Joana Almaça is a HIRN New Investigator and an Assistant Professor of Medicine at the University of Miami Miller School of Medicine. Her current research focuses on the vasculature of the islet. In her work, Dr. Almaça is testing the hypothesis that microvascular dysfunction in the islet leads to a disturbance of hormone secretion, to glucose intolerance, and eventually to diabetes.
Radhika Armandla is a Senior Research Specialist in the Powers & Brissova Research Group at Vanderbilt University. She is involved in projects dealing with human islet transplantation, in vitro analysis and imaging in order to study human islet survival, function, regeneration and proliferation.
Guillermo Arreaza-Rubin is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests are in diabetes and endocrine disease bioengineering and glucose sensing.
Rafael Arrojo e Drigo is a Gateway Award Recipient and co-Investigator on a HPAC Grant. He is an Assistant Professor in the Department of Molecular Physiology and Biophysics at Vanderbilt School of Medicine. His research focuses on understanding the mechanisms regulating post-mitotic cell homeostasis and longevity.
Mark Atkinson is currently the American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at the University of Florida. He also is the Director of the Diabetes Institute at the University of Florida. Additionally, he is the Executive Director of the JDRF Network for Pancreatic Organ donors with Diabetes (nPOD) program and the President of Insulin for Life USA, the world’s second largest charity dedicated to providing insulin to persons living with diabetes in the developing world. His research focuses on type 1 diabetes, pancreatic pathology, immune therapy, autoimmunity, clinical trials, translational research, emerging technologies, psychosocial behaviors, and metabolism.
Michael Betts is a Professor of Microbiology at the University of Pennsylvania. He studies human T lymphocyte function in order to understand the role of these cells in controlling or eliminating viral pathogens and providing protection from infection. His primary research interest is in determining how and if the human CD8+ T cell response to HIV controls viral replication.
Anil Bhushan is a Professor at the University of California, San Francisco. His research goal is to understand the role of tissue secretory senescent cells in aging, autoimmunity and metabolic diseases. One of his recent discoveries shows that pancreatic beta cells acquire a secretome during T1D in mice and human and exhibit many non-cell autonomous properties.
Olivier Blondel is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests lie in research that focuses on endocrine signaling, stem cell biology, organ development, regenerative medicine and biomarker discovery as it relates to diabetes (type 1 and type 2) and metabolic diseases, particularly in combination with experimental approaches such as large-scale genomics, synthetic biology, bioengineering, epigenetics, nuclear organization of mammalian genomes, chromatin biology, genome editing, gene therapy
Rita Bottino is the Director Islet Programs at Imagine Pharma. She has developed an islet isolation and tissue processing practice that supplies some of the leading academic diabetes centers in the United States.
Linford Briant was a Postdoctoral Research Fellow at the University of Oxford and is currently a Junior Research Fellow at Trinity College. His research
investigates the activity of delta-cells with optogenetics, electrophysiology and Ca2+ imaging, and revealed they are electrically coupled to beta-cells via gap junctions.
Marcela Brissova is an Research Professor of Medicine and Director of the Islet Procurement & Analysis Core at Vanderbilt University. She is also the Director of the Human Islet Phenotyping Program (HIPP) of IIDP. Her research focuses on the biology of pancreatic islets and pancreas and islet development, especially the development of pancreatic islet vasculature and innervation and their role in regulation of pancreatic islet function.
Alejandro Caicedo is a Professor of Medicine at the University of Miami Miller School of Medicine. iginally trained as a sensory neurobiologist, Dr. Caicedo started working in the field of pancreatic islet biology in 2005. His work focuses on fundamental aspects of the anatomy and physiology of the human islet. His primary goal is to provide detailed knowledge of islet biology that is relevant to understand the control of glucose homeostasis and its derangement in diabetes.
Josh Chiou was a graduate student in the lab of Kyle Gaulton at the University of California, San Diego. His primary responsibilities include performing integrative analyses of epigenome, transcriptome and diabetes genetic association data. He is currently a Computational Geneticist with Pfizer.
