The antigen presentation landscape of cytokine-stressed human pancreatic islets

Consortia: CMAI, HPAC

Nanaware PP, Calvo-Calle JM, Redick SD, Tarpley MW, Cruz J, Clement CC, Manganaro A, Velarde de la Cruz EE, Muneeruddin K, Faulkner M, Wang JP, Shaffer SA, Harlan DM, Santambrogio L, Kent SC, Stern LJ.
Cell Rep. 2025 Jul 18;44(8):115927. doi: 10.1016/j.celrep.2025.115927. PMID:40684438

All LONP1 loss causes mitochondrial mayhem in β-cells The antigen presentation landscape of cytokine-stressed human pancreatic islets A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens Exendin-4 enhances insulin-positive phenotype of human pluripotent stem cell-derived β cells during transplantation Improved conditioning for hematopoietic chimerism induces islet tolerance to cure diabetes OLIVE Provides Rapid Visualization and Analysis of Chromatin Tracing Experiments Inference of multi-enhancer interactions in T lymphocytes using Hi-Cociety Scalable 3D Bioprinting of Human Islets in a Pancreatic Decellularized Extracellular Matrix-Enriched Bioink for Beta-Cell Replacement Therapy Microvascular homeostasis is compromised in pancreatic islets in a mouse model of beta cell loss and low-grade inflammation Challenges and Opportunities for Understanding the Pathogenesis of Type 1 Diabetes: An Endocrine Society Scientific Statement Epigenetic 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diabetes candidate genes PTPN2 and BACH2 regulate novel IFN-α-induced crosstalk between the JAK/STAT and MAPKs pathways in human beta cells Genetic protection from type 1 diabetes resulting from accelerated insulin mRNA decay The epigenetic landscape of fate decisions in T cells Target Discovery to Diabetes Therapy-TXNIP From Bench to Bedside With NIDDK Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice IFN-α Induces Heterogenous ROS Production in Human β-Cells Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression The XCL1/XCR1 axis is upregulated in type 1 diabetes and aggravates its pathogenesis Expanding the engineered Treg multiverse TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and -independent mitophagy A Recombinase-Mediated Cassette Exchange Platform for a Triple Independent Inducible Expression System for Human Pluripotent Stem Cells
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