Midhat Abdulreda is an Associate Professor of Surgery, Microbiology and Immunology at the University of Miami Miller School of Medicine. Dr. Abdulreda has developed the “living window” model to study immune responses during diabetes development or rejection of transplanted pancreatic islets. With collaborators he is exploring islet transplantation into the anterior chamber of the eye as a potential clinical transplantation site in the treatment of type 1 diabetes.
Kristin Abraham is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her interests are the role of the immune response in metabolic dysfunction and type 2 Diabetes, and projects that develop and validate the utility of new animal models for basic and preclinical research in diabetes, endocrinology and metabolic diseases.
Domenico Accili a Professor of Medicine at Columbia University, Attending Physician at Columbia-Presbyterian Hospital and Director of the Columbia University Diabetes and Endocrinology Research Center in New York, New York. His research focuses on understanding how insulin-producing cells are born, live, function, and die.
Amanda Ackermann was an Assistant Professor at Children's Hospital of Philadelphia (CHOP) and is currently a Medical Director for Novo Nordisk.
Ashutosh Agarwal is an Associate Professor in the Department of Biomedical Engineering and Department of Pathology at the University of Miami Miller School of Medicine. He completed his postdoctoral research in Biomedical Engineering at Columbia University, and at the Wyss Institute for Biologically Inspired Engineering at Harvard University. The mission of his Physiomimetic Microsystems Laboratory at the University of Miami is to develop human relevant organ mimic platforms for discovery of therapies and drugs, for modeling of disease states, for conducting mechanistic studies, and for differentiation, maturation and evaluation of stem cells.
Joana Almaça is a HIRN New Investigator and an Assistant Professor of Medicine at the University of Miami Miller School of Medicine. Her current research focuses on the vasculature of the islet. In her work, Dr. Almaça is testing the hypothesis that microvascular dysfunction in the islet leads to a disturbance of hormone secretion, to glucose intolerance, and eventually to diabetes.
Juan Alvarez is a HIRN Emerging Leader Award Recipient and an Assistant Professor of Cell and Developmental Biology at the University of Pennsylvania Perelman School of Medicine. His research focuses on human stem cell-derived pancreatic islet organoids and mice as model systems to study islet development, physiology, and pathology, and to develop replacement therapies for insulin-dependent diabetes. We focus on the interplay between circadian rhythms, metabolism, and islet cell maturation.
Mark Anderson is an Endocrinologist and Professor of Medicine at the University of California, San Diego. His research focuses on examining the genetic control of autoimmune diseases to gain a better understanding of the mechanisms by which immune tolerance is broken. Current studies in the lab are directed at further understanding the relative contribution of specialized Aire-expressing cells to immune tolerance in multiple autoimmune disease models.
Charles Ansong was a Senior Research Scientist within the Integrative Omics group, Biological Sciences Division at PNNL. His research focused on the centers on the utilization of advanced mass spectrometry-based omics technologies and systems biology approaches to better understand complex biological systems relevant to human health and the environment. Currently, he is a Program Director at The National Institutes of Health at the National Institute of General Medical Sciences (NIGMS).
Radhika Armandla is a Senior Research Specialist in the Powers & Brissova Research Group at Vanderbilt University. She is involved in projects dealing with human islet transplantation, in vitro analysis and imaging in order to study human islet survival, function, regeneration and proliferation.
Lucas Armitage first participated in the HIRN while as a graduate student in the Wallet & Brusko Labs at the University of Florida. Currently, he is a Postdoctoral Research Fellow with the Russ Lab at the University of Colorado Denver.
Consortia: Consortium on Human Islet Biomimetics, Consortium on Modeling Autoimmune Interactions, Human Pancreas Analysis Consortium
Role: NIDDK Program Staff
Center: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Guillermo Arreaza-Rubin is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in diabetes and endocrine disease bioengineering and glucose sensing.
Rafael Arrojo e Drigo is a Gateway Award Recipient and co-Investigator on a HPAC Grant. He is an Assistant Professor in the Department of Molecular Physiology and Biophysics at Vanderbilt School of Medicine. His research focuses on understanding the mechanisms regulating post-mitotic cell homeostasis and longevity.
Peter Arvan is the Division of Metabolism, Endocrinology, & Diabetes at the University of Michigan. His research focus is to examine molecular mechanisms involved in the folding, trafficking, and targeting of newly-synthesized endocrine secretory proteins
Mark Atkinson is currently the American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at the University of Florida. He also is the Director of the Diabetes Institute at the University of Florida. Additionally, he is the Executive Director of the JDRF Network for Pancreatic Organ donors with Diabetes (nPOD) program and the President of Insulin for Life USA, the world’s second largest charity dedicated to providing insulin to persons living with diabetes in the developing world. His research focuses on type 1 diabetes, pancreatic pathology, immune therapy, autoimmunity, clinical trials, translational research, emerging technologies, psychosocial behaviors, and metabolism.
Dana Avrahami-Tzfati is scientist at Hadassah University Medical Center in Jerusalem, Israel.
Rhonda Bacher is an Assistant Professor of Biostatistics at the University of Florida. Her research focuses on the development of statistical methods and computational tools for analyzing high-throughput genomic and next-generation sequencing data. My current focus is on single-cell transcriptomics and epigenomics and time-course transcriptomics.
Hugh Bender was a Postdoctoral Research Fellow in the Chris Hughes Lab at the University of California, Irvine. He is now a Lead Scientist at Aracari Biosciences. Dr. Bender received his PhD in 2015 from Washington University in St. Louis. His research focuses on developing a novel micro-vascularized organ system for modeling Type I diabetes in the lab.
Michael Betts is a Professor of Microbiology at the University of Pennsylvania. He studies human T lymphocyte function in order to understand the role of these cells in controlling or eliminating viral pathogens and providing protection from infection. His primary research interest is in determining how and if the human CD8+ T cell response to HIV controls viral replication.
Sangeeta Bhatia is a biomedical researcher, MIT professor, and biotech entrepreneur who works to adapt technologies developed in the computer industry for medical innovation. he and her trainees have launched multiple biotechnology companies to improve human health. As a prolific inventor and passionate advocate for diversity in science and engineering, Bhatia has received many honors including the Lemelson-MIT Prize, known as the ‘Oscar for inventors,’ and the Heinz Medal for groundbreaking inventions and advocacy for women in STEM fields. She is a Howard Hughes Medical Institute Investigator, the Director of the Marble Center for Cancer Nanomedicine at the Koch Institute for Integrative Cancer Research at MIT, and an elected member of the National Academy of Sciences, the National Academy of Engineering, the American Academy of Arts and Science, the National Academy of Inventors, and Brown University’s Board of Trustees.
Anil Bhushan is a Professor at the University of California, San Francisco. His research goal is to understand the role of tissue secretory senescent cells in aging, autoimmunity and metabolic diseases. One of his recent discoveries shows that pancreatic beta cells acquire a secretome during T1D in mice and human and exhibit many non-cell autonomous properties.
