Consortium on Modeling Autoimmune Diabetes

Active Projects

  • A microwell perfusion plate for manufacturing and testing Islet-like clusters View
  • Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses View
  • Gene regulatory programs driving metabolic maturation of human pluripotent stem cell derived β-cells View
  • Identification of Novel Regulatory Mechanisms Driving Human Beta-Cell Maturation and Function View
  • Models to Study the Synergy between Autoimmunity and Metabolism in T1D View
  • Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies View
  • Studying the Mechanisms of Initiation and Progression of Beta Cell Death in T1D View
  • Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets View
  • Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models View

Closed Projects

  • Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
  • Measuring Islet-wide Function with Soft Integrated Nanoelectronics View

Enhancement Center

Active Projects

  • Human Islet Research Enhancement Center (HIREC) View

Human Pancreas Analysis Program

Active Projects

  • HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes View
  • HPAP T2D: Human Pancreas Analysis Program View

Closed Projects

  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt) View

Pancreas Knowledgebase Program

Active Projects

  • An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas View
  • Inferring and Perturbing Gene Regulatory Networks During Diabetes Progression View
  • PanKbase: A Community Hub for Integrated Pancreas Knowledge View

Consortium on Beta Cell Death & Survival

Active Projects

  • Assessment of thymic output in the context of genetics, environmental exposures, and progression to type 1 diabetes View
  • CERS2-Dependent Sphingolipid Control of Human Beta-Cell Function and Resilience View
  • Decoding the Cell-specific Impact of Epigenomic and Alternative Splicing Regulation during T1D Progression View
  • Defining Heterogeneity of Stress-induced Beta Cell Senescence Programs in Type 1 Diabetes View
  • Developing a Platform Technology for β-Cell-Targeted Drug Delivery View
  • Development of Platforms for Beta Cell-specific Delivery and Ligand Discovery View
  • Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D View
  • Driving Next Generation UPR Inhibitory Kinase Inhibitors for T1D View
  • GABP is a novel regulator of beta cell metabolism and proliferation View
  • Genetic dysregulation of mRNA translation in T1D View
  • Image based spatial transcriptomics to identify Beta Cell phenotypes in Type 1 Diabetes View
  • Interferon Signaling in the T1D Islet Microenvironment View
  • iSTAR Tregs View
  • Metabolic requirements of pancreatic beta cell proliferation View
  • Multi-omics Integrative Analyses of Human Islets in Type 1 Diabetes View
  • Role of Granular Acidification in the Pathogenesis of Type 1 Diabetes View
  • Role of Pancreatic Elastase in Beta Cell Health, Autoimmunity and Type 1 Diabetes View
  • Targeting Renalase for Early Stage Type 1 Diabetes Treatment View
  • Transduction Of Omega-3-Protective Signaling By Protein Adp-Ribosylation In Beta Cell View

Closed Projects

  • A Stress-Induced Vicious Cycle in the Development of T1D View
  • Alternative RNA splicing events contribute to the onset of islet dysfunction in T1D View
  • Biomarkers for Diabetes using Stem Cell-derived Beta Cells View
  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker) View
  • Defining Islet Heterogeneity Using Single Islet Transcriptomics View
  • Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression View
  • Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D View
  • Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes View
  • Elucidating the Human Beta Cell Translatome in Health and Disease View
  • Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D View
  • Functional and Molecular Characterization of the Human Islet Interferon Alpha Response View
  • Gene Therapy for Diabetes View
  • High-Resolution Analysis of Juvenile Human Pancreas Maturation View
  • Integrated Stress Response in Human Islets during Early T1D View
  • Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes View
  • Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
  • Lactate-mediated Metabolic Reprogramming of Beta Cells in T1D Contributes to their Enhanced Plasticity and Dedifferentiation View
  • Mapping the Association of Beta Cell Longevity and Senescence in T1D View
  • Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms View
  • Non-invasive Diagnosis of Human Beta Cell Damage and Death View
  • Real-time in vivo Analysis of Islet Redox Dynamics View
  • Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis View
  • Single Cell Resolution of Omics Analysis of T1D Islets View
  • Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging View

Consortium on Human Islet Biomimetics

Closed Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease View
  • A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes View
  • A Vascularized 3D Biomimetic for Islet Function and Physiology View
  • Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions View
  • Engineering a Human Physiomimetic Islet Microsystem View
  • Epigenomic Engineering of Stem Cell-Derived Pancreatic Cells View
  • Islet on a Chip View
  • Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes View
  • Modular Monitoring of Hormone Release from Human Islets View
  • The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival View
  • Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft View

Consortium on Modeling Autoimmune Interactions

Closed Projects

  • Analysis of Human Autoreactive T Cell Receptors in vivo View
  • Genetic Regulation of Human Beta Cell Destruction View
  • HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
  • Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function View
  • Humanized Mouse Avatars for T1D View
  • Identification of the Cognate Epitopes of Autoreactive T Cells in T1D View
  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells View
  • Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems View
  • On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells View
  • Therapeutic Targeting of the Human Islet Environment View
  • Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance View

Consortium on Targeting and Regeneration

Active Projects

  • Developing a Platform Technology for β-Cell-Targeted Drug Delivery View
  • Development of Platforms for Beta Cell-specific Delivery and Ligand Discovery View
  • GABP is a novel regulator of beta cell metabolism and proliferation View
  • iSTAR Tregs View
  • Metabolic requirements of pancreatic beta cell proliferation View

