Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity

Consortia: CTAR

Small JC, Joblin-Mills A, Carbone K, Kost-Alimova M, Ayukawa K, Khodier C, Dancik V, Clemons PA, Munkacsi AB, Wagner BK.
ACS Chem Biol. 2022 Apr 19. doi: 10.1021/acschembio.2c00052. Online ahead of print. PMID:35439415

All Enhanced development of functional human NK cells in NOD-scid-IL2rg(null) mice expressing human IL15 Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity Precision medicine in type 1 diabetes Alpha cell TXNIP deletion improves diabetes-associated hyperglycemia and hyperglucagonemia Every islet matters: improving the impact of human islet research Adaptation to chronic ER stress enforces pancreatic β-cell plasticity Predicting Misdiagnosed Adult-onset Type 1 Diabetes Using Machine Learning EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events? The Yin and Yang of Modulating β-Cell DNA Damage Response and Functional Mass Characterizing cis-regulatory elements using single-cell epigenomics Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling Type I but Not Type II Calreticulin Mutations Activate the IRE1α/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors Increasing insulin measurement throughput by fluorescence anisotropy imaging immunoassays α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes LGR4, a G Protein-Coupled Receptor With a Systemic Role: From Development to Metabolic Regulation Human CD4(+)CD25(+)CD226(-) Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4(+)CD25(+)CD127(lo/-) Tregs for Adoptive Cell Therapy T1D patient-derived hematopoietic stem cells are programmed to generate Tph, Tfh, and autoimmunity-associated B cell subsets in human immune system mice An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy Polycomb Repressive Complexes: Shaping Pancreatic Beta-Cell Destiny in Development and Metabolic Disease The Foundation for Engineering a Pancreatic Islet Niche Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice Genome Engineering Human ESCs or iPSCs with Cytosine and Adenine Base Editors Small molecules released from islets of Langerhans determined by liquid chromatography – mass spectrometry Trafficking and persistence of alloantigen-specific chimeric antigen receptor regulatory T cells in Cynomolgus macaque Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis Small-molecule discovery in the pancreatic beta cell Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis Generation of human islet cell type-specific identity genesets Phenotypic Screening for Small Molecules that Protect β-Cells from Glucolipotoxicity Anti-HLA-A2-CAR Tregs prolong vascularized mouse heterotopic heart allograft survival Citrullination of glucokinase is linked to autoimmune diabetes Rational Design of Silicon-Based Zinc Ionophores RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells Pulsatile Basal Insulin Secretion is Driven by Glycolytic Oscillations Expanded LUXendin Color Palette for GLP1R Detection and Visualization In Vitro and In Vivo Emerging Diabetes Therapies: Bringing back the β-cells Stripenn detects architectural stripes from chromatin conformation data using computer vision Development of a beta cell-specific expression control element for rAAV Deletion of Gdf15 reduces ER stress-induced beta cell apoptosis and diabetes Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes A LexAop > UAS > QUAS trimeric plasmid to generate inducible and interconvertible Drosophila overexpression transgenes Limited extent and consequences of pancreatic SARS-CoV-2 infection
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