Consortium on Modeling Autoimmune Diabetes
Active Projects
- A microwell perfusion plate for manufacturing and testing Islet-like clusters View
- Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses View
- Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
- Gene regulatory programs driving metabolic maturation of human pluripotent stem cell derived β-cells View
- Identification of Novel Regulatory Mechanisms Driving Human Beta-Cell Maturation and Function View
- Measuring Islet-wide Function with Soft Integrated Nanoelectronics View
- Models to Study the Synergy between Autoimmunity and Metabolism in T1D View
- Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies View
- Studying the Mechanisms of Initiation and Progression of Beta Cell Death in T1D View
- Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets View
- Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models View
Enhancement Center
Active Projects
- Human Islet Research Enhancement Center (HIREC) View
Human Pancreas Analysis Program
Pancreas Knowledgebase Program
Consortium on Beta Cell Death & Survival
Active Projects
- A Stress-Induced Vicious Cycle in the Development of T1D View
- Alternative RNA splicing events contribute to the onset of islet dysfunction in T1D View
- BioStructure & Function Team Leader View
- Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression View
- Developing a Platform Technology for β-Cell-Targeted Drug Delivery View
- Development of platforms for beta cell-specific delivery and ligand discovery View
- Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D View
- GABP is a novel regulator of beta cell metabolism and proliferation View
- Image based spatial transcriptomics to identify Beta Cell phenotypes in Type 1 Diabetes View
- Integrated Stress Response in Human Islets during Early T1D View
- Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
- iSTAR Tregs View
- Metabolic requirements of pancreatic beta cell proliferation View
Closed Projects
- Biomarkers for Diabetes using Stem Cell-derived Beta Cells View
- Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker) View
- Defining Islet Heterogeneity Using Single Islet Transcriptomics View
- Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D View
- Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes View
- Elucidating the Human Beta Cell Translatome in Health and Disease View
- Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D View
- Functional and Molecular Characterization of the Human Islet Interferon Alpha Response View
- Gene Therapy for Diabetes View
- High-Resolution Analysis of Juvenile Human Pancreas Maturation View
- Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes View
- Lactate-mediated Metabolic Reprogramming of Beta Cells in T1D Contributes to their Enhanced Plasticity and Dedifferentiation View
- Mapping the Association of Beta Cell Longevity and Senescence in T1D View
- Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms View
- Non-invasive Diagnosis of Human Beta Cell Damage and Death View
- Real-time in vivo Analysis of Islet Redox Dynamics View
- Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis View
- Single Cell Resolution of Omics Analysis of T1D Islets View
- Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging View
Consortium on Human Islet Biomimetics
Closed Projects
- A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease View
- A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes View
- A Vascularized 3D Biomimetic for Islet Function and Physiology View
- Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions View
- Engineering a Human Physiomimetic Islet Microsystem View
- Epigenomic Engineering of Stem Cell-Derived Pancreatic Cells View
- Islet on a Chip View
- Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes View
- Modular Monitoring of Hormone Release from Human Islets View
- The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival View
- Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft View
Consortium on Modeling Autoimmune Interactions
Closed Projects
- Analysis of Human Autoreactive T Cell Receptors in vivo View
- Genetic Regulation of Human Beta Cell Destruction View
- HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
- Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function View
- Humanized Mouse Avatars for T1D View
- Identification of the Cognate Epitopes of Autoreactive T Cells in T1D View
- Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells View
- Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems View
- On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells View
- Therapeutic Targeting of the Human Islet Environment View
- Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance View
Consortium on Targeting and Regeneration
Active Projects
- Developing a Platform Technology for β-Cell-Targeted Drug Delivery View
- Development of platforms for beta cell-specific delivery and ligand discovery View
- GABP is a novel regulator of beta cell metabolism and proliferation View
- iSTAR Tregs View
- Metabolic requirements of pancreatic beta cell proliferation View
Closed Projects
- Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity View
- Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery View
- CAR T Cell Targeting of Human Islets View
- Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells View
- Epigenetic Rejuvenation of Human Beta-Cells View
- Gene Therapy for Diabetes View
- Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling View
- Identification of the Cognate Epitopes of Autoreactive T Cells in T1D View
- In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors View
- Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas View
- Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells View
