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HIRN 2020 Trainee Scholarship Recipients

The following trainees are recipients of the HIRN 2020 Scholarship based on competitive review of abstracts by members of the HIRN Planning Committee.

 

Joshua Chiou
Institution: University of California, San Diego
Title:  Doctoral Graduate Student
Affiliation: HPAC (Gaulton Lab)

 

Dario De Jesus, PhD
Institution: Joslin Diabetes Center

Title:  Postdoctoral Research Fellow
Affiliation: CBDS (Kulkarni Lab)

 

Shen Dong, PhD
Institution: University of California, San Francisco

Title:  Postdoctoral Research Fellow
Affiliation: CMAI (Bluestone Lab)

 

Angela Kruse, PhD
Institution: Vanderbilt University

Title:  Postdoctoral Research Fellow
Affiliation: CBDS (Caprioli Lab)

  Rachel Madley
Institution: Columbia University Medical Center
Title:  Doctoral Graduate Student
Affiliation: CMAI (Sykes Lab
 

Padma Nanaware
Institution: University of Massachusetts Medical School

Title:  Postdoctoral Research Fellow
Affiliation: CMAI (Stern Lab)

 

Emilie Ronin, PhD
Institution: University of California, San Francisco

Title: Postdoctoral Research Fellow
Affiliation:  CMAI (Tang Lab)

 

Magdalena Samojlik
Institution: University of Florida
Title:  Doctoral Graduate Student
Affiliation: CHIB (Stabler Lab)

 

Alexandra Theis
Institution: University of Colorado Denver
Title:  Doctoral Graduate Student
Affiliation: CBDS (Sussel Lab)

New Awards from RFA-19-024: Discovery of Early Type 1 Diabetes Disease Processes in the Human Pancreas (CBDS)

New HIRN Grants from RFA-19-024: Discovery of Early Type 1 Diabetes Processes in the Pancreas (CBDS)

CBDS A Stress-Induced
Vicious Cycle in the Development of T1D
U01 DK127747 Peter Arvan*, PhD, University of Michigan
Leslie Satin, PhD, University of Michigan
Scott Soleimanpour, PhD, University of Michigan
CBDS Alternative RNA Splicing Events Contribute
to the Onset of Islet Dysfunction in T1D
U01 DK127505

Lori Sussel*, PhD, University of Colorado, Investigator
Charles Ansong, PhD, Investigator, Pacific Northwest National Laboratories
Maggie (Pui Yu) Lam,  PhD, co-Investigator, Pacific Northwest National Laboratories
Ernesto Nakayasu, PhD, co-Investigator, Pacific Northwest National Laboratory
Galya Orr, PhD, co-Investigator, Pacific Northwest National Laboratory
Shi Tujin, PhD, co-Investigator, Pacific Northwest National Laboratory

 

CBDS Determining the Intrinsic
and Environmental
Signal Contributing to
Early T1D Progression
U01 DK127777

Shuibing Chen*, PhD, Weill Cornell Medical College
Steven Parker, PhD, Investigator, University of Michigan
Chengyang Liu, PhD, Co-Investigator, University of Pennsylvania

 

CBDS Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D U01 DK127768

Golnaz Vahedi*, PhD, Investigator, University of Pennsylvania

 

CBDS The Integrated Stress Response in Human Islets during Early T1D U01 DK127786

Raghu Mirmira*, PhD, Investigator, University of Chicago
Decio Eizirik, PhD, Investigator, Indiana Biosciences Research Institute
Carmella Evans-Molina, MD, Investigator, Indiana University
Thomas Metz, PhD, Investigator, Pacific Northwest National Laboratory
Bobbie-Jo Webb-Robinson, PhD, Investigator, Pacific Northwest National Laboratory
Sasanka Ramandha, PhD, Investigator, University of Alabama at Birmingham
Scott Oakes, PhD, Co-Investigator, University of Chicago
Sarah Tersey, PhD, Co-Investigator, University of Chicago
Manami Hara, PhD, Co-Investigator, University of Chicago
Ernesto Nakayasu, PhD, Co-Investigator, Pacific Northwest National Laboratory
Emily Sims, MD, Co-Investigator, Indiana University
Wenting Wu, PhD, Co-Investigator, Indiana University
Xiaoyong Lei, PhD, Co-Investigator, University of Alabama at Birmingham

 

* Denotes Contact PI

NIH NIDDK Gateway Award Recipients (2020)

Congratulations tot the recipients of the NIH NIDDK Gateway Award New Investigator Awards

Congratulations to these four investigators on joining HIRN via the NIH NIDDK Gateway Award Initiative.  They will join their respective consortium conference calls and attend the HIRN Annual Investigator Meeting.

