mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes

Consortia: CMAI

Jaafar R, Tran S, Shah A, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A.
J Clin Invest. 2019 Jul 2;130:4124-4137. doi: 10.1172/JCI127021. PMID:31265435

All Transcription factors combine to paint the methylation landscape Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry Microvessels enhance vascularization and function of transplanted insulin-producing cells Adult-Onset Type 1 Diabetes: Current Understanding and Challenges The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas Human islet T cells are highly reactive to preproinsulin in type 1 diabetes Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance Probing β-Cell Biology in Space and Time ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR The Immunoregulatory Role of the Signal Regulatory Protein Family and CD47 Signaling Pathway in Type 1 Diabetes Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2 New-onset IgG autoantibodies in hospitalized patients with COVID-19 A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype Combinatorial transcription factor profiles predict mature and functional human islet α and β cells From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes What is a β cell? – Chapter I in the Human Islet Research Network (HIRN) Review Series The pancreatic β cell response to secretory demands and adaption to stress A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation Integrated Metabolomics and Proteomics Analyses in the Local Milieu of Islet Allografts in Rejection versus Tolerance Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion ENTPD3 Marks Mature Stem Cell Derived Beta Cells Formed by Self-Aggregation in Vitro Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass Beta Cell Autophagy in the Pathogenesis of Type 1 Diabetes Insulin immunotherapy for pretype 1 diabetes Overexpression of the PTPN22 Autoimmune Risk Variant LYP-620W Fails to Restrain Human CD4(+) T Cell Activation Generation of functional human thymic cells from induced pluripotent stem cells Strategies for durable β cell replacement in type 1 diabetes 100 years of insulin: celebrating the past, present and future of diabetes therapy A microfluidic system for monitoring glucagon secretion from human pancreatic islets of Langerhans Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP(C), in type 1 diabetes Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs Imaging alloreactive T cells provides early warning of organ transplant rejection Genetic engineering of T cells for immunotherapy From type 1 diabetes biology to therapy: The Human Islet Research Network Addressing Compound Reactivity and Aggregation Assay Interferences: Case Studies of Biochemical High-Throughput Screening Campaigns Benefiting from the National Institutes of Health Assay Guidance Manual Guidelines New Aspects of Diabetes Research and Therapeutic Development Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes? Designing biomaterials for the modulation of allogeneic and autoimmune responses to cellular implants in Type 1 Diabetes A New Hypothesis for Type 1 Diabetes Risk: The At-Risk Allele at rs3842753 Associates With Increased Beta-cell INS Messenger RNA in a Meta-Analysis of Single-Cell RNA-Sequencing Data
Follow
×

Follow

us on our social networks.

Email: hirnec@coh.org