Lab:

https://hirnetwork.org/about/participants#short-profile-midhat-abdulreda-phd

HIRN Investigator Profile:

http://www.example.com/

Projects

• Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity

Projects

• Epigenetic Rejuvenation of Human Beta-Cells

Lab:

https://hirnetwork.org/about/participants#short-profile-seung-kim-md-phd

Projects

• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Lab:

https://hirnetwork.org/about/participants#short-profile-al-powers-md

Projects

• High-Resolution Analysis of Juvenile Human Pancreas Maturation
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
• Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Projects

• Epigenetic Rejuvenation of Human Beta-Cells
• The Role of Beta Cell Senescence in the Pathogenesis of Diabetes

Bio

Olivier Blondel is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. His interests lie in research that focuses on endocrine signaling, stem cell biology, organ development, regenerative medicine and biomarker discovery as it relates to diabetes (type 1 and type 2) and metabolic diseases, particularly in combination with experimental approaches such as large-scale genomics, synthetic biology, bioengineering, epigenetics, nuclear organization of mammalian genomes, chromatin biology, genome editing, gene therapy

Projects

• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Projects

• In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas
• High-Resolution Analysis of Juvenile Human Pancreas Maturation
• HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.)
• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/Contributor/Index/marcela_brissova@hirnetwork.org

Projects

• Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity
• Engineering a Human Physiomimetic Islet Microsystem

Projects

• Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
• One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery

Projects

• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Bio

Sangeeta Dhawan is a HIRN New Investigator and an Assistant Professor in the Department of Translational Research & Cellular Therapeutics. Her research focuses on the understanding the biology of the insulin producing beta cells.

HIRN Investigator Profile:

https://hirnetwork.org/profile-dhawan

Projects

• Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Sangeeta+Dhawan

Bio

Yuval Dor is a Professor of Biology at the Hebrew University of Jerusalem. He has worked in the past mostly on diabetes and tissue regeneration in the pancreas, but in recent years much of our focus has shifted to a new technology that we are developing, for non-invasive monitoring of cell death in humans, based on circulating DNA.

Projects

• Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
• Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms
• Non-invasive Diagnosis of Human Beta Cell Damage and Death
• The Proteome of Replicating Cells

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=+Yuval+Dor

Bio

Abdelfattah El Ouaamari is a HIRN New Investigator and an Assistant Professor in Medicine at Robert Wood Johnson Medical School at Rutgers University. His research employs a multidisciplinary approach to identify local, systemic and neuronal signals regulating the number and the function of pancreatic islet insulin-producing β cells in mouse and human models of obesity and diabetes.

HIRN Investigator Profile:

https://hirnetwork.org/profile-elouaamari

Projects

• Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells.

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Abdel+El+Ouaamari

Projects

• Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery

Lab:

https://hirnetwork.org/about/participants#short-profile-markus-grompe-md

Projects

• In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors

Projects

• Epigenetic Rejuvenation of Human Beta-Cells
• The Role of Beta Cell Senescence in the Pathogenesis of Diabetes

Projects

• In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
• Gene Therapy for Diabetes
• Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry

Projects

• Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery
• Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Bio

Klaus Kaestner is the Thomas and Evelyn Suor Butterworth Professor in Genetics at the Perelman School of Medicine at the University of Pennsylvania and the Director of the Functional Genomics Core at the University of Pennsylvania. His research interest is in employing modern genetic, genomic and epigenomic approaches (ChIP-Seq, RNA-Seq, gene targeting, tissue-specific and inducible gene ablation, CyTOF) to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract. Disease areas targeted by our research include diabetes and cancer.

Projects

• Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
• Epigenetic Rejuvenation of Human Beta-Cells
• HPAP T1D: Integrated Human Pancreas Analysis Program (Univ. Pennsylvania)
• HPAP T2D: Human Pancreas Analysis Program (Univ. Pennsylvania)
• A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
• Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes?
• Mass Spectrometry-based Proteome Maps for Human Islet Cells

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Klaus+Kaestner

HIRN Webinar:

Projects

• In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
• Gene Therapy for Diabetes

HIRN Webinar:

Projects

• CAR T Cell Targeting of Human Islets
• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells
• Linking Islet Cell Function and Identity from in vitro to in situ
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
• Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata

Projects

• Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling

Bio

Rohit Kulkarni is Professor of Medicine at Harvard Medical School, Margaret A. Congleton Chair and Co-Head of the Section on Islet & Regenerative Biology at Joslin Diabetes Center. His research explores the significance of growth factor signaling mechanisms in the regulation of islet biology by creating genetic models to examine the roles of insulin/IGF-1 receptors and their substrate proteins.

Projects

• Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
• Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes
• Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
• One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/SearchResults/Results/?query=Rohit+Kulkarni

HIRN Webinar:

Projects

• Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes

Projects

• CAR T Cell Targeting of Human Islets
• Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells

Projects

• In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
• Gene Therapy for Diabetes

HIRN Webinar:

Projects

• Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes

Lab:

https://hirnetwork.org/about/participants#short-profile-seung-kim-md-phd

Projects

• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Projects

• High-Resolution Analysis of Juvenile Human Pancreas Maturation
• HPAP T1D: Integrated Program for Human Pancreas Analysis (Vanderbilt Univ.)
• HPAP T2D: Human Pancreas Analysis Program (Vanderbilt Univ.)
• Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells
• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
• Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata
• Single Cell Analysis of the Human Pancreas in Type 1 Diabetes

Projects

• Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity

Projects

• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
• Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata

Projects

• CAR T Cell Targeting of Human Islets
• Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry

Projects

• Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery
• Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging

Bio

Bridget Wagner is the chair of the Consortium of Targeting and Regeneration (CTAR) and the Trans-Network Committee (TNC). Additionlly, she is a CTAR Investigator. She is also the Director of Pancreatic Cell Biology and Metabolic Disease in the Chemical Biology and Therapeutic Sciences Program at the Broad Institute of MIT and Harvard, where she is also an institute scientist. Her research focuses on the chemical biology of diabetes, with the aim of identifying small molecules capable of increasing pancreatic beta cell number and function and the ultimate goal of discovering new therapeutic approaches for diabetes.

Lab:

https://www.broadinstitute.org/bios/bridget-wagner

HIRN Investigator Profile:

https://hirnetwork.org/investigator_profile_bwagner

Projects

• Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
• One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery

Investigator Contributed Resources:

https://resourcebrowser.hirnetwork.org/Contributor/Index/bridget_wagner@hirnetwork.org

HIRN Webinar:

Projects

• Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas

Bio

Xujing Wang is a NIH NIDDK Program Director in the Division of Diabetes, Endocrinology, and Metabolic Diseases. Her interests are in data science, computation modeling, integrative genomics, network biology, and genotype-phenotype relationships.

Projects

• Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling