Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis

Consortia: CBDS

Costa-Junior JM, Coomans de Brachène A, Musuaya AE, Zimath PL, Martin-Vazquez E, Oliveira JG, Carpentier J, Faoro V, Klass M, Cnop M, Eizirik DL.
Diabetologia. 2025 Apr 12. doi: 10.1007/s00125-025-06426-2. PMID:40220193

All Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative Type 1 diabetes presenting in adults: Trends, diagnostic challenges and unique features Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis Oxygen dynamics and delivery strategies to enhance beta cell replacement therapy Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators The type 1 diabetes candidate genes PTPN2 and BACH2 regulate novel IFN-α-induced crosstalk between the JAK/STAT and MAPKs pathways in human beta cells Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay Target Discovery to Diabetes Therapy-TXNIP From Bench to Bedside With NIDDK IFN-α Induces Heterogenous ROS Production in Human β-Cells Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes 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as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP Human peripancreatic adipose tissue paracrine signaling impacts insulin secretion, blood flow, and gene transcription Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium Emerging concepts and success stories in type 1 diabetes research: a roadmap for a bright future Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice Vagal sensory neuron-derived FGF3 controls insulin secretion Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase Thermal Denaturation of Fresh Frozen Tissue Enhances Mass Spectrometry Detection of Peptides
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