Single cell transcriptomics of human islet ontogeny defines the molecular basis of β cell dedifferentiation in T2D

Consortia: CTAR, HPAC

Avrahami D, Wang YJ, Schug J, Feleke E, Gao L, Liu C, Consortium HPAP, Naji A, Glaser B, Kaestner KH.
Mol Metab. 2020 Jul 30:101057. doi: 10.1016/j.molmet.2020.101057. PMID:32739450

All Increasing insulin measurement throughput by fluorescence anisotropy imaging immunoassays α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes T1D patient-derived hematopoietic stem cells are programmed to generate Tph, Tfh, and autoimmunity-associated B cell subsets in human immune system mice An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy Polycomb Repressive Complexes: Shaping Pancreatic Beta-Cell Destiny in Development and Metabolic Disease The Foundation for Engineering a Pancreatic Islet Niche Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice Genome Engineering Human ESCs or iPSCs with Cytosine and Adenine Base Editors Small molecules released from islets of Langerhans determined by liquid chromatography – mass spectrometry Trafficking and persistence of alloantigen-specific chimeric antigen receptor regulatory T cells in Cynomolgus macaque Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis Small-molecule discovery in the pancreatic beta cell Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis Generation of human islet cell type-specific identity genesets Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity Anti-HLA-A2-CAR Tregs prolong vascularized mouse heterotopic heart allograft survival Citrullination of glucokinase is linked to autoimmune diabetes Rational Design of Silicon-Based Zinc Ionophores RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells Pulsatile Basal Insulin Secretion is Driven by Glycolytic Oscillations Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo Emerging Diabetes Therapies: Bringing back the β-cells Stripenn detects architectural stripes from chromatin conformation data using computer vision Development of a beta cell-specific expression control element for rAAV Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes Deletion of Gdf15 reduces ER stress-induced beta cell apoptosis and diabetes Limited extent and consequences of pancreatic SARS-CoV-2 infection Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes Nmp4, a Regulator of Induced Osteoanabolism, Also Influences Insulin Secretion and Sensitivity GDF15: a potential therapeutic target for type 1 diabetes The IGFBP3/TMEM219 pathway regulates beta cell homeostasis From the dish to humans: A stem cell recipe for success Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state 3-D printed microfluidics for rapid prototyping and testing of electrochemical, aptamer-based sensor devices under flow conditions Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury Transgenic Drosophila lines for LexA-dependent gene and growth regulation Cryopreservation and post-thaw characterization of dissociated human islet cells Islet Lymphocytes Maintain a Stable Regulatory Phenotype Under Homeostatic Conditions and Metabolic Stress Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development Improving the Prediction of Type 1 Diabetes Across Ancestries HOMA2-B enhances assessment of type 1 diabetes risk among TrialNet Pathway to Prevention participants Robust differentiation of human enteroendocrine cells from intestinal stem cells Cell maturation: Hallmarks, triggers, and manipulation The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction
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