New NIH-funded Projects Joining the HIRN Network

CMAD 

• Beta Cell Impairment in T1D: Insights from Glucose Metabolism in Human Pancreas Slices 
  Edward Phelps*, PhD, University of Florida (R01 DK147991)
  Clayton Mathews PhD, Co-Investigator, University of Florida
  Craig Vander Kooi, PhD, Co-Investigator, University of Florida

• Interrogating the Role of Environmental and Cellular Factors in Human T1D Pathophysiology using a Physiological, Isogenic 3D Platform 
  Cherie Stabler*, PhD, University of Florida (R56 DK144181)
  Holger Russ, PhD, Co-Investigator, University of Florida

• Isogenic Modeling of Immune-Beta Cell Interactions, Alterations in Beta Cell Phenotype, and Vulnerability to Cytotoxic Killing 
  Eddie James*, PhD, Benaroya Research Institute (R56 DK147805) 
  Adam Lacy-Hulbert, PhD, Co-Investigator, Benaroya Research Institute
  Jia Zhu, PhD, Co-Investigator, University of Washington

HPAC

• Novel Technologies to Detect Disrupted RNA Processing Events in Diabetic Islets 
  Lori Sussel*, PhD, University of Colorado, Denver (DP1 DK147830)

PanKbase

• Agentic and Generative AI for In Silico Modeling of Human Pancreatic Tissue in T1D 
  Jia Liu*, PhD, Harvard University (DP1 DK147907)
  Juan Alvarez, PhD, Co-Investigator, University of Pennsylvania
  Xiao Wang, PhD, Co-Investigator, Massachusetts Institute of Technology

* Denotes Contact PI