NIH NIDDK Funding Opportunities

2023 Gateway Award Recipients

Please join us in Congratulating the newly funded 2023 NIH NIDDK HIRN Gateway Investigators. This initiative is designed to support a robust pipeline of innovative projects and talented new investigators in T1D research.

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HIRN 2023 Trainee PRESENTATION Award Recipients

Congratulations to the following three trainees who received an award at the 2023 Annual Investigator Meeting for their oral presentation. Award recipients were selected solely based on evaluations by HIRN members on their presentations at the Annual Investigator Meeting. 

 

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HIRN 2023 Trainee POSTER Award Recipients

Congratulations to the following seven trainees who received an award at the 2023 Annual Investigator Meeting for their scientific poster. Award recipients were selected solely based on evaluations by HIRN members on their presentations at the Annual Investigator Meeting. 

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Year 5 & Year 6 Executive Summary Report

The HIRN Year 5 & Year 6 Executive Summary Report is now available online! The report reflects significant HIRN breakthroughs, developments and advancements across the entire network. This 2-year report reflects activity from October 2018 through September 2020.

Cover Image: Dan Huh, Univ. Pennsylvania, CHIB Stanger UG3. A cross-sectional view of a vascularized three-dimensional biomimetic device visualized by scanning electron microscopy. A micro-capillary is seen in cross-section along with a functional pericyte (upper right) and surrounding matrix.

 

Learn more about all of our HIRN New Investigators at  

HUMAN ISLET RESEARCH NETWORK MISSION

To better understand how human beta cells are lost in Type 1 Diabetes and to find innovative strategies to protect or replace functional beta cell mass in diabetic patients.

Our Research

Supporting Collaborative Research since 2014

The Human Islet Research Network (HIRN) was established in 2014 to help organize and support collaborative research related to the loss of functional beta cell mass in Type 1 Diabetes (T1D). The project consists of five independent research initiatives.

Research Resources

Latest News

HIRN. Webinar. 2024 April 23

HIRN Webinar: Emerging role for tissue-specific extracellular vesicles in disease diagnosis: implications for Type 1 Diabetes

Click HERE to view YouTube recording of the webinar. Thursday, April 23, 2024 (1:00 pm Eastern / 10:00 am Pacific) Presentations by:    Saumya Das, MD, PhD, Massachusetts General Hospital…

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HIRN. Microfluidic Devices Webinar 2024 Feb

HIRN Webinar: “Microfluidic Models for Types 1 Diabetes on a Chip”

Click HERE to view YouTube recording of the webinar. Tuesday, February 13, 2024 (1:00 pm Eastern / 10:00 am Pacific)   Presentation by:      Ashutosh Agarwal, PhD, University of…

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Webinar. Jan 2024. Dor

HIRN Webinar: “Extensive Cell Turnover During Postnatal Pancreas Growth”

Click HERE to view YouTube recording of the webinar. Thursday, January 11, 2024 (1:00 pm Eastern / 10:00 am Pacific) Presentation by:     Yuval Dor, PhD, University Jerusalem Topics discussed:…

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Consortia

Independent Research Initiatives

Consortium on Beta Cell Death and Survival

CBDS is using human pancreatic tissues to discover mechanisms of cellular stress or dysfunction that may contribute to the development of autoimmunity in at-risk individuals, to identify specific biomarkers of the asymptomatic phase of T1D, and to develop innovative strategies to stop beta cell destruction early in the disease process.

Consortium on Human Islet Biomimetics

CHIB is combining advances in beta cell biology and stem cell biology with tissue engineering technologies to develop microdevices that support functional human islets.

Consortium on Modeling Autoimmune Interactions

The CMAI is developing innovative approaches to model basic aspects of human T1D immunobiology using novel in vivo and in vitro platforms.

Consortium on Targeting and Regeneration

CTAR is investigating methods to increase or maintain functional beta cell mass in T1D through targeted manipulation of islet plasticity or engineered protection of beta cells from immune-mediated destruction.

Human Pancreas Analysis Consortium

The Human Pancreas Analysis Consortium (HPAC) is investigating the physical and functional organization of the human islet tissue environment, the cell-cell relationships within the pancreatic tissue ecosystem, and the contributions of non-endocrine components (acinar, ductal, vascular, perivascular, neuronal, lymphatic, immune) to islet cell function and dysfunction.

Pancreas Knowledgebase Program

PanKbase is a centralized resource of the human pancreas for diabetes research that will provide access to deeply curated high-quality datasets, knowledge in computable forms, and advanced data science tools and workflows; and enable open and reproducible multidisciplinary collaboration toward accelerating biomarker and therapeutic target development.

HIRN-OPP

Opportunity Pool Projects

The Human Islet Research Network (HIRN) was established In 2014 to help organize and support collaborative research related to the loss of functional beta cell mass in Type 1 Diabetes (T1D). The project consists of five independent research initiatives.

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