NIH NIDDK New Investigator Gateway Award Recipients (2020)

Congratulations to the 2020 Recipients of the NIH NIDDK New Investigator Gateway Awards

Congratulations to these four investigators on joining HIRN via the NIH NIDDK Gateway Award Initiative.  This award was designed to ensure that a robust pipeline of talented new investigators will continue to embark on successful careers in type 1 diabetes (T1D) research. The recipients will be embedded within the HIRN scientific framework to provide unique opportunities for New and Early Stage Investigators to increase their understanding of key questions in the field, to network, and to establish unique and potentially long-lasting collaborations that will propel their careers forward. It is anticipated that the Gateway award will provide the support needed to enhance the success of future R01 submissions from New Investigators interested in pursuing careers in T1D research.

August 2020 Webinar: “The Development and Use of Adeno-Associated Virus (AAV) Vectors”

Click HERE to access the YouTube video of the recording.

August 24, 2020 (3:00 PM Eastern / 12:00 PM Pacific)

Presented by:
Hiroyuki Nakai, Oregon Heath & Science University

Mark Kay, Stanford University

Topics discussed:

–  Discuss how AAV Vectors were developed
–  Discuss how AAV vectors are and can be used in clinical medicine
– 
Discuss future applications of AAV vector technology
–  Learn AAV vector-related resources available to investigators

New Awards: RFA-DK-18-013: HIRN Consortium on Modeling Autoimmune Interactions (CMAI)

New HIRN Grants from RFA-18-013: HIRN Consortium on Modeling Autoimmune Interactions (CMAI)

Megan Sykes*, MD, Columbia University, Investigator
Mark Anderson, MD, PhD, University of California, San Francisco, Investigator
Matthias Hebrok, PhD, University of California, San Francisco, Investigator
Audrey Parent, PhD, University of California, San Francisco, Investigator 
Remi J Creusot, PhD, Columbia University, Co-Investigator
Robin Goland, MD, Columbia University, Co-Investigator

CMAI

Humanized Mouse Avatars
for T1D

UC4 DK104218**

Dale Greiner*, PhD, University of Massachusetts Medical School, Investigator
Michael Brehm, PhD, University of Massachusetts Medical School, Investigator
Leonard Schultz, PhD, The Jackson Laboratory, Investigator
George Daley, PhD, Harvard University, Investigator
Doug Melton, PhD, Harvard University, Investigator
Rene Maehr, PhD, University of Massachusetts Medical School, Co-Investigator
David Harlan, MD, University of Massachusetts Medical School, Co-Investigator

* Denotes Contact PI
** Grant Renewal

New Awards: RFA-DK-18-011: HIRN Consortium on Human Islet Biomimetics (CHIB)

New HIRN Grants from RFA-18-011: HIRN Consortium on Human Islet Biomimetics (CHIB)

Cherie Stabler, PhD (Univ. of Florida)*
Investigator: Ashu Agarwal, PhD (Univ. Miami)
Investigator: Todd Brusko, PhD (Univ. Florida)
Investigator: Clayton Mathews, PhD (Univ. Florida)
Co-Investigator: Rhonda Bacher, PhD (Univ. Florida)
Co-Investigator: Edward Phelps, PhD (Univ. Florida)
Co-Investigator: Naohiro Terada, PhD(Univ. Florida)

Maike Sander, MD (Univ. California, San Diego)*
Investigator: Christopher Hughes, PhD (Univ. California, Irvine)
Co-Investigator: Luc Teyton, MD, PhD (Scripps Research Institute)
Co-Investigator: Karen Christman, PhD (Univ. California, San Diego)
Co-Investigator: Steven George, PhD (Univ. California, Davis)

Ben Stanger, PhD (Univ. Pennsylvania)*
Investigator: Dan Hugh, PhD (Univ. Pennsylvania)
Investigator: James Riley, PhD (Univ. Pennsylvania) 
Co-Investigator: Ali Naji, MD (Univ. Pennsylvania)
Co-Investigator: Wenli Yang, PhD (Univ. Pennsylvania) 

* Denotes Contact PI

New Awards from RFA-18-014: HIRN Consortium on Targeting and Regeneration (CTAR)

Bridget Wagner*, PhD, Broad Institute, Investigator
Amit Choudhary, PhD, Broad Institute, Investigator
Rohit Kulkarni MD, PhD, Joslin Diabetes Center, Investigator

 

Gene Therapy for Diabetes

U01 DK123608

Hiroyuki Nakai*, PhD, Oregon Health and Science University, Investigator
Markus Grompe, PhD, Oregon Health and Science University, Investigator
Mark Kay, MD, PhD, Stanford University, Investigator

Feroz Papa*, MD, PhD, Univ. California, San Francisco, Investigator
Dustin Maly, PhD, University of Washington, Investigator

Seung Kim*, MD, PhD, Stanford University, Investigator
Everett Meyer, MD, PhD, Stanford University, Investigator
Alvin Powers, MD, Vanderbilt University, Investigator

* Denotes Contact PI

New Award: RFA-DK-18-021: Discovery of Early Type 1 Diabetes Disease Biomarkers in the Human Pancreas (CBDS)

One new HIRN CBDS grant was awarded “Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D” to Dr. Anath Shalev at the University of Alabama at Birmingham. 

Summary: The objective of this HIRN grant is to establish a non-invasive biomarker for pancreatic beta cell loss in humans with T1D and help develop novel approaches for the early diagnosis and treatment of T1D.

Anath Shalev, MD Shalev Lab Members Visual Schematic of Project

New Awards: RFA-DK-17-022: High-Resolution Exploration of the Human Islet Tissue Environment (HPAC)

New HIRN Grants from RFA-DK-17-022: High-Resolution Exploration of the Human Islet Tissue Environment (HPAC)

Juan Dominguez-Bendala (Univ. of Miami)*
Investigator: Ricardo Pastori (Univ. of Miami)
Co-Investigator: Alejandro Caicedo (Univ. of Miami)
Co-Investigator: Camillo Ricordi (Univ. of Miami.)

Maike Sander (Univ. California, San Diego)*
Kyle Jeffrie Gaulton (Univ. California, San Diego)
Co-Investigator: David Gorkin (Univ. California, San Diego)
Co-Investigator: Sebastian Preissl (Univ. California, San Diego)
Co-Investigator: Al Powers (Vanderbilt  Univ.)

Alejandro Caicedo (Univ. Miami)*
Co-Investigator: Marcela Brissova (Vanderbilt Univ.)
Co-Investigator: Stephan Speier (Paul Langerhans Institut)

Patrick MacDonald (Univ. of Alberta)*
Co-Investigator: Stephen Quake (Stanford Univ.)
Co-Investigator: Martin Hetzer (Salk Institute)
Co-Investigator: Emma Lundberg (KTH Stockholm)
Co-Investigator: Seung Kim (Stanford Univ.)/p>

* Denotes Contact PI

HIRN 2018 New Investigator Award Recipients

Recipients of the HIRN 2018 New Investigator Awards

Seven investigators were selected to carryout bold and highly innovative new research approaches to biological problems under current investigation in HIRN.  They will join their respective consortium conference calls and attend the HIRN Annual Investigator Meeting.