Consortia: Consortium on Beta Cell Death & Survival, Consortium on Targeting and Regeneration, Human Pancreas Analysis Consortium
Role: NIDDK Program Staff
Center: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Olivier Blondel is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests lie in research that focuses on endocrine signaling, stem cell biology, organ development, regenerative medicine and biomarker discovery as it relates to diabetes (type 1 and type 2) and metabolic diseases, particularly in combination with experimental approaches such as large-scale genomics, synthetic biology, bioengineering, epigenetics, nuclear organization of mammalian genomes, chromatin biology, genome editing, gene therapy
Jeffrey Bluestone is a Professor of Metabolism and Endocrinology at University of California, San Francisco. He is currently serving as the president and CEO of the Parker Institute for Cancer Immunotherapy. His current research focuses on the understanding Tregs has been discussed as an avenue to further developments in the treatment Type 1 Diabetes.
Bernd Bodenmiller is the Director of the Department of Quantitative Biomedicine at University of Zurich. He has pioneered a single-cell mass spectrometric imaging approach called "imaging mass cytometry". This technology allows the simultaneous and high-throughput imaging of approximately 50 markers, including proteins, their modifications, and transcripts on single cells in tissues in situ. The Bodenmiller group employs mass cytometry-based methods to study the cellular composition and regulation of tissue ecosystems, for insights into health and disease.
Rita Bortell was a Professor of Immunology and Microbiology at the University of Massachusetts Chan School of Medicine. Her research focused on pathogenesis of autoimmune diabetes.
Rita Bottino is the Director Islet Programs at Imagine Pharma. She has developed an islet isolation and tissue processing practice that supplies some of the leading academic diabetes centers in the United States.
Annie Bowles was a Postdoctoral Research Fellow in the Agarwal Lab at the University of Miami Miller School of Medicine. She is now a Senior Research Scientist at Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M).
Michael Brehm is an Associate Professor of Molecular Medicine and Co-Director of the Humanized Mouse Core Facility at UMass Chan Medical School. He works with these unique animal models of human immune responses to investigate approaches to downregulate as well as activate the human immune system for treatments of type 1 diabetes (T1D) and cancer. Dr. Brehm studies human beta cells from individuals with type 1 diabetes in a real-life setting as they interact with intact T1D immune systems.
Linford Briant was a Postdoctoral Research Fellow at the University of Oxford and is currently a Junior Research Fellow at Trinity College. His research investigates the activity of delta-cells with optogenetics, electrophysiology and Ca2+ imaging, and revealed they are electrically coupled to beta-cells via gap junctions.
Marcela Brissova is an Research Professor of Medicine and Director of the Islet Procurement & Analysis Core at Vanderbilt University. She is also the Director of the Human Islet Phenotyping Program (HIPP) of IIDP. Her research focuses on the biology of pancreatic islets and pancreas and islet development, especially the development of pancreatic islet vasculature and innervation and their role in regulation of pancreatic islet function.
Todd Brusko is a Professor at Department of Pathology, Immunology and Laboratory Medicine and the scientific director at University of Florida Diabetes Institute (UFDI). The research aims of Dr. Brusko’s academic lab are centrally themed around understanding the mechanisms by which the immune system maintains a state of control, often referred to as immunological tolerance and understanding how genetic risk variants and age influence this process, as well as identifying pathway defects in individuals who develop autoimmune diseases. These studies have focused primarily on genes impacting key checkpoints in T cell activation, including T cell receptor (TCR) signaling, co-stimulation, and the IL-2 signaling pathway. His laboratory is involved a number of ongoing team science initiatives including an NIH-NIAID P01 grant, NIH Director’s Initiative – Human BioMolecular Atlas Program (HuBMAP), Brehm Coalition, and the JDRF biomarker working group and autoimmunity working group.
Peter Buchwald is an Associate Professor in the Department of Molecular and Cellular Pharmacology at the University of Miami Miller School of Medicine and the Director of the Drug Discovery Program at the Diabetes Research Institute. He has published numerous articles in peer-reviewed journals focused on the physicochemical and metabolic aspects of drug design and drug action, as well as on computer-aided quantitative modeling. Dr. Buchwald is directing the DRI’s efforts aimed at developing safer and more effective drugs for islet replacement therapies.
Kristin Burnum-Johnson is a Senior Scientist and Team Lead of the Environmental Molecular Sciences Laboratory's Metabolomics group at Pacific Northwest National Laboratory. Her research is dedicated to characterizing the molecular landscape of heterogeneous samples using novel mass spectrometry approaches to address specific biological, medical, and environmental research questions. These approaches involve multi-dimensional liquid chromatography and ion mobility separations in conjunction with mass spectrometry to measure proteins, lipids, and metabolites.
Long Cai is a Professor of Biology and Biological Engineering at CalTech. His research develops sequential FISH (seqFISH), MEMOIR, and RNA SPOTs, apply them to study various biological questions.
Alejandro Caicedo is a Professor of Medicine at the University of Miami Miller School of Medicine. iginally trained as a sensory neurobiologist, Dr. Caicedo started working in the field of pancreatic islet biology in 2005. His work focuses on fundamental aspects of the anatomy and physiology of the human islet. His primary goal is to provide detailed knowledge of islet biology that is relevant to understand the control of glucose homeostasis and its derangement in diabetes.
Martha Campbell-Thompson is a Professor, Director of the Molecular Pathology Core at the University of Florida and Director of the JDRF nPOD Organ Procurement and Pathology Core. Her research interests are in beta cell biology, beta cell regeneration for type 1 diabetes, islet inflammation and neuromodulation of beta cell function.
Richard Caprioli is the Director of the Mass Spectrometry Research Center at Vanderbilt University School of Medicine and a Professor in the Departments of Chemistry and Pharmacology at Vanderbilt University. The research interests of this laboratory are aimed at the investigation of biological processes involving the synthesis, modification, storage and degradation of certain peptides and proteins using modern mass spectrometric methods of analysis to follow molecular events. In recent years there has been a great amount of interest in investigating the biochemical events involved in the metabolism of peptides, primarily in the brain and gut of mammals, encompassing the enzymatic breakdown of these peptides, their production from peptide and protein precursors, and the disruption of these processes by certain xenobiotics.
Xiaojuan (Jan) Chen is an Assistant Professor of Surgical Sciences and the Director of Islet Cell Transplantation at Columbia Center for Translational Immunology. She studies the physiology of human islet alpha and beta cells including their paracrine interaction as part of an effort in understanding the abnormalities in hormonal secretion by islets in both type 1 and type 2 diabetes.
Chris Chen a Professor of Biomedical Engineering at Boston University. His researches focuses on studying how the cooperation between adhesive, mechanical and biochemical signaling drives tissues to organize during development, adapt to physical stresses, and devolve during disease. Dr. Chen’s laboratory examines these questions through the development and application of innovative technologies to control how cells interact with their surroundings, advancing numerous technologies from microfluidics, microelectromechanical systems (MEMS), nanofabrication, mechanobiology, biomaterials, and synthetic and stem cell biology. Dr. Chen’s research applies insights from these efforts to the biology and engineering of stem cells, tissue vascularization, cardiac tissue, and cancer.
Hao Chen is an Associate Professor in the Department of Pharmacology, Addiction Science, and Toxicology at the University of Tennessee Health Science Center. His research interests are in Genetic variants influcing operant drug intake in rats, novel rat models of drug abuse, integrating computation into rodent behavioral experiments, and genomics and transcriptomics.
