Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.
Pseudo-islets made up of human alpha cells. These cells produce glucagon (blue), but can "learn" to make insulin (red). The GFP protein (green) allows tracing the origin of the cells, thus certifying their change of identity.
Nature. February 13, 2019
Image provided by P. Herrera
A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.
Cell Metabolism. 29, 1-14. March 5, 2019
Image provided by N. Damond
Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.
Cell Metabolism. 29, 1-15. March 5, 2019
Image provided by K. Kaestner
Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis
Image courtsey of D. Saunders & A. Powers
The mission of the Human Islet Research Network (HIRN) is to
better understand how human beta cells are lost in
Type 1 Diabetes and to find innovative strategies to protect or
replace functional beta cell mass in diabetic patients.