Consortium on Beta Cell Death & Survival, Consortium on Targeting and Regeneration, Human Pancreas Analysis Consortium
Role: Investigator
Email: kaestner@pennmedicine.upenn.edu
Center: University of Pennsylvania

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Klaus Kaestner is the Thomas and Evelyn Suor Butterworth Professor in Genetics at the Perelman School of Medicine at the University of Pennsylvania and the Director of the Functional Genomics Core at the University of Pennsylvania. His research interest is in employing modern genetic, genomic and epigenomic approaches (ChIP-Seq, RNA-Seq, gene targeting, tissue-specific and inducible gene ablation, CyTOF) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. Disease areas targeted by our research include diabetes and cancer.

Projects

  • Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
  • Epigenetic Rejuvenation of Human Beta-Cells
  • HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania)
  • HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)
  • A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
  • Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes?
  • Mass Spectrometry-based Proteome Maps for Human Islet Cells

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Klaus+Kaestner

HIRN Webinar:

John Kappler, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: kapplerj@njc.org
Center: National Jewish Medical & Research Center

Projects

  • Analysis of Human Autoreactive T Cell Receptors in vivo

Jeff Karp, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: jeffkarp@mit.edu
Center: Brigham and Women's Hospital

Projects

  • Islet on a Chip

Mark Kay, MD, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: markay@stanford.edu
Center: Stanford University

  • ORCID
  • ResearchGate
  • LinkedIn

Projects

  • In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
  • Gene Therapy for Diabetes

HIRN Webinar:

Sally Kent, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Sally.Kent@umassmed.edu
Center: University of Massachusetts Medical School

Projects

  • Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
  • Humanized Mouse Avatars for T1D
  • Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D

Timothy Kieffer, PhD

Role: External Scientific Panel
Email: tim.kieffer@ubc.ca
Center: University of British Columbia

Seung Kim, MD, PhD

Consortia: Human Pancreas Analysis Consortium, Consortium on Targeting and Regeneration
Role: Investigator
Email: seungkim@stanford.edu
Center: Stanford University

Projects

  • CAR T Cell Targeting of Human Islets
  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
  • Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells
  • Linking Islet Cell Function and Identity from in vitro to in situ
  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
  • Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata

Yuong-Mo Kim

Role: Research Staff
Email: yuongmo.kim@pnnl.gov
Center: Pacific Northwest National Laboratory

Lab:

https://hirnetwork.org/about/participants#short-profile-thomas-metz-phd

Siddharth Kishore

Role: Research Staff
Email: skishore@mail.med.upenn.edu
Center: University of Pennsylvania

Lab:

https://hirnetwork.org/about/participants#short-profile-paul-gadue-phd

Projects

  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Stephan Kissler, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: Stephan.Kissler@joslin.harvard.edu
Center: Joslin Diabetes Institute

Projects

  • Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling

Dave Ko

Consortia: Enhancement Center
Role: Administrator, HIREC Staff
Email: dko@coh.org
Center: City of Hope

  • ResearchGate
  • LinkedIn

HIRN Investigator Profile:

https://hirnetwork.org/hirecstaff_dko

Projects

  • Human Islet Research Enhancement Center (HIREC)

Hirotake Komatsu, PhD

Consortia: Consortium on Human Islet Biomimetics, New Investigators
Role: Investigator
Email: hkomatsu@coh.org
Center: City of Hope

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Hirotake Komatsu is a Gateway Award Recipient and an Assistant Research Professor in the Department of Translational Research & Cellular Therapeutics at City of Hope. His expertise is derived from a broad training in medicine and basic research in the fields of pancreas surgery and pancreatic islet transplantation.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-hirotake-komatsu?hilite=%27hirotake%27

Projects

  • Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft

Tatsu Kono, PhD

Role: Research Staff
Email: konot@iu.edu
Center: Indiana University School of Medicine

Lab:

https://hirnetwork.org/about/participants#short-profile-raghavendra-mirmira-md-phd

Vira Kravets, PhD

Consortia: Human Pancreas Analysis Consortium, New Investigators
Role: Investigator
Email: VIRA.KRAVETS@CUANSCHUTZ.EDU
Center: University of Colorado, Denver

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Vira Kravets is a HIRN Emerging Leader Award Recipient and a Postdoctoral Research Fellow in the Department of Bioengineering at the University of Colorado Anschutz Medical Campus. She is currently leading interdisciplinary projects in search for the underlying causes for Diabetes. Juvenile Diabetes Research Foundation supported Fellow, skilled in Islet Biology, Surface Plasmon Resonance, Microscopy, Optics and Public Speaking

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-vira-kavets

Projects

  • Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets

Rohit Kulkarni, MD, PhD

Consortia: Consortium on Beta Cell Death & Survival, Consortium on Targeting and Regeneration
Role: Investigator
Email: rohit.kulkarni@joslin.harvard.edu
Center: Joslin Diabetes Center

  • LinkedIn

Bio

Rohit Kulkarni is Professor of Medicine at Harvard Medical School, Margaret A. Congleton Chair and Co-Head of the Section on Islet & Regenerative Biology at Joslin Diabetes Center. His research explores the significance of growth factor signaling mechanisms in the regulation of islet biology by creating genetic models to examine the roles of insulin/IGF-1 receptors and their substrate proteins.