Jing Chen is an Associate Scientist in the Department of Pathology at the University of Florida. Her research interests are in autoimmune disease, diabetes, immunology of type 1 diabetes, and immunometabolism.
Shuibing Chen is an Associate Professor in the Department of Surgery and Department of Biochemistry at Weill Cornell Medical College. Her research interest is to manipulate stem cell fate using chemical and biological approaches and to generate functional tissues and organs that can be used for translational research.
Josh Chiou was a graduate student in the lab of Kyle Gaulton at the University of California, San Diego. His primary responsibilities include performing integrative analyses of epigenome, transcriptome and diabetes genetic association data. He is currently a Computational Geneticist with Pfizer.
Amit Choudhary is a Assistant Professor of Medicine at the Broad Institute and Harvard Medical School. His research focuses on quantum mechanical interactions to infectious disease and diabetes.
Karen Christman is a Professor of Bioengineering at the University of California in San Diego. Her lab focuses on developing novel biomaterials for tissue engineering and regenerative medicine applications. Projects are highly interdisciplinary and include the development of materials for in vitro differentiation of stem cells to injectable biomaterials for tissue repair and regeneration. The lab has a strong translational focus with the main goal of developing novel minimally invasive therapies for cardiovascular disease
Remi Creusot is an Associate Professor in the Department of Medicine at Columbia University Medical Center and an Investigator within the Columbia Center for Translational Immunology and the Naomi Berrie Diabetes Center. His research interests revolve around the pathogenesis and prevention of Type 1 Diabetes.
Chunhua Dai is a Research Associate Professor in the Powers & Brissova Research Group at Vanderbilt University. Her research focuses on the molecular, cellular, and vascular changes in human islets when they are challenged with hyperglycemia and/or insulin resistance in vivo. She is investigating in vivo age-dependent human beta cell proliferation and how current therapeutic agents for type 2 diabetes preserve and/or enhance human beta cell function or survival in vivo.
XiaoQing Dai is a Research Associate Professor in the MacDonald Lab at the University of Alberta. She is the lead electrophysiologist and involved in many collaborative projects.
George Daley is Professor of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. His research seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered human cell culture-based and murine models of human blood disease and cancer.
Nichole Danzl is an Associate Research Scientist at Columbia University Medical Center. Her research studies for optimization of the PI mouse model and implements these advances into the basic paired T1D versus Healthy Control comparative experiments. She also leads the in vivo functional testing of ES and iPS derivatives to make human islets and a human thymus from the hematopoietic stem cell donor.
Sangeeta Dhawan is a HIRN New Investigator and an Assistant Professor in the Department of Translational Research & Cellular Therapeutics. Her research focuses on the understanding the biology of the insulin producing beta cells.
Teresa DiLorenzo is a Professor in the Department of Microbiology and Immunology at Albert Einstein College of Medicine. He research focuses on autoimmune diseases and autoantigens; immunopathogenesis of type 1 diabetes; humanized disease models; immunomodulatory therapies.
Nicolai Doliba is a Research Associate Professor of Biochemistry and Biophysics at the University of Pennsylvania. His research focuses on the role of bioenergetics, ion transport and metabolic coupling factors in nutrient- and drug-stimulated insulin release at normal conditions and during diabetes mellitus.
Juan Dominguez-Bendala is a Research Professor of Surgery at the Diabetes Research Institute, University of Miami Miller School of Medicine. He is also the Director of Stem Cell & Pancreatic Regeneration and Research Professor of Surgery at the Diabetes Research Institute (DRI). His research focuses on the use of stem cells to obtain pancreatic islets that could potentially be transplanted into patients with type 1 diabetes. He is also currently working on new methods for expansion/regeneration of pancreatic beta cells.
Yuval Dor is a Professor of Biology at the Hebrew University of Jerusalem. He has worked in the past mostly on diabetes and tissue regeneration in the pancreas, but in recent years much of our focus has shifted to a new technology that we are developing, for non-invasive monitoring of cell death in humans, based on circulating DNA.
Thomas Eggerman is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in cystic fibrosis research and translation centers, inborn errors of metabolism, clinical trials, and islet transplantation, and inborn errors of metabolism.
Dieter Egli Assistant Professor at Columbia University. His research focuses on the generation of therapeutically relevant cells for diabetes. His work has relevance for the use of stem cells to study disease, screen for new drugs, and cell replacement therapy.
Decio L. Eizirik is a Professor at the ULB Center for Diabetes Research Medical Faculty, Universite Libre de Bruxells (ULB) in Brussels, Belgium. His research focuses on the molecular mechanisms regulating insulitis and beta cell apoptosis in type 1 diabetes and on the search for novel approaches to prevent the progressive loss of beta cell mass in diabetes.
Abdelfattah El Ouaamari is a HIRN New Investigator and an Assistant Professor in Medicine at Robert Wood Johnson Medical School at Rutgers University. His research employs a multidisciplinary approach to identify local, systemic and neuronal signals regulating the number and the function of pancreatic islet insulin-producing β cells in mouse and human models of obesity and diabetes.
Carmella Evans-Molina is the Director of the Indiana University Center for Diabetes and Metabolic Diseases, J. O. Ritchey Professor of Medicine and Pediatrics at Indiana University School of Medicine, and Director of the IDRC Islet and Physiology Core.. She directs the Diabetes Research Program in the Herman B. Wells Center for Pediatric Research and is a staff physician at the Richard L. Roudebush VA Medical Center. Her research is focused on defining the molecular and inflammatory etiologies of β-cell dysfunction that contribute to diabetes pathophysiology. She has a clinical research interest focused on leveraging activation of β-cell stress pathways to inform the development of biomarkers that predict diabetes risk and define disease endotypes.
Robert Babak Faryabi is an Assistant Professor of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. His research goal is to understand the epigenetic mechanisms of transcriptional addiction in cancer and exploit this information to advance cancer therapeutics.
Michael Feldman is a Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania. He is also the Vice Chair for Clinical Services, Department of Pathology and Laboratory Medicine and Director of the Office of Pathology Informatics.
Leonardo Ferreira is a HIRN Emerging Leader Award Recipient and an Assistant Professor of Microbiology and Immunology at the Medical University of South Carolina. His research focuses on phenomenon of immune tolerance, his long term goal is to control how the immune system defines self and non-self. Such knowledge will allow the design and development of powerful new engineered immune cell therapies to fight autoimmune disease, cancer, and aging.
Jorge Ferrer is Chair in Genetics and Medicine, Head of the Section of Epigenomics and Disease, and Lead for Genetics and Genomics in the NIHR Imperial Biomedical Research Centre. His research interest is in understanding genome regulation of pancreatic beta cells and its implications for human diabetes. His team has combined genetic model systems and advanced genomics to address key questions in human beta cell biology, regeneration, and disease.
Kenichiro Furuyama is currently a Junior Associate Professor at Kyoto University. Previously he was a postdoctoral research fellow in the laboratory of Pedro Herrera at Université de Genève.
Paul Gadue is a Professor of Pathology and Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania. His laboratory studies cell fate decisions, focusing on endoderm and mesoderm specification using human ES cells and iPS cells. ES/iPS cells can differentiate into all cell types in the body and can be propagated in culture almost indefinitely, generating a virtually unlimited supply of cells. These unique characteristics lead to the exciting prospect of using these cells to study disease processes and developmental pathways in vitro and eventually to treat a wide variety of diseases using cell replacement therapies.
