New Investigators (HIRN-NI)

Summary of New Investigators independently funded to participate in the Human Islet Research Network (HIRN):

  • Emerging Leaders are internally HIRN-funded awards to experienced senior postdoctoral fellows who intends to continue research careers in scientific areas supported by the Human Islet Research Network. This funding opportunity was designed to provide support & protected time for senior postdocs seeking to pursue studies that will enhance their transition toward independent research careers. The research proposed must be relevant to the goals of HIRN consortia.

    Recipients:

 

 

Juan Alvarez, PhD, Harvard University
Research Abstract: “Measuring islet-wide Function with Soft Integrated Nanoelectronics”
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HIRN Consortium: CHIB

Date Awarded: March 2021

   

Leonardo Ramos-Ferreira, PhD, University of California, San Francisco
Research Abstract: “Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells”
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HIRN Consortium: CMAI
Date Awarded: March 2021

   

Vira Kravets, PhD, University of Colorado Denver
Research Abstract: “Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets”
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HIRN Consortium: HPAC

Date Awarded: March 2021

   

Karla Leavens, MD, PhD, Children’s Hospital of Philadelphia
Research Abstract: “Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes”
HIRN Consortium: CBDS

Date Awarded: March 2021

   

Robert Sharp, PhD, University of Florida
Research Abstract: ““The SIRP:CD47 Signaling Pathway in Pancreatic b-Cell Survival”
HIRN Consortium: CHIB

Date Awarded: March 2021

 

  • Gateway Investigators are NIH NIDDK funded awards issued to young investigators to embark on successful careers in T1D research. Awardees are established in each of the HIRN consortia to increase their understanding of key questions in the field, to network, and to establish unique and potentially long-lasting collaborations that will propel their careers forward. It is anticipated that the Gateway award will provide the support needed to enhance the success of future R01 submissions from New Investigators interested in pursuing careers in T1D research.

    Recipients:

 

 

Rafael Arrojo e Drigo, PhD, Vanderbilt University
Research Abstract: “Mapping the Association of Beta Cell Longevity and Senescence in T1D
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HIRN Consortium: CBDS

Date Awarded: September 16, 2020

   

Jing Hughes, PhD, Washington University School of Medicine in St Louis
Research Abstract: “Primary Cilia in Human T1D Pancreas”
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HIRN Consortium: HPAC
Date Awarded: September 16, 2020

   

Alok Joglekar, PhD, University of Pittsburgh
Research Abstract: Identification of the Cognate Epitopes of Autoreactive T Cells in T1D
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HIRN Consortium: CMAI

Date Awarded: September 16, 2020

   

Amelia Linnemann, PhD, Indiana University
Research Abstract: “Functional and Molecular Characterization of the Human Islet Interferon Alpha Response”
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HIRN Consortium: CBDS

Date Awarded: September 16, 2020

 

  • New Investigators are internally HIRN-funded awards to apply bold and highly innovative new research approaches to biological problems under current investigation in HIRN. The HIRN New Investigator Pilot Award was designed to provide support for early career investigators who may need funding to explore feasibility of a new concept in support of an eventual R01 application. The research proposed must be relevant to the goals of HIRN consortia.

    Recipients:

 

 

Joana Almaca, PhD, University of Miami 
Research Abstract: “Changes in Human Islet Microvasculature during Type 1 Diabetes
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HIRN Consortium: HPAC
Date Awarded: June 1, 2018

   

Sangeeta Dhawan, PhD, Beckman Research Institute of the City of Hope
Research Abstract: “Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
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HIRN Consortium: CTAR

Date Awarded: June 1, 2018

   

Abdelfattah El Ouaamari, PhD, Rutgers University
Research Abstract: “Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells”
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HIRN Consortium: CTAR

Date Awarded: June 1, 2018

   

Eddie James, PhD, Benaroya Research Institute
Research Abstract: “HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes”
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HIRN Consortium: CMAI
Date Awarded: June 1, 2018

   

Amelia Linnemann, PhD, Indiana University
Research Abstract: “Real-time in vivo Analysis of Islet Redox Dynamics”
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HIRN Consortium: CBDS
Date Awarded: June 1, 2018

    Holger Russ, PhDUniversity of Colorado, Denver

Research Abstract: “Elucidating the Human Beta Cell Translatome in Health and Disease”
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HIRN Consortium: CBDS
Date Awarded: June 1, 2018

   

Prashanth Vallabhajosyula, MDYale University
Research Abstract: “Discovery & Investigation of Noninvasive Diagnostic Potential of Circulating Pancreatic Islet Beta Cell Exosomes as Biomarkers of Beta Cell Injury”
View Investigator Profile
HIRN Consortium: CBDS
Date Awarded: June 1, 2018

 

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