-
Tacrolimus- and sirolimus-induced human β cell dysfunction
is reversible and preventableJCI Insight. January 16, 2020 This work demonstrates that tacrolimus and sirolimus, commonly used immunosuppressive drugs, cause human β cell dysfunction by altering the transcriptional profile and insulin secretory granule processes.
Image provided by C. Dai & A. Powers
-
Comprehensive Proteomics Analysis of Stressed
Human Islets Identifies GDF15 as a Target for
Type 1 Diabetes InterventionCell Metabolism. February 4, 2020 Nakayasu et al. used a proteomics-based approach in human islets to study the T1D-related
process of β-cell destruction, identifying a protein, GDF15, that promotes the protection of β cells
and prevents diabetes onset in mice.
Image provided by T. Metz & R. Mirmira
-
New HIRN RFA Opportunities The NIH NIDDK has recently announced HIRN-related funding opportunities
RFA-DK-19-026: New Investigator Gateway Awards for Collaborative T1D Research
-
Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes This HIRN-funded work identifies pathways associated with normal islet cell function, apparent compensatory responses in metabolic stress, and beta- and alpha-cell dysfunction in both T1D and T2D.
Cell Metabolism. April 13, 2020
Image courtesy of P. McDonald
-
