Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity

Consortia: CTAR

Small JC, Joblin-Mills A, Carbone K, Kost-Alimova M, Ayukawa K, Khodier C, Dancik V, Clemons PA, Munkacsi AB, Wagner BK.
ACS Chem Biol. 2022 Apr 19. doi: 10.1021/acschembio.2c00052. Online ahead of print. PMID:35439415

All Genome Engineering Human ESCs or iPSCs with Cytosine and Adenine Base Editors Small molecules released from islets of Langerhans determined by liquid chromatography – mass spectrometry Trafficking and persistence of alloantigen-specific chimeric antigen receptor regulatory T cells in Cynomolgus macaque Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis Small-molecule discovery in the pancreatic beta cell Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis Generation of human islet cell type-specific identity genesets Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity Anti-HLA-A2-CAR Tregs prolong vascularized mouse heterotopic heart allograft survival Citrullination of glucokinase is linked to autoimmune diabetes Rational Design of Silicon-Based Zinc Ionophores RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells Pulsatile Basal Insulin Secretion is Driven by Glycolytic Oscillations Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo Emerging Diabetes Therapies: Bringing back the β-cells Stripenn detects architectural stripes from chromatin conformation data using computer vision Development of a beta cell-specific expression control element for rAAV Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes Deletion of Gdf15 reduces ER stress-induced beta cell apoptosis and diabetes Limited extent and consequences of pancreatic SARS-CoV-2 infection Exploratory study reveals far reaching systemic and cellular effects of verapamil treatment in subjects with type 1 diabetes Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes GDF15: a potential therapeutic target for type 1 diabetes The IGFBP3/TMEM219 pathway regulates beta cell homeostasis From the dish to humans: A stem cell recipe for success Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state 3-D printed microfluidics for rapid prototyping and testing of electrochemical, aptamer-based sensor devices under flow conditions Single-Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury Transgenic Drosophila lines for LexA-dependent gene and growth regulation Cryopreservation and post-thaw characterization of dissociated human islet cells Islet Lymphocytes Maintain a Stable Regulatory Phenotype Under Homeostatic Conditions and Metabolic Stress Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections Integration of single-cell transcriptomes and chromatin landscapes reveals regulatory programs driving pharyngeal organ development Improving the Prediction of Type 1 Diabetes Across Ancestries HOMA2-B enhances assessment of type 1 diabetes risk among TrialNet Pathway to Prevention participants Robust differentiation of human enteroendocrine cells from intestinal stem cells Cell maturation: Hallmarks, triggers, and manipulation The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function Paternal Exercise Improves the Metabolic Health of Offspring via Epigenetic Modulation of the Germline RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes The Deterrence of Rapid Metabolic Decline Within 3 Months After Teplizumab Treatment in Individuals at High Risk for Type 1 Diabetes Modeling human T1D-associated autoimmune processes Targeting the Pancreatic α-Cell to Prevent Hypoglycemia in Type 1 Diabetes Remote immune processes revealed by immune-derived circulating cell-free DNA Substance Use Affects Type 1 Diabetes Pancreas Pathology: Implications for Future Studies CAR T-Cell Therapy: Is CD28-CAR Heterodimerization Its Achilles’ Heel?


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