Projects

  • Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
  • Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes
  • Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
  • One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Rohit+Kulkarni

HIRN Webinar:

Taiyi Diana Kuo, PhD

Role: Research Staff
Email: tk2592@cumc.columbia.edu
Center: Columbia University

Lab:

https://hirnetwork.org/about/participants#short-profile-domenico-accili-md

Irina Kusmartseva, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: inkusmartseva@ufl.edu
Center: University of Florida

Projects

  • HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.)

Jennifer Kyle, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Postdoctoral Fellow
Email: jennifer.kyle@pnnl.gov
Center: Pacific Northwest National Laboratory

  • ORCID
  • Twitter

Bio

Jennifer Kyle was a Postdoctoral Research Fellow in the Metz Lab at Pacific Northwest National Laboratory. For her HIRN project, her responsibilities focused on refining liquid chromatography-mass spectrometry-based lipidomics analyses, including the development of novel informatics tools for confident lipid identification, and in performing lipidomics analyses of pancreatic islets.

Lab:

https://hirnetwork.org/about/participants#short-profile-thomas-metz-phd

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Jennifer+Kyle

Maggie Lam, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: Maggie.Lam@ucdenver.edu
Center: University of Colorado, Denver

  • ORCID

Bio

Maggie Lam

Projects

  • Alternative RNA Splicing Events Contribute to the Onset of islet dysfunction in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Maggie+Lam

Julia Laskin, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: jlaskin@purdue.edu
Center: Purdue University

  • ORCID
  • ResearchGate
  • Twitter

Bio

Julia Laskin is a Professor of Chemistry at Purdue University. Her research at the interface of physical and analytical chemistry is focused on the advanced development of preparative and analytical mass spectrometry for applications in materials synthesis, imaging and chemical analysis of biological systems at a subcellular level, and environmental sciences.

Projects

  • Single Cell Resolution of Omics Analysis of T1D Islets

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Julia+Laskin

Karla Leavens, MD, PhD

Consortia: Consortium on Beta Cell Death & Survival, New Investigators
Role: Investigator
Email: LEAVENSK@EMAIL.CHOP.EDU
Center: Children's Hospital of Pennsylvania

  • ORCID

Bio

Karla Leavens is a HIRN Emerging Leader Award Recipient and Pediatric Endocrinologist in the Division of Endocrinology at Children's Hospital of Philadelphia. She is also a Postdoctoral Research Fellow in the Gadue Lab.

Lab:

https://hirnetwork.org/about/participants#short-profile-paul-gadue-phd

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-karla-leavens

Projects

  • Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes
  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=karla+leavens

Xiaoyong Lei, PhD

Role: Investigator
Email: xlei@uab.edu

Projects

  • Integrated Stress Response in Human Islets during Early T1D

Ying Li

Role: Investigator
Email: yl2373@ufl.edu
Center: University of Floria

Lab:

https://hirnetwork.org/about/participants#short-profile-cherie-stabler-phd

Heiko Lickert, PhD

Role: External Scientific Panel
Email: heiko.lickert@zimbra.helmholtz-muenchen.de
Center: Institute of Diabetes and Regeneration Research

Wendell Lim, PhD

Role: Investigator
Email: Wendell.Lim@ucsf.edu
Center: University of California, San Francisco

Projects

  • Therapeutic Targeting of the Human Islet Environment

Amelia Linnemann, PhD

Consortia: Consortium on Beta Cell Death & Survival, New Investigators, Opportunity Pool Projects
Role: Investigator
Email: aklinnem@iu.edu
Center: Indiana University School of Medicine

  • ORCID
  • LinkedIn
  • Twitter

Bio

Amelia Linnemann is a HIRN Emerging Leader Award Recipient and a HIRN New Investigator. She is an Associate Professor of Pediatrics at the Indiana University School of Medicine. Her primary research focus is to understand mechanisms of pancreatic β-cell death/survival, islet compensatory adaptation to cellular stress, and how these factors contribute to diabetes pathogenesis.

Lab:

https://medicine.iu.edu/faculty/26337/linnemann-amelia

HIRN Investigator Profile:

https://hirnetwork.org/profile-linnemann

Projects

  • Real-time in vivo Analysis of Islet Redox Dynamics
  • Functional and Molecular Characterization of the Human Islet Interferon Alpha Response

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Amelia+Linnemann

Chengyang Liu, MD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: chliu@pennmedicine.upenn.edu

Projects

  • Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression

Baoyu Liu, PhD

Consortia: Consortium on Modeling Autoimmune Interactions, New Investigators
Role: Investigator
Email: baoyu.liu@path.utah.edu
Center: University of Utah

  • ResearchGate
  • LinkedIn

Bio

Bayou Liu is a Gateway Award Recipient and an Assistant Research Professor in the Department of Microbiology and Immunology at City of Hope. His expertise

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-baoyu-liu

Projects

  • On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells

Kent Lloyd, PhD

Role: External Scientific Panel
Email: kclloyd@ucdavis.edu
Center: University of California at Davis

Emma Lundberg, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: emma.lundberg@scilifelab.se
Center: KTH Royal Institute of Technology

