Author: Layla Rouse, MS

Webinar: Reprogramming Human Regulatory T Cells to Quell Autoimmunity and Transplant Rejection

Posted on | by Layla Rouse, MS

 

Register HERE

Date:                 Tuesday, September 6, 2022
Time:                 1:00 PM Eastern |  10:00 AM Pacific
Duration:          1 hour

Presentations by:         
Leonardo Ferreira, PhD, Medical University of South Carolina
Everett Meyer, MD, PhD, Stanford University

 Topics to be discussed:

–  What is a regulatory T cell (Treg)? When were they first discovered? What is a chimeric antigen receptor (CAR)?
–  How heterogenous is the Treg compartment? Do different Treg subsets perform different functions? How do tissue-resident Tregs differ from those in the periphery?
–  What are the hurdles in utilizing Tregs? Does engineering Tregs create new opportunities or new challenges?
–  How far along are Tregs in the clinic?

Webinar: Introduction and Overview of the HIRN HPAP Pancreas Database (“PancDB”)

Posted on | by Layla Rouse, MS

 

Click HERE to access the YouTube video of the recording.

Thursday, July 7, 2022 (1:00 PM Eastern |  10:00 AM Pacific)

Presented by:

Golnaz Vahedi, University of Pennsylvania
Colin McGovern, University of Pennsylvania
Michael Stauffer, University of Pennsylvania

Topics to be discussed:

  • Introduction to the Human Pancreas Analysis Program (HPAP)
  • Overview of the Pancreas Database (“PancDB”)
  • Demonstration of the v.20 PancDB Enhancements

Webinar: “Why the Immune System Kills Beta but not Alpha Cells”

Posted on | by Layla Rouse, MS

 

Click HERE to access the YouTube video of the recording.

 May 18, 2022 (1:00 PM Eastern |  10:00 AM Pacific)

Presented by: Dr. Decio Eizirik from the ULB Center of Diabetes Research

Topics to be discussed:

  • Alpha-cells are dysfunctional but not killed in type 1 diabetes
  • Are there different mechanisms for alpha-cell dysfunction in types 1 and 2 diabetes?
  • Learning from single cell RNAseq of alpha- and beta-cells exposed to pro-inflammatory cytokines
  • How do beta- and alpha-cells respond to viral infections?
  • How do beta- and alpha-cells respond to ER stress and other pro-apoptotic stimuli?
  • A preliminary hypothesis for the alpha-cells resistance to apoptosis in type 1 diabetes

April 2022 Webinar: “T Cell Antigen Discovery: Experimental & Computational Approaches”

Posted on | by Layla Rouse, MS

 

Click HERE to access the YouTube video of the recording.

April 27, 2022 (12:00 pm Eastern/9:00 am Pacific)

Webinar co-sponsored with dkNET

Presented by:           
Alok Joglekar, PhD, University of Pittsburgh          

Topics  discussed:

  • Antigen directed detection of T cells
  • TCR directed epitope discovery
  • Computational prediction of TCR specificity
  • Integrating antigen specificity with T cell function
  • Antigenic landscape of islet-infiltrating T cells in Type 1 Diabetes

January 2022 Webinar: “mRNA Modifications in Islet Biology”

Posted on | by Layla Rouse, MS

 

Click HERE to access the YouTube video of the recording.

January 27, 2022 (2:00 PM Eastern / 11:00 am Pacific)

Presented by:

Rohit N Kulkarni, MD, PhD, Joslin Diabetes Center
Dario F De Jesus, PhD, Joslin Diabetes Center

Topics discussed:

  • Introduction to the field of RNA modifications
  • Decoding the functions of m6A mRNA methylation
       – Sequencing strategies (e.g. MeRIP-seq)
       – Differential analyses of m6A data   
       –     Useful online tools and datasets
  • Application of MeRIP-seq in the study of Type 1 and
    Type 2 diabetes
  • Emerging Concepts and Challenges

Gateway Investigator RFA

Posted on | by Layla Rouse, MS

New Investigator Gateway Award for Collaborative T1D Research (RFA DK-21-030)

The New Investigator Gateway Award in T1D Research is designed to support a robust pipeline of innovative projects and talented new investigators in T1D research. In addition to providing support for preliminary research, the Gateway program provides an opportunity for new Program Directors/Principal Investigators (PD/PIs) to pursue their studies within the intellectual environment of a select number of large, ongoing collaborative research programs. Embedding awardees within an established scientific framework in each of these consortia will provide unique opportunities for New and Early Stage Investigators to increase their understanding of key questions in the field, to network, and to establish unique and potentially long-lasting collaborations that will propel their careers forward. Bringing New and Early Stage Investigators into existing collaborative research networks will also benefit the networks by providing new ideas and perspectives. 

Key Dates

  • Posted:  December 3, 2021
  • Letter of Intent Due: May 1, 2022 and February 20, 2023
  • Application Due Date: June 1, 2022 and March 20, 2023
  • Start Date: May 2023 and December 2023

HIRN Catalyst Initaitive (2021)

Posted on | by Layla Rouse, MS

Internal HIRN Funding Opportunity:

A new funding initiative to support investigators developing bold, innovative, and challenging projects that will catalyze the field and provide  important advances in topics of interest to the network. To be considered  “catalyzing”, the proposed research must address significant and currently intractable problems by employing approaches or ideas that are currently outside the mainstream of contemporary research.

Learn more at: https://hirnetwork.org/catalyst2021

Apply HERE

Key Dates

Posted Date:    
Letter of Intent Due Date:          
Application Due Date:   
Scientific Review:                        
Start Date:                                  
Expiration Date:                           

December 1, 2021
March 1, 2022
May 2, 2022  
May – July, 2022
August 1, 2022        
May 3, 2022

 

NIH NIDDK Workshop: “Integrated Physiology of the Exocrine & Endocrine Compartments in Pancreatic Diseases” (June 2022)

Posted on | by Layla Rouse, MS

NIH NIDDK Workshop “Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases Workshop”

The NIH NIDDK is hosting a  1.5 – day workshop will be to gather clinical and basic science investigators who are interested in diseases of the exocrine and/or endocrine pancreas and in achieving an understanding of how the two compartments interact in disease. This workshop will provide an opportunity for investigators in exocrine diseases to come together with those studying islets in diabetes as a means to foster interdisciplinary discussion and identify areas for advancement.

NEW Meeting Dates: June 29 – 30, 2022

Registration Deadline: June 13, 2022

Abstract Deadline: May 20, 2022

Learn more HERE.

 

November 2021 Webinar: “FAIR Data and You: Are you ready for 2023?”

Posted on | by Layla Rouse, MS

Learn how to succeed with your next NIH grant:  New Data Mandates and Opportunities

Click HERE to access the YouTube video of the recording.

*The slides from the webinar are posted here to download
HIRN Webinar. 2021 Nov. Introduction to the FAIR Data.pdf (525 downloads )

Tuesday, November 30, 2021 (11:00 AM Pacific | 2:00 PM Eastern)

Presented by:   

Jeff Grethe, University of California, San Diego

 

Topics to be discussed:

  • Open Science & Data Sharing: NIH 2023 Mandate
  • Data as a Research Output
  • FAIR Principles:  What & Why
  • Deeper Dive into FAIR: Use of Persistent Identifiers, Rich Metadata, Data Licenses, FAIR Vocabularies & Standards
  • Introduction to Data Repositories
  • FAIR data and you: Importance of Data Management
  • Discussion