Enhancement Center

Active Projects

  • Human Islet Research Enhancement Center (HIREC) View

Consortium on Beta Cell Death & Survival

Active Projects

  • A Stress-Induced Vicious Cycle in the Development of T1D View
  • Alternative RNA Splicing Events Contribute to the Onset of islet dysfunction in T1D View
  • Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression View
  • Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D View
  • Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D View
  • Elucidating the Human Beta Cell Translatome in Health and Disease View
  • Functional and Molecular Characterization of the Human Islet Interferon Alpha Response View
  • Integrated Stress Response in Human Islets during Early T1D View
  • Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes View
  • Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
  • Mapping the Association of Beta Cell Longevity and Senescence in T1D View
  • Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms View
  • Real-time in vivo Analysis of Islet Redox Dynamics View

Closed Projects

  • Biomarkers for Diabetes using Stem Cell-derived Beta Cells View
  • Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker) View
  • Defining Islet Heterogeneity Using Single Islet Transcriptomics View
  • Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes View
  • Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D View
  • High-Resolution Analysis of Juvenile Human Pancreas Maturation View
  • Non-invasive Diagnosis of Human Beta Cell Damage and Death View
  • Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis View
  • Single Cell Resolution of Omics Analysis of T1D Islets View
  • Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging View

Consortium on Human Islet Biomimetics

Active Projects

  • A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes View
  • Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions View
  • Measuring Islet-wide Function with Soft Integrated Nanoelectronics View
  • Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes View
  • Modular Monitoring of Hormone Release from Human Islets View
  • The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival” View
  • Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft View

Closed Projects

  • A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease View
  • A Vascularized 3D Biomimetic for Islet Function and Physiology View
  • Engineering a Human Physiomimetic Islet Microsystem View
  • Islet on a Chip View

Consortium on Modeling Autoimmune Interactions

Active Projects

  • Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
  • HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
  • Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function View
  • Humanized Mouse Avatars for T1D View
  • Identification of the Cognate Epitopes of Autoreactive T Cells in T1D View
  • Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems View
  • On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells View
  • Therapeutic Targeting of the Human Islet Environment View

Closed Projects

  • Analysis of Human Autoreactive T Cell Receptors in vivo View
  • Genetic Regulation of Human Beta Cell Destruction View
  • Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells View
  • Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance View

Consortium on Targeting and Regeneration

Active Projects

  • Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity View
  • Gene Therapy for Diabetes View
  • Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling View
  • Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells. View
  • One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery View
  • Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes View
  • Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
  • Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells View

Closed Projects

  • Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery View
  • CAR T Cell Targeting of Human Islets View
  • Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells View
  • Epigenetic Rejuvenation of Human Beta-Cells View
  • In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors View
  • Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas View
  • Targeting TXNIP to Enhance Beta Cell Mass in T1D View

Human Pancreas Analysis Consortium

Active Projects

  • Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
  • Changes in Human Islet Microvasculature during Type 1 Diabetes View
  • High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential View
  • HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania) View
  • HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.) View
  • HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania) View
  • HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.) View
  • In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas View
  • In vivo effects of physical exercise on human islet structure and function View
  • Linking Islet Cell Function and Identity from in vitro to in situ View
  • Primary Cilia in Human T1D Pancreas View
  • Single Cell Analysis of the Human Pancreas in Type 1 Diabetes View

Opportunity Pool Projects

Active Projects

  • Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
  • Changes in Human Islet Microvasculature during Type 1 Diabetes View
  • Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
  • Elucidating the Human Beta Cell Translatome in Health and Disease View
  • HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
  • Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
  • Measuring Islet-wide Function with Soft Integrated Nanoelectronics View
  • Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells. View
  • Real-time in vivo Analysis of Islet Redox Dynamics View
  • Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
  • The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival” View

Closed Projects

  • A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells View
  • Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry View
  • Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes? View
  • Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D View
  • Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata View
  • Functional Testing of Candidate HSC-derived Islet Cells View
  • Generation of Functional Endocrine Cell Reporter Pluripotent Cell Lines View
  • Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells View
  • Mass Spectrometry-based Proteome Maps for Human Islet Cells View
  • Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM View
  • Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems View
  • The Proteome of Replicating Cells View
  • The Role of Beta Cell Senescence in the Pathogenesis of Diabetes View
  • Workshop for Continued Harmonization of Beta Cell Death Assays View

New Investigators

Active Projects

  • Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
  • Changes in Human Islet Microvasculature during Type 1 Diabetes View
  • Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
  • Elucidating the Human Beta Cell Translatome in Health and Disease View
  • Functional and Molecular Characterization of the Human Islet Interferon Alpha Response View
  • HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
  • Identification of the Cognate Epitopes of Autoreactive T Cells in T1D View
  • In vivo effects of physical exercise on human islet structure and function View
  • Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
  • Mapping the Association of Beta Cell Longevity and Senescence in T1D View
  • Measuring Islet-wide Function with Soft Integrated Nanoelectronics View
  • Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells. View
  • On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells View
  • Primary Cilia in Human T1D Pancreas View
  • Real-time in vivo Analysis of Islet Redox Dynamics View
  • Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
  • The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival” View
  • Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft View
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Email: hirnec@coh.org