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Patrick MacDonald, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: pem@ualberta.ca
Center: University of Alberta

Projects

  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
  • Linking Islet Cell Function and Identity from in vitro to in situ

Rachel Madley

Role: Postdoctoral Fellow
Email: rcm2172@cumc.columbia.edu

Rene Maehr, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: rene.maehr@umassmed.edu
Center: University of Massachusetts Medical School

Projects

  • Humanized Mouse Avatars for T1D

Mohsen Khosravi Maharlooei, PhD

Role: Postdoctoral Fellow
Email: mkm2182@cumc.columbia.edu
Center: Columbia University

Lab:

https://hirnetwork.org/about/participants#short-profile-megan-sykes-md

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Dustin Maly, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: maly@chem.washington.edu
Center: University of Washington

Projects

  • Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes

Mark Mamula, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: mark.mamula@yale.edu
Center: Yale University

  • ORCID
  • ResearchGate
  • LinkedIn

Projects

  • Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Mark+Mamula

Jocelyn Fox, PhD

Role: Research Staff
Email: jm33@ualberta.ca
Center: University of Alberta

Lab:

https://hirnetwork.org/about/participants#short-profile-patrick-macdonald-phd

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Anna Martinez Casalas, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Postdoctoral Fellow
Email: annamc@kth.se
Center: KTH Royal Institute of Technology

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Clayton Mathews, PhD

Consortia: Consortium on Human Islet Biomimetics, Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: cxm@ufl.edu
Center: University of Florida

Projects

  • Defining Islet Heterogeneity Using Single Islet Transcriptomics
  • Genetic Regulation of Human Beta Cell Destruction
  • Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata
  • Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
  • Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Ileana Matta

Role: Research Staff
Email: lmatta@ucsd.edu
Center: University of California, San Diego

Lab:

https://hirnetwork.org/about/participants#short-profile-maike-sander-md

Projects

  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Jason McDermott, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: jason.mcdermott@pnnl.gov
Center: Pacific Northwest National Laboratory

  • ORCID
  • ResearchGate
  • LinkedIn

Projects

  • Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Jason+McDermott

Richard McIndoe, PhD

Role: External Scientific Panel
Email: rmcindoe@augusta.edu
Center: Augusta University

Douglas Melton, PhD

Consortia: Consortium on Human Islet Biomimetics, Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: dmelton@harvard.edu
Center: Harvard University

Projects

  • Biomarkers for Diabetes using Stem Cell-derived Beta Cells
  • Humanized Mouse Avatars for T1D
  • Islet on a Chip

Thomas Metz, PhD

Role: Investigator
Email: thomas.metz@pnnl.gov
Center: Pacific Northwest National Laboratory

Projects

  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
  • Integrated Stress Response in Human Islets during Early T1D
  • Single Cell Resolution of Omics Analysis of T1D Islets

Everett Meyer, MD, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: evmeyer@stanford.edu
Center: Stanford University

Projects

  • CAR T Cell Targeting of Human Islets
  • Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells

Aaron Michels, MD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: aaron.michels@ucdenver.edu
Center: University of Colorado at Denver

Projects

  • Analysis of Human Autoreactive T Cell Receptors in vivo

Jeffrey Millman, PhD

Role: External Scientific Panel
Email: jmillman@wustl.edu
Center: Washington University School of Medicine

Raghavendra Mirmira, MD, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: mirmira@uchicago.edu
Center: University of Chicago

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Raghavendra Mirmira is the Director of the Department of Medicine Translational Research Center and Professor of Medicine in the Department of Endocrinology, Diabetes and Metabolism at the University of Chicago. His research focuses his efforts on the pathogenesis of diabetes mellitus and the biology of the islet. His laboratory is interested in three key areas: the role of mRNA translation in the cellular response of islet β cells to inflammation; the role of lipoxygenases in dysfunction of β cells in Type 1 and Type 2 diabetes; and the identification of biomarkers of β-cell stress and death in diabetes.

Projects

  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
  • Integrated Stress Response in Human Islets during Early T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Mirmira

HIRN Webinar:

Jason Moore, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: jhmoore@mail.med.upenn.edu
Center: University of Pennsylvania

Projects

  • HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania)
  • HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)

Margaret Morris, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: MorrisMA@evms.edu
Center: Eastern Virginia Medical School

  • LinkedIn

Bio

Charles Ansong was an Associate Professor and Director of the Biomedical Sciences Graduate Program at Eastern Virginia Medical School. . Currently, she is a Scientific Review Officer at National Institute of Allergy and Infectious Diseases (NIAID).

