Diversity Outbred Pilot Grant Program – Understanding the Impacts of Genetic Diversity on Experimental Outcomes (Pilot Grant Program)

The Jackson Laboratory

The purpose of the Diversity Outbred Pilot Grant Program is to explore new uses for genetic diversity in biomedical research. This program aims to enable a greater understanding of the impact of genetic diversity on experimental outcomes and to assess its contribution to phenotypic variability across a range of research areas.

Research Studies are typically designed with the intention of reducing the number of experimental variables to better understand specific biological processes. While this can be helpful in early-stage research, reducing variability at later stages may negatively impact translatability. This is particularly relevant to mouse biomedical research as inbred mice are genetically homogeneous populations. Although inbred mice can enable researchers to isolate and interrogate defined experimental variables, they are unable to recapitulate the genetic diversity observed across human populations. Testing in a single inbred mouse strain is thus genetically akin to testing in a single person, and this can lead to numerous challenges when attempting to translate experimental findings to humans.

Application due date: December 3, 2021

 

High-Resolution Exploration of the Human Islet Tissue Environment [HIRN Human Pancreas Analysis Consortium (HPAC)] (U01 – Clinical Trial Not Allowed) (RFA-DK-21-017)

National Institute of Diabetes and Digestive and Kidney Diseases

This Funding Opportunity Announcement (FOA) invites cooperative agreement applications that will contribute to a higher resolution understanding of the organization of the human pancreatic tissue environment by describing the composition and function of important components of the pancreatic islet and peri-islet tissue architecture, the cell-cell relationships and means of communications used by cell types and cell subtypes within the pancreatic tissue ecosystem, and the contribution of adjacent tissues to islet cell function and dysfunction. Successful projects will integrate the Human Pancreas Analysis Consortium (HPAC) that is part of the Human Islet Research Network or HIRN. HIRN’s overall mission is to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional beta cell mass in humans. This FOA will only support studies with a primary focus on increasing our understanding of human tissue structure and function, and human disease biology, as opposed to exploring the biology specific to any animal models.

Application Due Date: March 3, 2022
Expiration Date: March 4, 2022

Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed) (PAR-20-140)

National Institute of Diabetes and Digestive and Kidney Diseases

This Funding Opportunity Announcement (FOA) is intended to support tool or technology development projects, opening new areas of science or translational research. The projects supported by this FOA could involve proof-of-concept studies, prototyping, optimization of a technology for the unique anatomy or physiology of these organ systems, and refinement of technical specifications for subsequent deployment of the technology in laboratory or clinical settings.

Application due date: Standard dates apply
Expiration date: May 8, 2023

Bioinformatics Interdisciplinary Predoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases (F31) (PAR-19-378)

National Institute of Diabetes and Digestive and Kidney Diseases

This funding opportunity is to enable promising predoctoral fellows to obtain interdisciplinary training during the dissertation phase of their training from outstanding faculty sponsors in bioinformatics and scientific research relevant to the mission of NIDDK’s Division of Diabetes, Endocrinology and Metabolic Diseases (DDEMD). This training will require mentorship in both bioinformatics and metabolic disease disciplines. In order to advance bioinformatics science and encourage its application to these diseases and disorders, NIDDK invites applications from individuals with novel individual development plans (IDP). The fellowship training plan should focus on interdisciplinary approaches and mentorship among data or computer science and medicine in topics related to diabetes, endocrinology and metabolic diseases.

Application due date: Standard dates apply 
Expiration date: September 8, 2022

Bioinformatics Interdisciplinary Postdoctoral Fellowship in Diabetes, Endocrinology and Metabolic Diseases (F32) (PAR-19-379)

National Institute of Diabetes and Digestive and Kidney Diseases

This Funding Opportunity Announcement (FOA) is to enable promising postdoctoral fellows to obtain interdisciplinary training from outstanding faculty sponsors in bioinformatics and scientific research relevant to the mission of NIDDK’s Division of Diabetes, Endocrinology and Metabolic Diseases (DDEMD). This training will require mentorship in both bioinformatics and metabolic disease disciplines. In order to advance bioinformatics science and encourage its application to these diseases and disorders, NIDDK invites applications from individuals with novel individual development plans (IDP). The fellowship training plan should focus on interdisciplinary approaches and mentorship among data or computer science and medicine in topics related to diabetes, endocrinology and metabolic diseases.

Application due date: Standard dates apply 
Expiration date: September 8, 2022

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