HOMA2-B enhances assessment of type 1 diabetes risk among TrialNet Pathway to Prevention participants

Consortia: CBDS

Felton JL, Cuthbertson D, Warnock M, Lohano K, Meah F, Wentworth JM, Sosenko J, Evans-Molina C; Type 1 Diabetes TrialNet Study Group.
Diabetologia. 2022 Jan;65(1):88-100. doi: 10.1007/s00125-021-05573-6. Epub 2021 Oct 12. PMID:34642772

All A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes Reference compounds for characterizing cellular injury in high-content cellular morphology assays Redox Regulation of m (6) A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes Scanning electron microscopy of human islet cilia Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes Cell Replacement Therapy for Type 1 Diabetes Patients: Potential Mechanisms Leading to Stem-Cell-Derived Pancreatic β-Cell Loss upon Transplant NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity An integrated map of cell type-specific gene expression in pancreatic islets Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss AnnoSpat annotates cell types and quantifies cellular arrangements from spatial proteomics Regulatory T cell homeostasis: Requisite signals and implications for clinical development of biologics Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression Editorial: Study of pancreatic islets based on human models to understand pathogenesis of diabetes DNA methylation Dependent Restriction of Tyrosine Hydroxylase Contributes to Pancreatic β-cell Heterogeneity A DNA methylation atlas of normal human cell types Computational workflow and interactive analysis of single-cell expression profiling of islets generated by the Human Pancreas Analysis Program Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes Micropyramid-patterned, oxygen-permeable bottomed dish for high density culture of pancreatic islets Synthetic cytokine circuits that drive T cells into immune-excluded tumors The emerging landscape of spatial profiling technologies Protocol to isolate immune cells from mouse pancreatic lymph nodes and whole pancreas for mass cytometric analyses Restoring glutamate receptor signaling in pancreatic alpha cells rescues glucagon responses in type 1 diabetes The emerging role of regulatory cell-based therapy in autoimmune disease Human stem cell derived beta-like cells engineered to present PD-L1 improve transplant survival in NOD mice carrying human HLA class I Acute Recurrent Pancreatitis in a Child With INS-Related Monogenic Diabetes and a Heterozygous Pathogenic CFTR Mutation Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes Ca2+ Oscillations, Waves, and Networks in Islets from Human Donors With and Without Type 2 Diabetes Islet cilia and glucose homeostasis Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation Microwell culture platform maintains viability and mass of human pancreatic islets The dichotomous outcomes of TNFα signaling in CD4(+) T cells Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning Generation of non-human primate CAR Tregs using artificial antigen-presenting cells, simian tropic lentiviral vectors, and antigen-specific restimulation Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis Geometric engineering of organoid culture for enhanced organogenesis in a dish Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity Exploring Computational Data Amplification and Imputation for the Discovery of Type 1 Diabetes (T1D) Biomarkers from Limited Human Datasets The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells Mouse models and human islet transplantation sites for intravital imaging Direct Reprogramming of Different Cell Lineages into Pancreatic β-Like Cells Yo-Yo Dieting: Mixed Messages for β-Cell Plasticity Stem cell-based multi-tissue platforms to model human autoimmune diabetes Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress
Follow
×

Follow

us on our social networks.

Email: hirnec@coh.org