Multi-omics Integrative Analyses of Human Islets in Type 1 Diabetes
Contact PI: Liu Wang, PhD, Mayo Clinic Arizona
Start Date: October 2025
HIRN Data Scholars Award Recipient
Summary
This project aims to identify type 1 diabetes-associated SNPs within cell type specific chromatin regions of human islet cells. By integrating GWAS with scATAC-seq, scRNA-seq, and single-cell multiomic data, and applying computational approaches such as transcription factor motif analysis and chromatin footprinting, we will uncover functionally relevant variants that alter transcriptional regulation. These findings will provide new insights into the cis-regulatory architecture of islet cells and reveal mechanisms by which noncoding variants contribute to T1D pathogenesis.
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