Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes

Consortia: HPAC

Medina-Serpas MA, Brusko M, Golden GJ, Campbell-Thompson M, Rogers T, Reardon S, Posgai AL, Bacher R, Luning Prak ET, Liu C, Kaestner KH, Naji A, Betts MR, McIntyre LM, Atkinson MA, Brusko TM. Cell Rep. 2026 Mar 23;45(4):117144. doi: 10.1016/j.celrep.2026.117144. PMID: 41875135 

Published Works Development and validation of a model using routine clinical features to improve diabetes diagnosis Defining the islet: a minimum size threshold and opportunities for standardization Type 1 diabetes SIRPG risk variants increase SIRPγ expression and CD47 loss enhances CD8(+) T cell cytotoxicity Discovery of Post-Translationally Modified Epitopes in Autoimmunity: Someone Has to Fish so Everyone Can Eat Biosensor cell array reveals temporal GABA secretion dynamics from pancreatic islets Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate m(6)A mRNA methylation regulates pancreatic α-cell plasticity Deletion of the T1D risk gene Ormdl3 in β-cells does not impact disease progression Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy The SenKiller Mouse: Enabling Cell Type-Specific Ablation of Senescent Cells Developmental Control of DNA Damage Responses in α- and β-Cells Shapes the Selective β-Cell Susceptibility in Diabetes Applications of Stem Cell-Derived Islets and Emerging Experimental Platforms to Understand Diabetes Dissecting human organ development using spatial technologies AutoPCR: automated phenotype concept recognition by prompting Imaging mass cytometry reveals functional and immunological changes during type 1 diabetes progression in human pancreata Mapping histologic and functional maturation of human endocrine pancreas across early postnatal periods Challenges and future directions of AIRR-seq-based diagnostics Assessing Extracellular Vesicle Proteins as Predictive Biomarkers for Developing Type 1 Diabetes Optimizing post-transplantation detection of subcutaneously transplanted islets using dithizone staining Real-time in vivo analysis of murine β cells reveals autophagic flux defects before onset of autoimmune diabetes A mitochondrial ROS-dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetes Supervised machine learning identifies impaired mitochondrial quality control in β-cells with development of type 2 diabetes Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport New and emerging therapies in type 1 diabetes mellitus Accounting for Age-Related Increases in HbA1c More Accurately Quantifies Risk of Type 1 Diabetes Progression in Islet Autoantibody-Positive Adults Differential Contributions of IgM and IgG Autoantibodies to Serologic IA2 Reactivity in Type 1 Diabetes Epigenetic adaptation of beta cells across lifespan and disease Beta cell microRNAs function as molecular hubs of type 1 diabetes pathogenesis and as biomarkers of diabetes risk Whole-genome CRISPR screening identifies genetic modifiers of stem cell-derived islet transplantation Beyond bystanders: How β cell stress shapes the autoimmune response in T1D Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes Enhanced hypoxia resistance distinguishes human pluripotent stem cell-derived islets from primary islets Paracrine inhibition via G protein inwardly rectifying potassium channels regulates glucagon secretion from human pancreatic alpha cells Islet-derived T cells from both mice and humans recognize conserved insulin A-chain peptides presented by HLA-C*03:04 Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles Lysine Targeting Group-Transfer Chimeras for Proximity Induction Differential immune- and apoptosis-related gene signatures in pancreatic alpha and beta cells contribute to their fate in type 1 diabetes BRD4 Phosphorylation Regulates the Structure of Chromatin Nanodomains Longitudinal monitoring of type 1 diabetes progression to disease onset Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets Baseline Insulin Secretion Determines Response to Abatacept in Stage 1 Type 1 Diabetes Persistent urinary metabolic signatures in children with type 1 diabetes Activating Muscarinic Receptor Signaling in Intrapancreatic Neurons Is Required for Parasympathetic Cholinergic Control of Pancreatic Cell Function The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis DEC1 regulates human β cell functional maturation and circadian rhythm Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells ADAR1 editing is necessary for only a small subset of cytosolic dsRNAs to evade MDA5-mediated autoimmunity CelLink: integrating single-cell multi-omics data with weak feature linkage and imbalanced cell populations Compressed sensing expands the multiplexity of imaging mass cytometry Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge
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Email: hirnec@coh.org