 

 
Rafael Arrojo e Drigo, PhD
Vanderbilt University
Mapping the Association of Beta Cell Longevity and Senescence in T1D” (CBDS)
  Jing Hughes, PhD
Washington Univ. School of Medicine in Saint Louis
Primary Cilia in Human T1D Pancreas” (HPAC)
     

 
Alok Joglekar, PhD
University of Pittsburgh
Identification of the Cognate Epitopes of Autoreactive T Cells in T1D” (CMAI)
  Amelia Linnemann, PhD
Indiana University.
Real-time in vivo Analysis of Islet Redox Dynamics” (CBDS)

 

New Awards from RFA-18-014: HIRN Consortium on Targeting and Regeneration (CTAR)

New HIRN Grants from RFA-18-014: HIRN Consortium on Targeting and Regeneration (CTAR)

CTAR

One-compound, one-islet: A high-throughput platform for small molecule discovery

 U01 DK123717

 Bridget Wagner*, PhD, Broad Institute, Investigator
 Amit Choudhary, PhD, Broad Institute, Investigator
 Rohit Kulkarni MD, PhD, Joslin Diabetes Center, Investigator
 
CTAR  Gene Therapy for Diabetes  U01 DK123608  Hiroyuki Nakai*, PhD, Oregon Health and Science University, Investigator
 Markus Grompe, PhD, Oregon Health and Science University, Investigator
 Mark Kay, MD, PhD, Stanford University, Investigator 
CTAR

Partial Antagonists of IRE1 RNASE – ‘pairs’ – to treat T1D

 U01 DK123609

 Feroz Papa*, MD, PhD, Univ. California, San Francisco, Investigator
 Dustin Maly, PhD, University of Washington, Investigator

CTAR

 Therapeutic targeting of human islets with recombinant regulatory T cells

 U01 DK123743

 Seung Kim*, MD, PhD, Stanford University, Investigator
 Everett Meyer, MD, PhD, Stanford University, Investigator
 Alvin Powers, MD, Vanderbilt University, Investigator

 

* Denotes Contact PI

New Awards: RFA-DK-18-013: HIRN Consortium on Modeling Autoimmune Interactions (CMAI)

New HIRN Grants from RFA-18-013: HIRN Consortium on Modeling Autoimmune Interactions (CMAI)

CMAI

Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D
Immune Systems 

U01 DK123559

 Megan Sykes*, MD, Columbia University, Investigator
 Mark Anderson, MD, PhD, University of California, San Francisco, Investigator
 Matthias Hebrok, PhD, University of California, San Francisco, Investigator
 Audrey Parent, PhD, University of California, San Francisco, Investigator 
 Remi J Creusot, PhD, Columbia University, Co-Investigator
 Robin Goland, MD, Columbia University, Co-Investigator
 

 

 

 

CMAI

Humanized Mouse Avatars
for T1D

UC4 DK104218**

 Dale Greiner*, PhD, University of Massachusetts Medical School, Investigator
 Michael Brehm, PhD, University of Massachusetts Medical School, Investigator
 Leonard Schultz, PhD, The Jackson Laboratory, Investigator
 George Daley, PhD, Harvard University, Investigator
 Doug Melton, PhD, Harvard University, Investigator
 Rene Maehr, PhD, University of Massachusetts Medical School, Co-Investigator
 David Harlan, MD, University of Massachusetts Medical School, Co-Investigator

 

* Denotes Contact PI
** Grant Renewal 

New Awards: RFA-DK-18-011: HIRN Consortium on Human Islet Biomimetics (CHIB)

New HIRN Grants from RFA-18-011: HIRN Consortium on Human Islet Biomimetics (CHIB)

