Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes

Consortia: HPAC

Qadir MMF, Elgamal RM, Song K, Kudtarkar P, Sakamuri SSVP, Katakam PV, El-Dahr SS, Kolls JK, Gaulton KJ, Mauvais-Jarvis F.
EMBO J. 2024 Nov 20. doi: 10.1038/s44318-024-00313-z. Online ahead of print. PMID:39567827

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LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels Roadblocks confronting widespread dissemination and deployment of Organs on Chips AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater Unfolding emergency calls stress granules to the ER
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