Projects

  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Margaret+Morris%2C

Jerry Nadler, MD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: nadlerjl@evms.edu
Center: Eastern Virginia Medical School

Projects

  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)

Ali Naji, MD, PhD

Consortia: Human Pancreas Analysis Consortium, Consortium on Human Islet Biomimetics
Role: Investigator
Email: Ali.Naji@uphs.upenn.edu
Center: University of Pennsylvania

Projects

  • Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
  • HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania)
  • HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)
  • Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes

Hiroyuki Nakai, MD, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: nakaih@ohsu.edu
Center: Oregon Health & Science University

Projects

  • In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
  • Gene Therapy for Diabetes

HIRN Webinar:

Maki Nakayama, MD, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: maki.nakayama@ucdenver.edu
Center: University of Colorado at Denver

Projects

  • Analysis of Human Autoreactive T Cell Receptors in vivo
  • Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D

Ernesto Nakayasu, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: ernesto.nakayasu@pnnl.gov
Center: Pacific Northwest National Laboratory

Projects

  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
  • Alternative RNA Splicing Events Contribute to the Onset of islet dysfunction in T1D

Grace Nauman

Role: Research Staff
Email: gn2242@cumc.columbia.edu
Center: Columbia University

Lab:

https://hirnetwork.org/about/participants#short-profile-megan-sykes-md

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Chris Newgard, PhD

Role: Collaborator
Email: chris.newgard@duke.edu
Center: Duke University

Projects

  • Functional Testing of Candidate HSC-derived Islet Cells

Kim-Vy Nguyen-Ngoc, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Postdoctoral Fellow
Email: knguyenngoc@ucsd.edu
Center: University of California at San Diego

Lab:

https://hirnetwork.org/about/participants#short-profile-maike-sander-md

Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease

Dario Nicetto, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Postdoctoral Fellow
Email: dnicetto@mail.med.upenn.edu
Center: University of Pennsylvania

Lab:

https://hirnetwork.org/about/participants#short-profile-ken-zaret-phd

Projects

  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Harry Nick, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: hnick@ufl.edu
Center: University of Florida

Projects

  • Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Joyce Niland, PhD

Consortia: Enhancement Center
Role: Investigator
Email: jniland@coh.org
Center: City of Hope

  • ORCID
  • LinkedIn
  • Twitter

Bio

Joyce Niland is the co-Principal Investigator of the Human Islet Research Enhancement Center (HIREC). She is also the Chair and Professor in the Department of Diabetes & Cancer Discovery Science within the Arthur Riggs Diabetes & Metabolism Research Institute at City of Hope. is an interdisciplinary center for research methodology involving high-complexity clinical research/phenotypic data.

Lab:

https://tinyurl.com/nilandlab

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_jniland

Projects

  • Human Islet Research Enhancement Center (HIREC)

Jeremy Norris, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: j..norris@vanderbilt.edu
Center: Vanderbilt University

Projects

  • High-Resolution Analysis of Juvenile Human Pancreas Maturation

Julius Nyalwidhe, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: nyalwijo@evms.edu
Center: Eastern Virginia Medical School

Projects

  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)

scott_oakes

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: soakes@uchicago.edu
Center: University of Chicago

Projects

  • Integrated Stress Response in Human Islets during Early T1D

Jose Oberholzer, MD

Role: External Scientific Panel
Email: jo5je@hscmail.mcc.virginia.edu
Center: University of Virginia

Galya Orr, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: gayla.orr@pnnl.gov
Center: Pacific Northwest National Laboratory

Projects

  • Single Cell Resolution of Omics Analysis of T1D Islets
  • Alternative RNA Splicing Events Contribute to the Onset of islet dysfunction in T1D

Feroz Papa, MD, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: Feroz.Papa@ucsf.edu
Center: University of California, San Francisco

Projects

  • Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes

Audrey Parent, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Audrey.parent@ucsf.edu
Center: University of California, San Francisco

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Audrey Parent is a CMAI co-Investigator and a member of the Trans-Network Committee (TNC). She is Assistant Adjunct Professor and her research is focused on immune tolerance with a particular interest in the thymus.

Lab:

https://hirnetwork.org/about/participants#short-profile-mark-s-anderson-md-phd

Projects

  • Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Audrey+Parent

Kit Parker, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: kkparker@seas.harvard.edu
Center: Harvard University

Projects

  • Islet on a Chip

Stephen Parker, PhD

Role: Investigator
Email: scjp@umich.edu

Projects

  • Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression

Ricardo Pastori, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: RPastori@med.miami.edu
Center: University of Miami

Projects

  • High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential

Smit Patel

Role: Research Staff
Email: smit31@ufl.edu
Center: University of Floria

Lab:

https://hirnetwork.org/about/participants#short-profile-cherie-stabler-phd

Projects

  • Engineering a Human Physiomimetic Islet Microsystem

Heshan Peiris, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Postdoctoral Fellow
Email: hpeiris@stanford.edu
Center: Stanford University

Lab:

https://hirnetwork.org/about/participants#short-profile-seung-kim-md-phd

Projects

  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Ian Penkala

Role: Research Staff
Email: ianpenk@vet.upenn.edu
Center: University of Pennsylvania

Lab:

https://hirnetwork.org/about/participants#short-profile-ben-stanger-md-phd

Projects

  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Vladislav Petyuk, PhD

Role: Investigator
Email: vladislav.petyuk@pnnl.gov
Center: Pacific Northwest National Laboratory

Projects

  • Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Ed Phelps, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: EPhelps@bme.ufl.edu
Center: University of Florida

Projects

  • Engineering a Human Physiomimetic Islet Microsystem
  • Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Greg Poffenberger

Role: Research Staff
Email: greg.poffenberger@Vanderbilt.Edu
Center: Vanderbilt University

