New Investigators (HIRN-New Investigators)

View  Recent Accomplishments by our HIRN New Investigators!  

HIRN. New Investigator Update. 2023 December (937 downloads )
HIRN. New Investigator Update. 2023 January.pdf (1276 downloads )
HIRN. New Investigator Update. 2022 July (1393 downloads )
HIRN. New Investigator Update. 2022 January (1433 downloads )
HIRN. New Investigator Update. 2021 August (1509 downloads )

Summary of New Investigators funded to participate in the Human Islet Research Network (HIRN):

  • Gateway Investigators are NIH NIDDK funded awards issued to young investigators to embark on successful careers in T1D research. Awardees are established in each of the HIRN consortia to increase their understanding of key questions in the field, to network, and to establish unique and potentially long-lasting collaborations that will propel their careers forward. It is anticipated that the Gateway award will provide the support needed to enhance the success of future R01 submissions from New Investigators interested in pursuing careers in T1D research.

    Recipients:

  

Romina Bevacqua, PhD, Mount Sinai School of Medicine
Research Abstract: “Identification of Novel Regulatory Mechanisms Driving Human Beta-Cell Maturation and Function” 
HIRN Consortium: CHIB
Date Awarded: November 15, 2023

 

Han Zhu, PhD, University of Colorado Anschutz Medical Campus
Research Abstract: Gene regulatory programs driving metabolic maturation of human pluripotent stem cell derived β-cells”
HIRN Consortium: CHIB
Date Awarded: November 15, 2023

 

Amish Asthana, PhD, Wake Forest University Health Sciences
Research Abstract: “A microwell perfusion plate for manufacturing & testing islet-like clusters”
HIRN Consortium: CHIB
Date Awarded: May 1, 2023

 

Jason Bini, PhD, Yale University 
Research Abstract: “Positron emission tomography to characterize beta cell mass in individuals from multiple stages in the progression of T1D”
HIRN Consortium: HPAC
Date Awarded: May 1, 2023

 

Richard Aaron Cox, PhD, University of Texas Health Science Center at Houston
Research Abstract: “GABP is a novel regulator of beta cell metabolism & proliferation”
HIRN Consortium: CTAR
Date Awarded: May 1, 2023

 

Jing Liu, PhD, Indiana University-Purdue University
Research Abstract: “Image based spatial transcriptomics to identify b cell phenotypes in T1D”
HIRN Consortium: CBDS
Date Awarded: May 1, 2023

 

Matthew Wortham, PhD, University of Colorado Anschutz Medical Campus
Research Abstract: “Metabolic requirements of pancreatic beta cell proliferation”
HIRN Consortium: CTAR
Date Awarded: May 1, 2023

 

Hirotake Komatsu, PhD, City of Hope
Research Abstract: “Vascular Network-mimetic Oxygen-transporting Mesh for Islet Graft“
View Investigator Profile
HIRN Consortium: CHIB
Date Awarded: July 1, 2021

 

Baoyu Liu, PhD, University of Utah
Research Abstract: “On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells“
View Investigator Profile
HIRN Consortium: CMAI
Date Awarded: July 1, 2021

 

Joao Pedro Saar Werneck de Castro, PhD, University of Miami
Research Abstract: “In vivo Effects of Physical Exercise on Human Islet Structure and Function“
View Investigator Profile
HIRN Consortium: HPAC
Date Awarded: July 1, 2021
Date Completed: June 30, 2023

 

Rafael Arrojo e Drigo, PhD, Vanderbilt University
Research Abstract: “Mapping the Association of Beta Cell Longevity and Senescence in T1D”
View Investigator Profile
HIRN Consortium: CBDS
Date Awarded: September 16, 2020
Date Completed: June 30, 2023
 

Jing Hughes, PhD, Washington University School of Medicine in St Louis
Research Abstract: “Primary Cilia in Human T1D Pancreas”
View Investigator Profile
HIRN Consortium: HPAC
Date Awarded: September 16, 2020
Date Completed: June 30, 2023
 