- One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery View
- Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes View
- Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
- Targeting TXNIP to Enhance Beta Cell Mass in T1D View
- Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells View
Human Pancreas Analysis Consortium
Active Projects
- Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
- HPAP T1D: Human Pancreas Analysis Program for Type 1 Diabetes View
- HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania) View
- HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.) View
- Integrative Analysis of Multiomic Signatures and Cellular Function in Human Pancreas Across Developmental Timeline at Single-cell Spatial Resolution View
- Linking Human Islet Structural Heterogeneity to Beta Cell State View
- Positron emission tomography to characterize beta cell mass in individuals from multiple stages in the progression of type 1 diabetes View
- Survival and Potential of Insulin-deficient Beta Cells in Type 1 Diabetes View
- The Role of Senescent Beta Cells in Type 1 Diabetes and Type 2 Diabetes View
- Using ex vivo, in vivo Models and Patient Mutations to Interrogate Pancreatic Exocrine-Endocrine Cross Talk View
Closed Projects
- Changes in Human Islet Microvasculature during Type 1 Diabetes View
- Cooperativity between Calcium and cAMP-inducing Agents in Human Alpha and Beta Cells View
- High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential View
- In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas View
- In vivo Effects of Physical Exercise on Human Islet Structure and Function View
- Integrated Program for Human Pancreas Procurement and Analysis View
- Linking Islet Cell Function and Identity from in vitro to in situ View
- Primary Cilia in Human T1D Pancreas View
- Single Cell Analysis of the Human Pancreas in Type 1 Diabetes View
- Ultra-sensitive Probes for High Resolution Imaging of Hormone Secretion in Islet Cells of Physiological Preparations View
Opportunity Pool Projects
Active Projects
- Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
- Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
- Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
- Measuring Islet-wide Function with Soft Integrated Nanoelectronics View
- Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets View
Closed Projects
- A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells View
- Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry View
- Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes? View
- Changes in Human Islet Microvasculature during Type 1 Diabetes View
- Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D View
- Elucidating the Human Beta Cell Translatome in Health and Disease View
- Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata View
- Functional Testing of Candidate HSC-derived Islet Cells View
- Generation of Functional Endocrine Cell Reporter Pluripotent Cell Lines View
- HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
- Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells View
- Lactate-mediated Metabolic Reprogramming of Beta Cells in T1D Contributes to their Enhanced Plasticity and Dedifferentiation View
- Mass Spectrometry-based Proteome Maps for Human Islet Cells View
- Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells View
- Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM View
- Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems View
- Real-time in vivo Analysis of Islet Redox Dynamics View
- Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
- The Proteome of Replicating Cells View
- The Role of Beta Cell Senescence in the Pathogenesis of Diabetes View
- The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival View
- Workshop for Continued Harmonization of Beta Cell Death Assays View
New Investigators
Active Projects
- A microwell perfusion plate for manufacturing and testing Islet-like clusters View
- Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
- Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
- GABP is a novel regulator of beta cell metabolism and proliferation View
- Gene regulatory programs driving metabolic maturation of human pluripotent stem cell derived β-cells View
- Identification of Novel Regulatory Mechanisms Driving Human Beta-Cell Maturation and Function View
- Image based spatial transcriptomics to identify Beta Cell phenotypes in Type 1 Diabetes View
- Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
- Measuring Islet-wide Function with Soft Integrated Nanoelectronics View
- Metabolic requirements of pancreatic beta cell proliferation View
- Positron emission tomography to characterize beta cell mass in individuals from multiple stages in the progression of type 1 diabetes View
Closed Projects
- Changes in Human Islet Microvasculature during Type 1 Diabetes View
- Elucidating the Human Beta Cell Translatome in Health and Disease View
- Functional and Molecular Characterization of the Human Islet Interferon Alpha Response View
- HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
- Identification of the Cognate Epitopes of Autoreactive T Cells in T1D View
- In vivo Effects of Physical Exercise on Human Islet Structure and Function View
- Mapping the Association of Beta Cell Longevity and Senescence in T1D View
- Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells View
- On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells View
- Primary Cilia in Human T1D Pancreas View
- Real-time in vivo Analysis of Islet Redox Dynamics View
- Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
- The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival View
- Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft View
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