March 2021 Webinar: Designing Tools and Materials to Create a Benchtop Window into the Islet-immune Interface

Click HERE to access the YouTube video of the recording.

March 2, 2021 (3:00 PM Eastern / 12:00 PM Pacific)

Presentations on:

  • Introduction to HIRN Consortium on Human Islet Biomimetics (CHIB) by Dr. Cherie Stabler, University of Florida
  • Single Cell Gene Expression Analysis, TCR Sequencing and Avatar T Cells by Dr. Luc Teyton, Scripps Research
  • Gene Editing of Primary Human Cells and Human IPSCs by Leanna Peters, University of Florida
  • Sensing Pancreatic Islet Secretions within Microfluidic Devices by Dr. Daniel Steyer, Florida State University
  • Vascular Networks in Microphysiological Systems (MPS) by Dr. Dan Huh, University of Pennsylvania

HIRN 2020 Trainee Scholarship Recipients

The following trainees are recipients of the HIRN 2020 Scholarship based on competitive review of abstracts by members of the HIRN Planning Committee.

Joshua Chiou

Institution: University of California, San Diego

Title: Doctoral Graduate Student

Affiliation: HPAC (Gaulton Lab)

Dario De Jesus, PhD

Institution : Joslin Diabetes Center

Title : Postdoctoral Research Fellow

Affiliation : CBDS (Kulkarni Lab)

Shen Dong, PhD

Institution : University of California, San Francisco

Title : Postdoctoral Research Fellow

Affiliation : CMAI (Bluestone Lab)

Angela Kruse, PhD

Institution : Vanderbilt University

Title : Postdoctoral Research Fellow

Affiliation : CBDS (Caprioli Lab)

Rachel Madley

Institution : Columbia University Medical Center

Title : Doctoral Graduate Student

Affiliation : CMAI (Sykes Lab)

Padma Nanaware

Institution : University of Massachusetts Medical School

Title : Postdoctoral Research Fellow

Affiliation : CMAI (Stern Lab)

Emilie Ronin

Institution : University of California, San Francisco

Title : Postdoctoral Research Fellow

Affiliation : CMAI (Tang Lab)

Magdalena Samojlik

Institution : University of Florida

Title : Doctoral Graduate Student

Affiliation : CHIB (Stabler Lab)

Alexandra Theis

Institution : University of Colorado Denver

Title : Doctoral Graduate Student

Affiliation : CBDS (Sussel Lab)

New Awards from RFA-19-024: Discovery of Early Type 1 Diabetes Disease Processes in the Human Pancreas (CBDS)

Peter Arvan*, PhD, University of Michigan
Leslie Satin, PhD, University of Michigan
Scott Soleimanpour, PhD, University of Michigan

Lori Sussel*, PhD, University of Colorado, Investigator
Charles Ansong, PhD, Investigator, Pacific Northwest National Laboratories
Maggie (Pui Yu) Lam,  PhD, co-Investigator, Pacific Northwest National Laboratories
Ernesto Nakayasu, PhD, co-Investigator, Pacific Northwest National Laboratory
Galya Orr, PhD, co-Investigator, Pacific Northwest National Laboratory
Shi Tujin, PhD, co-Investigator, Pacific Northwest National Laboratory

Shuibing Chen*, PhD, Weill Cornell Medical College
Steven Parker, PhD, Investigator, University of Michigan
Chengyang Liu, PhD, Co-Investigator, University of Pennsylvania

Golnaz Vahedi*, PhD, Investigator, University of Pennsylvania

Raghu Mirmira*, PhD, Investigator, University of Chicago
Decio Eizirik, PhD, Investigator, Indiana Biosciences Research Institute
Carmella Evans-Molina, MD, Investigator, Indiana University
Thomas Metz, PhD, Investigator, Pacific Northwest National Laboratory
Bobbie-Jo Webb-Robinson, PhD, Investigator, Pacific Northwest National Laboratory
Sasanka Ramandha, PhD, Investigator, University of Alabama at Birmingham
Scott Oakes, PhD, Co-Investigator, University of Chicago
Sarah Tersey, PhD, Co-Investigator, University of Chicago
Manami Hara, PhD, Co-Investigator, University of Chicago
Ernesto Nakayasu, PhD, Co-Investigator, Pacific Northwest National Laboratory
Emily Sims, MD, Co-Investigator, Indiana University
Wenting Wu, PhD, Co-Investigator, Indiana University
Xiaoyong Lei, PhD, Co-Investigator, University of Alabama at Birmingham

* Denotes Contact PI

NIH NIDDK New Investigator Gateway Award Recipients (2020)

Congratulations to the 2020 Recipients of the NIH NIDDK New Investigator Gateway Awards

Congratulations to these four investigators on joining HIRN via the NIH NIDDK Gateway Award Initiative.  This award was designed to ensure that a robust pipeline of talented new investigators will continue to embark on successful careers in type 1 diabetes (T1D) research. The recipients will be embedded within the HIRN scientific framework to provide unique opportunities for New and Early Stage Investigators to increase their understanding of key questions in the field, to network, and to establish unique and potentially long-lasting collaborations that will propel their careers forward. It is anticipated that the Gateway award will provide the support needed to enhance the success of future R01 submissions from New Investigators interested in pursuing careers in T1D research.

