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Projects
Consortium on Modeling Autoimmune Diabetes
Stem Cell-based Modeling of Type 1 Diabetes to Accelerate Translation of Therapies
Studying the Mechanisms of Initiation and Progression of Beta Cell Death in T1D
Understanding Thymic Epithelial and Hematopoietic Stem Cell-intrinsic Immune Abnormalities Driving T1D in Optimized HIS Mouse Models
Advanced Pancreatic-immune Organoid Models of Type 1 Diabetes Subtypes and Therapeutic Responses
Models to Study the Synergy between Autoimmunity and Metabolism in T1D
Enhancement Center
Human Islet Research Enhancement Center (HIREC)
Pancreas Knowledgebase Program
PanKbase: A Community Hub for Integrated Pancreas Knowledge
An Interactive Resource to Generate and Provide Integrated Knowledge of the Human Pancreas
Consortium on Beta Cell Death & Survival
Active Projects
Image based spatial transcriptomics to identify Beta Cell phenotypes in Type 1 Diabetes
BioStructure & Function Team Leader
Lactate-mediated Metabolic Reprogramming of Beta Cells in T1D Contributes to their Enhanced Plasticity and Dedifferentiation
Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes
Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D
Closed Projects
Mapping the Association of Beta Cell Longevity and Senescence in T1D
Functional and Molecular Characterization of the Human Islet Interferon Alpha Response
Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D
Elucidating the Human Beta Cell Translatome in Health and Disease
Real-time in vivo Analysis of Islet Redox Dynamics
Consortium on Human Islet Biomimetics
Active Projects
Identification of Novel Regulatory Mechanisms Driving Human Beta-Cell Maturation and Function
Gene regulatory programs driving metabolic maturation of human pluripotent stem cell derived β-cells
A microwell perfusion plate for manufacturing and testing Islet-like clusters
Epigenomic Engineering of Stem Cell-Derived Pancreatic Cells
Measuring Islet-wide Function with Soft Integrated Nanoelectronics
Closed Projects
Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft
The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival
Modular Monitoring of Hormone Release from Human Islets
Islet on a Chip
A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
Consortium on Modeling Autoimmune Interactions
Active Projects
Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets
Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells
Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
Humanized Mouse Avatars for T1D
Closed Projects
On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells
Identification of the Cognate Epitopes of Autoreactive T Cells in T1D
HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes
Therapeutic Targeting of the Human Islet Environment
Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
Consortium on Targeting and Regeneration
Active Projects
iSTAR Tregs
Development of platforms for beta cell-specific delivery and ligand discovery
Developing a Platform Technology for β-Cell-Targeted Drug Delivery
Metabolic requirements of pancreatic beta cell proliferation
GABP is a novel regulator of beta cell metabolism and proliferation
Closed Projects
Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells
Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes
One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery
Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells
Human Pancreas Analysis Consortium
Active Projects
Positron emission tomography to characterize beta cell mass in individuals from multiple stages in the progression of type 1 diabetes
Cooperativity between Calcium and cAMP-inducing Agents in Human Alpha and Beta Cells
Linking Human Islet Structural Heterogeneity to Beta Cell State
The Role of Senescent Beta Cells in Type 1 Diabetes and Type 2 Diabetes
Survival and Potential of Insulin-deficient Beta Cells in Type 1 Diabetes
Closed Projects
In vivo Effects of Physical Exercise on Human Islet Structure and Function
Primary Cilia in Human T1D Pancreas
In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas
Single Cell Analysis of the Human Pancreas in Type 1 Diabetes
High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential
Opportunity Pool Projects
Closed Projects
Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes?
The Role of Beta Cell Senescence in the Pathogenesis of Diabetes
A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
The Proteome of Replicating Cells
Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
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