Yuqian Gao is an analytical chemist working on the development of targeted mass spectrometry assays to validate new biomarker candidates that are initially identified in untargeted mass spectrometry-based omics analyses.
Kyle Gaulton is an Associate Professor in the Department of Pediatrics at the University of California, San Diego. His research focuses on human genetics and single cell genomics to define cell type-specific gene regulatory programs that affect risk of complex disease, in particular type 1 diabetes.
George Davis is a Professor and the Department Chair of Biomedical Engineering at the University of California, Davis. His research uses stem cell, microfluidic and computational technologies to develop 3D mimics of human organs, known as "organs-on-a-chip." The lab specifically focuses on cancer (pancreatic, colorectal and breast), the cardiovascular system (perfused microcirculation, cariomyocytes) and the pancreas.
Ivan Gerling is a Professor of Medicine in the Division of Medical Endocrinology at the University of Tennessee Health Science Center. His research interests are in autoimmunity, diabetes, oxidative stress, aldosteronism, and systems biology.
Ronald Gill is a Professor of Surgery and Immunology a the University of Colorado, Denver. His research is focused on nature of immune-mediated injury and tolerance induction to tissue and organ transplants. His primary research activity has been in the area pancreatic islet transplantation as a treatment for insulin-dependent diabetes.
Benjamin Glaser is a Professor at the Diabetes Research Center at the Hebrew University of Jerusalem. His research focuses on the effect of glucose on beta cell proliferation and dysfunction and on mechanisms of islet cell maturation and dismaturation in Type 2 Diabetes.
Anna Gloyn is a Professor of Pediatrics, Endocrinology and Genetics at Stanford University. Her research uses human genetics as a tool to understand cellular and molecular mechanisms for pancreatic beta cell failure in diabetes and related conditions. he aim of her research is to capitalize on an improved mechanistic understanding of pancreatic islet cell dysfunction to improve treatment options for patients via the identification of safe and effective therapeutic targets (drug development) and patient stratification (precision medicine).
Robin Goland is a Professor of Medicine and Pediatrics at Columbia University, and directs the patient care and clinical research programs at the Berrie Diabetes Center.
David Gorkin was previously the Associate Director of Epigenomics at the University of California San Diego Center for Epigenomics, Cellular and Molecular Medicine. He is currently an Assistant Professor at Emory University.
Peter Gottlieb is a Professor at the University of Colorado Anschutz Medical Campus. His laboratory projects are designed to advance basic knowledge of the immune response to autoantigens in type 1 diabetes with the goal of designing immunotherapies for prediabetes and new onset type 1 subjects.
Viviana Gradinaru is a Professor of Neuroscience and Biological Engineering and the Director of the Center for Molecular and Cellular Neuroscience at California Institute of Technology (CalTech). Her research has focused on developing technologies for neuroscience and using them to probe circuits underlying locomotion, reward, and sleep.
Rafael Gras is an Associate Research Scientist in the laboratory of Hans Snoeck at Columbia University. His research focuses on mitochondrial dynamics and calcium regulation in hematopoietic stem cells.
Carla Greenbaum is the Director, of the Center for Interventional Immunology and the Director of the Diabetes Research Program at Benaroya Research Institute. Her research interests are in clinical investigations and trials to prevent or intervene in the diabetes autoimmune disease process.
Dale Greiner is the Chair in Biomedical Research and Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. His research focuses on the development and use of a unique mouse model, engrafted with functional human cells and tissues. His work has generated high interest in the biomedical research community for use as a preclinical model for the investigation of human diabetes, cancer, infectious disease, regenerative medicine and autoimmunity.
Markus Grompe is Professor and Director Family Pediatric Research Institute at Oregon Health & Science University in Portland, Oregon. His research focuses on the use of in vivo selection to enhance gene and cell transplantation therapy for inherited diseases.
Kirk Hansen is a Professor at the University of Colorado Anschutz Medical Campus. He participated in HIRN as a collaborator on an internally funded Opportunity Pool Project. His research is focused on developing strategies for the detection and characterization of extracellular proteins in health and disease. Our goal is to understand underlying mechanisms of tissue microenvironments, including innate immunity, in disease processes using mass spectrometry.
Manami Hara is a Research Professor in the Division of Endocrinology, Diabetes and Metabolism at the University of Chicago. Her research focus is on the developmental biology of pancreatic islets. The islet of Langerhans is a micro-organ composed of insulin-secreting beta-cells and other endocrine cells that work together to maintain glucose homeostasis.
Dale Greiner is a Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at UMass Chan Medical School. He has led basic and clinical research exploring the pathophysiology underlying diabetes. Dr. Harlan conducts clinical trials to test new therapies and explain human biology as it relates to diabetes and its treatment. His current research focuses on exploring beta cell biology and the anti-beta cell immune response underlying type 1 diabetes.
Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry at the University of Chicago. His research spans a broad range of chemical biology, nucleic acid chemistry and biology, epigenetics, and bioinorganic chemistry.
Matthias Hebrok is an Professor in Diabetes Research and Director of the Diabetes Center at the University of California, San Francisco. His research focuses on the mechanisms that underlie mammalian pancreas organogenesis and pancreatic diseases, including diabetes and pancreatic cancer. His laboratory has made seminal contributions to our understanding of how embryonic signals control the fetal development of the pancreas and its insulin-producing beta cells. His recent work has implemented the information gained from these studies to generate functional beta cells from human stem cell populations for cell therapy purposes.
Kevan Herold is the C.N.H. Long Professor of Immunobiology and of Medicine at Yale School of Medicine. He studies autoimmune diseases, whether they occur naturally or as a consequence of immunomodulator therapy.
Pedro Herrera is a Professor in the Department of Genetic Medicine and Development at the University of Geneva. His research specializes in the early development of the pancreas and in the field of beta cell regeneration. He studies the pancreatic cell lineages and the mechanisms of cell fate determination, either during embryonic development or after injury, i.e. during adult regeneration, using different transgenic mouse models.
Martin Hetzer is Senior Vice President and Chief Scientific Officer at the Salk Institute in La Jolla, CA. His research focuses on genomics, proteomics and advanced imaging techniques to pose questions about how adult tissues are maintained and repaired and why long-lived cells fail to work properly as a cell ages
Dirk Homann is a physician and immunologist/virologist in Berlin, Boston, Paris and La Jolla, CA. His research focuses on the development, adaptation and optimization of therapeutic strategies that effectively curtail (autoimmunity) or embellish (infectious disease) T cell responses with prophylactic and/or curative intent. Dr. Homann has expanded his research program to encompass a broader context of pancreatic islet cell biology and histopathology in human T1D, and he has launched multiple collaborative efforts to better leverage complementary expert knowledge, unique technology access and more effective overall implementation of research strategies.
Jing Hughes is a Gateway Award Recipient and an Assistant Professor of Medicine in the Division of Endocrinology, Metabolism, and Lipid Research at the Washington University School of Medicine in St Louis. Her research focuses on the islet cell-cell interactions and the regulation of islet hormone secretion.
