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Projects
Enhancement Center
Human Islet Research Enhancement Center (HIREC)
Consortium on Beta Cell Death & Survival
Active Projects
BioStructure & Function Team Leader
Lactate-mediated Metabolic Reprogramming of Beta Cells in T1D Contributes to their Enhanced Plasticity and Dedifferentiation
Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes
Dissecting Transcriptomics and Epigenomic Signatures of Immune Cells in T1D
Mapping the Association of Beta Cell Longevity and Senescence in T1D
Closed Projects
Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes
Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
High-Resolution Analysis of Juvenile Human Pancreas Maturation
Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging
Single Cell Resolution of Omics Analysis of T1D Islets
Consortium on Human Islet Biomimetics
Active Projects
Epigenomic Engineering of Stem Cell-Derived Pancreatic Cells
Vascular Network-mimetic Oxygen-Transporting Mesh for Islet Graft
Measuring Islet-wide Function with Soft Integrated Nanoelectronics
Microphysiological Systems for Modeling Autoimmunity in Type 1 Diabetes
Engineering a Human Microphysiological System for the Characterization of Islet-Immune Interactions
Closed Projects
The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival
Modular Monitoring of Hormone Release from Human Islets
Islet on a Chip
A 3D Biomimetic Human Islet to Model Beta Cell Function in Health and Disease
A Vascularized 3D Biomimetic for Islet Function and Physiology
Consortium on Modeling Autoimmune Interactions
Active Projects
Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets
On the Plasticity of Beta-cell Antigen Recognition by Diabetogenic CD8 T cells
Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells
Identification of the Cognate Epitopes of Autoreactive T Cells in T1D
Modeling Autoimmune Pathogenesis and Beta Cell Destruction by T1D Immune Systems
Closed Projects
Therapeutic Targeting of the Human Islet Environment
Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance
Analysis of Human Autoreactive T Cell Receptors in vivo
Genetic Regulation of Human Beta Cell Destruction
Consortium on Targeting and Regeneration
Active Projects
Therapeutic Targeting of Human Islets with Recombinant Regulatory T Cells
Gene Therapy for Diabetes
Partial Antagonists of IRE1 RNASE - 'pairs' - to treat type 1 diabetes
One-compound, one-islet: A High-throughput Platform for Small-molecule Discovery
Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
Closed Projects
CAR T Cell Targeting of Human Islets
Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity
Epigenetic Rejuvenation of Human Beta-Cells
In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
Human Pancreas Analysis Consortium
Active Projects
Cooperativity between Calcium and cAMP-inducing Agents in Human Alpha and Beta Cells
Linking Human Islet Structural Heterogeneity to Beta Cell State
The Role of Senescent Beta Cells in Type 1 Diabetes and Type 2 Diabetes
Survival and Potential of Insulin-deficient Beta Cells in Type 1 Diabetes
Using ex vivo, in vivo Models and Patient Mutations to Interrogate Pancreatic Exocrine-Endocrine Cross Talk
Closed Projects
Integrated Program for Human Pancreas Procurement and Analysis
Opportunity Pool Projects
Closed Projects
Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes?
The Role of Beta Cell Senescence in the Pathogenesis of Diabetes
A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
The Proteome of Replicating Cells
Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
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