Lab:

https://hirnetwork.org/about/participants#short-profile-al-powers-md

Projects

  • High-Resolution Analysis of Juvenile Human Pancreas Maturation
  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Vincent Poitout, PhD

Role: External Scientific Panel
Email: Vincent.poitout@umontreal.ca
Center: Universite de Montreal

Ben Pope, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Postdoctoral Fellow
Email: pope@seas.harvard.edu
Center: Harvard University

Lab:

https://hirnetwork.org/about/participants#short-profile-kit-parker-phd

Projects

  • Islet on a Chip

Al Powers, MD

Consortia: Consortium on Targeting and Regeneration, Human Pancreas Analysis Consortium
Role: Investigator
Email: al.powers@vanderbilt.edu
Center: Vanderbilt University

Projects

  • High-Resolution Analysis of Juvenile Human Pancreas Maturation
  • HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.)
  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
  • Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells
  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
  • Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata
  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Sebastian Preissl, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: spreissl@ucsd.edu
Center: University of California, San Diego

Projects

  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Fahd Qadir

Role: Research Staff
Email: Fahd.qadir@med.miami.edu
Center: University of Miami

Lab:

https://hirnetwork.org/about/participants#short-profile-juan-dominguez-bendala-phd

Projects

  • High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential

Wei-Jun Qian, PhD

Role: Investigator
Email: weijun.qian@pnnl.gov
Center: Pacific Northwest National Laboratory

Projects

  • Mass Spectrometry-based Proteome Maps for Human Islet Cells
  • Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Stephen Quake, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: quake@stanford.edu
Center: Stanford University

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Sasanka Ramanadham, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: sramvem@uab.edu

Projects

  • Integrated Stress Response in Human Islets during Early T1D

Siddarth Rawal, MD

Role: Research Staff
Email: SRawal@miami.edu
Center: University of Miami

Lab:

https://hirnetwork.org/about/participants#short-profile-ashu-agarwal-phd

Projects

  • Engineering a Human Physiomimetic Islet Microsystem

Christopher Rhodes, PhD

Role: External Scientific Panel
Email: rhodesc@medimmune.com
Center: MedImmune

Camillo Ricordi, MD

Consortia: Consortium on Human Islet Biomimetics, Human Pancreas Analysis Consortium
Role: Investigator
Email: ricordi@miami.edu
Center: University of Miami

Projects

  • Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity
  • High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential
  • Engineering a Human Physiomimetic Islet Microsystem

James Riley, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: rileyj@upenn.edu
Center: University of Pennsylvania

Bart Roep MD, PhD

Role: External Scientific Panel
Email: broep@coh.org
Center: City of Hope

Michael Roper, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: roper@chem.fsu.edu
Center: Florida State University

Projects

  • Modular Monitoring of Hormone Release from Human Islets

Patrik Rorsman, PhD

Role: Collaborator
Email: patrik.rorsman@hmc.ox.ac.uk
Center: University of Oxford

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Derrick Rossi, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: derrick.rossi@childrens.harvard.edu
Center: Children’s Hospital Corp

Layla Rouse, MS

Consortia: Enhancement Center
Role: HIREC Staff, Administrator
Email: lrouse@coh.org
Center: City of Hope

  • ResearchGate
  • LinkedIn
  • Twitter

HIRN Investigator Profile:

https://hirnetwork.org/hirecstaff_lrouse

Projects

  • Human Islet Research Enhancement Center (HIREC)

Kole Roybal, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Kole.Roybal@ucsf.edu
Center: University of California, San Francisco

Projects

  • Therapeutic Targeting of the Human Islet Environment

Marjan Rupnik, PhD

Role: Collaborator
Email: marjan.slakrupnik@meduniwien.ac.at
Center: Medical University of Vienna

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Holger Russ, PhD

Consortia: Consortium on Beta Cell Death & Survival, New Investigators, Opportunity Pool Projects
Role: Investigator
Email: HOLGER.RUSS@UCDENVER.EDU
Center: University of Colorado, Denver

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Holger Russ is a HIRN New Investigator and an Assistant Professor of Pediatrics at the University of Colorado Denver. His research focuses on using human stem cells to generate novel sources of beta cells for transplantation and to model human T1D in a dish.

HIRN Investigator Profile:

https://hirnetwork.org/profile-rholger

Projects

  • Elucidating the Human Beta Cell Translatome in Health and Disease

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Holger+Russ

Guy Rutter, PhD

Role: External Scientific Panel
Email: g.rutter@imperial.ac.uk
Center: Imperial College of London

Joao Pedro Saar Werneck de Castro, PhD

Consortia: Human Pancreas Analysis Consortium, New Investigators
Role: Investigator
Email: j.werneckdecastro@med.miami.edu
Center: University of Miami

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Juan Alvarez is a Gateway Award Recipient and an Assistant Research Professor in the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine. Currently he is investigating the pathways by which thyroid hormones regulates skeletal muscle physiology and the role of type-2 deiodinase in muscle biology and its importance to plasma T3 pool.