Christopher Hughes is a Professor of Molecular Biology and Biochemistry School of Biological Sciences and Professor of Biomedical Engineering at the University of California, Irvine. His lab has identified several genes involved in regulating the multiple steps of angiogenesis and are developing reagents to specifically interfere with these processes.
Dan Huh is an Associate Professor of Engineering at the University of Pennsylvania. He is a pioneer of “organ-on-a-chip” technology, and his research group at Penn focuses on developing microengineered models of human physiological systems for a wide variety of biomedical applications.
Albert Hwa is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in the basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease; generation of islet cells from stem cells for disease modeling and regenerative medicine.
Matthew Ishahak was a graduate student with the Agarwal Lab at the University of Miami and is currently a Postdoctoral Research Associate with in the Millman Lab at Washington University School of Medicine in St Louis. His work developing a glomerulus-on-chip was funded by a National Research Service Award Predoctoral Fellowship (F31) from the NIH. Additionally, Matthew co-founded a Bio-Vitro, a startup aimed at commercializing the organ-on-chip technology he helped developed.
Eddie James is a HIRN New Investigator and a Principal Investigator at Benaroya Research Institute. His research involves applying tetramers to identify the chemical patters recognized by T cells in desirable protective immune responses directed against viruses (such as tetanus and HPV) and in undesirable destructive immune responses directed against self or therapeutic proteins (including GAD, insulin, and Factor VIII).
Alok Joglekar is a Gateway Award Recipient and an Assistant Research Professor of Immunology at the University of Pittsburgh. His research aims to examine the shifting antigenic landscape of anti-tumor T cell responses, determine the fundamental rules of TCR-pMHC interactions, and to investigate novel immunotherapies to autoimmune diseases.
Consortia: Consortium on Beta Cell Death & Survival, Consortium on Targeting and Regeneration, Human Pancreas Analysis Consortium
Center: University of Pennsylvania
Klaus Kaestner Professor in Genetics at the Perelman School of Medicine at the University of Pennsylvania and the Director of the Functional Genomics Core at the University of Pennsylvania. His research interest is in employing modern genetic, genomic and epigenomic approaches (ChIP-Seq, RNA-Seq, gene targeting, tissue-specific and inducible gene ablation, CyTOF) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. Disease areas targeted by our research include diabetes and cancer.
Roger Kamm is a Professor of Biological and Mechanical Engineering at Massachusetts Institute of Technology (MIT). The Kamm research group works on five broad areas: Biological Machines/Microfluidics, Angiogenesis/Vasculogenesis, Neurological Diseases, Cancer, and Simulation and modeling.
John Kappler is a researcher in the Department of Immunology and Genomic Medicine at National Jewish Health. His research is focused in the basic biology of lymphocytes and application of knowledge about lymphocytes to human disease. He and his collaborators discovered the T cell receptor in 1983.
Jeff Karp is a Professor of Medicine at Brigham and Women’s Hospital, Harvard Medical School. He research focuses on the fields of drug delivery, medical devices, stem cell therapeutics, and tissue adhesives. In addition to his research goals, Karp is dedicated to developing the careers of the next generation bioengineers at the forefront of regenerative medicine.
Mark Kay is a Professor of Pediatrics and Genetics at Stanford University. His laboratory is focused in the development of gene transfer vectors for gene therapy as well as manipulating non-coding RNAs for therapeutic purposes. His research has focused on two vector systems, mini-circles and recombinant AAVs (rAAV). Using gene transfer vectors, we studied the potential of using transcriptional-based RNAi to treat human disease.
Sally Kent is an Associate Professor in the Department of Medicine at the UMass Chan Medical School. My research focuses on the area of the autoimmune response in human T1D: in particular, T cell responses in the periphery, in spleen and pancreatic lymph nodes and in islet-infiltrating lymphocytes from subjects with T1D, at-risk for T1D and from controls.
Timothy Kieffer is a Professor, Cellular & Physiological Sciences and Surgery, University of British Columbia. He is also the Chief Scientific Officer at Viacyte. His laboratory is focused on islet biology and the development of novel gene and cell therapy approaches to treat diabetes.
Seung Kim is a Professor of Developmental Biology and Medicine (Oncology) at Stanford University School of Medicine. His research focuses on the developmental biology of the pancreas, a vital organ with endocrine and exocrine functions in the vertebrate digestive tract. One goal of our work is to translate our studies into novel diagnostic and therapeutic strategies for common pancreatic disease states in humans, particularly diabetes mellitus and pancreatic cancer.
Yuong-Mo Kim is an analytical chemist and expert in gas chromatography-mass spectrometry-based metabolomics analysis. His participates in various research projects using mass spectrometry based metabolomics approaches to solve biological questions from microbial transformation, synthetic biology, biofuel production, microbiome, carbon flow in the environment and a few others.
Stephan Kissler is an Associate Professor in Department of Medicine at Harvard Medical School. He established a new mouse genome editing core facility of which he is currently the director at the Joslin Diabetes Institute. His laboratory is trying to unravel the complexity of the autoimmunity that underlies Type 1 diabetes.
Hirotake Komatsu is a Gateway Award Recipient and an Assistant Research Professor in the Department of Translational Research & Cellular Therapeutics at City of Hope. His expertise is derived from a broad training in medicine and basic research in the fields of pancreas surgery and pancreatic islet transplantation.
Vira Kravets is a HIRN Emerging Leader Award Recipient and a Postdoctoral Research Fellow in the Department of Bioengineering at the University of Colorado Anschutz Medical Campus. She is currently leading interdisciplinary projects in search for the underlying causes for Diabetes. Juvenile Diabetes Research Foundation supported Fellow, skilled in Islet Biology, Surface Plasmon Resonance, Microscopy, Optics and Public Speaking
Rohit Kulkarni is a Professor of Medicine at Harvard Medical School and Co-Head of the Section on Islet & Regenerative Biology at Joslin Diabetes Center. His research explores the significance of growth factor signaling mechanisms in the regulation of islet biology by creating genetic models to examine the roles of insulin/IGF-1 receptors and their substrate proteins.
Irina Kusmartseva is the Director of the JDRF nPOD Organ Processing and Pathology Core. She has unique experience with the molecular and primary cell culture. Her key area of expertise includes mechanisms of immunoregulation in inflammation, cancer and autoimmune diseases.
Jennifer Kyle was a Postdoctoral Research Fellow in the Metz Lab at Pacific Northwest National Laboratory. For her HIRN project, her responsibilities focused on refining liquid chromatography-mass spectrometry-based lipidomics analyses, including the development of novel informatics tools for confident lipid identification, and in performing lipidomics analyses of pancreatic islets.
Maggie Lam is an Assistant Professor in the Division of Cardiology at the University of Colorado Anschutz Medical Campus. Her research focuses on mass spectrometry and computational techniques to understand the mechanisms driving disease progression in humans, protein dynamics, protein alternative isoform, and protein annotation methods.
Julia Laskin is a Professor of Chemistry at Purdue University. Her research at the interface of physical and analytical chemistry is focused on the advanced development of preparative and analytical mass spectrometry for applications in materials synthesis, imaging and chemical analysis of biological systems at a subcellular level, and environmental sciences.
Karla Leavens is a HIRN Emerging Leader Award Recipient and Pediatric Endocrinologist in the Division of Endocrinology at Children's Hospital of Philadelphia. She is also a Postdoctoral Research Fellow in the Gadue Lab.
