Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

Consortia: CHIB, HPAC, Opportunity Pool Projects

Jun Y, Nguyen-Ngoc KV, Sai S, Bender RHF, Gong W, Kravets V, Zhu H, Hatch CJ, Schlichting M, Gaetani R, Mallick M, Hachey SJ, Christman KL, George SC, Hughes CCW, Sander M.
Dev Cell. 2025 May 20:S1534-5807(25)00262-X. doi: 10.1016/j.devcel.2025.04.024. PMID:40412386

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protein partners of short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD) reveals keratin 8 as a novel candidate for interaction in pancreatic β-cells Insulin post-transcriptional regulation via PARP12-mediated ADP- ribosylation 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors Molecular and Inflammatory Etiologies of ß Cell Dysfunction in Type 1 Diabetes Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet 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crosstalk between the JAK/STAT and MAPKs pathways in human beta cells Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay The epigenetic landscape of fate decisions in T cells
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Email: hirnec@coh.org