3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

Consortia: HIREC, HPAC

Rippa A, Posgai AL, Currlin S, Brusko M, Williams MD, Kaddis JS, Kusmartseva I, Wasserfall CH, Campbell-Thompson M, Atkinson MA.
bioRxiv [Preprint]. 2025 May 18:2025.05.14.654045. doi: 10.1101/2025.05.14.654045. PMID:40463108

All T cell and autoantibody recognition of nucleus-associated islet autoantigens in individuals with type 1 diabetes Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets 3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors Molecular and Inflammatory Etiologies of ß Cell Dysfunction in Type 1 Diabetes Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative Bend It Like Occam: Ductal 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