Inferring and Perturbing Gene Regulatory Networks During Diabetes Progression
Contact PI: Mattthew Ishahak, PhD, Washington University in St. Louis
Start Date: October 2025
HIRN Data Scholars Award Recipient
Summary
The goal of this project is to improve our understanding of how diabetes disrupts gene regulatory networks in pancreatic islets. By integrating single cell transcriptomic and chromatin accessibility data from healthy and diabetic patients, we will be able to define cell-state-specific gene regulatory networks for each pancreatic islet cell type and perform simulated genetic perturbation experiments to uncover transcription factors that drive diabetes progression. This work will result in new computational approaches utilizing patient data to elucidate the pathogenesis of islet dysfunction in diabetes.
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