Bio

Marcela Brissova is an Research Professor of Medicine and Director of the Islet Procurement & Analysis Core at Vanderbilt University. She is also the Director of the Human Islet Phenotyping Program (HIPP) of IIDP. Her research focuses on the biology of pancreatic islets and pancreas and islet development, especially the development of pancreatic islet vasculature and innervation and their role in regulation of pancreatic islet function.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_brissova?hilite=Marcela+Brissova

Projects

• Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution
• In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas
• High-Resolution Analysis of Juvenile Human Pancreas Maturation
• HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes
• Integrated Program for Human Pancreas Procurement and Analysis
• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt)
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/Contributor/Index/marcela_brissova@hirnetwork.org

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas

Projects

• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Bio

Shuibing Chen is a Professor in the Department of Surgery and Department of Biochemistry at Weill Cornell Medical College. Her research interest is to manipulate stem cell fate using chemical and biological approaches and to generate functional tissues and organs that can be used for translational research.

Projects

• Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression
• Decoding the Cell-specific Impact of Epigenomic and Alternative Splicing Regulation during T1D Progression
• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Shuibing+Chen

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas

Bio

Kyle Gaulton is an Associate Professor in the Department of Pediatrics at the University of California, San Diego. His research focuses on human genetics and single cell genomics to define cell type-specific gene regulatory programs that affect risk of complex disease, in particular type 1 diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_gaulton?hilite=Kyle+Gaulton

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas
• Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Kyle+Gaulton

HIRN Webinar:

Bio

Anna Gloyn is a Professor of Pediatrics, Endocrinology and Genetics at Stanford University. Her research uses human genetics as a tool to understand cellular and molecular mechanisms for pancreatic beta cell failure in diabetes and related conditions. he aim of her research is to capitalize on an improved mechanistic understanding of pancreatic islet cell dysfunction to improve treatment options for patients via the identification of safe and effective therapeutic targets (drug development) and patient stratification (precision medicine).

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas
• HPAP T2D: Human Pancreas Analysis Program
• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt)

Bio

PanKbase Program Manager

Projects

• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Projects

• Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution

Bio

Stephen Parker is an Associate Professor of Computational Medicine and Bioinformatics at the University of Michigan. The major goal of his lab is to generate mechanistic knowledge about how disease susceptibility is encoded in the non-coding portion of the genome, with a focus on type 2 diabetes.

Projects

• Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution
• Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression
• Decoding the Cell-specific Impact of Epigenomic and Alternative Splicing Regulation during T1D Progression
• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=stephen+parker

Projects

• PanKbase: A Community Hub for Integrated Pancreas Knowledge

Bio

Ben Voight is Associate Professor of Pharmacology and Director of the Bioinformatics Concentration at the University of Pennsylvania. His lab develops and utilizes statistical genetics, computational biology, and population genetics-based approaches to understand the biological underpinnings and evolutionary history of human traits and complex disease

Projects

• An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas

Bio

Xujing Wang is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her interests are in data science, computation modeling, integrative genomics, network biology, and genotype-phenotype relationships.