Topics Discussed:

• Introduction: RNA processing is an important layer of regulation in the islet
• RNA Splicing
  • Endocrine cell-specific RNA-Splicing
  • Alternate splicing in diabetic islets
  • Splicing defects contribute to beta cell dysfunction

• RNA Modifications
  • Types of mRNA modifications in metabolic tissues
  • Significance of m6A mRNA methylation in type 1 and type 2 diabetes
  • Role of m6A and pseudouridine in mRNA and carRNA regulation