Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay

Consortia: HIREC

van Tienhoven R, O’Meally D, Scott TA, Morris KV, Williams JC, Kaddis JS, Zaldumbide A, Roep BO.
Cell. 2025 May 1;188(9):2407-2416.e9. doi: 10.1016/j.cell.2025.02.018. Epub 2025 Mar 19. PMID:40112799

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as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes Maturation and persistence of CAR T cells derived from human pluripotent stem cells via chemical inhibition of G9a/GLP Human peripancreatic adipose tissue paracrine signaling impacts insulin secretion, blood flow, and gene transcription Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium Emerging concepts and success stories in type 1 diabetes research: a roadmap for a bright future Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice Vagal sensory neuron-derived FGF3 controls insulin secretion Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase Thermal Denaturation of Fresh Frozen Tissue Enhances Mass Spectrometry Detection of Peptides
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