Year 5 & Year 6 Executive Summary Report
The HIRN Year 5 & Year 6 Executive Summary Report is now available online! The report reflects significant HIRN breakthroughs, developments and advancements across the entire network. This 2-year report reflects activity from October 2018 through September 2020.
Cover Image: Dan Huh, Univ. Pennsylvania, CHIB Stanger UG3. A cross-sectional view of a vascularized three-dimensional biomimetic device visualized by scanning electron microscopy. A micro-capillary is seen in cross-section along with a functional pericyte (upper right) and surrounding matrix.
HIRN 2022 Annual Investigator Meeting
All members of of the HIRN network are invited to participate in the Annual Investigator Meeting which will be held Wednesday September 14 – Friday September 16, 2022. The meeting will be a hybrid format. We strongly encourage in-person attendance but we will utilize zoom webinar to support remote attendees.
*Update abstracted submission deadline: Wednesday, July 13th at 5:00 pm Pacific
Contact the HIREC for registration details or information on how to participate as an exhibitor.
HIRN Funding Opportunities
- HIRN CTAR (RFA-DK-22-009)
Due: October 26, 2022
Requesting projects to develop strategies to target the human pancreatic environment in-vivo to deliver regulatory cells, molecules or gene constructs that can protect or replenish functional beta cell mass, or to engineer cellular or synthetic sentinel biomarkers that can safely monitor the islet tissue environment in individuals at risk of developing T1D.
- NIH Integrated Physiology of Exocrine and Endocrine Pancreas in T1D (RFA-DK-22-022)
Due February 21, 2023
- NIH Gateway Awards (RFA-DK-21-030)
Due March 20, 2023
- HIRN CTAR (RFA-DK-22-009)
NIH NIDDK Workshop: "Healthy Reference Tissue and Standards Workshop"
The National Institute of Diabetes and Digestive and Kidney Diseases is planning a public workshop to discuss the challenges and best practices for obtaining and using healthy reference tissue as a benchmark for disease and for assessing the technical variability of imaging and -omic assays. This workshop also will identify state-of-the-art, fit-for-purpose standards for these assays and stimulate discussion of the next generation of standards. The workshop aims to address these issues through the lens of kidney precision medicine while surfacing lessons learned from other fields and sharing solutions that could enhance all atlas-building efforts broadly.
Date/Time: July 25, 2022 (10 am – 5pm Eastern)
HIRN 2021 Trainee Scholarship Recipients
The following are recipients of HIRN 2021 Trainee Scholarships. These trainees submitted submitted abstracts that were competitively reviewed by members of the HIRN Annual Meeting Planning Committee and selected as being highly meritorious.
HUMAN ISLET RESEARCH NETWORK MISSION
To better understand how human beta cells are lost in Type 1 Diabetes and to find innovative strategies to protect or replace functional beta cell mass in diabetic patients.
The HIRN 2022 Annual Investigator Meeting will be held Wednesday, September 14 – Friday, September 16, 2022 at the Omni Shoreham Hotel in Washington, DC. Remote participation will be supported…Read More
Click HERE to access the YouTube video of the recording. January 27, 2022 (2:00 PM Eastern / 11:00 am Pacific) Presented by: Rohit N Kulkarni, MD, PhD, Joslin Diabetes Center Dario F…Read More
Independent Research Initiatives
CBDS is using human pancreatic tissues to discover mechanisms of cellular stress or dysfunction that may contribute to the development of autoimmunity in at-risk individuals, to identify specific biomarkers of the asymptomatic phase of T1D, and to develop innovative strategies to stop beta cell destruction early in the disease process.
CHIB is combining advances in beta cell biology and stem cell biology with tissue engineering technologies to develop microdevices that support functional human islets.
The CMAI is developing innovative approaches to model basic aspects of human T1D immunobiology using novel in vivo and in vitro platforms.
CTAR is investigating methods to increase or maintain functional beta cell mass in T1D through targeted manipulation of islet plasticity or engineered protection of beta cells from immune-mediated destruction.
The Human Pancreas Analysis Consortium (HPAC) is investigating the physical and functional organization of the human islet tissue environment, the cell-cell relationships within the pancreatic tissue ecosystem, and the contributions of non-endocrine components (acinar, ductal, vascular, perivascular, neuronal, lymphatic, immune) to islet cell function and dysfunction.
Opportunity Pool Projects
The Human Islet Research Network (HIRN) was established In 2014 to help organize and support collaborative research related to the loss of functional beta cell mass in Type 1 Diabetes (T1D). The project consists of five independent research initiatives.