Immunoprotection of cellular transplants for autoimmune type 1 diabetes through local drug delivery

Consortia: CHIB

Lansberry TR, Stabler CL.
Adv Drug Deliv Rev. 2024 Mar;206:115179. doi: 10.1016/j.addr.2024.115179. Epub 2024 Jan 28. PMID:38286164

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LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels Roadblocks confronting widespread dissemination and deployment of Organs on Chips AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model Do We Need a New Hypothesis for KATP Closure in β-Cells? 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