CHIB

Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions

UG3 DK122638

Cherie Stabler, PhD (Univ. of Florida)*
Investigator: Ashu Agarwal, PhD (Univ. Miami)
Investigator: Todd Brusko, PhD (Univ. Florida)
Investigator: Clayton Mathews, PhD (Univ. Florida)
Co-Investigator: Rhonda Bacher, PhD (Univ. Florida)
Co-Investigator: Edward Phelps, PhD (Univ. Florida)
Co-Investigator: Naohiro Terada, PhD(Univ. Florida)

CHIB

A 3D Vascularized Islet Biomimetic to Model Type 1 Diabetes

UG3 DK122639

Maike Sander, MD (Univ. California, San Diego)*
Investigator: Christopher Hughes, PhD (Univ. California, Irvine)
Co-Investigator: Luc Teyton, MD, PhD (Scripps Research Institute)
Co-Investigator: Karen Christman, PhD (Univ. California, San Diego)
Co-Investigator: Steven George, PhD (Univ. California, Davis)

CHIB

Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes

UG3 DK122644

Ben Stanger, PhD (Univ. Pennsylvania)*
Investigator: Dan Hugh, PhD (Univ. Pennsylvania)
Investigator: James Riley, PhD (Univ. Pennsylvania) 
Co-Investigator: Ali Naji, MD (Univ. Pennsylvania)
Co-Investigator: Wenli Yang, PhD (Univ. Pennsylvania) 

 

* Denotes Contact PI

New Award: RFA-DK-18-021: Discovery of Early Type 1 Diabetes Disease Biomarkers in the Human Pancreas (CBDS)

One new HIRN CBDS grant was awarded “Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D” to Dr. Anath Shalev at the University of Alabama at Birmingham. 

Summary: The objective of this HIRN grant is to establish a non-invasive biomarker for pancreatic beta cell loss in humans with T1D and help develop novel approaches for the early diagnosis and treatment of T1D.

Anath Shalev, MD Shalev Lab Members Visual Schematic of Project

New Awards: RFA-DK-17-022: High-Resolution Exploration of the Human Islet Tissue Environment (HPAC)

New HIRN Grants from RFA-DK-17-022: High-Resolution Exploration of the Human Islet Tissue Environment (HPAC)

HPAC

High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential

U01 DK120393

Juan Dominguez-Bendala (Univ. of Miami)*
Investigator: Ricardo Pastori (Univ. of Miami)
Co-Investigator: Alejandro Caicedo (Univ. of Miami)
Co-Investigator: Camillo Ricordi (Univ. of Miami.)

HPAC

Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

U01 DK120429

Maike Sander (Univ. California, San Diego)*
Kyle Jeffrie Gaulton (Univ. California, San Diego)
Co-Investigator: David Gorkin (Univ. California, San Diego)
Co-Investigator: Sebastian Preissl (Univ. California, San Diego)
Co-Investigator: Al Powers (Vanderbilt  Univ.)

HPAC

In situ Analysis of Functional Endocrine,   Vascular, and Immune Cell Interactions during Early Postnatal Development
 of the Human Pancreas

U01 DK120456

Alejandro Caicedo (Univ. Miami)*
Co-Investigator: Marcela Brissova (Vanderbilt Univ.)
Co-Investigator: Stephan Speier (Paul Langerhans Institut)

HPAC

 Linking Islet Cell Function and
 Identity from in vitro to in situ

U01 DK120447

Patrick MacDonald (Univ. of Alberta)*
Co-Investigator: Stephen Quake (Stanford Univ.)
Co-Investigator: Martin Hetzer (Salk Institute)
Co-Investigator: Emma Lundberg (KTH Stockholm)
Co-Investigator: Seung Kim (Stanford Univ.)

* Denotes Contact PI

HIRN 2018 New Investigator Award Recipients

Recipients of the HIRN 2018 New Investigator Awards

Seven investigators were selected to carryout bold and highly innovative new research approaches to biological problems under current investigation in HIRN.  They will join their respective consortium conference calls and attend the HIRN Annual Investigator Meeting.

