The IsletTester mouse: an immunodeficient model with stable hyperglycemia for the study of human islets

Consortia: CHIB, HPAC

Waite EL, Tigue M, Yu M, Lahori D, Kelly K, May CL, Naji A, Roman J, Doliba N, Avrahami D, Nguyen-Ngoc KV, Sander M, Glaser B, Kaestner KH.
Diabetes. 2024 Nov 21:db230887. doi: 10.2337/db23-0887. Online ahead of print. PMID:39571094

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LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes Inhibition of the eukaryotic initiation factor-2-α kinase PERK decreases risk of autoimmune diabetes in mice Enhancing Therapeutic Insulin Transport from Macroencapsulated Islets Using Sub-Minute Pressure at Physiological Levels Roadblocks confronting widespread dissemination and deployment of Organs on Chips AAV Capsid Screening for Translational Pig Research Using a Mouse Xenograft Liver Model Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater Unfolding emergency calls stress granules to the ER
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