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Project Abstracts - HPAC

HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)

Contact PI: Al Powers, MD, Vanderbilt University (U01 DK123716)

Mark Atkinson, PhD, Investigator, University of Florida
Marcela Brissova, PhD, Investigator, Vanderbilt University
Patrick MacDonald, PhD, Investigator, University of Alberta
Seung Kim, MD, PhD, Investigator, Stanford University
Anna Golyn, PhD, Investigator, Stanford University
Rita Bottino, PhD, Investigator, Allegheny Health Network
Dirk Homann, MD, Investigator, Icahn School of Medicine at Mount Sinai
Chunhua Dai, MD, Investigator, Vanderbilt University

 

Summary of Project Abstract & Publications

Start Date: September 30, 2019

 

Abstract

To understand the molecular mechanisms responsible for islet dysfunction in type 2 diabetes mellitus (T2D), investigators in the Human Pancreas Analysis Program (HPAP-T2D) are working to interrogate T2D human pancreatic tissue and islets from clinically phenotyped donors using a range of experimental approaches including single cell analysis, multiplexing technology, cell function, and genetic analysis. Data from these studies will be deposited into the comprehensive, open-access, searchable HPAP database (PANC-DB) to serve the community of scientists interested in understanding human pancreatic and islet biology in T2D. Investigators are working to create, enhance, and leverage partnerships with complementary programs like HPAP-T1D, HIRN, IIDP, nPOD, AMP-T2D, and QUOD. Investigators in this grant are working collaboratively with investigators at the University of Pennsylvania (U01DK123594) to understand the molecular mechanisms responsible for islet dysfunction in type 2 diabetes.

Meet the Grant Team

Investigators 

 

Alvin Powers, MD

Vanderbilt University

 

Mark Atkinson, PhD

University of Florida

 

Marcela Brissova, PhD

Vanderbilt University

 

Patrick MacDonald, PhD

University of Alberta

Seung Kim, PhD

Stanford University

Anna Golyn, PhD

Stanford University

Ria Bottino, PhD

Allegheny Health Network

Dirk Homann, MD

Icahn School of Medicine at Mount Sinai

Chunhua Dai, PhD

Vanderbilt University