Chunhua Dai is a Research Associate Professor in the Powers & Brissova Research Group at Vanderbilt University. Her research focuses on the molecular, cellular, and vascular changes in human islets when they are challenged with hyperglycemia and/or insulin resistance in vivo. She is investigating in vivo age-dependent human beta cell proliferation and how current therapeutic agents for type 2 diabetes preserve and/or enhance human beta cell function or survival in vivo.
Nicolai Doliba is a Research Associate Professor of Biochemistry and Biophysics at the University of Pennsylvania. His research focuses on the role of bioenergetics, ion transport and metabolic coupling factors in nutrient- and drug-stimulated insulin release at normal conditions and during diabetes mellitus.
Juan Dominguez-Bendala is a Research Professor of Surgery at the Diabetes Research Institute, University of Miami Miller School of Medicine. He is also the Director of Stem Cell & Pancreatic Regeneration and Research Professor of Surgery at the Diabetes Research Institute (DRI). His research focuses on the use of stem cells to obtain pancreatic islets that could potentially be transplanted into patients with type 1 diabetes. He is also currently working on new methods for expansion/regeneration of pancreatic beta cells.
Robert Babak Faryabi is an Assistant Professor of Pathology and Laboratory Medicine at the University of Pennsylvania Perelman School of Medicine. His research goal is to understand the epigenetic mechanisms of transcriptional addiction in cancer and exploit this information to advance cancer therapeutics.
Michael Feldman is a Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania. He is also the Vice Chair for Clinical Services, Department of Pathology and Laboratory Medicine and Director of the Office of Pathology Informatics.
Kyle Gaulton is an Associate Professor in the Department of Pediatrics at the University of California, San Diego. His research focuses on human genetics and single cell genomics to define cell type-specific gene regulatory programs that affect risk of complex disease, in particular type 1 diabetes.
Anna Gloyn is a Professor of Pediatrics, Endocrinology and Genetics at Stanford University. Her research uses human genetics as a tool to understand cellular and molecular mechanisms for pancreatic beta cell failure in diabetes and related conditions. he aim of her research is to capitalize on an improved mechanistic understanding of pancreatic islet cell dysfunction to improve treatment options for patients via the identification of safe and effective therapeutic targets (drug development) and patient stratification (precision medicine).
David Gorkin was previously the Associate Director of Epigenomics at the University of California San Diego Center for Epigenomics, Cellular and Molecular Medicine. He is currently an Assistant Professor at Emory University.
Martin Hetzer is Senior Vice President and Chief Scientific Officer at the Salk Institute in La Jolla, CA. His research focuses on genomics, proteomics and advanced imaging techniques to pose questions about how adult tissues are maintained and repaired and why long-lived cells fail to work properly as a cell ages
Jing Hughes is a Gateway Award Recipient and an Assistant Professor of Medicine in the Division of Endocrinology, Metabolism, and Lipid Research at the Washington University School of Medicine in St Louis. Her research focuses on the islet cell-cell interactions and the regulation of islet hormone secretion.
Klaus Kaestner Professor in Genetics at the Perelman School of Medicine at the University of Pennsylvania and the Director of the Functional Genomics Core at the University of Pennsylvania. His research interest is in employing modern genetic, genomic and epigenomic approaches (ChIP-Seq, RNA-Seq, gene targeting, tissue-specific and inducible gene ablation, CyTOF) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. Disease areas targeted by our research include diabetes and cancer.
Seung Kim is a Professor of Developmental Biology and Medicine (Oncology) at Stanford University School of Medicine. His research focuses on the developmental biology of the pancreas, a vital organ with endocrine and exocrine functions in the vertebrate digestive tract. One goal of our work is to translate our studies into novel diagnostic and therapeutic strategies for common pancreatic disease states in humans, particularly diabetes mellitus and pancreatic cancer.
Vira Kravets is a HIRN Emerging Leader Award Recipient and a Postdoctoral Research Fellow in the Department of Bioengineering at the University of Colorado Anschutz Medical Campus. She is currently leading interdisciplinary projects in search for the underlying causes for Diabetes. Juvenile Diabetes Research Foundation supported Fellow, skilled in Islet Biology, Surface Plasmon Resonance, Microscopy, Optics and Public Speaking
Irina Kusmartseva is the Director of the JDRF nPOD Organ Processing and Pathology Core. She has unique experience with the molecular and primary cell culture. Her key area of expertise includes mechanisms of immunoregulation in inflammation, cancer and autoimmune diseases.