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-joao-pedro-werneck-de-castro

Projects

  • In vivo effects of physical exercise on human islet structure and function

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Joao+Pedro+Werneck+de+Castro

Nilanjana Samanta

Role: Research Staff
Email: Nilanjana.Samanta@pennmedicine.upenn.edu

Maike Sander, MD

Consortia: Human Pancreas Analysis Consortium, Consortium on Human Islet Biomimetics
Role: Investigator
Email: masander@ucsd.edu
Center: University of California, San Diego

Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
  • Functional Testing of Candidate HSC-derived Islet Cells
  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes
  • A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes

Leslie Satin, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: lsatin@umich.edu
Center: University of Michigan

Projects

  • A Stress-Induced Vicious Cycle in the Development of T1D

Sheryl Sato, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: NIDDK Program Staff
Email: satos@extra.niddk.nih.gov
Center: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Bio

Sheryl Sato is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her research interest is the basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease.

Diane Saunders, PhD

Role: Research Staff
Email: diane.saunders@vumc.org
Center: Vanderbilt University

Alexei Savinov, MD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: alexei.savinov@sanfordhealth.org
Center: Sanford Research/Univ. of South Dakota

Projects

  • Genetic Regulation of Human Beta Cell Destruction

Desmond Schatz, MD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: schatda@peds.ufl.edu
Center: University of Florida

Projects

  • Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms
  • Non-invasive Diagnosis of Human Beta Cell Damage and Death

Lisa Scudder, PhD

Role: Postdoctoral Fellow
Email: lscudder@seas.harvard.edu
Center: Harvard University

Lab:

https://hirnetwork.org/about/participants#short-profile-kit-parker-phd

Projects

  • Islet on a Chip

Howie Seay

Role: Research Staff
Email: hrseay@ufl.edu
Center: University of Florida

Lab:

https://hirnetwork.org/about/participants#short-profile-todd-brusko-phd

Projects

  • Genetic Regulation of Human Beta Cell Destruction

Paolo Serafini, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: PSerafini@med.miami.edu
Center: University of Miami

Projects

  • Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity

Anath Shalev, MD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: shalev@uab.edu
Center: University of Alabama at Birmingham

  • ORCID

Bio

Anath Shalev is the chair of the Consortium of Beta Cell Death and Survival (CBDS) and a member of the Trans-Network Committee (TNC). She is the Director of the University of Alabama at Birmingham Comprehensive Diabetes Center, Professor of Medicine and Senior Scientist. Her research focuses on Molecular biology of diabetes, beta cell biology, apoptosis, oxidative stress, transcriptional regulation of gene expression, and diabetes complications.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_shalev

Projects

  • Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D
  • Targeting TXNIP to Enhance Beta Cell Mass in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Anath+Shalev

Robert Sharp, PhD

Consortia: Consortium on Human Islet Biomimetics, New Investigators
Role: Investigator
Email: rsharp07@ufl.edu
Center: University of Florida

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Robert Sharp is a HIRN Emerging Leader Award Recipient and a Postdoctoral Research Fellow in the Brusko Lab at the University of Florida. His research interests are in the area of study involves examining immunoregulation in type 1 diabetes, focusing on lymphocyte regulation genes including PTPN22 (protein tyrosine phosphatase non-receptor type 22), SIRPG (signal regulatory protein gamma), and cluster of differentiation 47 (CD47).

HIRN Investigator Profile:

https://hirnetwork.org/investigator-profile-robert-c-sharp

Projects

  • The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival”

Ruth Shemer, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: shemer.ru@mail.huji.ac.il
Center: Hebrew University of Jerusalem

Projects

  • Non-invasive Diagnosis of Human Beta Cell Damage and Death

Bhupinder Shergill

Role: Research Staff
Email: bdshergill@gmail.com
Center: University of California, Davis

Lab:

https://hirnetwork.org/about/participants#short-profile-steven-george-md-phd

Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease

Tujin Shi, PhD

Role: Investigator
Email: tujin.shi@pnnl.gov
Center: Pacific Northwest National Laboratory

Projects

  • Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Kevin Shores

Role: Research Staff
Email: kshores@g.harvard.edu
Center: Harvard University

Lab:

https://hirnetwork.org/about/participants#short-profile-kit-parker-phd

Projects

  • Islet on a Chip

Leonard Shultz, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: lenny.shultz@jax.org
Center: The Jackson Laboratory

Projects

  • Humanized Mouse Avatars for T1D

Dmitry "Dima" Shvarstman, Ph.D.

Role: Research Staff
Email: Dmitry_shvartsman@harvard.edu
Center: Harvard University

Lab:

https://hirnetwork.org/about/participants#short-profile-douglas-melton-phd

Ruth Singer

Role: Research Staff
Email: Ruthasinger@gmail.com
Center: Columbia University

Lab:

https://hirnetwork.org/about/participants#short-profile-lori-sussel-phd

Projects

  • Single Cell Resolution of Omics Analysis of T1D Islets

Hans Snoeck, MD, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: hs2680@columbia.edu
Center: Columbia University

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Scott Soleimanpour, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: ssol@med.umich.edu
Center: University of Michigan

Projects

  • A Stress-Induced Vicious Cycle in the Development of T1D

Zhen Song

Role: Research Staff
Email: sonzh@ohsu.edu
Center: Oregon Health and Science University

