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The Identity of Human Tissue-Emigrant CD8(+) T Cells
Consortia:
HPAC
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Intrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity
Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes
SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
m 6 A mRNA Methylation Regulates Early Pancreatic β-Cell Differentiation
Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes
Protein disorder in the regulatory control of mitophagy
Human immune phenotyping reveals accelerated aging in type 1 diabetes
Stromal Interaction Molecule 1 Maintains β Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling
The pathogenic “symphony” in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas
Inferring regulators of cell identity in the human adult pancreas
Generation of the NeoThy mouse model for human immune system studies
GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models
Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity
Protocol to generate and utilize pancreatic tissue slices to study endocrine and exocrine physiology in situ from mouse and human tissue
Major β cell-specific functions of NKX2.2 are mediated via the NK2-specific domain
Human circulating and tissue-resident memory CD8(+) T cells
Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes
Pancreatic regional blood flow links the endocrine and exocrine diseases
Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response
Analysis of a macrophage carbamylated proteome reveals a function in post-translational modification crosstalk
Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing
Title: β Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes Risk
Enrichment of stem cell-derived pancreatic beta-like cells and controlled graft size through pharmacological removal of proliferating cells
Acrylic-based culture plate format perfusion device to establish liver endothelial-epithelial interface
cytoviewer: an R/Bioconductor package for interactive visualization and exploration of highly multiplexed imaging data
m (6) A mRNA Methylation in Brown Adipose Tissue Regulates Systemic Insulin Sensitivity via an Inter-Organ Prostaglandin Signaling Axis
Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood
Immune engineered extracellular vesicles to modulate T cell activation in the context of type 1 diabetes
Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model
Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation
Immunotherapy With Low-Dose IL-2/CD25 Prevents β-Cell Dysfunction and Dysglycemia in Prediabetic NOD Mice
Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8(+) T cells
A genomic data archive from the Network for Pancreatic Organ donors with Diabetes
Integrating genetics with single-cell multiomic measurements across disease states identifies mechanisms of beta cell dysfunction in type 2 diabetes
Senescence: a double-edged sword in beta-cell health and failure?
Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells
β-Cell Function and Insulin Sensitivity in Youth With Early Type 1 Diabetes From a 2-Hour 7-Sample OGTT
Strong ubiquitous micro-promoters for recombinant adeno-associated viral vectors
Extrahepatic transplantation of 3D cultured stem cell-derived islet organoids on microporous scaffolds
Single-cell expression profiling of islets generated by the Human Pancreas Analysis Program
Origin, phenotype and autoimmune potential of T cells in human immune system mice receiving neonatal human thymus tissue
Interpreting non-coding disease-associated human variants using single-cell epigenomics
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
Rediscovering Primary Cilia in Pancreatic Islets
The human α cell in health and disease
Stomach-derived human insulin-secreting organoids restore glucose homeostasis
Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration
Ca(2+) Release or Ca(2+) Entry, that is the Question: What Governs Ca(2+) Oscillations in Pancreatic Beta Cells?
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