Heiko Lickert is a Professor and Chair of Beta Cell Biology in the Medical Faculty of the Technical University Munich, the Director of the Institute of Diabetes and Regeneration Research and Principal Investigator in the Institute of Stem Cell Research at the Helmholtz Center Munich.
Emma Lundberg is a Professor in Cell Biology Proteomics at KTH Royal Institute of Technology, Sweden, and Director of the Cell Atlas, of the Human Protein Atlas program. She recently joined the Stanford University Bioengineering Department as an Associate Professor of Bioengineering. Her research is focused on spatial proteomics and cell biology.
Patrick MacDonald is Professor of Pharmacology at the University of Alberta and the Director of the Alberta Diabetes Institute (ADI) IsletCore. His research focuses on pancreatic islet function in health and diabetes. The research from his laboratory has spanned areas that include biophysical characterization of ion channels, intracellular signal transduction and exocytosis, and the cellular regulation of glucagon secretion.
Jason Moore was a Professor of Informatics and Director of the University of Pennsylvania Institute for Biomedical Informatics. He is currently the Chair of the Department of Computational Biomedicine at Cedars-Sinai Medical Center in Los Angeles, CA. His research is focused on the development of artificial intelligence and machine learning algorithms for the analysis of complex biomedical data.
Ali Naji is Professor of Surgical Research at the University of Pennsylvania School of Medicine and the Associate Director of the Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine. His research efforts have focused on the immunobiology of transplantation and immune pathogenesis of autoimmune diabetes
Ricardo Pastori is Research Professor of Medicine, Immunology, and Microbiology and the Director of the Molecular Biology Laboratory at the Diabetes Research Institute, University of Miami Miller School of Medicine. His laboratory has developed novel molecular tools and applied them to study β-cell biology and to improve the outcome of islet transplantation such as the development and utilization of protein transduction (PT) technology, a method that utilizes small protein transduction domains (PTDs), to deliver proteins into cells.
Al Powers is a Professor of Medicine, Molecular Physiology and Biophysics at Vanderbilt University. He is also the Director of the Vanderbilt Diabetes Center, Director of the Vanderbilt Diabetes Research and Training Center, and Chief of the Vanderbilt Division of Diabetes, Endocrinology, and Metabolism. His research focuses on pancreatic islet biology, vascularization, development, regeneration, and imaging.
Sebastian Preissl was previously the Associate Director of Single Cell Genomics at the University of California San Diego Center for Epigenomics, Cellular and Molecular Medicine. He is currently a Principal Investigator at Deutsche Forschungsgemeinschaft (DFG) in Freiburg, Germany.
Stephen Quake is a Professor of Bioengineering and Professor of Applied Physics at Stanford University and is co-President of the Chan Zuckerberg Biohub. Quake has invented many measurement tools for biology, including new DNA sequencing technologies that have enabled rapid analysis of the human genome and microfluidic automation that allows scientists to efficiently isolate individual cells and decipher their genetic code. Quake is also well known for inventing new diagnostic tools, including the first non-invasive prenatal test for Down syndrome and other aneuploidies.
Dr. Chris Rhdoes is the Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, and Chair of AstraZeneca’s postdoc programme. He is a renowned leader in the field of diabetes, obesity and metabolism research, with a career spanning over three decades. He has more than 180 published manuscripts, and has held industry and academic leadership roles at top institutions that include Harvard Medical School and the University of Washington. Chris is also Professor Emeritus at the University of Chicago, Department of Medicine
Camillo Ricordi is Professor of Medicine, Professor of Biomedical Engineering, and Microbiology and Immunology at the University of Miami (UM) in Florida. He serves as Director of the Diabetes Research Institute (DRI) and the Cell Transplant Program. Dr. Ricordi been serving as Responsible Head of the NIH-funded cGMP (current Good Manufacturing Practices) Human Cell Processing Facility (1993-present), for the manufacturing of advanced human cell and other biologic products.
