Funding Opportunity: HIRN Emerging Leaders in Type 1 Diabetes (T1D)
A new competitive announcement to provide support and protected time for senior postdoctoral fellows seeking to pursue studies that will enhance their transition toward independent research careers. This opportunity is designed specifically for applicants proposing research that does not involve leading an independent clinical trial, a clinical trial feasibility study, or an ancillary study to a clinical trial that is itself comprised of a clinical trial intervention.
In vivo studies of glucagon secretion by human islets transplanted in mice
To measure glucagon secretion by transplanted human islets, Tellez et al. generated an immunocompromised mouse (NSG) that lacks mature glucagon (GKO), while producing other proglucagon-derived peptides. This GKO-NSG mouse line allowed unprecedented in vivo studies of glucagon regulation in human islets from previously-healthy or diabetic donors.
Nature Metabolism. June 8, 2020
Image courtesy of S. Kim
Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
Extended lifespan of human pancreatic slices (HPS) enables dynamic lineage tracing and quantification of new -cell formation in samples from both non-diabetic and T2D donors.
Nature Communications. June 29, 2020
Image courtesy of J. Dominguez-Bendala
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes
This HIRN-funded work identifies pathways associated with normal islet cell function, apparent compensatory responses in metabolic stress, and beta- and alpha-cell dysfunction in both T1D and T2D.
The mission of the Human Islet Research Network (HIRN) is to
better understand how human beta cells are lost in
Type 1 Diabetes and to find innovative strategies to protect or
replace functional beta cell mass in diabetic patients.