 

New Awards: RFA-DK-17-003: Therapeutic Targeting of the Human Islet Environment (UC4)

New HIRN Grants from RFA-DK-17-003: Therapeutic Targeting of the Human Islet Environment (UC4)

CTAR

Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity

UC4 DK116241

Paolo Serafini (Univ. of Miami)*
Midhat Abdulreda (Univ. of Miami)
Co-Investigator: Peter Buchwald (Univ. of Miami)
Co-Investigator: Camillo Ricordi (Univ. of Miami)
Co-Investigator: Natasa Strbo (Univ. of Miami)

CTAR

Therapeutic Targeting of the Human Islet Environment

UC4 DK116264

Jeffrey Bluestone (Univ. California, San Francisco)*
Wendell Lim (Univ. California, San Francisco)
Co-Investigator: Qizhi Tang (Univ. California, San Francisco)
Co-Investigator: Kole Roybal (Univ. California, San Francisco)

CTAR

CAR T Cell Targeting of Human Islets

UC4 DK116252

Seung Kim (Stanford Univ.)*
Everett Meyer (Stanford Univ)
Co-Investigator: Philip Streeter (Oregon Health & Science Univ.)

CTAR

Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells

UC4 DK116255

Amit Choudhary (Broad Institute)*
Bridget Wagner (Broad Institute)
Rohit Kulkarni (Joslin Diabetes Center)

* Denotes Contact PI

RFA-DK-17-004: Competitive Collaborative Projects for Human Islet Biology (UC4)

New Awards: RFA-DK-17-004: Competitive Collaborative Projects for Human Islet Biology (UC4)

CTAR

Generating Novel Sources of Functional
Human Insulin-secreting Cells for T1D Modeling

UC4 DK116280

Qiao Zhou (Harvard Univ.)*
Stephan Kissler (Joslin Diabetes Center)

CMAI

Human Islet-Infiltrating T Cell Biology:
Reactivity, Structure and Function

UC4 DK116284

 

Sally Kent (Univ. of Massachusetts Medical School)*
David Harlan (Univ. of Massachusetts Medical School)
Lawrence Stern (Univ. of Massachusetts Medical School)
Co-Investigator: Dirk Homann (Mount Sinai School of Medicine)

CHIB

Modular Monitoring of Hormone Release
from Human Islets

UC4 DK116283

 

Michael Roper (Florida State Univ.)*
Christopher Hughes (Univ. of California, Irvine)
Ryan White (Univ. of Cincinatti)

CBDS

Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms

UC4 DK116274

Desmond Schatz (Univ. Florida)*
Yuval Dor (Hebrew Univ. of Jerusalem)
Carla Greenbaum (Benaroya Research Institute at Virginia Mason)

CBDS

Interrogation of Dynamic RNA Modifications in
Beta Cells in Type 1 Diabetes

UC4 DK116278

Rohit Kulkarni (Joslin Diabetes Center)*
Chuan He (Univ. of Chicago)

CBDS

Drivers and Consequences of Beta Cell DNA
Damage in Type 1 Diabetes

UC4 DK116271

Klaus Kaestner (Univ. of Pennsylvania)*
Yuval Dor (Hebrew Univ. of Jerusalem)
Ali Naji (Univ. of Pennsylvania)

* Denotes Contact PI

 

New HPAP Consortium – October 2016

A fifth consortium, Human Pancreas Analysis Program (HPAP), has been added to HIRN.  These two awards were made in response to a NIH NIDDK initiative (RFA-DK-15-027). The primary goal of HPAP is to accumulate, analyze, and distribute high value T1D datasets to the diabetes research community.  

New CMAI Award – October 2016

One new project has been added to the CMAI portfolio, “Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance“. This project is led by Drs. Mark Anderson, Jeffrey Bluestone and Matthias Hebrok at the University of California, San Francisco.

Three New HIRN CBDS Awards – Oct 2015

Three new projects have been added to the CBDS porfolio. These three awards were made in response to the second HIRN/CBDS initiative (RFA-DK-14-021) that supports the development of medium- to high-throughput “omics” technologies that can be used to explore human pancreatic tissues with single cell- or near single cell- resolution. The three new teams/projects are: “Single Cell Resolution Omics Analysis of T1D islets”, “Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging“, and “High-Resolution Analysis of Juvenile Human Pancreas Maturation”.