Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells

Consortia: CBDS, CMAI, Opportunity Pool Projects

Barra JM, Robino RA, Castro-Gutierrez R, Proia J, Russ HA, Ferreira LMR.
Cell Rep. 2024 Nov 18;43(11):114994. doi: 10.1016/j.celrep.2024.114994. PMID:39561045

All The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets Sex-specific regulatory architecture of pancreatic islets from subjects with and without type 2 diabetes Combinatorial genetic engineering strategy for immune protection of stem cell-derived beta cells by chimeric antigen receptor regulatory T cells β-Cell gene expression stress signatures in types 1 and 2 diabetes 12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP Human peripancreatic adipose tissue paracrine signaling impacts insulin secretion, blood flow, and gene transcription The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium Emerging concepts and success stories in type 1 diabetes research: a roadmap for a bright future Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice Vagal sensory neuron-derived FGF3 controls insulin secretion HumanIslets.com: Improving accessibility, integration, and usability of human research islet data Cryopreservation of Stem Cell-Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset Role of Sec61α2 translocon in insulin biosynthesis m(6)A mRNA methylation by METTL14 regulates early pancreatic cell differentiation Genotype inference from aggregated chromatin accessibility data reveals genetic regulatory mechanisms RNA Splicing Events in Circulation Distinguish Individuals with and without New-Onset Type 1 Diabetes m(6)A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1 Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead Limitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived β cells CNTools: A computational toolbox for cellular neighborhood analysis from multiplexed images Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk Exploring new frontiers in type 1 diabetes through advanced mass-spectrometry-based molecular measurements Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression Sodium butyrate prevents cytokine-induced β-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry 12-Lipoxygenase inhibition suppresses islet immune and inflammatory responses and delays autoimmune diabetes in human gene replacement mice Everything You Wanted to Know About Pancreatic Ducts But Didn’t Know Where to Look No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data Diabetes mellitus-Progress and opportunities in the evolving epidemic Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h Identification of unique cell type responses in pancreatic islets to stress The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes HumanIslets: An integrated platform for human islet data access and analysis A metabolic redox relay supports ER proinsulin export in pancreatic islet β-cells Untangling the genetics of beta cell dysfunction and death in type 1 diabetes Beta cell dedifferentiation in type 1 diabetes: sacrificing function for survival? LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels Roadblocks confronting widespread dissemination and deployment of Organs on Chips AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater Unfolding emergency calls stress granules to the ER
Follow
×

Follow

us on our social networks.

Email: hirnec@coh.org