Closed Projects

  • Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity View
  • Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery View
  • CAR T Cell Targeting of Human Islets View
  • Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells View
  • Epigenetic Rejuvenation of Human Beta-Cells View
  • Gene Therapy for Diabetes View
  • Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling View
  • Identification of the Cognate Epitopes of Autoreactive T Cells in T1D View
  • In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors View
  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas View
  • Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells View
  • One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery View
  • Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes View
  • Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
  • Targeting TXNIP to Enhance Beta Cell Mass in T1D View
  • Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells View

Human Pancreas Analysis Consortium

Active Projects

  • Beta Cell Death in early Type 1 Diabetes caused by Innate Immune Response to Inefficient RNA Editing View
  • Discovery of Pathways and Molecular Mediators of Early T1D Pathogenesis using Spatial Multi-Omics View
  • HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes View
  • HPAP T2D: Human Pancreas Analysis Program View
  • Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution View
  • Investigating the Role of RNA Editing in T1D in Humans View
  • Linking Human Islet Structural Heterogeneity to Beta Cell State View
  • Positron emission tomography to characterize beta cell mass in individuals from multiple stages in the progression of type 1 diabetes View
  • Role of Senescent Beta Cells in Type 1 Diabetes and Type 2 Diabetes View
  • Survival and Potential of Insulin-deficient Beta Cells in Type 1 Diabetes View
  • Three-Dimensional Spatial and Translational profiling of Stress Response Pathways in T1D View
  • Tissue Context Matters: How exocrine cells regulate islet function in human pancreas View
  • Uncovering the spatial lipid-gene relationships underlying type 1 diabetes using multimodal imaging View
  • Using ex vivo, in vivo Models and Patient Mutations to Interrogate Pancreatic Exocrine-Endocrine Cross Talk View
  • Wright View

Closed Projects

  • Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
  • Changes in Human Islet Microvasculature during Type 1 Diabetes View
  • Cooperativity between Calcium and cAMP-inducing Agents in Human Alpha and Beta Cells View
  • High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential View
  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt) View
  • In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas View
  • In vivo Effects of Physical Exercise on Human Islet Structure and Function View
  • Integrated Program for Human Pancreas Procurement and Analysis View
  • Linking Islet Cell Function and Identity from in vitro to in situ View
  • Primary Cilia in Human T1D Pancreas View
  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes View
  • Ultra-sensitive Probes for High Resolution Imaging of Hormone Secretion in Islet Cells of Physiological Preparations View

Opportunity Pool Projects

Active Projects

  • Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets View

Closed Projects

  • A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells View
  • Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry View
  • Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
  • Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes? View
  • Changes in Human Islet Microvasculature during Type 1 Diabetes View
  • Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D View
  • Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
  • Elucidating the Human Beta Cell Translatome in Health and Disease View
  • Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata View
  • Functional Testing of Candidate HSC-derived Islet Cells View
  • Generation of Functional Endocrine Cell Reporter Pluripotent Cell Lines View
  • HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
  • Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
  • Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells View
  • Lactate-mediated Metabolic Reprogramming of Beta Cells in T1D Contributes to their Enhanced Plasticity and Dedifferentiation View
  • Mass Spectrometry-based Proteome Maps for Human Islet Cells View
  • Measuring Islet-wide Function with Soft Integrated Nanoelectronics View
  • Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells View
  • Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM View
  • Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems View
  • Real-time in vivo Analysis of Islet Redox Dynamics View
  • Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
  • The Proteome of Replicating Cells View
  • The Role of Beta Cell Senescence in the Pathogenesis of Diabetes View
  • The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival View
  • Workshop for Continued Harmonization of Beta Cell Death Assays View

New Investigators

Active Projects

  • A microwell perfusion plate for manufacturing and testing Islet-like clusters View
  • Assessment of thymic output in the context of genetics, environmental exposures, and progression to type 1 diabetes View
  • CERS2-Dependent Sphingolipid Control of Human Beta-Cell Function and Resilience View
  • GABP is a novel regulator of beta cell metabolism and proliferation View
  • Gene regulatory programs driving metabolic maturation of human pluripotent stem cell derived β-cells View
  • Genetic dysregulation of mRNA translation in T1D View
  • Identification of Novel Regulatory Mechanisms Driving Human Beta-Cell Maturation and Function View
  • Image based spatial transcriptomics to identify Beta Cell phenotypes in Type 1 Diabetes View
  • Investigating the Role of RNA Editing in T1D in Humans View
  • Metabolic requirements of pancreatic beta cell proliferation View
  • Positron emission tomography to characterize beta cell mass in individuals from multiple stages in the progression of type 1 diabetes View
  • Three-Dimensional Spatial and Translational profiling of Stress Response Pathways in T1D View
  • Tissue Context Matters: How exocrine cells regulate islet function in human pancreas View
  • Uncovering the spatial lipid-gene relationships underlying type 1 diabetes using multimodal imaging View
  • Wright View

Closed Projects

  • Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
  • Changes in Human Islet Microvasculature during Type 1 Diabetes View
  • Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
  • Elucidating the Human Beta Cell Translatome in Health and Disease View
  • Functional and Molecular Characterization of the Human Islet Interferon Alpha Response View
  • HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
  • Identification of the Cognate Epitopes of Autoreactive T Cells in T1D View
  • In vivo Effects of Physical Exercise on Human Islet Structure and Function View
  • Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
  • Mapping the Association of Beta Cell Longevity and Senescence in T1D View
  • Measuring Islet-wide Function with Soft Integrated Nanoelectronics View
  • Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells View
  • On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells View
  • Primary Cilia in Human T1D Pancreas View
  • Real-time in vivo Analysis of Islet Redox Dynamics View
  • Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
  • The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival View
  • Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft View
Follow
×

Follow

us on our social networks.

Email: hirnec@coh.org