Alok Joglekar, PhD, University of Pittsburgh
Research Abstract: “Identification of the Cognate Epitopes of Autoreactive T Cells in T1D“
View Investigator Profile
HIRN Consortium: CMAI
Date Awarded: September 16, 2020
Date Completed: June 30, 2023
 

Amelia Linnemann, PhD, Indiana University
Research Abstract: “Functional and Molecular Characterization of the Human Islet Interferon Alpha Response”
View Investigator Profile
HIRN Consortium: CBDS
Date Awarded: September 16, 2020
Date Completed: June 30, 2023

 

  • Emerging Leaders are internally HIRN-funded awards to experienced senior postdoctoral fellows who intends to continue research careers in scientific areas supported by the Human Islet Research Network. This funding opportunity was designed to provide support & protected time for senior postdocs seeking to pursue studies that will enhance their transition toward independent research careers. The research proposed must be relevant to the goals of HIRN consortia.

    Recipients:

  

Juan Alvarez, PhD, University of Pennsylvania
Research Abstract: “Measuring islet-wide Function with Soft Integrated Nanoelectronics”
View Investigator Profile
HIRN Consortium: CHIB
Date Awarded: March 2021
 

Leonardo Ferreira, PhD, Medical University of South Carolina
Research Abstract: “Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells”
View Investigator Profile
HIRN Consortium: CMAI
Date Awarded: March 2021
 

Vira Kravets, PhD, University of California, San Diego
Research Abstract: “Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets”
View Investigator Profile
HIRN Consortium: HPAC
Date Awarded: March 2021
 

Karla Leavens, MD, PhD, Children’s Hospital of Philadelphia
Research Abstract: “Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes”
View Investigator Profile
HIRN Consortium: CBDS
Date Awarded: March 2021
 

Robert Sharp, PhD, University of Florida
Research Abstract: “The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival”
View Investigator Profile
HIRN Consortium: CHIB
Date Awarded: March 2021
Date Completed: June 30, 2022
  • New Investigators are internally HIRN-funded awards to apply bold and highly innovative new research approaches to biological problems under current investigation in HIRN. The HIRN New Investigator Pilot Award was designed to provide support for early career investigators who may need funding to explore feasibility of a new concept in support of an eventual R01 application. The research proposed must be relevant to the goals of HIRN consortia.  

    Recipients:

  

Joana Almaca, PhD, University of Miami 
Research Abstract: “Changes in Human Islet Microvasculature during Type 1 Diabetes
View Investigator Profile
HIRN Consortium: HPAC
Date Awarded: June 1, 2018
Date Completed: June 30, 2023
 

Sangeeta Dhawan, PhD, Beckman Research Institute of the City of Hope
Research Abstract: “Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function“
View Investigator Profile
HIRN Consortium: CTAR
Date Awarded: June 1, 2018
Date Completed: June 30, 2023
 

Abdelfattah El Ouaamari, PhD, New York Medical College
Research Abstract: “Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells”
View Investigator Profile
HIRN Consortium: CTAR
Date Awarded: June 1, 2018
Date Completed: June 30, 2023
 

Eddie James, PhD, Benaroya Research Institute
Research Abstract: “HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes”
View Investigator Profile
HIRN Consortium: CMAI
Date Awarded: June 1, 2018
Date Completed: June 30, 2023
 

Amelia Linnemann, PhD, Indiana University
Research Abstract: “Real-time in vivo Analysis of Islet Redox Dynamics”
View Investigator Profile
HIRN Consortium: CBDS
Date Awarded: June 1, 2018
Date Completed: June 30, 2023
  Holger Russ, PhD, University of Florida
Research Abstract: “Elucidating the Human Beta Cell Translatome in Health and Disease”
View Investigator Profile
HIRN Consortium: CBDS
Date Awarded: June 1, 2018
Date Completed: June 30, 2023

 

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