Human insulin as both antigen and protector in type 1 diabetes

Consortia: CMAI

Amdare NP, Shultz LD, Greiner DL, DiLorenzo TP.
Eur J Immunol. 2024 May 22:e2350949. doi: 10.1002/eji.202350949. Online ahead of print. PMID:38778498

All Unfolding emergency calls stress granules to the ER Human insulin as both antigen and protector in type 1 diabetes A Golden Hour and Golden Opportunity for β-Cell Preservation The integrated stress response in pancreatic development, tissue homeostasis, and cancer Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets CD4+ T Cells From Individuals With Type 1 Diabetes Respond to a Novel Class of Deamidated Peptides Formed in Pancreatic Islets Modeling type 1 diabetes progression using machine learning and single-cell transcriptomic measurements in human islets Proinflammatory stress activates neutral sphingomyelinase 2 based generation of a ceramide-enriched β cell EV subpopulation De novo identification of CD4(+) T cell epitopes Single cell regulatory architecture of human pancreatic islets suggests sex differences in β cell function and the pathogenesis of type 2 diabetes Do We Need a New Hypothesis for KATP Closure in β-Cells? Distinguishing the Baby From the Bathwater High affinity chimeric antigen receptor signaling induces an inflammatory program in human regulatory T cells Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturation miR-146a-5p mediates inflammation-induced β cell mitochondrial dysfunction and apoptosis Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis Diabetes as a Pancreatic Microvascular Disease-A Pericytic Perspective Interferons are key cytokines acting on pancreatic islets in type 1 diabetes Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis Immuno-Scanning Electron Microscopy of Islet Primary Cilia Reduction of chemokine CXCL9 expression by omega-3 fatty acids via ADP-ribosylhydrolase ARH3 in MIN6 insulin-producing cells A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort The immunology of type 1 diabetes Comparative and integrative single cell analysis reveals new insights into the transcriptional immaturity of stem cell-derived β cells DNA methylation-based assessment of cell composition in human pancreas and islets A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis Stress and human health in diabetes: A report from the 19(th) Chicago Biomedical Consortium symposium Mapping the daily rhythmic transcriptome in the diabetic retina Local dialogues between the endocrine and exocrine cells in the pancreas KD025 is a casein kinase 2 inhibitor that protects against glucolipotoxicity in beta cells SliceChip: a benchtop fluidic platform for organotypic culture and serial assessment of human and rodent pancreatic slices Discordant Effects of Polyamine Depletion by DENSpm and DFMO on β-cell Cytokine Stress and Diabetes Outcomes in Mice Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry RedRibbon: A new rank-rank hypergeometric overlap for gene and transcript expression signatures Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition NADPH Oxidase 2-Derived Reactive Oxygen Species Promote CD8+ T Cell Effector Function Protection of β cells against pro-inflammatory cytokine stress by the GDF15-ERBB2 signaling How to Test Human CAR T Cells in Solid Tumors, the Next Frontier of CAR T Cell Therapy Redirecting Human Conventional and Regulatory T Cells Using Chimeric Antigen Receptors Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes RFX6 maintains gene expression and function of adult human islet α cells Simplified homology-assisted CRISPR for gene editing in Drosophila Genetic risk converges on regulatory networks mediating early type 2 diabetes An Intraislet Paracrine Signaling Pathway That Enables Glucagon to Stimulate Pancreatic β-Cells Beta-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network A proteomic meta-analysis refinement of plasma extracellular vesicles


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