Opportunity Pool Projects (HIRN-OPP)
Summary of internally funded HIRN research projects utilizing network Opportunity Pool Funds.
New Investigator Award Recipients
- Joana Almaca, PhD, University of Miami
Project Abstract: Changes in Human Islet Microvasculature during Type 1 Diabetes
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Consortium: HPAC - Sangeeta Dhawan, PhD, Beckman Research Institute of the City of Hope
Project Abstract: Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
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Consortium: CTAR
- Abdelfattah El Ouaamari, PhD, Rutgers University
Project Abstract: Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells
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Consortium: CMAI - Amelia Linnemann, PhD, Indiana University
Project Abstract: Real-time in vivo Analysis of Islet Redox Dynamics
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Consortium: CBDS - Holger Russ, PhD, University of Colorado, Denver
Project Abstract: Elucidating the Human Beta Cell Translatome in Health and Disease
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Consortium: CBDS - Prashanth Vallabhajosyula, MD, Yale University.
Discovery & Investigation of Noninvasive Diagnostic Potential of Circulating Pancreatic Islet Beta Cell Exosomes as Biomarkers of Beta Cell Injury
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Consortium: CBDS
Current Opportunity Pool Projects
Completed Opportunity Pool Projects
- Antibodies for beta-cell subtype identification by immunohistochemistry
- Characterization of in silico reconstruction of TCRs for modeling autoreactive T cells in T1D
- Exploiting the Power of CyTOF/Mass Cytometry (MC) to Elucidate the Complex Interactions of Islet and Immune Cells in Human Type 1 Diabetes Pancreata
- Exploiting the Power of CyTOF/Mass Cytometry (MC) to Elucidate the Complex Interactions of Islet and Immune Cells in Human Type 1 Diabetes Pancreata
- Functional Testing of Candidate HSC-derived Islet Cells
- Generation of Functional Endocrine Cell Receptor Stem Cell lines
- Islet-reactive TCR Clones in Humanized Mice Generated with Type 1 Diabetes Patient vs. Healthy Control Hematopoietic Stem Cells
- Mass Spectrometry-based Proteome Maps for Human Islet Cells
- A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
- The Proteome of Replicating Cells
- Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM
- Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems
- Workshop for Continued Harmonization of Beta Cell Death Assays