Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead

Consortia: CBDS, Opportunity Pool Projects

Grattoni A, Korbutt G, Tomei AA, García AJ, Pepper AR, Stabler C, Brehm M, Papas K, Citro A, Shirwan H, Millman JR, Melero-Martin J, Graham M, Sefton M, Ma M, Kenyon N, Veiseh O, Desai TA, Nostro MC, Marinac M, Sykes M, Russ HA, Odorico J, Tang Q, Ricordi C, Latres E, Mamrak NE, Giraldo J, Poznansky MC, de Vos P.
Nat Rev Endocrinol. 2024 Sep 3. doi: 10.1038/s41574-024-01029-0. PMID:39227741

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in orchestrating brown and white adipocyte transcriptomes and systemic metabolism CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading BETA CELL DYSFUNCTION OCCURS INDEPENDENTLY OF INSULITIS IN TYPE 1 DIABETES PATHOGENESIS TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition The N6-methyladenosine RNA epigenetic modification modulates the amplification of coxsackievirus B1 in human pancreatic beta cells G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells Changes in immunofluorescence staining during islet regeneration in a cystic fibrosis-related diabetes (CFRD) ferret model SARS-CoV-2 Spike S1 subunit triggers pericyte and microvascular dysfunction in human pancreatic islets T Cell Development and Responses in Human Immune 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homeostasis and longevity in mice Vagal sensory neuron-derived FGF3 controls insulin secretion Itaconate drives mtRNA-mediated type I interferon production through inhibition of succinate dehydrogenase Thermal Denaturation of Fresh Frozen Tissue Enhances Mass Spectrometry Detection of Peptides Characterization of non-coding variants associated with transcription factor binding through ATAC-seq-defined footprint QTLs in liver HumanIslets.com: Improving accessibility, integration, and usability of human research islet data Cryopreservation of Stem Cell-Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function Sol-moiety: Discovery of a water-soluble prodrug technology for enhanced oral bioavailability of insoluble therapeutics Increased Inflammation as well as Decreased Endoplasmic Reticulum Stress and Translation Differentiate Pancreatic Islets of Pre-symptomatic Stage 1 Type 1 Diabetes and Non-diabetic Cases Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset Role of Sec61α2 translocon in insulin biosynthesis m(6)A mRNA methylation by METTL14 regulates early pancreatic cell differentiation
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