Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention
Cell Metabolism. February 4, 2020
Nakayasu et al. used a proteomics-based approach in human islets to study the T1D-related process of β-cell
destruction, identifying a protein, GDF15, that promotes the protection of β cells and prevents diabetes onset in mice.
Image provided by T. Metz & R. Mirmira
New Investigator Pilot Program in Bioinformatics
This pilot program, through the NIDDK Information Network (dkNET), is designed to encourage new investigators to apply innovative bioinformatics approaches to important research problems in Diabetes, Endocrinology and Metabolic Diseases (DEMD). The dkNET New Investigator Pilot Program is designed to: (i) facilitate the ability of Early Stage and New Investigators with computational and bioinformatics expertise to pursue research questions in DEMD, or (ii) allow Early Stage and New PIs currently pursuing DEMD-related research to explore incorporating computational, statistical, and/or bioinformatics approaches into their research projects.
In vivo-mimicking microfluidic perfusion culture of pancreatic islet spheroids
Microenvironmental control of interstitial flow around pancreatic islets effectively maintains islet morphology and function in vitro.
Scientific Advances. November 5, 2019
Image courtesy of Yesl Jun & Maike Sander
The mission of the Human Islet Research Network (HIRN) is to
better understand how human beta cells are lost in
Type 1 Diabetes and to find innovative strategies to protect or
replace functional beta cell mass in diabetic patients.