Opportunity Pool Projects (HIRN-OPP)
Summary of internally funded HIRN research projects utilizing network Opportunity Pool Funds.
2021 Emerging Leader Award Recipients
- Juan Alvarez, PhD, Harvard University
- Leonardo Ramos-Ferreira, PhD, University of California, San Francisco
- Vira Kravets, PhD, University of Colorado, Denver
- Karla Leavens, MD, PhD, Children’s Hospital of Philadelphia
- Robert Sharp, PhD, University of Florida
2018 New Investigator Award Recipients
- “Changes in Human Islet Microvasculature during Type 1 Diabetes” (HPAC)
Joana Almaca, PhD, University of Miami - “Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function” (CTAR)
Sangeeta Dhawan, PhD, Beckman Research Institute of the City of Hope - “Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells” (CTAR)
Abdelfattah El Ouaamari, PhD, Rutgers University - “HLA Multimer based Characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes” (CMAI)
Eddie James, PhD, Benaroya Research Institute - “Real-time in vivo Analysis of Islet Redox Dynamics” (CBDS)
Amelia Linnemann, PhD, Indiana University - “Elucidating the Human Beta Cell Translatome in Health and Disease” (CBDS)
Holger Russ, PhD, University of Colorado, Denver
Current Opportunity Pool Projects
Completed Opportunity Pool Projects
- Antibodies for beta-cell subtype identification by immunohistochemistry
- Characterization of in silico reconstruction of TCRs for modeling autoreactive T cells in T1D
- Exploiting the Power of CyTOF/Mass Cytometry (MC) to Elucidate the Complex Interactions of Islet and Immune Cells in Human Type 1 Diabetes Pancreata
- Exploiting the Power of CyTOF/Mass Cytometry (MC) to Elucidate the Complex Interactions of Islet and Immune Cells in Human Type 1 Diabetes Pancreata
- Functional Testing of Candidate HSC-derived Islet Cells
- Generation of Functional Endocrine Cell Receptor Stem Cell lines
- Islet-reactive TCR Clones in Humanized Mice Generated with Type 1 Diabetes Patient vs. Healthy Control Hematopoietic Stem Cells
- Mass Spectrometry-based Proteome Maps for Human Islet Cells
- A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
- The Proteome of Replicating Cells
- Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM
- Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems
- Workshop for Continued Harmonization of Beta Cell Death Assays
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