Wen-Hong Li is an Associate Professor at University of Texas Southwestern Medical Center. He is an endowed Scholar in Medical Research in the Department of Cell Biology and Biochemistry.
Consortia: Consortium on Targeting and Regeneration, Human Pancreas Analysis Consortium
Role: External Scientific Panel
Center: Institute of Diabetes and Regeneration Research
Heiko Lickert is a Professor and Chair of Beta Cell Biology in the Medical Faculty of the Technical University Munich, the Director of the Institute of Diabetes and Regeneration Research and Principal Investigator in the Institute of Stem Cell Research at the Helmholtz Center Munich.
Center: University of California, San Francisco
Wendell Lim is a Professor of Cellular and Molecular Pharmacology at the University of California, San Francisco. His research focuses on cell signaling, synthetic biology, and cell engineering, particularly in immune cells. Lim's work in immune cell engineering led to the founding of the early cell therapy engineering company Cell Design Labs in 2015, which was acquired by Gilead Sciences in 2017.
Amelia Linnemann is a HIRN Emerging Leader Award Recipient and a HIRN New Investigator. She is an Associate Professor of Pediatrics at the Indiana University School of Medicine. Her primary research focus is to understand mechanisms of pancreatic β-cell death/survival, islet compensatory adaptation to cellular stress, and how these factors contribute to diabetes pathogenesis.
Chengyang Liu is an Adjunct Professor of Surgery and the Director of the Human Islet Laboratory & Clinical GMP Facility at the University of Pennsylvania School of Medicine.
Bayou Liu is a Gateway Award Recipient and an Assistant Professor in the Department of Pathology at the University of Utah. His research focuses on autoimmune diseases (e.g., type I diabetes) via understanding self-antigen recognition by the immune system.
Emma Lundberg is a Professor in Cell Biology Proteomics at KTH Royal Institute of Technology, Sweden, and Director of the Cell Atlas, of the Human Protein Atlas program. She recently joined the Stanford University Bioengineering Department as an Associate Professor of Bioengineering. Her research is focused on spatial proteomics and cell biology.
Patrick MacDonald is Professor of Pharmacology at the University of Alberta and the Director of the Alberta Diabetes Institute (ADI) IsletCore. His research focuses on pancreatic islet function in health and diabetes. The research from his laboratory has spanned areas that include biophysical characterization of ion channels, intracellular signal transduction and exocytosis, and the cellular regulation of glucagon secretion.
Rene Maehr is an Associate Professor in Molecular Medicine at UMass Chan Medical School. His research focuses on investigating how normal differentiation of the thymic epithelial cell lineage is regulated, and recapitulating that process with pluripotent stem cells.
Mohsen Khosravi Maharlooei is an Associate Research Scientist at the Columbia Center for Translational Immunology. His research is focused in "immune tolerance", specifically basic and translational researches in the fields of autoimmunity, transplantation and cancer.
Dustin Maly is a Professor of Chemistry at the University of Washington. His research focuses on generating novel signaling proteins that can be controlled with cell permeable small molecules.
Mark Mamula is a Professor of Medicine (Rheumatology) at the Yale School of Medicine. His research focuses on biochemical forms of autoantigens capable of breaking immunologic tolerance to intracellular autoantigens in systemic lupus erythematosus (SLE), and type 1 diabetes (T1D).
Clayton Mathews is a Professor of Pathology, Immunology, and Laboratory Medicine at the University of Florida. His studies seek to improve our collective understanding on the means by which type 1 diabetes develops, both in humans and in mouse models of the disease. His efforts are extremely novel in that while the majority of researchers addressing the notion of how the disease develops focus on identifying defects in cells of the immune system.
Jason McDermott is a Senior Research Scientist at Pacific Northwest National Laboratory. His has extensive research experience in molecular and structural virology and data resource design, data integration and prediction of biological networks, bridging experimental and computational biology.
Role: External Scientific Panel
Center: Augusta University
Douglas A. Melton is a Professor at Harvard University, and an investigator at the Howard Hughes Medical Institute. His current research interests include pancreatic developmental biology and the directed differentiation of human embryonic stem cells, particularly in pertinence to type 1 diabetes.
Thomas Metz is a principal investigator in the Integrative Omics group within the Biological Sciences Division and is the team lead for a group of scientists that focuses on development and applications of high throughput metabolomics and lipidomics methods to various biological questions. His research interests span the development of both untargeted and targeted metabolomics and lipidomics capabilities, based on liquid and gas chromatography coupled with mass spectrometry, both for fundamental studies of metabolism and metabolic interactions
Everett Meyer is an Assciate Professor of Medicine at Stanford University Medical School. His research focus is in hematopoietic stem cell transplantation and Treg cell immunotherapy, with an emphasis on the treatment of graft-versus-host disease as well as immune tolerance induction for transplantation and autoimmunity. He is an expert on the role of T-cell populations in immune dysregulation, specifically through the mechanistic study of how CD1d-restricted invariant NKT mediate allergy and asthma in both mouse models and human clinical samples.
Aaron Michels is an Endocrinologist and an Associate Professor at the University of Colorado Anschutz Medical Campus. His research focuses on understanding the underlying immunology of autoimmune disorders with a focus on type 1 diabetes. He discovered that small ‘drug-like’ molecules targeted to diabetes risk HLA molecules can block T cell responses and prevent diabetes onset in spontaneous animal models of autoimmune diabetes.
Jeffrey Millman is an Associate Professor of Medicine and Biomedical Engineering at Washington University School of Medicine in St Louis. His research focus is in the in vitro production and study of pancreatic insulin-producing β cells from human pluripotent stem cells for use in cellular replacement therapy and drug screening.
Raghavendra Mirmira is the Director of the Department of Medicine Translational Research Center and Professor of Medicine in the Department of Endocrinology, Diabetes and Metabolism at the University of Chicago. His research focuses his efforts on the pathogenesis of diabetes mellitus and the biology of the islet. His laboratory is interested in three key areas: the role of mRNA translation in the cellular response of islet β cells to inflammation; the role of lipoxygenases in dysfunction of β cells in Type 1 and Type 2 diabetes; and the identification of biomarkers of β-cell stress and death in diabetes.
Jason Moore was a Professor of Informatics and Director of the University of Pennsylvania Institute for Biomedical Informatics. He is currently the Chair of the Department of Computational Biomedicine at Cedars-Sinai Medical Center in Los Angeles, CA. His research is focused on the development of artificial intelligence and machine learning algorithms for the analysis of complex biomedical data.
Margaret Morris was an Assistant Professor at Eastern Virginia Medical School. Currently, she is a Scientific Review Officer at National Institute of Allergy and Infectious Diseases (NIAID).
Jerry Nadler is a Professor of Medicine and Pharmacology and the Dean of the School of Medicine of New York Medical College. He is an internationally recognized diabetes researcher and has been a member of a Special Advisory Committee on Type I Diabetes with the director of the NIH. As a prominent voice in his field, he has authored more than 200 peer-reviewed publications and has been an invited speaker at major international conferences, including the American Diabetes Association, Australian Diabetes Association, World Diabetes Congress and International Meetings of the European Association of Diabetes.