August 2020 Webinar: “The Development and Use of Adeno-Associated Virus (AAV) Vectors”

Click HERE to access the YouTube video of the recording.

August 24, 2020 (3:00 PM Eastern / 12:00 PM Pacific)

Presented by:
Hiroyuki Nakai, Oregon Heath & Science University

Mark Kay, Stanford University

Topics discussed:

–  Discuss how AAV Vectors were developed
–  Discuss how AAV vectors are and can be used in clinical medicine
– 
Discuss future applications of AAV vector technology
–  Learn AAV vector-related resources available to investigators

New Awards: RFA-DK-18-013: HIRN Consortium on Modeling Autoimmune Interactions (CMAI)

New HIRN Grants from RFA-18-013: HIRN Consortium on Modeling Autoimmune Interactions (CMAI)

Megan Sykes*, MD, Columbia University, Investigator
Mark Anderson, MD, PhD, University of California, San Francisco, Investigator
Matthias Hebrok, PhD, University of California, San Francisco, Investigator
Audrey Parent, PhD, University of California, San Francisco, Investigator 
Remi J Creusot, PhD, Columbia University, Co-Investigator
Robin Goland, MD, Columbia University, Co-Investigator

CMAI

Humanized Mouse Avatars
for T1D

UC4 DK104218**

Dale Greiner*, PhD, University of Massachusetts Medical School, Investigator
Michael Brehm, PhD, University of Massachusetts Medical School, Investigator
Leonard Schultz, PhD, The Jackson Laboratory, Investigator
George Daley, PhD, Harvard University, Investigator
Doug Melton, PhD, Harvard University, Investigator
Rene Maehr, PhD, University of Massachusetts Medical School, Co-Investigator
David Harlan, MD, University of Massachusetts Medical School, Co-Investigator

* Denotes Contact PI
** Grant Renewal

New Awards: RFA-DK-18-011: HIRN Consortium on Human Islet Biomimetics (CHIB)

New HIRN Grants from RFA-18-011: HIRN Consortium on Human Islet Biomimetics (CHIB)

Cherie Stabler, PhD (Univ. of Florida)*
Investigator: Ashu Agarwal, PhD (Univ. Miami)
Investigator: Todd Brusko, PhD (Univ. Florida)
Investigator: Clayton Mathews, PhD (Univ. Florida)
Co-Investigator: Rhonda Bacher, PhD (Univ. Florida)
Co-Investigator: Edward Phelps, PhD (Univ. Florida)
Co-Investigator: Naohiro Terada, PhD(Univ. Florida)

Maike Sander, MD (Univ. California, San Diego)*
Investigator: Christopher Hughes, PhD (Univ. California, Irvine)
Co-Investigator: Luc Teyton, MD, PhD (Scripps Research Institute)
Co-Investigator: Karen Christman, PhD (Univ. California, San Diego)
Co-Investigator: Steven George, PhD (Univ. California, Davis)

Ben Stanger, PhD (Univ. Pennsylvania)*
Investigator: Dan Hugh, PhD (Univ. Pennsylvania)
Investigator: James Riley, PhD (Univ. Pennsylvania) 
Co-Investigator: Ali Naji, MD (Univ. Pennsylvania)
Co-Investigator: Wenli Yang, PhD (Univ. Pennsylvania) 

* Denotes Contact PI

New Awards from RFA-18-014: HIRN Consortium on Targeting and Regeneration (CTAR)

Bridget Wagner*, PhD, Broad Institute, Investigator
Amit Choudhary, PhD, Broad Institute, Investigator
Rohit Kulkarni MD, PhD, Joslin Diabetes Center, Investigator

 

Gene Therapy for Diabetes

U01 DK123608

Hiroyuki Nakai*, PhD, Oregon Health and Science University, Investigator
Markus Grompe, PhD, Oregon Health and Science University, Investigator
Mark Kay, MD, PhD, Stanford University, Investigator

Feroz Papa*, MD, PhD, Univ. California, San Francisco, Investigator
Dustin Maly, PhD, University of Washington, Investigator

Seung Kim*, MD, PhD, Stanford University, Investigator
Everett Meyer, MD, PhD, Stanford University, Investigator
Alvin Powers, MD, Vanderbilt University, Investigator

* Denotes Contact PI