The HIRN 2019 Annual Investigator Meeting will be held April 28 – May 1, 2019 at the Capital Hilton in Washington, DC.
Author: Layla Rouse, MS
New Award: RFA-DK-18-021: Discovery of Early Type 1 Diabetes Disease Biomarkers in the Human Pancreas (CBDS)
One new HIRN CBDS grant was awarded “Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D” to Dr. Anath Shalev at the University of Alabama at Birmingham.
Summary: The objective of this HIRN grant is to establish a non-invasive biomarker for pancreatic beta cell loss in humans with T1D and help develop novel approaches for the early diagnosis and treatment of T1D.
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| Anath Shalev, MD | Shalev Lab Members | Visual Schematic of Project |
New Awards: RFA-DK-17-022: High-Resolution Exploration of the Human Islet Tissue Environment (HPAC)
New HIRN Grants from RFA-DK-17-022: High-Resolution Exploration of the Human Islet Tissue Environment (HPAC)
HPAC
High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential
U01 DK120393
Juan Dominguez-Bendala (Univ. of Miami)*
Investigator: Ricardo Pastori (Univ. of Miami)
Co-Investigator: Alejandro Caicedo (Univ. of Miami)
Co-Investigator: Camillo Ricordi (Univ. of Miami.)
Maike Sander (Univ. California, San Diego)*
Kyle Jeffrie Gaulton (Univ. California, San Diego)
Co-Investigator: David Gorkin (Univ. California, San Diego)
Co-Investigator: Sebastian Preissl (Univ. California, San Diego)
Co-Investigator: Al Powers (Vanderbilt Univ.)
HPAC
In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions during Early Postnatal Development of the Human Pancreas
U01 DK120456
Alejandro Caicedo (Univ. Miami)*
Co-Investigator: Marcela Brissova (Vanderbilt Univ.)
Co-Investigator: Stephan Speier (Paul Langerhans Institut)
Patrick MacDonald (Univ. of Alberta)*
Co-Investigator: Stephen Quake (Stanford Univ.)
Co-Investigator: Martin Hetzer (Salk Institute)
Co-Investigator: Emma Lundberg (KTH Stockholm)
Co-Investigator: Seung Kim (Stanford Univ.)/p>
* Denotes Contact PI
HIRN 2018 New Investigator Award Recipients
Recipients of the HIRN 2018 New Investigator Awards
Seven investigators were selected to carryout bold and highly innovative new research approaches to biological problems under current investigation in HIRN. They will join their respective consortium conference calls and attend the HIRN Annual Investigator Meeting.
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Joana Almaca, PhD, University of Miami
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Sangeeta Dhawan, PhD, Beckman Research Institute of the City of Hope
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Abdelfattah El Ouaamari, PhD, Rutgers University
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Eddie James, PhD, Benaroya Research Institute
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Amelia Linnemann, PhD, Indiana University
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Holger Russ, PhD, University of Colorado, Denver
HIRN 2018 Annual Investigator Meeting: May 8 – 11, 2018
The 2018 HIRN Annual Investigator Meeting will be held from May 8 – 11, 2018 at the Capital Hilton in Washington DC.
New Awards: RFA-DK-17-003: Therapeutic Targeting of the Human Islet Environment (UC4)
New HIRN Grants from RFA-DK-17-003: Therapeutic Targeting of the Human Islet Environment (UC4)
Paolo Serafini (Univ. of Miami)*
Midhat Abdulreda (Univ. of Miami)
Co-Investigator: Peter Buchwald (Univ. of Miami)
Co-Investigator: Camillo Ricordi (Univ. of Miami)
Co-Investigator: Natasa Strbo (Univ. of Miami)
Jeffrey Bluestone (Univ. California, San Francisco)*
Wendell Lim (Univ. California, San Francisco)
Co-Investigator: Qizhi Tang (Univ. California, San Francisco)
Co-Investigator: Kole Roybal (Univ. California, San Francisco)
Seung Kim (Stanford Univ.)*
Everett Meyer (Stanford Univ)
Co-Investigator: Philip Streeter (Oregon Health & Science Univ.)
CTAR
Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
UC4 DK116255
Amit Choudhary (Broad Institute)*
Bridget Wagner (Broad Institute)
Rohit Kulkarni (Joslin Diabetes Center)
* Denotes Contact PI
RFA-DK-17-004: Competitive Collaborative Projects for Human Islet Biology (UC4)
New Awards: RFA-DK-17-004: Competitive Collaborative Projects for Human Islet Biology (UC4)
CTAR
Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling
UC4 DK116280
Qiao Zhou (Harvard Univ.)*
Stephan Kissler (Joslin Diabetes Center)
Sally Kent (Univ. of Massachusetts Medical School)*
David Harlan (Univ. of Massachusetts Medical School)
Lawrence Stern (Univ. of Massachusetts Medical School)
Co-Investigator: Dirk Homann (Mount Sinai School of Medicine)
Michael Roper (Florida State Univ.)*
Christopher Hughes (Univ. of California, Irvine)
Ryan White (Univ. of Cincinatti)
CBDS
Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms
UC4 DK116274
Desmond Schatz (Univ. Florida)*
Yuval Dor (Hebrew Univ. of Jerusalem)
Carla Greenbaum (Benaroya Research Institute at Virginia Mason)
Rohit Kulkarni (Joslin Diabetes Center)*
Chuan He (Univ. of Chicago)
Klaus Kaestner (Univ. of Pennsylvania)*
Yuval Dor (Hebrew Univ. of Jerusalem)
Ali Naji (Univ. of Pennsylvania)
* Denotes Contact PI
HIRN CHIB In-Person Investigator Meeting: October 23 – 24, 2017
HIRN CHIB In-Person Investigator: The meeting will take place The CHIB in-person Investigator Meeting will be held on Monday, October 23 – Tuesday, October 24, 2017 at the University of California, San Diego in California. A Welcome Reception will be held on late afternoon on Sunday, October 22, 2016
New HPAP Consortium – October 2016
A fifth consortium, Human Pancreas Analysis Program (HPAP), has been added to HIRN. These two awards were made in response to a NIH NIDDK initiative (RFA-DK-15-027). The primary goal of HPAP is to accumulate, analyze, and distribute high value T1D datasets to the diabetes research community.
New CMAI Award – October 2016
One new project has been added to the CMAI portfolio, “Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance“. This project is led by Drs. Mark Anderson, Jeffrey Bluestone and Matthias Hebrok at the University of California, San Francisco.
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