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HIRN
> Projects
Projects
AdminHub - Administrative Hub
Bioinformatics Center (BC)
Coordinating Center (CC)
CBDS - Consortium on Beta Cell Death & Survival
Biomarkers for Diabetes using Stem Cell-derived Beta Cells
Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
Defining Islet Heterogeneity Using Single Islet Transcriptomics
Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D
High-Resolution Analysis of Juvenile Human Pancreas Maturation
Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes
Real-time in vivo Analysis of Islet Redox Dynamics
Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms
Non-invasive Diagnosis of Human Beta Cell Damage and Death
Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
Elucidating the Human Beta Cell Translatome in Health and Disease.
Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging
Single Cell Resolution of Omics Analysis of T1D Islets
Discovery and Investigation of Noninvasive Diagnostic Potential of Circulating Pancreatic Islet Beta Cell Exosomes as Biomarkers of b Cell Injury
CHIB - Consortium on Human Islet Biomimetics
A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
Engineering a Human Physiomimetic Islet Microsystem
Islet on a Chip
Modular Monitoring of Hormone Release from Human Islets
A Vascularized 3D Biomimetic for Islet Function and Physiology
CMAI - Consortium on Modeling Autoimmune Interactions
Analysis of Human Autoreactive T Cell Receptors in vivo
Genetic Regulation of Human Beta Cell Destruction
Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
Humanized Mouse Avatars for T1D
HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes
Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance
CTAR - Consortium on Targeting & Regeneration
Changes in Human Islet Microvasculature during Type 1 Diabetes
Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity
Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery
CAR T Cell Targeting of Human Islets
Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells.
Epigenetic Rejuvenation of Human Beta-Cells
Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling
In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
Targeting TXNIP to Enhance Beta Cell Mass in T1D
Therapeutic Targeting of the Human Islet Environment
HPAP - Human Pancreas Analysis Program
Penn Integrated Human Pancreas Analysis Program
Integrated Program for Human Pancreas Analysis
OPP - Opportunity Pool Projects
Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
Functional Testing of Candidate HSC-derived Islet Cells
A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
The Role of Beta Cell Senescence in the Pathogenesis of Diabetes
Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes?
The Proteome of Replicating Cells
Mass Spectrometry-based Proteome Maps for Human Islet Cells
Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D
Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry
Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM
Workshop for Continued Harmonization of Beta Cell Death Assays
Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems
Generation of Functional Endocrine Cell Reporter Pluripotent Cell Lines
Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata
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OPP