Lab:

https://hirnetwork.org/about/participants#short-profile-hiroyuki-nakai-md-phd

Projects

  • In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors

Stephan Speier, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: stephan.speier@tu-dresden.de
Center: Paul-Langerhans-Institute Dresden

  • ORCID
  • LinkedIn
  • Twitter

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_speier

Projects

  • In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Stephan+Speier

HIRN Webinar:

Cherie Stabler, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: cstabler@bme.ufl.edu
Center: University of Florida

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

HIRN Investigator Profile:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Cherie+Stabler

Projects

  • Engineering a Human Physiomimetic Islet Microsystem
  • Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

HIRN Webinar:

Ben Stanger, MD, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: bstanger@upenn.edu
Center: University of Pennsylvania

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Ben Stanger is the chair of the Consortium of Human Islet Biomimetics (CHIB) (CTAR) and a member of the Trans-Network Committee (TNC). He is also the Director of the Penn Pancreatic Cancer Research Center (PCRC), the Hanna Wise Professor in Cancer Research, and a Professor of Cell and Developmental Biology.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_bstanger

Projects

  • Functional Testing of Candidate HSC-derived Islet Cells
  • Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes
  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Ben+Stanger

Lawrence Stern, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Lawrence.stern@umassmed.edu
Center: University of Massachusetts Medical Center

Projects

  • Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function

Andrew Stewart, MD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: andrew.stewart@mssm.edu
Center: Mount Sinai Hospital

Projects

  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
  • Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata

Doris Stoffers, MD, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: stoffers@mail.med.upenn.edu
Center: University of Pennsylvania

  • ORCID
  • ResearchGate
  • LinkedIn

Bio

Doris Stoffers is a HPAC Investigator and a member of the Trans-Network Committee (TNC). She is a the Director of the Pancreatic Islet Cell Biology Core, Director of the Pilot Feasibility Program and a Professor of Medicine at the University of Pennsylvania. Her research focuses on the embryonic development and adult regeneration of the endocrine pancreas, and the relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.

Projects

  • HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania)
  • HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)

Andraz Stozer, MD, PhD

Role: Collaborator
Email: andraz.stozer@um.si
Center: University of Maribor

Projects

  • Linking Islet Cell Function and Identity from in vitro to in situ

Natasa Strbo, MD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: nstrbo@umail.miami.edu
Center: University of Miami

Philip Streeter, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: streetep@ohsu.edu
Center: Oregon Health & Science University

Projects

  • CAR T Cell Targeting of Human Islets
  • Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry

Lina Sui, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Postdoctoral Fellow
Email: ls3178@cumc.columbia.edu
Center: Columbia University

Lab:

https://hirnetwork.org/about/participants#short-profile-dieter-egli-phd

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Lori Sussel, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: lgs2@cumc.columbia.edu
Center: University of Colorado, Denver

Projects

  • Single Cell Resolution of Omics Analysis of T1D Islets
  • Alternative RNA Splicing Events Contribute to the Onset of islet dysfunction in T1D

Megan Sykes, MD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: ms3976@cumc.columbia.edu
Center: Columbia University

Projects

  • Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
  • Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems

Alejandro Tamayo-Garcia

Role: Research Staff
Email: atamayogarcia@med.miami.edu
Center: University of Miami

Lab:

https://hirnetwork.org/about/participants#short-profile-peter-buchwald-phd

Projects

  • Engineering a Human Physiomimetic Islet Microsystem

Qizhi Tang, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: Qizhi.Tang@ucsf.edu
Center: University of California, San Francisco

Projects

  • Therapeutic Targeting of the Human Islet Environment

Naohiro Terada, MD, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: terada@pathology.ufl.edu
Center: University of Florida

Projects

  • Genetic Regulation of Human Beta Cell Destruction
  • Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

Nato Teteloshvilil

Role: Postdoctoral Fellow
Email: nt2446@cumc.columbia.edu

Luc Teyton, MD, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: lteyton@scripps.edu

  • ORCID

HIRN Webinar:

Lance Thielen, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Postdoctoral Fellow
Email: lthielen@uab.edu
Center: University of Alabama at Birmingham

Fabrizio Thorel, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: fabrizio.thorel@unige.ch
Center: University of Geneva

Projects

  • Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery
  • Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Roland Tisch, PhD

Role: External Scientific Panel
Email: roland_tisch@med.unc.edu
Center: University of North Carolina, Chapel Hill

Golnaz Vahedi, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: vahedi@pennmedicine.upenn.edu

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Projects

  • Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Golnaz+Vahedi

HIRN Webinar:

Prashanth Vallabhajosyula, MD

Consortia: Consortium on Beta Cell Death & Survival, New Investigators, Opportunity Pool Projects
Role: Investigator
Email: prashanth.vallabhajosyula@yale.edu
Center: Yale University

Ben Voight, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: bvoight@pennmedicine.upenn.edu

Matthias von Herrath, MD

Role: External Scientific Panel
Email: matthias@liai.org
Center: La Jolla Institute for Allergy and Immunology

Anh Nguyet Vu

Role: Administrator
Email: avu@coh.org

Bridget Wagner, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: bwagner@broadinstitute.org
Center: Broad Institute

  • ORCID
  • ResearchGate
  • LinkedIn
  • Twitter

Bio

Bridget Wagner is the chair of the Consortium of Targeting and Regeneration (CTAR) and the Trans-Network Committee (TNC). Additionlly, she is a CTAR Investigator. She is also the Director of Pancreatic Cell Biology and Metabolic Disease in the Chemical Biology and Therapeutic Sciences Program at the Broad Institute of MIT and Harvard, where she is also an institute scientist. Her research focuses on the chemical biology of diabetes, with the aim of identifying small molecules capable of increasing pancreatic beta cell number and function and the ultimate goal of discovering new therapeutic approaches for diabetes.

