Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable
JCI Insight. January 16, 2020
This work demonstrates that tacrolimus and sirolimus, commonly used immunosuppressive drugs, cause human β cell dysfunction by altering the transcriptional profile and insulin secretory granule processes.
Image provided by C. Dai & A. Powers
Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention
Cell Metabolism. February 4, 2020
Nakayasu et al. used a proteomics-based approach in human islets to study the T1D-related process of β-cell
destruction, identifying a protein, GDF15, that promotes the protection of β cells and prevents diabetes onset in mice.
Image provided by T. Metz & R. Mirmira
New HIRN RFA Opportunities
The NIH NIDDK has recently announced HIRN-related funding opportunities
The mission of the Human Islet Research Network (HIRN) is to
better understand how human beta cells are lost in
Type 1 Diabetes and to find innovative strategies to protect or
replace functional beta cell mass in diabetic patients.