Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

Consortia: CBDS, CHIB, HPAC

Huber MK, Widener AE, Cuaycal AE, Smurlick D, Butterworth EA, Lenchik NI, Chen J, Beery M, Hiller H, Verney E, Kusmartseva I, Rupnik MS, Campbell-Thompson M, Gerling IC, Atkinson MA, Mathews CE, Phelps EA.
Cell Rep. 2025 Aug 26;44(9):116174. doi: 10.1016/j.celrep.2025.116174. Online ahead of print. PMID:40875294

All Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis Protein carbamylation and proteomics: from artifacts to elucidation of biological functions Histopathology-based protein multiplex generation using deep learning The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes Increased longevity of circulating human IgG in an NSG Fc gamma receptor-1 deficient humanized mouse model Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy Divergent Cell-Type Specific Hypoxia Responses in Human Stem Cell-Derived and Primary Islets Spatially Bound Functional Heterogeneity Drives Modular Organization in Beta Cell Networks Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes The pathophysiology, presentation and classification of Type 1 diabetes The Heterogeneity of Type 1 Diabetes: Implications for Pathogenesis, 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integrating diverse genomic modalities and comprehensive genomic knowledge Diabetes mellitus polygenic risk scores: heterogeneity and clinical translation Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors Molecular and Inflammatory Etiologies of ß Cell Dysfunction in Type 1 Diabetes Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative Advances in Cell Replacement Therapies for Diabetes Functional and Mechanistic Explanation for the Unique Clinical Success of the Glucokinase Activator Dorzagliatin in the Treatment of Type 2 Diabetes Bend It Like Occam: Ductal Origin of New Islet Cells in Human Pancreas After Injury DEC1 Regulates Human β Cell Functional Maturation and Circadian Rhythm Chimeric anti-HLA antibody receptor engineered human regulatory T cells suppress alloantigen-specific B cells from pre-sensitized transplant recipients
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Email: hirnec@coh.org