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Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity
Consortia:
HPAC
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Interpreting non-coding disease-associated human variants using single-cell epigenomics
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation
Rediscovering Primary Cilia in Pancreatic Islets
The human α cell in health and disease
Stomach-derived human insulin-secreting organoids restore glucose homeostasis
Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration
Ca(2+) Release or Ca(2+) Entry, that is the Question: What Governs Ca(2+) Oscillations in Pancreatic Beta Cells?
Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?
Peeling the onion: another layer in the regulation of insulin secretion
Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings
Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death
ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition
Simultaneous Measurement of Changes in Mitochondrial and Endoplasmic Reticulum Free Calcium in Pancreatic Beta Cells
Generation of functional thymic organoids from human pluripotent stem cells
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes
BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced Apoptosis
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
Redox Regulation of m (6) A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes
Scanning electron microscopy of human islet cilia
Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes
Reciprocal regulatory balance within the CLEC16A-RNF41 mitophagy complex depends on an intrinsically disordered protein region
Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant
NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity
Metabolic Messengers: glucagon
An integrated map of cell type-specific gene expression in pancreatic islets
Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data
Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness
A genetic strategy to measure insulin signaling regulation and physiology in Drosophila
Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss
AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics
Regulatory T cell homeostasis: Requisite signals and implications for clinical development of biologics
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
Editorial: Study of pancreatic islets based on human models to understand pathogenesis of diabetes
DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-cell Heterogeneity
A DNA methylation atlas of normal human cell types
Computational workflow and interactive analysis of single-cell expression profiling of islets generated by the Human Pancreas Analysis Program
Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes
Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets
Synthetic cytokine circuits that drive T cells into immune-excluded tumors
The emerging landscape of spatial profiling technologies
Protocol to isolate immune cells from mouse pancreatic lymph nodes and whole pancreas for mass cytometric analyses
Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding
Restoring glutamate receptor signaling in pancreatic alpha cells rescues glucagon responses in type 1 diabetes
The emerging role of regulatory cell-based therapy in autoimmune disease
Acute Recurrent Pancreatitis in a Child With INS-Related Monogenic Diabetes and a Heterozygous Pathogenic CFTR Mutation
Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I
Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity
A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes
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hirnec@coh.org