Lab:

https://www.broadinstitute.org/bios/bridget-wagner

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_bwagner

Projects

  • Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
  • One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/Contributor/Index/bridget_wagner@hirnetwork.org

HIRN Webinar:

John Walker

Consortia: Human Pancreas Analysis Consortium
Role: Postdoctoral Fellow
Email: j.walker@vanderbilt.edu
Center: Vanderbilt University

Mark Wallet, PhD

Consortia: Consortium on Modeling Autoimmune Interactions
Role: Investigator
Email: mawallet@pathology.ufl.edu
Center: University of Florida

Projects

  • Genetic Regulation of Human Beta Cell Destruction
HIRN Investigator

Peng Wang, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: peng.wang@mssm.edu
Center: Mount Sinai Hospital

Projects

  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Xujing Wang, PhD

Consortia: Consortium on Beta Cell Death & Survival, Consortium on Targeting and Regeneration
Role: NIDDK Program Staff
Email: xujing.wang@nih.gov
Center: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Bio

Xujing Wang is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her interests are in data science, computation modeling, integrative genomics, network biology, and genotype-phenotype relationships.

Paul Wang, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: wangpaul@pennmedicine.upenn.edu

  • LinkedIn

HIRN Webinar:

Clive Wasserfall

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: clive@uf.edu
Center: University of Florida

Projects

  • Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Bobbie-Jo Webb-Robertson, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: bobbie-jo.webb-robertson@pnnl.gov
Center: Pacific Northwest National Laboratory

Projects

  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
  • Integrated Stress Response in Human Islets during Early T1D

Ryan White, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: ryan.white@uc.edu
Center: University of Cincinnati

Projects

  • Modular Monitoring of Hormone Release from Human Islets

Matthew Wortham, PhD

Role: Postdoctoral Fellow
Email: mwortham@ucsd.edu
Center: University of California at San Diego

Lab:

https://hirnetwork.org/about/participants#short-profile-maike-sander-md

Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease

Christopher Wright, D Phil

Consortia: Consortium on Beta Cell Death & Survival
Role: Investigator
Email: chris.wright@vanderbilt.edu
Center: Vanderbilt University

Projects

  • High-Resolution Analysis of Juvenile Human Pancreas Maturation

Wenting Wu, PhD

Role: Investigator
Email: wuwent@iu.edu

Projects

  • Integrated Stress Response in Human Islets during Early T1D

Guanlan Xu, PhD

Consortia: Consortium on Beta Cell Death & Survival
Role: Postdoctoral Fellow
Email: guanlanxu@uabmc.edu
Center: University of Alabama at Birmingham

Projects

  • Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D

Yong-Guang Yang, MD, PhD

Role: Investigator
Email: yy2324@columbia.edu
Center: Columbia University

Projects

  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells

Mingder Yang, PhD

Consortia: Human Pancreas Analysis Consortium
Role: Investigator
Email: mdyang@ufl.edu
Center: University of Florida

Lab:

https://hirnetwork.org/about/participants#short-profile-mark-atkinson-phd

Projects

  • HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.)

Kisuk Yang, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Postdoctoral Fellow
Email: kisuky@mit.edu
Center: Massachusetts Institute of Technology

Lab:

https://hirnetwork.org/about/participants#short-profile-jeff-karp-phd

Projects

  • Islet on a Chip

Christine Yoon

Role: Research Staff
Email: cjyoon@bu.edu
Center: Boston University

Lab:

https://hirnetwork.org/about/participants#short-profile-chris-chen-md-phd

Projects

  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Ken Zaret, PhD

Consortia: Consortium on Human Islet Biomimetics
Role: Investigator
Email: zaret@mail.med.upenn.edu
Center: University of Pennsylvania

Projects

  • Functional Testing of Candidate HSC-derived Islet Cells
  • A Vascularized 3D Biomimetic for Islet Function and Physiology

Chun Zeng, PhD

Consortia: Consortium on Human Islet Biomimetics, Human Pancreas Analysis Consortium
Role: Postdoctoral Fellow
Email: c2zeng@ucsd.edu
Center: University of California, San Diego

Bio

Optimize strategies to enrich T1D-relevant cells from pancreatic tissue for ATAC-seq analysis

Lab:

https://hirnetwork.org/about/participants#short-profile-maike-sander-md

Projects

  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Joe Zhou, PhD

Consortia: Consortium on Targeting and Regeneration
Role: Investigator
Email: jqz4001@med.cornell.edu
Center: Weill Cornell Medical College

Projects

  • Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling
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      • Consortium on Beta Cell Death and Survival (CBDS)
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