James Riley is a Professor of Microbiology at University of Pennsylvania Perelman School of Medicine. His lab studies the signaling pathways that control primary human T cell activation and function with special attention to how these manipulations can be exploited to develop T cell therapies for HIV, autoimmune disease and cancer. The lab is also focused on designing HIV resistant, HIV specific T cells to be key players in the HIV Cure effort.
Dr. Bart O. Roep is Professor of Diabetology, Immunopathology & Intervention and Director of the National Diabetes Center of Excellence at the Leiden University Medical Center in The Netherlands and Visiting Professor of the Danish Diabetes Academy. He is also Founding Chair and Professor of Medicine of the Department of Diabetes Immunology, and holds the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes at the Diabetes & Metabolism Research Institute at the Beckman Research Institute of the City of Hope in Los Angeles.
Guy Rutter is a Professor of Cell Biology and Functional Genomics at Imperial College of London. His research focuses on signal transduction in the pancreatic β-cell in health and disease - my chief focus is in using functional genomics at the cellular and whole organism level to dissect the role of genes associated with Type 2 diabetes.
Juan Alvarez is a Gateway Award Recipient and an Assistant Research Professor in the Division of Endocrinology, Diabetes and Metabolism at the University of Miami Miller School of Medicine. Currently he is investigating the pathways by which thyroid hormones regulates skeletal muscle physiology and the role of type-2 deiodinase in muscle biology and its importance to plasma T3 pool.
Nilanjana Samanta is the Data Curator for the Human Pancreas Analysis Program (HPAP) Pancreas Database (PancDB). She uses her data analysis skills for meaningful interpretation of factors associated with health outcomes, monitor healthcare access, and health disparity.
Maike Sander is a Professor in the Departments of Pediatrics and Cellular & Molecular Medicine at the University of California, San Diego (UCSD) and Co-Director of the Center on Diabetes in the Institute of Engineering in Medicine at UCSD. Her primary research interest is to understand the molecular mechanisms that underlie the formation and function of the diverse cell types of the pancreas, in particular the insulin-producing beta cells. A recent major focus has been to establish a human pluripotent stem cell-based pancreatic beta cell differentiation platform to model mechanisms that underlie the pathogenesis of diabetes.
Stephan Speier is a Professor of Physiology and the Director of the Institute of Phyiology at Technische Universität Dresden in Dresden, Germany. His lab studies islet cell physiology within an intact tissue environment or the systemic setting. He investigates the role of beta cell mass and function at distinct stages of diabetes pathogenesis and aims to discover novel therapeutic targets for beta cell protection and recovery in type 1 and type 2 diabetes
Doris Stoffers is a HPAC Investigator and a member of the Trans-Network Committee (TNC). She is a the Director of the Pancreatic Islet Cell Biology Core, Director of the Pilot Feasibility Program and a Professor of Medicine at the University of Pennsylvania. Her research focuses on the embryonic development and adult regeneration of the endocrine pancreas, and the relationship of defects in these pathways to the pathophysiology of diabetes mellitus, a disease caused by a deficiency in the production or action of insulin.
Dr. Golnaz Vahedi is currently an Associate Professor of Genetics (with tenure) at the Perelman School of Medicine, University of Pennsylvania. Golnaz. She studied Electrical Engineering at Sharif University of Technology in Iran. As an independent investigator, she uses systems-based approaches to understand molecular details of gene regulation in the immune system. She is the recipient of a number of awards including the NIH Director’s Award (twice), NIAID K22 Career Transition Award (perfect score), Alfred P. Sloan Fellowship, Chan Zuckerberg Initiative Award, W. W. Smith Charitable Trust, Burroughs Wellcome Fund, and Michael S. Brown New Investigator Research Award. She serves on the advisory boards of Cell Press journal Immunity and Science Immunology and is a standing member of GCAT study section.
Ben Voight is Associate Professor of Pharmacology and Director of the Bioinformatics Concentration at the University of Pennsylvania. His lab develops and utilizes statistical genetics, computational biology, and population genetics-based approaches to understand the biological underpinnings and evolutionary history of human traits and complex disease