Author: Layla Rouse, MS

September 2021 Webinar: “Introduction to the HIRN Human Pancreas Analysis Program (HPAP): Real World Examples of Successful Data Analyses”

Posted on | by Layla Rouse, MS

Click HERE to access the YouTube video of the recording.

Thursday, September 9, 2021 (2:00 PM Eastern / 11:00 AM Pacific)

Presented by:   
Klaus Kaestner, University of Pennsylvania
Paul Wang, University of Pennsylvania
Maria Hatzoglou, Case Western Reserve University
Golnaz Vahedi, University of Pennsylvania

Topics discussed:
– Introduction to the Human Pancreas Analysis Program (HPAP)
– Overview of the Pancreas Database (“PancDB”)
– Presentation of PancDB in recent publications (Use Cases)

Office Hours

Posted on | by Layla Rouse, MS

Want to learn more about HIRN? Have a question that needs an answer? Join the Human Islet Research Enhancement Center (HIREC) on Zoom during our monthly office hours to ask a questions or learn more about new techniques (see below). Standing zoom invite on the first Thursday of every month at 11:00 AM Pacific | 2:00 PM Eastern. 

* Zoom link (will only be active during the office hours)

Learn more about:

  • HIRN Resources: How to enter a new resource or search existing resources in the Resource Browser *
  • How to get an RRID for a resource (required by Cell Press journals and others) *
  • How to make your protocols more widely available on protocols.io *
  • How to Dockerize your pipeline/application for more reproducible code *
  • FAIR: Is your research FAIR? Get suggestions on how to make your output more FAIR
  • How to make your data more FAIR by depositing in Zenodo *
  • Social Media: Learn how to self-promote your research and/or lab
  • And any other HIRN-related questions you may have!

*  “How to” work best if you bring your specific resource (code, data, protocol) to discuss

Moderator(s):

Human Islet Research Enhancement Center (HIREC) at City of Hope:

  • Layla Rouse, MS, HIRN Program Manager

June 2021 Webinar: “Exploring Humanized Mouse Models For Diabetes Research and Beyond”

Posted on | by Layla Rouse, MS

Click HERE to access the YouTube video of the recording.

June 24, 2021 (2:00 PM Eastern / 11:00 AM Pacific)

Presented by: Michael Brehm, Univ. Massachusetts Medical School

Topics discussed:

  • Overview of history and applications of humanized mice in biomedical research
  • Factors to consider for specific strain selection
  • Models to study human beta cell function
  • Human immune system engraftment parameters and limitations
  • Overview of T1D specific models

 

April 2021 Webinar: “From Donation to Automation: The Ins and Outs of High-Throughput Islet Cell Culture “

Posted on | by Layla Rouse, MS

Click HERE to access the YouTube video of the recording.

April 28, 2021 (2:00 PM Eastern / 11:00 AM Pacific)

Presented by: Bridget Wagner, Broad Institute

Topics discussed:

  • How islets can be used for high-density applications, (e.g. chemical screening)
  • New efforts to use whole islets in high-throughput culture
  • Advantages and disadvantages to each of these methods 
  • Tips on how to apply these methods in your own lab!

March 2021 Webinar: Designing Tools and Materials to Create a Benchtop Window into the Islet-immune Interface

Posted on | by Layla Rouse, MS

Click HERE to access the YouTube video of the recording.

March 2, 2021 (3:00 PM Eastern / 12:00 PM Pacific)

Presentations on:

  • Introduction to HIRN Consortium on Human Islet Biomimetics (CHIB) by Dr. Cherie Stabler, University of Florida
  • Single Cell Gene Expression Analysis, TCR Sequencing and Avatar T Cells by Dr. Luc Teyton, Scripps Research
  • Gene Editing of Primary Human Cells and Human IPSCs by Leanna Peters, University of Florida
  • Sensing Pancreatic Islet Secretions within Microfluidic Devices by Dr. Daniel Steyer, Florida State University
  • Vascular Networks in Microphysiological Systems (MPS) by Dr. Dan Huh, University of Pennsylvania

HIRN 2020 Trainee Scholarship Recipients

Posted on | by Layla Rouse, MS

The following trainees are recipients of the HIRN 2020 Scholarship based on competitive review of abstracts by members of the HIRN Planning Committee.

