Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase

Consortia: CBDS

O’Carroll SM, Peace CG, Toller-Kawahisa JE, Min Y, Hooftman A, Charki S, Kehoe L, O’Sullivan MJ, Zoller A, Mcgettrick AF, Zotta A, Day EA, Simarro M, Armstrong N, Annes JP, O’Neill LAJ.
Nat Metab. 2024 Nov;6(11):2060-2069. doi: 10.1038/s42255-024-01145-1. Epub 2024 Oct 15. PMID:39406969

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