Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice

Consortia: CTAR

Auyeung VC, Steinberg TL, Olivier A, Suzuki L, Moreno ME, Khan IS, Downey MS, Thamsen M, Guo L, Maly DJ, Backes BJ, Sheppard D, Papa FR.
J Clin Invest. 2025 Oct 15;135(20):e184522. doi: 10.1172/JCI184522. eCollection 2025 Oct 15. PMID:41090357

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β-cell regeneration in situ by the ALK3 agonist THR-123 Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy
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