Dr. Justin Annes specializes in the treatment of hereditary endocrine disorders with particular focus on neuroendocrine-related conditions.
He developed the Stanford Endocrine Genetics Clinic in 2012 which is part of the interdisciplinary Stanford Hypertension Center and Stanford Neuroendocrine Tumor Program. Additionally, he has had a medical practice focused on hereditary endocrine disease since 2008.
Radhika Armandla is a Senior Research Specialist in the Powers & Brissova Research Group at Vanderbilt University. She is involved in projects dealing with human islet transplantation, in vitro analysis and imaging in order to study human islet survival, function, regeneration and proliferation.
Olivier Blondel is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests lie in research that focuses on endocrine signaling, stem cell biology, organ development, regenerative medicine and biomarker discovery as it relates to diabetes (type 1 and type 2) and metabolic diseases, particularly in combination with experimental approaches such as large-scale genomics, synthetic biology, bioengineering, epigenetics, nuclear organization of mammalian genomes, chromatin biology, genome editing, gene therapy
Marcela Brissova is an Research Professor of Medicine and Director of the Islet Procurement & Analysis Core at Vanderbilt University. She is also the Director of the Human Islet Phenotyping Program (HIPP) of IIDP. Her research focuses on the biology of pancreatic islets and pancreas and islet development, especially the development of pancreatic islet vasculature and innervation and their role in regulation of pancreatic islet function.
Peter Buchwald is an Associate Professor in the Department of Molecular and Cellular Pharmacology at the University of Miami Miller School of Medicine and the Director of the Drug Discovery Program at the Diabetes Research Institute. He has published numerous articles in peer-reviewed journals focused on the physicochemical and metabolic aspects of drug design and drug action, as well as on computer-aided quantitative modeling. Dr. Buchwald is directing the DRI’s efforts aimed at developing safer and more effective drugs for islet replacement therapies.
Paul Clemons is an institute scientist and the director of computational chemical biology research in the Chemical Biology and Therapeutics Science Program at the Broad Institute of MIT and Harvard. Clemons and his team use quantitative measurement, computational, and visualization techniques to enable systematic use of small molecules to explore biology, especially disease biology.
Chunhua Dai is a Research Associate Professor in the Powers & Brissova Research Group at Vanderbilt University. Her research focuses on the molecular, cellular, and vascular changes in human islets when they are challenged with hyperglycemia and/or insulin resistance in vivo. She is investigating in vivo age-dependent human beta cell proliferation and how current therapeutic agents for type 2 diabetes preserve and/or enhance human beta cell function or survival in vivo.
Sangeeta Dhawan is a HIRN New Investigator and an Assistant Professor in the Department of Translational Research & Cellular Therapeutics. Her research focuses on the understanding the biology of the insulin producing beta cells.
Yuval Dor is a Professor of Biology at the Hebrew University of Jerusalem. He has worked in the past mostly on diabetes and tissue regeneration in the pancreas, but in recent years much of our focus has shifted to a new technology that we are developing, for non-invasive monitoring of cell death in humans, based on circulating DNA.
Abdelfattah El Ouaamari is a HIRN New Investigator and an Assistant Professor in Medicine at Robert Wood Johnson Medical School at Rutgers University. His research employs a multidisciplinary approach to identify local, systemic and neuronal signals regulating the number and the function of pancreatic islet insulin-producing β cells in mouse and human models of obesity and diabetes.
Markus Grompe is Professor and Director Family Pediatric Research Institute at Oregon Health & Science University in Portland, Oregon. His research focuses on the use of in vivo selection to enhance gene and cell transplantation therapy for inherited diseases.
Klaus Kaestner Professor in Genetics at the Perelman School of Medicine at the University of Pennsylvania and the Director of the Functional Genomics Core at the University of Pennsylvania. His research interest is in employing modern genetic, genomic and epigenomic approaches (ChIP-Seq, RNA-Seq, gene targeting, tissue-specific and inducible gene ablation, CyTOF) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. Disease areas targeted by our research include diabetes and cancer.
Mark Kay is a Professor of Pediatrics and Genetics at Stanford University. His laboratory is focused in the development of gene transfer vectors for gene therapy as well as manipulating non-coding RNAs for therapeutic purposes. His research has focused on two vector systems, mini-circles and recombinant AAVs (rAAV). Using gene transfer vectors, we studied the potential of using transcriptional-based RNAi to treat human disease.
Seung Kim is a Professor of Developmental Biology and Medicine (Oncology) at Stanford University School of Medicine. His research focuses on the developmental biology of the pancreas, a vital organ with endocrine and exocrine functions in the vertebrate digestive tract. One goal of our work is to translate our studies into novel diagnostic and therapeutic strategies for common pancreatic disease states in humans, particularly diabetes mellitus and pancreatic cancer.
Rohit Kulkarni is a Professor of Medicine at Harvard Medical School and Co-Head of the Section on Islet & Regenerative Biology at Joslin Diabetes Center. His research explores the significance of growth factor signaling mechanisms in the regulation of islet biology by creating genetic models to examine the roles of insulin/IGF-1 receptors and their substrate proteins.
Michael McManus is a Professor in the Department of Microbiology and Immunology at the University of California, San Francisco and a member of the Chan Zuckerberg Biohub, the Helen Diller Comprehensive Cancer Center, the Diabetes Center, the Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, and the Innovative Genomics Institute.
Everett Meyer is an Assciate Professor of Medicine at Stanford University Medical School. His research focus is in hematopoietic stem cell transplantation and Treg cell immunotherapy, with an emphasis on the treatment of graft-versus-host disease as well as immune tolerance induction for transplantation and autoimmunity. He is an expert on the role of T-cell populations in immune dysregulation, specifically through the mechanistic study of how CD1d-restricted invariant NKT mediate allergy and asthma in both mouse models and human clinical samples.
Hiroyuki Nakai is a Professor of Molecular and Medical Genetics at the Oregon Health and Science University School of Medicine. His research goals are to comprehensively understand the biology of recombinant AAV vectors and the vector-host interactions and to develop new AAV vector-mediated gene and cell therapies to treat various human diseases.
Feroz Papa is a Professor in the Department of Medicine at the University of California, San Francisco Biomedical Sciences Graduate Program. His lab uses molecular, cellular, and organismal approaches to address broad questions revolving around protein misfolding and disease. His research focuses in protein misfolding in the endoplasmic reticulum (ER) organelle.
Al Powers is a Professor of Medicine, Molecular Physiology and Biophysics at Vanderbilt University. He is also the Director of the Vanderbilt Diabetes Center, Director of the Vanderbilt Diabetes Research and Training Center, and Chief of the Vanderbilt Division of Diabetes, Endocrinology, and Metabolism. His research focuses on pancreatic islet biology, vascularization, development, regeneration, and imaging.
Xujing Wang is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her interests are in data science, computation modeling, integrative genomics, network biology, and genotype-phenotype relationships.
Matthew Wortham is a Gateway Award Recipient and an Assistant Professor at the University of California, San Diego. His research is to define the mechanisms whereby beta cells detect and respond to changes in their metabolic environment.