Editorial: alternative antigen processing and presentation in immune disorders

Consortia: CMAI, Opportunity Pool Projects

Alvarez I, Antón LC, James EA.
Front Immunol. 2022 Sep 7;13:993393. doi: 10.3389/fimmu.2022.993393. eCollection 2022. PMID:36159790

All K(ATP) channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells Checkpoint kinase 2 controls insulin secretion and glucose homeostasis HNF1α maintains pancreatic α and β cell functions in primary human islets Stress-induced β cell early senescence confers protection against type 1 diabetes Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles Inhibition of polyamine biosynthesis preserves β cell function in type 1 diabetes Dynamic scRNA-seq of live human pancreatic slices reveals functional endocrine cell neogenesis through an intermediate ducto-acinar stage An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals A bright future for glucagon and alpha cell biology Exocrine pancreas in type 1 and type 2 diabetes: different patterns of fibrosis, metaplasia, angiopathy, and adiposity Benchmarking algorithms for joint integration of unpaired and paired single-cell RNA-seq and ATAC-seq data Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes Deconstructing the integrated oscillator model for pancreatic β-cells The leptin receptor has no role in delta-cell control of beta-cell function in the mouse Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development Generation and molecular characterization of human pluripotent stem cell-derived pharyngeal foregut endoderm Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells Scalable generation of 3D pancreatic islet organoids from human pluripotent stem cells in suspension bioreactors Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses The beta cell-immune cell interface in type 1 diabetes (T1D) Complementary Approaches to Interrogate Mitophagy Flux in Pancreatic β-Cells Fatty acid-mediated signaling as a target for developing type 1 diabetes therapies Beta cell primary cilia mediate somatostatin responsiveness via SSTR3 DNA-barcoded signal amplification for imaging mass cytometry enables sensitive and highly multiplexed tissue imaging Generation of LexA enhancer-trap lines in Drosophila by an international scholastic network Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2 Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes A Chicken Tapasin ortholog can chaperone empty HLA-B∗37:01 molecules independent of other peptide-loading components SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells m 6 A mRNA Methylation Regulates Early Pancreatic β-Cell Differentiation Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes Protein disorder in the regulatory control of mitophagy Not the second fiddle: α cell development, identity and function in health and diabetes Human immune phenotyping reveals accelerated aging in type 1 diabetes Stromal Interaction Molecule 1 Maintains β Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas Cancer-associated fibroblast classification in single-cell and spatial proteomics data Inferring regulators of cell identity in the human adult pancreas Generation of the NeoThy mouse model for human immune system studies GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity


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