Engineering synthetic suppressor T cells that execute locally targeted immunoprotective programs

Consortia: CTAR

Reddy NR, Maachi H, Xiao Y, Simic MS, Yu W, Tonai Y, Cabanillas DA, Serrano-Wu E, Pauerstein PT, Tamaki W, Allen GM, Parent AV, Hebrok M, Lim WA.
Science. 2024 Dec 6;386(6726):eadl4793. doi: 10.1126/science.adl4793. Epub 2024 Dec 6. PMID:39636990

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Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset Role of Sec61α2 translocon in insulin biosynthesis m(6)A mRNA methylation by METTL14 regulates early pancreatic cell differentiation Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanisms RNA Splicing Events in Circulation Distinguish Individuals with and without New-Onset Type 1 Diabetes m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1 Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead Limitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived β cells CNTools: A computational toolbox for cellular neighborhood analysis from multiplexed images Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression Sodium butyrate prevents cytokine-induced β-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry 12-Lipoxygenase inhibition suppresses islet immune and inflammatory responses and delays autoimmune diabetes in human gene replacement mice Everything You Wanted to Know About Pancreatic Ducts But Didn’t Know Where to Look No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data Diabetes mellitus-Progress and opportunities in the evolving epidemic Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h Identification of unique cell type responses in pancreatic islets to stress The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes HumanIslets: An integrated platform for human islet data access and analysis A metabolic redox relay supports ER proinsulin export in pancreatic islet β-cells Untangling the genetics of beta cell dysfunction and death in type 1 diabetes Beta cell dedifferentiation in type 1 diabetes: sacrificing function for survival? LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels
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