Ali Naji is Professor of Surgical Research at the University of Pennsylvania School of Medicine and the Associate Director of the Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine. His research efforts have focused on the immunobiology of transplantation and immune pathogenesis of autoimmune diabetes
Hiroyuki Nakai is a Professor of Molecular and Medical Genetics at the Oregon Health and Science University School of Medicine. His research goals are to comprehensively understand the biology of recombinant AAV vectors and the vector-host interactions and to develop new AAV vector-mediated gene and cell therapies to treat various human diseases.
Maki Nakayama is an Associate Professor in the School of Medicine at the University of Colorado Anschutz Medical Campus. Her research strives to understand the mechanism of initiation of anti-beta cell autoimmunity. She focuses on the tri-molecular complex consisting of antigen, major histocompatibility complex (MHC), and T cell receptor (TCR) that could be a key component for the development of T1D.
Ernesto Nakayasu is a senior research scientist focused on understanding molecular mechanisms of diseases. Nakayasu has been applying systems biology and mass spectrometry-based omics measurements to study how pathogens and metabolic alterations cause human diseases; the goal is to identify diagnostic and therapeutic targets. He has been integrating multi-omics approaches to develop biomarkers of diseases and to study signaling and metabolic pathways that are altered or targeted in infectious and metabolic diseases.
Role: Research Staff
Center: Columbia University
Grace Nauman was a Postdoctoral Research Associate in the Sykes Laboratory at Columbia University. She is currently a scientist at Mitobridge. Her HIRN research was focused on improving human antigen presenting cell reconstitution in the Personalized Immune Mouse system.
Center: Duke University
Kim-Vy Nguyen-Ngoc is currently an Assistant Project Scientist in the Laboratory of Maike Sander at the University of California, San Diego. Her HIRN research focuses on establishing 3D organotypic culture models of pancreatic cells derived from hESCs. Identify strategies to vascularize islet organoids in 3D culture.
Harry Nick, PHD, is a Professor of Neuroscience at the University of Florida. Dr Nick has funding from the National Institutes of Health, JDRF, and the Leona M. and Harry B. Helmsley Charitable Trust, and the JDRF nPOD.
Joyce Niland, Ph.D., holder of City of Hope’s Estelle & Edward Alexander Chair in Information Sciences, is professor and chair in the Department of Diabetes & Cancer Discovery Science within the Diabetes & Metabolism Research Institute at City of Hope. An internationally recognized leader in her field with hundreds of publications to her name, she has more than 30 years of experience in biostatistics, biomedical informatics, computational statistics, system development and deployment, and collaboration in translational research.
Jeremy Norris is the Managing Director of the Vanderbilt University Mass Spectrometry Research Center and a Research Associate Professor in the Department of Biochemistry. Jeremy earned his Ph.D. in analytical and organic chemistry from Vanderbilt University in 2003. His research interests are in the application of mass spectrometry and separations science to measure biologically and clinically important analytes. He is the Managing Director for the National Resource for Imaging Mass Spectrometry and the DARPA-funded Rapid Threat Assessment Program at Vanderbilt University.
Julius Nyalwidhe has become a pioneer in the field of proteomics and is now a leading cancer researcher with an international reputation. His laboratory focuses on molecular biology, functional genomics and proteomic approaches to study cancer for the purposes of understanding cancer biology as well as to discover clinical biomarkers. The focus is on understanding the molecular events and signaling mechanisms that are involved in cancer progression and disease severity. The objective is to identify and disrupt signaling mechanisms that are involved in cancer progression and severity.
Scott Oakes’s laboratory studies how mammalian cells commit “suicide” in response to various forms of damage and what goes wrong with this process in cancer and other diseases. In particular, they focus on a type of stress that occurs when the cell’s protein folding factory—an organelle called the endoplasmic reticulum—is overwhelmed and protein quality control fails. He is actively engaged in developing drugs to control cell fate under these conditions, which have potential to benefit patients with diseases from cancer to neurodegeneration.
Role: External Scientific Panel
Center: University of Virginia
Dr. Galya Orr is a biomedical scientist with the Cell Signaling and Communications team in PNNL’s Environmental Molecular Sciences Division and the Environmental Molecular Sciences Laboratory (EMSL) user program. For over 20 years, she has led the development and capability applications for biological research at the single-cell and single-molecule levels. Orr and her team are pursuing interdisciplinary efforts that combine the development of non-conventional quantitative fluorescence imaging and molecular biology approaches and their applications to better understand cellular and molecular processes in the intact cells and tissues.
Feroz Papa is a Professor in the Department of Medicine at the University of California, San Francisco Biomedical Sciences Graduate Program. His lab uses molecular, cellular, and organismal approaches to address broad questions revolving around protein misfolding and disease. His research focuses in protein misfolding in the endoplasmic reticulum (ER) organelle.
Audrey Parent is a CMAI co-Investigator and a member of the Trans-Network Committee (TNC). She is Assistant Adjunct Professor and her research is focused on immune tolerance with a particular interest in the thymus.
Kit Parker is a Professor of Bioengineering and Applied Physics at Harvard University School of Engineering and Applied Sciences. His research focuses on cardiac cell biology and tissue engineering, traumatic brain injury, and biological applications of micro- and nanotechnologies. Working in both Biomimetic Microsystems and Programmable Nanomaterials, he is involved in projects ranging from developing nanofabrics for applications in tissue regeneration to creating organs-on-chips to address pediatric diseases such as asthma, muscular dystrophy, diabetes, brain injury and congenital heart disease.
Stephen Parker is an Associate Professor of Computational Medicine and Bioinformatics at the University of Michigan. The major goal of his lab is to generate mechanistic knowledge about how disease susceptibility is encoded in the non-coding portion of the genome, with a focus on type 2 diabetes.
Ricardo Pastori is Research Professor of Medicine, Immunology, and Microbiology and the Director of the Molecular Biology Laboratory at the Diabetes Research Institute, University of Miami Miller School of Medicine. His laboratory has developed novel molecular tools and applied them to study β-cell biology and to improve the outcome of islet transplantation such as the development and utilization of protein transduction (PT) technology, a method that utilizes small protein transduction domains (PTDs), to deliver proteins into cells.
Vladislav Petyuk is a Scientist at Pacific Northwest National Laboratory. His research focuses on quantitative proteomics and in particular involves development of algorithms for data preprocessing, assessment of data quality and statistical approaches for data exploration, hypothesis testing and inference of new biological knowledge.
Edward Phelps is an Assistant Professor in the Department of Biomedical Engineering at the University of Florida. His research focuses on biomaterials, regenerative medicine and immunoengineering.
Greg Poffenberger is a Senior Research Specialist in the Powers & Brissova Lab at Vanderbilt University. His areas of expertise are small animal surgeries, functional islet analysis/assays in vitro and in vivo.
Vincent Poitout is a Professor in the Department of Medicine at the University of Montreal. His research focuses on the regulation of pancreatic beta-cell function and its dysregulation in type 2 diabetes. He is exploring the role of nutrient-sensing G Protein-Coupled Receptors (GPCRs) and Regulators of G protein Signaling (RGS proteins) in pancreatic islet function and glucose homeostasis.
