IFN-α Induces Heterogenous ROS Production in Human β-Cells

Consortia: CBDS, HPAC

Wagner LE, Melnyk O, Turner A, Duffett BE, Muralidharan C, Martinez-Irizarry MM, Arvin MC, Orr KS, Manduchi E, Kaestner KH, Brozinick JT, Linnemann AK.
bioRxiv. 2025 Feb 20:2025.02.19.639120. doi: 10.1101/2025.02.19.639120. PMID:40027743

All IFN-α Induces Heterogenous ROS Production in Human β-Cells Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis Expanding the engineered Treg multiverse TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy A Recombinase-Mediated Cassette Exchange Platform for a Triple Independent Inducible Expression System for Human Pluripotent Stem Cells Retrograde mitochondrial signaling governs the identity and maturity of metabolic tissues Identification of a vimentin-expressing α-cell phenotype in CF and normal pancreas Data from a multi-year targeted proteomics study of a longitudinal birth cohort of type 1 diabetes Generation of Human Chimeric Antigen Receptor Regulatory T Cells NKX2.2 and KLF4 cooperate to regulate α-cell identity Divergent roles of m(6)A 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