Active Projects

  • Beta-cells 1st Responders and Functional Paracrine Networks in Healthy and Diabetic Human Islets View
  • Dissecting Chimeric Antigen Receptor Function in Human Regulatory T Cells View
  • Investigation of the Role of HNF1A in Increasing Susceptibility to Type 1 Diabetes View
  • Lactate-mediated Metabolic Reprogramming of Beta Cells in T1D Contributes to their Enhanced Plasticity and Dedifferentiation View
  • Measuring Islet-wide Function with Soft Integrated Nanoelectronics View
  • Tregs as Vehicles for Targeted Delivery of Therapeutic Payload to Human Islets View

Closed Projects

  • A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells View
  • Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry View
  • Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes? View
  • Changes in Human Islet Microvasculature during Type 1 Diabetes View
  • Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D View
  • Elucidating the Human Beta Cell Translatome in Health and Disease View
  • Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata View
  • Functional Testing of Candidate HSC-derived Islet Cells View
  • Generation of Functional Endocrine Cell Reporter Pluripotent Cell Lines View
  • HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes View
  • Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells View
  • Mass Spectrometry-based Proteome Maps for Human Islet Cells View
  • Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells View
  • Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM View
  • Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems View
  • Real-time in vivo Analysis of Islet Redox Dynamics View
  • Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function View
  • The Proteome of Replicating Cells View
  • The Role of Beta Cell Senescence in the Pathogenesis of Diabetes View
  • The SIRP:CD47 Signaling Pathway in Pancreatic Beta-Cell Survival View
  • Workshop for Continued Harmonization of Beta Cell Death Assays View
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Email: hirnec@coh.org