Al Powers is a Professor of Medicine, Molecular Physiology and Biophysics at Vanderbilt University. He is also the Director of the Vanderbilt Diabetes Center, Director of the Vanderbilt Diabetes Research and Training Center, and Chief of the Vanderbilt Division of Diabetes, Endocrinology, and Metabolism. His research focuses on pancreatic islet biology, vascularization, development, regeneration, and imaging.
Sebastian Preissl was previously the Associate Director of Single Cell Genomics at the University of California San Diego Center for Epigenomics, Cellular and Molecular Medicine. He is currently a Principal Investigator at Deutsche Forschungsgemeinschaft (DFG) in Freiburg, Germany.
Wei-Jun Qian is a bioanalytical chemist whose research centers primarily on the development and applications of mass spectrometry-based approaches for better quantify the dynamic changes in protein abundances and protein post-translational modifications in biological and clinical applications. His current research involves the development of chemical proteomic approaches for site-specific quantification of cysteine-based redox modifications and more sensitive selected reaction monitoring (SRM)-based targeted quantification techniques with applications in pancreatic islets, diabetes, and oxidative stress-related disease areas.
Stephen Quake is a Professor of Bioengineering and Professor of Applied Physics at Stanford University and is co-President of the Chan Zuckerberg Biohub. Quake has invented many measurement tools for biology, including new DNA sequencing technologies that have enabled rapid analysis of the human genome and microfluidic automation that allows scientists to efficiently isolate individual cells and decipher their genetic code. Quake is also well known for inventing new diagnostic tools, including the first non-invasive prenatal test for Down syndrome and other aneuploidies.
Sasanka Ramanadham is a Professor in the Department of Cell, Developmental and Integrative Biology (CDIB) and senior scientist in the Comprehensive Diabetes Center (UCDC).
Dr. Chris Rhdoes is the Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, and Chair of AstraZeneca’s postdoc programme. He is a renowned leader in the field of diabetes, obesity and metabolism research, with a career spanning over three decades. He has more than 180 published manuscripts, and has held industry and academic leadership roles at top institutions that include Harvard Medical School and the University of Washington. Chris is also Professor Emeritus at the University of Chicago, Department of Medicine
Camillo Ricordi is Professor of Medicine, Professor of Biomedical Engineering, and Microbiology and Immunology at the University of Miami (UM) in Florida. He serves as Director of the Diabetes Research Institute (DRI) and the Cell Transplant Program. Dr. Ricordi been serving as Responsible Head of the NIH-funded cGMP (current Good Manufacturing Practices) Human Cell Processing Facility (1993-present), for the manufacturing of advanced human cell and other biologic products.
James Riley is a Professor of Microbiology at University of Pennsylvania Perelman School of Medicine. His lab studies the signaling pathways that control primary human T cell activation and function with special attention to how these manipulations can be exploited to develop T cell therapies for HIV, autoimmune disease and cancer. The lab is also focused on designing HIV resistant, HIV specific T cells to be key players in the HIV Cure effort.
Dr. Bart O. Roep is Professor of Diabetology, Immunopathology & Intervention and Director of the National Diabetes Center of Excellence at the Leiden University Medical Center in The Netherlands and Visiting Professor of the Danish Diabetes Academy. He is also Founding Chair and Professor of Medicine of the Department of Diabetes Immunology, and holds the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes at the Diabetes & Metabolism Research Institute at the Beckman Research Institute of the City of Hope in Los Angeles.
Mike Roper is a Professor in the Department of Chemistry and Biochemistry at Florida State University. His research focuses on how the secretion of multiple peptides and small molecules from islets of Langerhans contribute to proper glucose clearance in the body. This lab develops new analytical methods and techniques to investigate biological signaling.
Center: University of Oxford
Derrick Rossi was an Associate Professor at the Stem Cell and Regenerative Biology Department at Harvard Medical School and Harvard University. His efforts in the development of cutting-edge technologies and novel therapeutic strategies are at the forefront of regenerative medicine and biotechnology. In 2010, he co-founded Moderna based on discovery that pluripotent stem cells can be transformed and reprogrammed. He is currently retired from all of his Harvard positions in order to focus on his activities as an entrepreneur.
Kole Roybal is an Associate Professor of Microbiology and Immunology at the University of California, San Francisco. His research utilizes tools of synthetic and chemical biology to enhance the therapeutic potential of engineered immune cells. He also studies the logic of natural cellular signaling systems, and the underlying principles of cellular communication and collective cell behavior during an immune response.
Holger Russ is a HIRN New Investigator and an Assistant Professor of Pediatrics at the University of Colorado Denver. His research focuses on using human stem cells to generate novel sources of beta cells for transplantation and to model human T1D in a dish.
Guy Rutter is a Professor of Cell Biology and Functional Genomics at Imperial College of London. His research focuses on signal transduction in the pancreatic β-cell in health and disease - my chief focus is in using functional genomics at the cellular and whole organism level to dissect the role of genes associated with Type 2 diabetes.
Juan Alvarez is a Gateway Award Recipient and an Assistant Research Professor in the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine. Currently he is investigating the pathways by which thyroid hormones regulates skeletal muscle physiology and the role of type-2 deiodinase in muscle biology and its importance to plasma T3 pool.
Nilanjana Samanta is the Data Curator for the Human Pancreas Analysis Program (HPAP) Pancreas Database (PancDB). She uses her data analysis skills for meaningful interpretation of factors associated with health outcomes, monitor healthcare access, and health disparity.
Maike Sander is a Professor in the Departments of Pediatrics and Cellular & Molecular Medicine at the University of California, San Diego (UCSD) and Co-Director of the Center on Diabetes in the Institute of Engineering in Medicine at UCSD. Her primary research interest is to understand the molecular mechanisms that underlie the formation and function of the diverse cell types of the pancreas, in particular the insulin-producing beta cells. A recent major focus has been to establish a human pluripotent stem cell-based pancreatic beta cell differentiation platform to model mechanisms that underlie the pathogenesis of diabetes.
Dr. Leslie Satin is a Professor of Pharmacology in the University of Michigan Medical School. Dr. Satin’s research has combined several strands, involving studies of the electrophysiology of neurons and synaptic changes after traumatic brain injury, the production of oscillations in neurosecretory cells and their theoretical basis, and the regulation of intracellular free Calcium and ion channels by cell fuel metabolism. Dr. Satin is an expert on the cellular signaling mechanisms, ion channel biophysics, the application of theoretical models to biomedical systems, and synaptic mechanisms of plasticity in the brain. He has served on the editorial boards of Neurochemistry International, Endocrinology, Endocrine, Diabetes, J. Biol. Chem., and American Journal of Physiology. He has served on many NIH study sections, including those devoted to TBI and stroke, and diabetes and metabolic diseases.
Sheryl Sato was a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her research interest is the basic mechanisms underlying the organogenesis and regeneration of pancreatic islets during health and disease.
Role: Research Staff
Center: Vanderbilt University
Diane Saunders is a Research Instruct with the Powers & Brissova Lab at the Vanderbilt University. She is currently leading efforts in multiplexed imaging and characterization of the young human pancreas, including delineation of endocrine-immune cell interactions and the establishment of islet architecture. Diane is also the Co-Scientific Director of Pancreatlas, an online image resource that houses reference datasets from human pancreas samples.