Projects
- Development of an Early Diagnostic Biomarker and Novel Treatment Strategy for T1D
- Discovery and Investigation of Noninvasive Diagnostic Potential of Circulating Pancreatic Islet Beta Cell Exosomes as Biomarkers of Beta Cell Injury
- Drivers and Consequences of Beta Cell DNA Damage in Type 1 Diabetes
- Elucidating the Human Beta Cell Translatome in Health and Disease
- High-Resolution Analysis of Juvenile Human Pancreas Maturation
- Interrogation of Dynamic RNA Modifications in Beta Cells in Type 1 Diabetes
- Non-invasive Detection of Cell Death in Type 1 Diabetes: Insight into Novel Disease Mechanisms
- Real-time in vivo Analysis of Islet Redox Dynamics
- Single Cell Resolution of Omics Analysis of T1D Islets
- Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed Imaging
- Biomarkers for Diabetes using Stem Cell-derived Beta Cells
- Biomarkers of Beta Cell Stress in Type 1 Diabetes (BetaMarker)
- Defining Islet Heterogeneity Using Single Islet Transcriptomics
- Epigenetic, Protein, and Cellular Biomarkers of Beta Cell Function in T1D
- Non-invasive Diagnosis of Human Beta Cell Damage and Death
- Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis
- Analysis of Human Autoreactive T Cell Receptors in vivo
- Genetic Regulation of Human Beta Cell Destruction
- HLA multimer based characterization of Islet Resident CD4+ T Cells that Target Beta Cell Epitopes and Neo-epitopes
- Human Islet-Infiltrating T cell Biology: Reactivity, Structure and Function
- Humanized Mouse Avatars for T1D
- Mice with Autologous Human T1D-Derived Immune Systems and iPSC-Derived Beta Cells
- Using Human Stem Cell-derived Thymic Epithelium to Remodel T1D Immune Tolerance
- Aptamer Chimeras for the in vivo Modulation of Beta Cell Mass and Immunogenicity
- Beta-cell Regeneration by Islet Cell Type Interconversion: Exploiting Islet Cell Plasticity for Diabetes Recovery
- CAR T Cell Targeting of Human Islets
- Development of Small Molecule-based Methods for Targeted Cargo Delivery to Beta Cells
- Epigenetic Rejuvenation of Human Beta-Cells
- Generating Novel Sources of Functional Human Insulin-secreting Cells for T1D Modeling
- In vivo Targeting of Diabetes-relevant Human Cell Types with rAAV Vectors
- Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human Pancreas
- Neuromodulation for Type 1 Diabetes: Harnessing Sensory Innervation to Promote Regeneration and Function of Insulin-Producing Cells.
- Targeting DNA Hydroxymethylation to Promote Human Beta Cell Function
- Therapeutic Targeting of the Human Islet Environment
- Changes in Human Islet Microvasculature during Type 1 Diabetes
- High-Resolution Characterization of Human Ductal Progenitor Cells and their Regeneration Potential
- In situ Analysis of Functional Endocrine, Vascular, and Immune Cell Interactions During Early Postnatal Development of the Human Pancreas
- Integrated Program for Human Pancreas Analysis
- Linking Islet Cell Function and Identity from in vitro to in situ
- Penn Integrated Human Pancreas Analysis Program
- Single Cell Analysis of the Human Pancreas in Type 1 Diabetes
- A New Immunodeficient Mouse Model with Stable Hyperglycemia for the Study of Human Beta-cells
- Can Genomic Mosaicism explain the Lobular Nature of Type 1 Diabetes?
- Functional Testing of Candidate HSC-derived Islet Cells
- Generation of Functional Endocrine Cell Reporter Pluripotent Cell Lines
- Quantitative Mass Spectrometry Analysis of Human Islet and Pancreas ECM
- Real-time Detection of Insulin Surrogate Markers within Physiomimetic Islet Microsystems
- The Proteome of Replicating Cells
- The Role of Beta Cell Senescence in the Pathogenesis of Diabetes
- Workshop for Continued Harmonization of Beta Cell Death Assays
- Antibodies for Beta-Cell Subtype Identification by Immunohistochemistry
- Characterization of in silico Reconstruction of TCRs for Modeling Autoreactive T cells in T1D
- Exploiting the power of CyTOF/Mass Cytometry (MC) to elucidate the complex interactions of islet and immune cells in human type 1 diabetes pancreata
- Islet-reactive TCR clones in humanized mice generated with type 1 diabetes patient vs. healthy control hematopoietic stem cells
- Mass Spectrometry-based Proteome Maps for Human Islet Cells