Enhancement Center
Active Projects
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Human Islet Research Enhancement Center (HIREC)
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Consortium on Beta Cell Death & Survival
Active Projects
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A Stress-Induced Vicious Cycle in the Development of T1D
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Alternative RNA Splicing Events Contribute to the Onset of islet dysfunction in T1D
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Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression
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Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D
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Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D
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Elucidating the Human Beta Cell Translatome in Health and Disease
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Functional and Molecular Characterization of the Human Islet Interferon Alpha Response
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Integrated Stress Response in Human Islets during Early T1D
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Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes
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Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes
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Mapping the Association of Beta Cell Longevity and Senescence in T1D
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Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms
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Real-time in vivo Analysis of Islet Redox Dynamics
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Closed Projects
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Biomarkers for Diabetes using Stem Cell-derived Beta Cells
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Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
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Defining Islet Heterogeneity Using Single Islet Transcriptomics
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Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
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Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D
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High-Resolution Analysis of Juvenile Human Pancreas Maturation
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Non-invasive Diagnosis of Human Beta Cell Damage and Death
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Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
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Single Cell Resolution of Omics Analysis of T1D Islets
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Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging
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Consortium on Human Islet Biomimetics
Active Projects
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A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes
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Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
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Measuring Islet-wide Function with Soft Integrated Nanoelectronics
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Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes
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Modular Monitoring of Hormone Release from Human Islets
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The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival”
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Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft
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Closed Projects
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A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
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A Vascularized 3D Biomimetic for Islet Function and Physiology
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Engineering a Human Physiomimetic Islet Microsystem
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Islet on a Chip
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Consortium on Modeling Autoimmune Interactions
Active Projects
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Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells
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HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes
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Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
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Humanized Mouse Avatars for T1D
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Identification of the Cognate Epitopes of Autoreactive T Cells in T1D
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Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
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On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells
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Therapeutic Targeting of the Human Islet Environment
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Closed Projects
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Analysis of Human Autoreactive T Cell Receptors in vivo
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Genetic Regulation of Human Beta Cell Destruction
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Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
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Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance
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Consortium on Targeting and Regeneration
Active Projects
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Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity
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Gene Therapy for Diabetes
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Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling
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Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells.
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One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery
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Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes
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Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
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Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells
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Closed Projects
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Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery
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CAR T Cell Targeting of Human Islets
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Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
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Epigenetic Rejuvenation of Human Beta-Cells
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In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
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Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
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Targeting TXNIP to Enhance Beta Cell Mass in T1D
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Human Pancreas Analysis Consortium
Active Projects
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Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets
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Changes in Human Islet Microvasculature during Type 1 Diabetes
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High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential
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HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania)
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HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.)
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HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)
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HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
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In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas
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In vivo effects of physical exercise on human islet structure and function
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Linking Islet Cell Function and Identity from in vitro to in situ
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Primary Cilia in Human T1D Pancreas
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Single Cell Analysis of the Human Pancreas in Type 1 Diabetes
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Opportunity Pool Projects
Active Projects
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Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets
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Changes in Human Islet Microvasculature during Type 1 Diabetes
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Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells
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Elucidating the Human Beta Cell Translatome in Health and Disease
View
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HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes
View
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Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes
View
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Measuring Islet-wide Function with Soft Integrated Nanoelectronics
View
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Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells.
View
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Real-time in vivo Analysis of Islet Redox Dynamics
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Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
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The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival”
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Closed Projects
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A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
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Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry
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Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes?
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Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D
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Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata
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Functional Testing of Candidate HSC-derived Islet Cells
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Generation of Functional Endocrine Cell Reporter Pluripotent Cell Lines
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Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
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Mass Spectrometry-based Proteome Maps for Human Islet Cells
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Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM
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Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems
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The Proteome of Replicating Cells
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The Role of Beta Cell Senescence in the Pathogenesis of Diabetes
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Workshop for Continued Harmonization of Beta Cell Death Assays
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New Investigators
Active Projects
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Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets
View
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Changes in Human Islet Microvasculature during Type 1 Diabetes
View
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Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells
View
-
Elucidating the Human Beta Cell Translatome in Health and Disease
View
-
Functional and Molecular Characterization of the Human Islet Interferon Alpha Response
View
-
HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes
View
-
Identification of the Cognate Epitopes of Autoreactive T Cells in T1D
View
-
In vivo effects of physical exercise on human islet structure and function
View
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Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes
View
-
Mapping the Association of Beta Cell Longevity and Senescence in T1D
View
-
Measuring Islet-wide Function with Soft Integrated Nanoelectronics
View
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Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells.
View
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On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells
View
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Primary Cilia in Human T1D Pancreas
View
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Real-time in vivo Analysis of Islet Redox Dynamics
View
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Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
View
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The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival”
View
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Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft
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