Joshua Chiou

Institution: University of California, San Diego

Title: Doctoral Graduate Student

Affiliation: HPAC (Gaulton Lab)

Dario De Jesus, PhD

Institution : Joslin Diabetes Center

Title : Postdoctoral Research Fellow

Affiliation : CBDS (Kulkarni Lab)

Shen Dong, PhD

Institution : University of California, San Francisco

Title : Postdoctoral Research Fellow

Affiliation : CMAI (Bluestone Lab)

Angela Kruse, PhD

Institution : Vanderbilt University

Title : Postdoctoral Research Fellow

Affiliation : CBDS (Caprioli Lab)

Rachel Madley

Institution : Columbia University Medical Center

Title : Doctoral Graduate Student

Affiliation : CMAI (Sykes Lab)

Padma Nanaware

Institution : University of Massachusetts Medical School

Title : Postdoctoral Research Fellow

Affiliation : CMAI (Stern Lab)

Emilie Ronin

Institution : University of California, San Francisco

Title : Postdoctoral Research Fellow

Affiliation : CMAI (Tang Lab)

Magdalena Samojlik

Institution : University of Florida

Title : Doctoral Graduate Student

Affiliation : CHIB (Stabler Lab)

Alexandra Theis

Institution : University of Colorado Denver

Title : Doctoral Graduate Student

Affiliation : CBDS (Sussel Lab)

New Awards from RFA-19-024: Discovery of Early Type 1 Diabetes Disease Processes in the Human Pancreas (CBDS)

Posted on | by Layla Rouse, MS

A Stress-Induced
Vicious Cycle in the Development of T1D

U01 DK127747

Peter Arvan*, PhD, University of Michigan
Leslie Satin, PhD, University of Michigan
Scott Soleimanpour, PhD, University of Michigan

 

Alternative RNA Splicing Events Contribute
to the Onset of Islet Dysfunction in T1D

U01 DK127505

Lori Sussel*, PhD, University of Colorado, Investigator
Charles Ansong, PhD, Investigator, Pacific Northwest National Laboratories
Maggie (Pui Yu) Lam,  PhD, co-Investigator, Pacific Northwest National Laboratories
Ernesto Nakayasu, PhD, co-Investigator, Pacific Northwest National Laboratory
Galya Orr, PhD, co-Investigator, Pacific Northwest National Laboratory
Shi Tujin, PhD, co-Investigator, Pacific Northwest National Laboratory

 

Determining the Intrinsic and Environmental
Signal Contributing to Early T1D Progression

U01 DK127777

Shuibing Chen*, PhD, Weill Cornell Medical College
Steven Parker, PhD, Investigator, University of Michigan
Chengyang Liu, PhD, Co-Investigator, University of Pennsylvania

 

Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D

U01 DK127768

Golnaz Vahedi*, PhD, Investigator, University of Pennsylvania

 

The Integrated Stress Response in Human Islets during Early T1D

U01 DK127786

Raghu Mirmira*, PhD, Investigator, University of Chicago
Decio Eizirik, PhD, Investigator, Indiana Biosciences Research Institute
Carmella Evans-Molina, MD, Investigator, Indiana University
Thomas Metz, PhD, Investigator, Pacific Northwest National Laboratory
Bobbie-Jo Webb-Robinson, PhD, Investigator, Pacific Northwest National Laboratory
Sasanka Ramandha, PhD, Investigator, University of Alabama at Birmingham
Scott Oakes, PhD, Co-Investigator, University of Chicago
Sarah Tersey, PhD, Co-Investigator, University of Chicago
Manami Hara, PhD, Co-Investigator, University of Chicago
Ernesto Nakayasu, PhD, Co-Investigator, Pacific Northwest National Laboratory
Emily Sims, MD, Co-Investigator, Indiana University
Wenting Wu, PhD, Co-Investigator, Indiana University
Xiaoyong Lei, PhD, Co-Investigator, University of Alabama at Birmingham

* Denotes Contact PI

NIH NIDDK New Investigator Gateway Award Recipients (2020)

Posted on | by Layla Rouse, MS

Congratulations to the 2020 Recipients of the NIH NIDDK New Investigator Gateway Awards

Congratulations to these four investigators on joining HIRN via the NIH NIDDK Gateway Award Initiative.  This award was designed to ensure that a robust pipeline of talented new investigators will continue to embark on successful careers in type 1 diabetes (T1D) research. The recipients will be embedded within the HIRN scientific framework to provide unique opportunities for New and Early Stage Investigators to increase their understanding of key questions in the field, to network, and to establish unique and potentially long-lasting collaborations that will propel their careers forward. It is anticipated that the Gateway award will provide the support needed to enhance the success of future R01 submissions from New Investigators interested in pursuing careers in T1D research.

Rafael Arrojo e Drigo, PhD

Vanderbilt University

“Mapping the Association of Beta Cell Longevity and Senescence in T1D” (CBDS)

Jing Hughes, PhD

Washington Univ. School of Medicine in Saint Louis

“Primary Cilia in Human T1D Pancreas” (HPAC)

Alok Joglekar, PhD

University of Pittsburgh

“Identification of the Cognate Epitopes of Autoreactive T Cells in T1D” (CMAI)

Amelia Linnemann, PhD

Indiana University.

“Real-time in vivo Analysis of Islet Redox Dynamics” (CBDS)