Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes?

Contact PI: Klaus Kaestner, PhD


Abstract

We propose to conduct a preliminary evaluation of this provocative hypothesis. We will employ laser
capture microdissection to isolate genomic DNA from specific pancreatic lobules in T1D and healthy
individuals. We will then perform exome sequencing to catalogue somatic mutations common to specific
lobules, with the final goal of correlating the presence or burden of mutations to autoimmune status of
lobule as determined histologically.

Opportunity Pool Project Sponsored by CBDS & CTAR.
Awarded: 2018

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